Abstract：
BACKGROUND:Lateral neck lymph node (LN) metastases (N1b) have been identified as independent risk factors of recurrence in patients with papillary thyroid carcinoma (PTC). OBJECTIVE:This study aimed to determine the predictive factors of recurrence in N1b PTC patients and to clarify the postoperative event patterns. METHODS:All patients who underwent operation for N1b PTC between 1978 and 2012 were reviewed. The median follow-up period was 6.5 years. RESULTS:In total, 344 N1b patients were included. Twenty-four patients (7%) were lost to long-term follow-up. Among the remaining 320 patients, the mean (± SD) follow-up time was 8.9 ± 8.8 years (median, 6.5; range, 2-36.4). Eighty-two patients (26%) presented with lymph node recurrence (LR). Multivariate analyses showed that LN metastases with extracapsular extension and the LN ratio (ratio between the number of N1 and number of resected LN) in the lateral compartment were independent predictors of recurrent disease. The median time to reoperation was 19 months (range, 3-173), with 79% of reoperations occurring within 2 years after the initial thyroidectomy. Reoperations for LR (75 patients) were performed in 76% of the patients with a focused minimal access approach or selective LN dissection. After curative reoperative surgery for recurrence, complications occurred in 6 patients (8%), including a 1% permanent complication rate. CONCLUSION:Extranodal extension of LN metastases and the LN ratio in the lateral compartment are prognostic factors for recurrence. In most cases, reoperation for LR can be performed with a focused minimal access approach, with a low morbidity rate.
journal_name
Surgeryjournal_title
Surgeryauthors
Chéreau N,Buffet C,Trésallet C,Tissier F,Leenhardt L,Menegaux Fdoi
10.1016/j.surg.2015.08.033subject
Has Abstractpub_date
2016-03-01 00:00:00pages
755-62issue
3eissn
0039-6060issn
1532-7361pii
S0039-6060(15)00704-7journal_volume
159pub_type
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