当前位置： SCI文献检索 > PHYSICS IN MEDICINE AND BIOLOGY期刊下所有文献 > 50 μm pixel pitch wafer-scale CMOS active pixel sensor x-ray detector for digital breast tomosynthesis.

50 μm pixel pitch wafer-scale CMOS active pixel sensor x-ray detector for digital breast tomosynthesis.

Abstract：

:Wafer-scale CMOS active pixel sensors (APSs) have been developed recently for x-ray imaging applications. The small pixel pitch and low noise are very promising properties for medical imaging applications such as digital breast tomosynthesis (DBT). In this work, we evaluated experimentally and through modeling the imaging properties of a 50 μm pixel pitch CMOS APS x-ray detector named DynAMITe (Dynamic Range Adjustable for Medical Imaging Technology). A modified cascaded system model was developed for CMOS APS x-ray detectors by taking into account the device nonlinear signal and noise properties. The imaging properties such as modulation transfer function (MTF), noise power spectrum (NPS), and detective quantum efficiency (DQE) were extracted from both measurements and the nonlinear cascaded system analysis. The results show that the DynAMITe x-ray detector achieves a high spatial resolution of 10 mm(-1) and a DQE of around 0.5 at spatial frequencies  <1 mm(-1). In addition, the modeling results were used to calculate the image signal-to-noise ratio (SNRi) of microcalcifications at various mean glandular dose (MGD). For an average breast (5 cm thickness, 50% glandular fraction), 165 μm microcalcifications can be distinguished at a MGD of 27% lower than the clinical value (~1.3 mGy). To detect 100 μm microcalcifications, further optimizations of the CMOS APS x-ray detector, image aquisition geometry and image reconstruction techniques should be considered.

journal_name

Phys Med Biol

journal_title

Physics in medicine and biology

authors

Zhao C,Konstantinidis AC,Zheng Y,Anaxagoras T,Speller RD,Kanicki J

doi

10.1088/0031-9155/60/23/8977

subject

Has Abstract

pub_date

2015-12-07 00:00:00

pages

8977-9001

issue

23

eissn

0031-9155

issn

1361-6560

journal_volume

60

pub_type

杂志文章

相关文献

PHYSICS IN MEDICINE AND BIOLOGY文献大全
  • Evaluation of high performance data acquisition boards for simultaneous sampling of fast signals from PET detectors.

    abstract：:Detectors used for positron emission tomography (PET) provide fast, randomly distributed signals that need to be digitized for further processing. One possibility is to sample the signals at the peak initiated by a trigger from a constant fraction discriminator (CFD). For PET detectors, simultaneous acquisition of man...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/50/1/003

    authors： Judenhofer MS,Pichler BJ,Cherry SR

    更新日期：2005-01-07 00:00:00

  • A fast inverse consistent deformable image registration method based on symmetric optical flow computation.

    abstract：:Deformable image registration is widely used in various radiation therapy applications including daily treatment planning adaptation to map planned tissue or dose to changing anatomy. In this work, a simple and efficient inverse consistency deformable registration method is proposed with aims of higher registration ac...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/53/21/017

    authors： Yang D,Li H,Low DA,Deasy JO,El Naqa I

    更新日期：2008-11-07 00:00:00

  • On MEG forward modelling using multipolar expansions.

    abstract：:Magnetoencephalography (MEG) is a non-invasive functional imaging modality based on the measurement of the external magnetic field produced by neural current sources within the brain. The reconstruction of the underlying sources is a severely ill-posed inverse problem typically tackled using either low-dimensional par...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/47/4/301

    authors： Jerbi K,Mosher JC,Baillet S,Leahy RM

    更新日期：2002-02-21 00:00:00

  • A new optimal wavelength for treatment of port wine stains?

    abstract：:In this study we investigate light penetration into skin in order to define the optimal wavelength for the treatment of port wine stains. A two-layer model (epidermis and dermis) is applied with a cylindric tube representing the ectatic blood vessel. Light propagation is calculated by the Monte Carlo method. Values fo...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/40/10/001

    authors： Kienle A,Hibst R

    更新日期：1995-10-01 00:00:00

  • The validation of tomotherapy dose calculations in low-density lung media.

    abstract：:The dose-calculation accuracy of the tomotherapy Hi-Art II(R) (Tomotherapy, Inc., Madison, WI) treatment planning system (TPS) in the presence of low-density lung media was investigated. In this evaluation, a custom-designed heterogeneous phantom mimicking the mediastinum geometry was used. Gammex LN300 and balsa wood...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/54/8/004

    authors： Chaudhari SR,Pechenaya OL,Goddu SM,Mutic S,Rangaraj D,Bradley JD,Low D

    更新日期：2009-04-21 00:00:00

  • Independent Monte-Carlo dose calculation for MLC based CyberKnife radiotherapy.

