Postoperative oral nutritional supplementation after major gastrointestinal surgery: a randomized controlled clinical trial.

Abstract:

BACKGROUND AND OBJECTIVES:This study aimed to evaluate the efficacy of post-operative oral nutrition supplementation after major gastrointestinal surgery. METHODS AND STUDY DESIGN:A prospective randomized controlled trial was conducted to evaluate 174 subjects who were discharged within 2 weeks after major gastrointestinal surgery. The subjects in the study group were prescribed 400 ml/day of Encover® from the day of discharge for 8 weeks, but no supplementation was allowed in the control group. The primary endpoint was the weight loss rate at 8 weeks after discharge compared with the pre-operative weight, and the secondary endpoints included changes in body weight, body mass index, Patient-Generated Subjective Global Assessment score/grade, hematological/ biochemical parameters, and adverse events evaluated at 2, 4, and 8 weeks after discharge. RESULTS:The weight loss rate at 8 weeks after discharge did not differ between two groups (4.23±5.49% vs 4.80±4.84%, p=0.481). The total lymphocyte count, the level of total cholesterol, total protein, and albumin were significantly higher in the study group after discharge. Diarrhea was the most frequent adverse event, and the incidence of adverse events with a severity score of >=3 did not differ between groups (2.3% vs 1.2%). CONCLUSIONS:The utility of routine oral nutritional support after major gastrointestinal surgery was not proven in terms of weight loss at 8 weeks after discharge. However, it can be beneficial for early recovery of biochemical parameters.

journal_name

Asia Pac J Clin Nutr

authors

Kong SH,Park JS,Lee IK,Ryu SW,Park YK,Yang HK,Han SU,Yoon KY,Jeong SY,Jeong MR,Hwang DW,Suh YS,Yoon YS,Seo KW,Park JW,Byun CS,Hur H,Won H,Choi Y,Lee HJ

doi

10.6133/apjcn.112016.02

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

811-819

issue

5

eissn

0964-7058

issn

1440-6047

journal_volume

26

pub_type

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