Abstract:
:Epidemiologic studies have revealed higher concentrations of the metabolites of phthalic acid esters (mPAEs) in patients with type 2 diabetes. On the other hand, oxidative stress, adiponectin, and inflammatory cytokines play important roles in the pathogenesis of diabetes and its complications. However, little information is known about the association between exposure to PAEs and these physiological parameters. Hence, paired urine and blood samples were collected from a total of 329 volunteers, and 11 main mPAEs and malondialdehyde (MDA), as a biomarker of oxidative stress, were measured in the urine samples. Serum adiponectin and tumor necrosis factor-α (TNF-α), a biomarker of inflammation, were also measured. Multivariable linear regression was used to assess the association between urinary mPAEs and these physiological parameters in the total subjects and subjects stratified by age, sex, and body mass index (BMI) to elucidate their possible interactions. All 11 mPAEs were detected in the urine with detection rates of 42.9%-100% and geometric means of 0.30-54.52ng/mL (0.44-79.93μg/g creatinine). The mPAEs were all positively associated with MDA levels. There were significant positive associations between monomethyl phthalate (mMP) and TNF-α, and inverse associations between mMP and adiponectin levels. In the stratified analysis, there were age-, sex-, and BMI-specific differences for these associations. The positive associations between mPAEs and MDA were insignificant in some subgroups, especially in the larger age group. However, in the larger BMI group, summed metabolites of di-(2-ethylhexyl) phthalate (∑DEHP) and mono(2-ethylhexyl) phthalate were positively associated with TNF-α, and the concentrations of ∑DEHP were negatively associated with adiponectin. Our findings suggested that PAE exposure is associated with oxidative stress, adiponectin, and inflammatory cytokines in diabetic patients; further studies on toxicology and a comparison with general population are needed.
journal_name
Environ Intjournal_title
Environment internationalauthors
Duan Y,Wang L,Han L,Wang B,Sun H,Chen L,Zhu L,Luo Ydoi
10.1016/j.envint.2017.09.002subject
Has Abstractpub_date
2017-12-01 00:00:00pages
53-63eissn
0160-4120issn
1873-6750pii
S0160-4120(17)30779-1journal_volume
109pub_type
杂志文章abstract::A five-step sequential extraction procedure was applied for the determination of the distribution of seven elements (Cd, Pb, Cr, Cu, Mn, Zn, Fe) in sediment samples collected at two lakes, Volvi and Koronia, located in N. Greece. Samples were taken in two seasons, and the average concentration of the elements was calc...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/S0160-4120(03)00143-0
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Limited studies have investigated the association between prenatal and early childhood phthalate exposures and thyroid function among children. OBJECTIVES:To investigate the association between early life phthalate exposure and thyroid function among school-age children, considering both prenatal and early ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2020.105782
更新日期:2020-08-01 00:00:00
abstract::Phthalates and bisphenol A (BPA) are ubiquitous in our environment. These chemicals have been characterized as endocrine disruptors that can cause functional impairment of development and reproduction. Processed and packaged foods are among the major sources of human exposure to these chemicals. No previous report sho...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.08.005
更新日期:2014-12-01 00:00:00
abstract::Multiple classes of environmental contaminants have been found in aquatic environments, globally. Understanding internalised concentrations in the organism could further improve the risk assessment process. The present study is concerned with the determination of several contaminant classes (107 compounds) in Gammarus...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.04.038
更新日期:2019-08-01 00:00:00
abstract::The COVID-19 pandemic placed public health measures against infectious diseases at the core of global health challenges, especially in cities where more than half of the global population lives. SARS-CoV-2 is an exposure agent recently added to the network of exposures that comprise the human exposome, i.e. the totali...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2020.106246
更新日期:2021-01-01 00:00:00
abstract::A variety of experimental and epidemiological studies lend support to the Developmental Origin of Health and Disease (DOHaD) concept. Yet, the actual mechanisms accounting for mid- and long-term effects of early-life exposures remain unclear. Epigenetic alterations such as changes in DNA methylation, histone modificat...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2018.02.014
更新日期:2018-05-01 00:00:00