    abstract：:This work aims to develop, implement and validate a Monte Carlo (MC)-based independent dose calculation (IDC) framework to perform patient-specific quality assurance (QA) for multi-leaf collimator (MLC)-based CyberKnife® (Accuray Inc., Sunnyvale, CA) treatment plans. The IDC framework uses an XML-format treatment plan...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aa97f8

    authors： Mackeprang PH,Vuong D,Volken W,Henzen D,Schmidhalter D,Malthaner M,Mueller S,Frei D,Stampanoni MFM,Dal Pra A,Aebersold DM,Fix MK,Manser P

    更新日期：2017-12-19 00:00:00

  • Accurate and efficient modeling of the detector response in small animal multi-head PET systems.

    abstract：:In fully three-dimensional PET imaging, iterative image reconstruction techniques usually outperform analytical algorithms in terms of image quality provided that an appropriate system model is used. In this study we concentrate on the calculation of an accurate system model for the YAP-(S)PET II small animal scanner,...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/58/19/6713

    authors： Cecchetti M,Moehrs S,Belcari N,Del Guerra A

    更新日期：2013-10-07 00:00:00

  • Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering.

    abstract：:This paper addresses fundamental issues that underlie the interpretation of images acquired from turbid tissues by optical-coherence tomography (OCT). The attenuation and backscattering properties of freshly excised rat arteries and their dependence on the focusing and collection optics of the OCT system were measured...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/39/10/013

    authors： Schmitt JM,Knüttel A,Yadlowsky M,Eckhaus MA

    更新日期：1994-10-01 00:00:00

  • Accounting for range uncertainties in the optimization of intensity modulated proton therapy.

    abstract：:Treatment plans optimized for intensity modulated proton therapy (IMPT) may be sensitive to range variations. The dose distribution may deteriorate substantially when the actual range of a pencil beam does not match the assumed range. We present two treatment planning concepts for IMPT which incorporate range uncertai...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/52/10/009

    authors： Unkelbach J,Chan TC,Bortfeld T

    更新日期：2007-05-21 00:00:00

  • Investigation of practical approaches to evaluating cumulative dose for cone beam computed tomography (CBCT) from standard CT dosimetry measurements: a Monte Carlo study.

    abstract：:A function called Gx(L) was introduced by the International Commission on Radiation Units and Measurements (ICRU) Report-87 to facilitate measurement of cumulative dose for CT scans within long phantoms as recommended by the American Association of Physicists in Medicine (AAPM) TG-111. The Gx(L) function is equal to t...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/60/14/5413

    authors： Abuhaimed A,Martin CJ,Sankaralingam M,Gentle DJ

    更新日期：2015-07-21 00:00:00

  • An algorithm to include the bremsstrahlung contamination in the determination of the absorbed dose in electron beams.

    abstract：:None of the existing protocols or codes of practice for high-energy electron dosimetry take any account of the accelerator-generated bremsstrahlung always present in electron beams. This results in a systematic error in the derivation of the absorbed dose. The purpose of this study is to draw attention to this omissio...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/39/7/004

    authors： Klevenhagen SC

    更新日期：1994-07-01 00:00:00

  • Curvature correction of retinal OCTs using graph-based geometry detection.

    abstract：:In this paper, we present a new algorithm as an enhancement and preprocessing step for acquired optical coherence tomography (OCT) images of the retina. The proposed method is composed of two steps, first of which is a denoising algorithm with wavelet diffusion based on a circular symmetric Laplacian model, and the se...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/58/9/2925

    authors： Kafieh R,Rabbani H,Abramoff MD,Sonka M

    更新日期：2013-05-07 00:00:00

  • A multi-scale framework with unsupervised joint training of convolutional neural networks for pulmonary deformable image registration.

    abstract：:To achieve accurate and fast deformable image registration (DIR) for pulmonary CT, we proposed a Multi-scale DIR framework with unsupervised Joint training of Convolutional Neural Network (MJ-CNN). MJ-CNN contains three models at multi-scale levels for a coarse-to-fine DIR to avoid being trapped in a local minimum. It...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab5da0

    authors： Jiang Z,Yin FF,Ge Y,Ren L

    更新日期：2020-01-13 00:00:00

  • A Monte Carlo investigation of dual-energy-window scatter correction for volume-of-interest quantification in 99Tcm SPECT.

