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Obesity aggravates toxic effect of BPA on spermatogenesis.

Abstract：

:Both bisphenol A (BPA) and obesity affect male reproductive system. However, whether there is an interaction between them remains poorly understood. The aim of the present study was to evaluate the interaction between BPA exposure and obesity on semen quality and elucidate the mechanism in humans and animals. We firstly analyzed the interaction on semen volume, sperm count per ejaculate, sperm concentration and sperm motility in 357 men, and found that urinary BPA concentration was significantly correlated with sperm count per ejaculate in obese men (β=-34.62; 95% CI: -60.75, -8.48; P=0.01). Then we validated the interaction using lean and obese mice with administration of BPA. Significant interactions between BPA exposure and obesity on sperm count and sperm concentration was observed in mice. Finally, we conducted metabolomics analyses to identify metabolites related to the interaction. Metabolites related to the interaction, including capric acid, dodecanoic acid, l-palmitoylcarnitine, niacinamide, etc., are known to play critical roles in fatty acid oxidation and tricarboxylic acid cycle indicating increased oxidative stress associated with male reproductive dysfunction. Thus, our study finds an interaction between BPA exposure and obesity on sperm count and reveals potential metabolic mechanisms. It emphasizes the importance to study interactions between endocrine disrupting chemicals and obesity, and opens avenues for the possible use of animal models in identifying the interactions.

journal_name

Environ Int

journal_title

Environment international

authors

Hu W,Dong T,Wang L,Guan Q,Song L,Chen D,Zhou Z,Chen M,Xia Y,Wang X

doi

10.1016/j.envint.2017.04.014

subject

Has Abstract

pub_date

2017-08-01 00:00:00

pages

56-65

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(17)30432-4

journal_volume

105

pub_type

杂志文章

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