Abstract：
BACKGROUND AND OBJECTIVE:Serum vitamin D influences cellular immunity against Mycobacterium tuberculosis, particularly in under-five children. Vitamin D insufficiency and deficiency as well as tuberculosis (TB) are highly prevalent in Indonesia. This study described the association of serum vitamin D in the incidence of latent TB in under-five children with a history of close TB contact. METHODS AND STUDY DESIGN:This cross-sectional study examined 178 under-five children with a history of close TB contact, with 98 index cases from primary health care facilities in Padang. Latent TB was defined based on a positive tuberculin skin test. Serum vitamin D was determined using ELISA method. General characteristics for age, sex, socioeconomic status, contact score, BCG scars, and nutritional status were also collected. RESULTS:Of 168 eligible subjects, 40.5% had latent TB, however no differences between 'latent TB' and 'without latent TB' were observed in participant characteristics. Vitamin D deficiency, insufficiency, and sufficiency were observed in 23.3%, 43.5%, and 33.3% of children, respectively. In general, the 'latent TB' group had lower serum vitamin D than those in the 'without latent TB' group, stratified by age, contact score and nutritional status; however, significant differences were observed in children age <1 years (18.0±2.6 vs 31.2±10.5, respectively, p=0.013). Nevertheless, no associations between the two groups were observed using multivariate analysis. CONCLUSION:Vitamin D status was not associated with the incidence of latent TB among under-five children with a history of close TB contact, although this may not obtain in children aged <1 year old.
journal_name
Asia Pac J Clin Nutrjournal_title
Asia Pacific journal of clinical nutritionauthors
Yani FF,Lipoeto NI,Supriyatno B,Darwin E,Basir Ddoi
10.6133/apjcn.062017.s2subject
Has Abstractpub_date
2017-06-01 00:00:00pages
S68-S72issue
Suppl 1eissn
0964-7058issn
1440-6047journal_volume
26pub_type
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journal_title：Asia Pacific journal of clinical nutrition
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pub_type： 杂志文章,评审
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journal_title：Asia Pacific journal of clinical nutrition
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journal_title：Asia Pacific journal of clinical nutrition
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journal_title：Asia Pacific journal of clinical nutrition
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journal_title：Asia Pacific journal of clinical nutrition
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journal_title：Asia Pacific journal of clinical nutrition
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journal_title：Asia Pacific journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
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pub_type： 杂志文章
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更新日期：2003-01-01 00:00:00
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journal_title：Asia Pacific journal of clinical nutrition
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更新日期：1998-12-01 00:00:00
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journal_title：Asia Pacific journal of clinical nutrition
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更新日期：1992-09-01 00:00:00
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journal_title：Asia Pacific journal of clinical nutrition
pub_type： 杂志文章
doi：10.1046/j.1440-6047.2000.00180.x
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journal_title：Asia Pacific journal of clinical nutrition
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journal_title：Asia Pacific journal of clinical nutrition
pub_type： 杂志文章,评审
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journal_title：Asia Pacific journal of clinical nutrition
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doi：
更新日期：2007-01-01 00:00:00
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journal_title：Asia Pacific journal of clinical nutrition
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