Cross-Species Insights Into Genomic Adaptations to Hypoxia.

abstract：:Analysis of the relationships among wild species of section Moutan in the plant genus Paeonia has traditionally been problematic. Interspecies relationships cannot be effectively determined using phenotypic traits alone or through analysis of nuclear or chloroplast DNA fragments. Elucidation of complete chloroplast ge...

journal_title：Frontiers in genetics

authors： Wu L,Nie L,Xu Z,Li P,Wang Y,He C,Song J,Yao H

更新日期：2020-09-18 00:00:00

abstract：:Purpose: The present study examines the role of Sox11 in the initial response of retinal ganglion cells (RGCs) to axon damage and in optic nerve regeneration in mouse. Methods: Markers of retinal injury were identified using the normal retina database and optic nerve crush (ONC) database on GeneNetwork2 (www.genenetwo...

journal_title：Frontiers in genetics

authors： Li Y,Struebing FL,Wang J,King R,Geisert EE

更新日期：2018-12-18 00:00:00

abstract：:History of East-Central Europe has been intertwined with the history of Turks in the past. A significant part of this region of Europe has been fallen under Ottoman control during the 150 years of Ottoman occupation in the 16-17th centuries. The presence of the Ottoman Empire affected this area not only culturally but...

journal_title：Frontiers in genetics

authors： Bánfai Z,Melegh BI,Sümegi K,Hadzsiev K,Miseta A,Kásler M,Melegh B

更新日期：2019-06-13 00:00:00

abstract：:Metastasis is a complex process that involved in various genetic and epigenetic alterations during the progression of breast cancer. Recent evidences have indicated that the mutation in the genome sequence may not be the key factor for increasing metastatic potential. Epigenetic changes were revealed to be important f...

journal_title：Frontiers in genetics

authors： Zhuang J,Huo Q,Yang F,Xie N

更新日期：2020-10-29 00:00:00

abstract：:The effective population size over time (demographic history) can be retraced from a sample of contemporary DNA sequences. In this paper, we propose a novel methodology based on importance sampling (IS) for exploring such demographic histories. Our starting point is the generalized skyline plot with the main differenc...

journal_title：Frontiers in genetics

authors： Ait Kaci Azzou S,Larribe F,Froda S

更新日期：2015-08-07 00:00:00

abstract：:Pharmacogenomics is the study of how genes affect a person's response to drugs. Thus, understanding the effect of drug at the molecular level can be helpful in both drug discovery and personalized medicine. Over the years, transcriptome data upon drug treatment has been collected and several databases compiled before ...

journal_title：Frontiers in genetics

authors： Oh M,Park S,Lee S,Lee D,Lim S,Jeong D,Jo K,Jung I,Kim S

更新日期：2020-11-12 00:00:00

abstract：:Genetically inherited defects in lipoprotein metabolism affect more than 10 million individuals around the globe with preponderance in some parts where consanguinity played a major role in establishing founder mutations. Mutations in four genes have been so far linked to the dominant and recessive form of the disease....

journal_title：Frontiers in genetics

authors： Kamar A,Khalil A,Nemer G

更新日期：2021-01-15 00:00:00

abstract：:Genetic variants can influence the expression of mRNA and protein. Genetic regulatory loci such as expression quantitative trait loci (eQTLs) and protein quantitative trait loci (pQTLs) exist in several species. However, it remains unclear how human genetic variants regulate mRNA and protein expression. Here, we chara...

journal_title：Frontiers in genetics

authors： Wang Y,He B,Zhao Y,Reiter JL,Chen SX,Simpson E,Feng W,Liu Y

更新日期：2019-09-10 00:00:00

abstract：:Ethylmalonic encephalopathy (EE) is a very rare autosomal recessive metabolic disorder that primarily affects children. Less than one hundred EE patients have been diagnosed worldwide. The clinical manifestations include chronic diarrhea, petechiae, orthostatic acrocyanosis, psychomotor delay and regression, seizures,...

journal_title：Frontiers in genetics

authors： Chen X,Han L,Yao H

更新日期：2020-04-17 00:00:00

abstract：:A variety of statistical methods, such as admixture models, have been used to estimate genomic breed composition (GBC). These methods, however, tend to produce non-zero components to reference breeds that shared some genomic similarity with a test animal. These non-essential GBC components, in turn, offset the estimat...

journal_title：Frontiers in genetics

authors： Wang Y,Wu XL,Li Z,Bao Z,Tait RG Jr,Bauck S,Rosa GJM

更新日期：2020-06-11 00:00:00

abstract：:In this article, we make a theoretical and in silico study for uncovering and evaluating biomarkers in colon and rectal cancer (CRC) by the dynamic network biomarker (DNB) theory. We propose a strategy to employ the theoretical concept of UICC TNM classification in CRC. To reveal the critical transition of CRC, the DN...