    abstract：:Using Monte Carlo simulation of 99Tcm single-photon-emission computed tomography (SPECT), we investigate the effects of tissue-background activity, tumour location, patient size, uncertainty of energy windows, and definition of tumour region on the accuracy of quantification. The dual-energy-window method of correctio...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/40/1/015

    authors： Luo JQ,Koral KF,Ljungberg M,Floyd CE Jr,Jaszczak RJ

    更新日期：1995-01-01 00:00:00

  • A CCD-based optical CT scanner for high-resolution 3D imaging of radiation dose distributions: equipment specifications, optical simulations and preliminary results.

    abstract：:Methods based on magnetic resonance imaging for the measurement of three-dimensional distributions of radiation dose are highly developed. However, relatively little work has been done on optical computed tomography (OCT). This paper describes a new OCT scanner based on a broad beam light source and a two-dimensional ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/46/12/309

    authors： Doran SJ,Koerkamp KK,Bero MA,Jenneson P,Morton EJ,Gilboy WB

    更新日期：2001-12-01 00:00:00

  • Dose evaluation of boron neutron capture synovectomy using the THOR epithermal neutron beam: a feasibility study.

    abstract：:Rheumatoid arthritis is one of the most common epidemic diseases in the world. For some patients, the treatment with steroids or nonsteroidal anti-inflammatory drugs is not effective, thus necessitating physical removal of the inflamed synovium. Alternative approaches other than surgery will provide appropriate diseas...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/52/6/014

    authors： Wu J,Chang SJ,Chuang KS,Hsueh YW,Yeh KC,Wang JN,Tsai WP

    更新日期：2007-03-21 00:00:00

  • Relative Patlak plot for dynamic PET parametric imaging without the need for early-time input function.

    abstract：:The Patlak graphical method is widely used in parametric imaging for modeling irreversible radiotracer kinetics in dynamic PET. The net influx rate of radiotracer can be determined from the slope of the Patlak plot. The implementation of the standard Patlak method requires the knowledge of full-time input function fro...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aad444

    authors： Zuo Y,Qi J,Wang G

    更新日期：2018-08-10 00:00:00

  • Reconstructing uniformly attenuated rotating slant-hole SPECT projection data using the DBH method.

    abstract：:This work applies a previously developed analytical algorithm to the reconstruction problem in a rotating multi-segment slant-hole (RMSSH) SPECT system. The RMSSH collimator has greater detection efficiency than the parallel-hole collimator with comparable spatial resolution at the expense of limited common volume-of-...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/54/13/024

    authors： Huang Q,Xu J,Tsui BM,Gullberg GT

    更新日期：2009-07-07 00:00:00

  • Calibration of CT Hounsfield units for radiotherapy treatment planning of patients with metallic hip prostheses: the use of the extended CT-scale.

    abstract：:Heterogeneity corrections for radiotherapy dose calculations are based on the electron density of the disturbing heterogeneity. However, when CT planning a radiotherapy treatment, where metallic hip implants are present, considerable artefacts are seen in the images. Often, an additional problem arises whereby no info...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/48/11/308

    authors： Coolens C,Childs PJ

    更新日期：2003-06-07 00:00:00

  • The IPEM code of practice for determination of the reference air kerma rate for HDR (192)Ir brachytherapy sources based on the NPL air kerma standard.

    abstract：:This paper contains the recommendations of the high dose rate (HDR) brachytherapy working party of the UK Institute of Physics and Engineering in Medicine (IPEM). The recommendations consist of a Code of Practice (COP) for the UK for measuring the reference air kerma rate (RAKR) of HDR (192)Ir brachytherapy sources. I...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/55/11/011

    authors： Bidmead AM,Sander T,Locks SM,Lee CD,Aird EG,Nutbrown RF,Flynn A,IPEM Working Party.

    更新日期：2010-06-07 00:00:00

  • Feasibility study of range verification based on proton-induced acoustic signals and recurrent neural network.

    abstract：:Range verification in proton therapy is a critical quality assurance task. We studied the feasibility of online range verification based on proton-induced acoustic signals, using a bidirectional long-short-term-memory recurrent neural network and various signal processing techniques. Dose distribution of 1D pencil pro...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/abaa5e

    authors： Yao S,Hu Z,Zhang X,Lou E,Liang Z,Wang Y,Peng H

    更新日期：2020-11-05 00:00:00

  • Radio-enhancement by gold nanoparticles and their impact on water radiolysis for x-ray, proton and carbon-ion beams.

