Childhood Pemphigus Foliaceus with Exclusive Immunoglobulin G Autoantibodies to Desmocollins.

Abstract:

:Pemphigus refers to a group of potentially fatal blistering skin diseases that are often due to the deleterious effects of autoantibodies directed against desmosomal antigens. Although desmogleins have been mainly implicated as autoantigens in pemphigus, a steadily growing body of evidence suggests that other desmosomal proteins may be causally involved as well. Antibodies directed against desmocollin-3 have been shown to play a direct role in the pathogenesis of several types of pemphigus. Here we describe the case of a child with localized pemphigus foliaceus and immunoglobulin G (IgG) reactivity exclusively directed to desmocollins. The present report suggests that autoantibodies against nondesmoglein antigens may play a role in the pathogenesis of superficial pemphigus, in addition to pemphigus vulgaris, paraneoplastic pemphigus, and IgA pemphigus.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Geller S,Gat A,Harel A,Mashiah J,Zeeli T,Eming R,Ishii N,Hertl M,Hashimoto T,Sprecher E

doi

10.1111/pde.12729

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

e10-3

issue

1

eissn

0736-8046

issn

1525-1470

journal_volume

33

pub_type

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