Abstract:
:Pemphigus refers to a group of potentially fatal blistering skin diseases that are often due to the deleterious effects of autoantibodies directed against desmosomal antigens. Although desmogleins have been mainly implicated as autoantigens in pemphigus, a steadily growing body of evidence suggests that other desmosomal proteins may be causally involved as well. Antibodies directed against desmocollin-3 have been shown to play a direct role in the pathogenesis of several types of pemphigus. Here we describe the case of a child with localized pemphigus foliaceus and immunoglobulin G (IgG) reactivity exclusively directed to desmocollins. The present report suggests that autoantibodies against nondesmoglein antigens may play a role in the pathogenesis of superficial pemphigus, in addition to pemphigus vulgaris, paraneoplastic pemphigus, and IgA pemphigus.
journal_name
Pediatr Dermatoljournal_title
Pediatric dermatologyauthors
Geller S,Gat A,Harel A,Mashiah J,Zeeli T,Eming R,Ishii N,Hertl M,Hashimoto T,Sprecher Edoi
10.1111/pde.12729subject
Has Abstractpub_date
2016-01-01 00:00:00pages
e10-3issue
1eissn
0736-8046issn
1525-1470journal_volume
33pub_type
杂志文章abstract::Trichothiodystrophy (TTD) is a hair abnormality that may be associated with a large number of alterations affecting the skin phenotype and skin appendages, nervous system, eyes, bones, and immune, gonadal, and endocrine systems. We report the first case of TTD associated with a urologic malformation and primary hyperc...
journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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doi:10.1111/pde.12092
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
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journal_title:Pediatric dermatology
pub_type: 杂志文章
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journal_title:Pediatric dermatology
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doi:10.1111/pde.14250
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