    abstract：:Gold nanoparticle (GNP) radio-enhancement is a promising technique to increase the dose deposition in a tumor while sparing neighboring healthy tissue. Previous experimental studies showed effects on cell survival and tumor control for keV x-rays but surprisingly also for MV-photons, proton and carbon-ion beams. In a ...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/ab314c

    authors： Rudek B,McNamara A,Ramos-Méndez J,Byrne H,Kuncic Z,Schuemann J

    更新日期：2019-08-28 00:00:00

  • Proof-of-concept delivery of intensity modulated arc therapy on the Elekta Unity 1.5 T MR-linac.

    abstract：:In this work we present the first delivery of intensity modulated arc therapy on the Elekta Unity 1.5 T MR-linac. The machine's current IMRT based control system was modified suitably to enable dynamic delivery of radiation, for the purpose of exploring MRI-guided radiation therapy adaptation modes in a research setti...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/abd66d

    authors： Kontaxis C,Woodhead PL,Bol GH,Lagendijk JJW,Raaymakers BW

    更新日期：2020-12-23 00:00:00

  • Characterization of 3D joint space morphology using an electrostatic model (with application to osteoarthritis).

    abstract：:Joint space morphology can be indicative of the risk, presence, progression, and/or treatment response of disease or trauma. We describe a novel methodology of characterizing joint space morphology in high-resolution 3D images (e.g. cone-beam CT (CBCT)) using a model based on elementary electrostatics that overcomes a...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/60/3/947

    authors： Cao Q,Thawait G,Gang GJ,Zbijewski W,Reigel T,Brown T,Corner B,Demehri S,Siewerdsen JH

    更新日期：2015-02-07 00:00:00

  • Experimental validation of the DPM Monte Carlo code using minimally scattered electron beams in heterogeneous media.

    abstract：:A comprehensive set of measurements and calculations has been conducted to investigate the accuracy of the Dose Planning Method (DPM) Monte Carlo code for electron beam dose calculations in heterogeneous media. Measurements were made using 10 MeV and 50 MeV minimally scattered, uncollimated electron beams from a racet...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/47/11/301

    authors： Chetty IJ,Moran JM,Nurushev TS,McShan DL,Fraass BA,Wilderman SJ,Bielajew AF

    更新日期：2002-06-07 00:00:00

  • Dose distribution to spinal structures from intrathecally administered yttrium-90.

    abstract：:Previous treatment of cerebrospinal fluid (CSF) malignancies by intrathecal administration of (131)I-radiolabelled monoclonal antibodies has led to the assumption that more healthy tissue will be spared when a pure beta-emitter such as (90)Y replaces (131)I. The purpose of this study is to compare and quantitatively e...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/51/1/014

    authors： Mardirossian G,Hall M,Montebello J,Stevens P

    更新日期：2006-01-07 00:00:00

  • Percentile-specific computational phantoms constructed from ICRP mesh-type reference computational phantoms (MRCPs).

    abstract：:Recently, the Task Group 103 of the International Commission on Radiological Protection (ICRP) has developed new mesh-type reference computational phantoms (MRCPs) for adult male and female. When compared to the current voxel-type reference computational phantoms in ICRP Publication 110, the MRCPs have several advanta...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/1361-6560/aafcdb

    authors： Lee H,Yeom YS,Nguyen TT,Choi C,Han H,Shin B,Zhang X,Kim CH,Chung BS,Zankl M

    更新日期：2019-02-05 00:00:00

  • Positron range in PET imaging: an alternative approach for assessing and correcting the blurring.

    abstract：:Positron range impairs resolution in PET imaging, especially for high-energy emitters and for small-animal PET. De-blurring in image reconstruction is possible if the blurring distribution is known. Furthermore, the percentage of annihilation events within a given distance from the point of positron emission is releva...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/57/12/3931

    authors： Jødal L,Le Loirec C,Champion C

    更新日期：2012-06-21 00:00:00

  • The response of cells in culture to fractionated radiation: a theoretical approach.

    abstract：:A mathematical model has been constructed to simulate the response of cells in vitro to fractionated doses of radiation. The model is capable of describing most of the radiobiological functions that are commonly studied. Input data are measurable cell properties. The details of the model and methods of acquiring the i...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/21/5/011

    authors： Niederer J,Cunningham JR

    更新日期：1976-09-01 00:00:00

  • Sources of Atomic and Nuclear Data for Biomedical Purposes.

    abstract：:Users of nuclear and atomic data for biomedical purposes often have difficulty in identifying the most up-to-date and appropriate sources of such data. The biomedical Subcommittee of the UK Nuclear Data Committee have prepared a list of recommended data sources available at the beginning of 1978 on radioactive decay s...

    journal_title：Physics in medicine and biology

    pub_type： 杂志文章

    doi：10.1088/0031-9155/24/1/001

    authors： Holt PD

    更新日期：1979-01-01 00:00:00