journal_title：Frontiers in genetics

authors： Tong Y,Song Y,Xia C,Deng S

更新日期：2020-10-20 00:00:00

abstract：:The study of microorganisms that pervade each and every part of this planet has encountered many challenges through time such as the discovery of unknown organisms and the understanding of how they interact with their environment. The aim of this review is to take the reader along the timeline and major milestones tha...

journal_title：Frontiers in genetics

authors： Escobar-Zepeda A,Vera-Ponce de León A,Sanchez-Flores A

更新日期：2015-12-17 00:00:00

abstract：:Excessive fat deposition can cause chicken health problem, and affect production efficiency by causing great economic losses to the industry. However, the molecular underpinnings of the complex adiposity trait remain elusive. In the current study, we constructed and compared the gene co-expression networks on four tra...

journal_title：Frontiers in genetics

authors： Gao Z,Ding R,Zhai X,Wang Y,Chen Y,Yang CX,Du ZQ

更新日期：2020-05-29 00:00:00

abstract：:Assortative mating is a universal feature of human societies, and individuals from ethnically diverse populations are known to mate assortatively based on similarities in genetic ancestry. However, little is currently known regarding the exact phenotypic cues, or their underlying genetic architecture, which inform anc...

journal_title：Frontiers in genetics

authors： Norris ET,Rishishwar L,Wang L,Conley AB,Chande AT,Dabrowski AM,Valderrama-Aguirre A,Jordan IK

更新日期：2019-04-24 00:00:00

abstract：:Mosquitoes are one of the deadliest animals on earth because of their ability to transmit a wide range of human pathogens. Traditional mosquito control methods use chemical insecticides, but with dwindling long-term effectiveness and negative effects on the environment, microbial forms of control have become common al...

journal_title：Frontiers in genetics

authors： Dacey DP,Chain FJJ

更新日期：2020-10-07 00:00:00

abstract：:Familial hemophagocytic lymphohistiocytosis Type 2 (FHL2) associated central nervous system (CNS) involvement is less understood in children, especially when considering neurologic manifestations as part of the initial presentation. We conducted a retrospective review of the clinical manifestations and genetic abnorma...

journal_title：Frontiers in genetics

authors： Feng WX,Yang XY,Li JW,Gong S,Wu Y,Zhang WH,Han TL,Zhuo XW,Ding CH,Fang F

更新日期：2020-03-04 00:00:00

abstract：:In the last few years, the role of non-coding regulatory elements and their involvement in human disease have received great attention. Among the non-coding regulatory sequences, enhancers are particularly important for the proper establishment of cell type-specific gene-expression programs. Furthermore, the disruptio...

journal_title：Frontiers in genetics

authors： Sánchez-Gaya V,Mariner-Faulí M,Rada-Iglesias A

更新日期：2020-07-20 00:00:00

abstract：:Aspirin exacerbated respiratory disease (AERD) is a set of diseases of the unified airway, and its physiopathology is related to disruption of the metabolism of arachidonic acid (AA). Genetic association studies in AERD had explored single nucleotide polymorphism (SNPs) in several genes related to many mechanisms (AA ...

journal_title：Frontiers in genetics

authors： Pavón-Romero GF,Pérez-Rubio G,Ramírez-Jiménez F,Ambrocio-Ortiz E,Bañuelos-Ortiz E,Alvarado-Franco N,Xochipa-Ruiz KE,Hernández-Juárez E,Flores-García BA,Camarena ÁE,Terán LM,Falfán-Valencia R

更新日期：2018-09-11 00:00:00

abstract：:Identification of non-protein-coding RNAs (ncRNAs) in genomes is a crucial task for not only molecular cell biology but also bioinformatics. Secondary structures of ncRNAs are employed as a key feature of ncRNA analysis since biological functions of ncRNAs are deeply related to their secondary structures. Although the...

journal_title：Frontiers in genetics

authors： Okada Y,Saito Y,Sato K,Sakakibara Y

更新日期：2011-08-31 00:00:00

abstract：:Detection of differentially expressed genes is a common task in single-cell RNA-seq (scRNA-seq) studies. Various methods based on both bulk-cell and single-cell approaches are in current use. Due to the unique distributional characteristics of single-cell data, it is important to compare these methods with rigorous st...

journal_title：Frontiers in genetics

authors： Mou T,Deng W,Gu F,Pawitan Y,Vu TN

更新日期：2020-01-17 00:00:00

abstract：:The microbiome is known to have a profound effect on the development, physiology and health of its host. Whether and how it also contributes to evolutionary diversification of the host is, however, unclear. Here we hypothesize that disruption of the microbiome by new stressful environments interferes with host-microbe...

journal_title：Frontiers in genetics

authors： Soen Y

更新日期：2014-06-20 00:00:00

abstract：:In 1994, it was suggested that AGG interruptions affect the stability of the fragile X triplet repeat. Until recently, however, this hypothesis was not explored on a large scale due primarily to the technical difficulty of determining AGG interruption patterns of the two alleles in females. The recent development of a...

journal_title：Frontiers in genetics

authors： Latham GJ,Coppinger J,Hadd AG,Nolin SL

更新日期：2014-07-29 00:00:00

abstract：:In spite of the significant advancements in the treatment modalities, 30% of advanced stage ovarian cancer (OC) patients do not respond to the standard chemotherapeutic regimen and most of the responders finally relapse over time due to the escalation of multidrug resistance (MDR) Phenomenon. Our present study evaluat...

journal_title：Frontiers in genetics

authors： Haque A,Sait KHW,Alam Q,Alam MZ,Anfinan N,Wali AWN,Rasool M

更新日期：2020-05-26 00:00:00

abstract：:Cardiovascular diseases are a leading cause of morbidity and mortality in Western societies. It is now well established that microRNAs (miRNAs) are determinant regulators in various medical conditions including cardiovascular diseases. The recent discovery that miRNAs, while associated with different carriers, can be ...

journal_title：Frontiers in genetics

authors： Kinet V,Halkein J,Dirkx E,Windt LJ

更新日期：2013-11-12 00:00:00

abstract：:Imprinted loci play a critical role in fetal development. Their expression is often regulated by CCCTC-binding factor (CTCF) protein binding at imprinting control regions (ICRs). Prenatal alcohol exposure has been shown to reduce global DNA methylation in the developing mouse fetus. This study explored the effect of p...

journal_title：Frontiers in genetics

authors： Knezovich JG,Ramsay M

更新日期：2012-02-22 00:00:00

abstract：:The tropical Andes are a hotspot of biodiversity, but detailed altitudinal and latitudinal distribution patterns of species are poorly understood. We compare the distribution and diversity patterns of four Andean plant groups on the basis of georeferenced specimen data: the genus Nasa (Loasaceae), the two South Americ...

journal_title：Frontiers in genetics

authors： Mutke J,Jacobs R,Meyers K,Henning T,Weigend M

更新日期：2014-10-10 00:00:00

abstract：:In this case report, we characterize a novel inherited frameshift mutation c.4700_4701del (p.Phe1567Cysfs*221) in a single copy of the SCN5A gene and its association with Brugada syndrome (BrS). The proband experienced a life-threatening ventricular arrhythmia successfully treated with DC-shock and he also suffered fr...

journal_title：Frontiers in genetics

authors： Micaglio E,Monasky MM,Ciconte G,Vicedomini G,Conti M,Mecarocci V,Giannelli L,Giordano F,Pollina A,Saviano M,Pozzi PR,Di Resta C,Benedetti S,Ferrari M,Santinelli V,Pappone C

更新日期：2019-06-06 00:00:00

abstract：:Pearl millet is a climate-resilient, drought-tolerant crop capable of growing in marginal environments of arid and semi-arid regions globally. Pearl millet is a staple food for more than 90 million people living in poverty and can address the triple burden of malnutrition substantially. It remained a neglected crop un...

journal_title：Frontiers in genetics

authors： Srivastava RK,Singh RB,Pujarula VL,Bollam S,Pusuluri M,Chellapilla TS,Yadav RS,Gupta R

更新日期：2020-02-28 00:00:00

abstract：:The genetic diversity of the sheep breeds in the Arab countries might be considered to be a mirror of the ecology of the region. In this study, the genetic structure and diversity of sheep breeds from Saudi Arabia (Harri, Najdi, Naemi, Arb, and Rufidi) and Awassi sheep from Jordan as an out-group were investigated usi...

journal_title：Frontiers in genetics

authors： Al-Atiyat RM,Aljumaah RS,Alshaikh MA,Abudabos AM

更新日期：2018-09-25 00:00:00

abstract：:An increasing number of studies have shown that long intergenic non-coding RNAs (lincRNAs) are a very important class of non-coding RNAs that plays a vital role in many biological processes. Adipose tissue is an important place for storing energy, but few studies on lincRNAs were related to pig subcutaneous fat develo...

journal_title：Frontiers in genetics

authors： Shi G,Chen L,Chen G,Zou C,Li J,Li M,Fang C,Li C

更新日期：2019-03-04 00:00:00