abstract::The serious fine particle (PM2.5) pollution in China causes millions of premature deaths. Driven by swift economic growth and stringent control policies, air pollutant emissions in China have changed significantly in the last decade, but the change in the source contribution of PM2.5-related health impacts remains unc...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105111
更新日期:2019-11-01 00:00:00
abstract::Microbiological quality of surface waters can be affected by microbial load in runoff from grazing lands. This effect, with other factors, depends on the survival of microorganisms in animal waste deposited on pastures. Since temperature is a leading environmental parameter affecting survival, it indirectly impacts wa...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2012.12.013
更新日期:2013-04-01 00:00:00
abstract::Long-term air quality data with high temporal and spatial resolutions are needed to understand some important processes affecting the air quality and corresponding environmental and health effects. The annual and diurnal variations of each criteria pollutant including PM2.5 and PM10 (particulate matter with aerodynami...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2015.11.003
更新日期:2016-01-01 00:00:00
abstract::Airborne microorganisms (AM), vital components of particulate matters (PM), are widespread in the atmosphere. Since some AM have pathogenicity, they can lead to a wide range of diseases in human and other organisms, meanwhile, some AM act as cloud condensation nuclei and ice nuclei which let them can affect the climat...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2018.01.007
更新日期:2018-04-01 00:00:00
abstract::Five hexachloronorbornene-based flame retardants, Dechlorane Plus (DP), Dechlorane 602 (Dec 602), Dechlorane 603 (Dec 603), Dechlorane 604 (Dec 604) and hexachlorocyclopentadienyl-dibromocyclooctane (HCDBCO), were measured in human milk and maternal serum. Dec 602, Dec 603 and HCDBCO were detected in both sample matri...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2014.01.010
更新日期:2014-05-01 00:00:00
abstract:BACKGROUND:Perfluorinated compounds (PFCs) were reported to result in the endocrine disruption by activating the estrogen receptor (ER) and inducing ER-mediated transcriptions. OBJECTIVE:The aim of the present work was to perform cross-species comparisons on the characteristics of eight PFCs binding to humans ERα and ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105284
更新日期:2020-01-01 00:00:00
abstract::Environmental contamination caused by extra heavy oil-based drill cuttings (DCs) is a major problem in the Liaohe Oilfield, northeastern China. To study the potential effectiveness of the mature reed wetland in removing extra heavy oil contained in drill cuttings, biodegradation of extra heavy oils and study of the ef...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2003.10.003
更新日期:2004-06-01 00:00:00
abstract::The Paso del Norte region is characterized by its dynamic industries and active agriculture. Throughout the years, urban and agricultural soils from this region have been exposed to xenobiotics, heavy metals, and excess of hydrocarbons. In this study, samples of urban [domestic workshops (DW)] and agricultural-intende...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.12.055
更新日期:2019-02-01 00:00:00
abstract::For the purpose of synthesizing a compendium of efforts aimed at environmental pollution control through the use of constructed wetlands systems (CWs) in Ireland, a detailed review of CWs was undertaken. Emphasis was placed on the diverse range of development, practice and researches on CWs technology, placing them in...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2007.06.013
更新日期:2008-01-01 00:00:00
abstract::Small-scale geographical variation in the occurrence of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs) and polybrominated diphenyl ethers (PBDEs) was investigated using the eggs of a terrestrial residential songbird species, the great tit (Parus major). In addition, we investigated the influence of...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2007.07.014
更新日期:2008-02-01 00:00:00
abstract::Soil has been regarded as a rich source of antibiotic resistance genes (ARGs) due to the complex microbial community and diverse antibiotic-producing microbes in soil, however, little is known about the ARGs in unculturable bacteria. To investigate the diversity and distribution of ARGs in soil and assess the impact o...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.12.010
更新日期:2014-04-01 00:00:00
abstract::Globally, many of our urban agriculture sites (UAS) contain high levels of lead (Pb), a contaminant of toxicological concern to humans. To improve the derivation of soil assessment criteria at UAS, and avoid inappropriate closure of these valuable community spaces, we sampled nearly 280 paired soil and crop samples ac...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2018.10.054
更新日期:2019-01-01 00:00:00
abstract::Humans are simultaneously exposed to a multitude of chemicals. Human health risk assessment of chemicals is, however, normally performed on single substances, which may underestimate the total risk, thus bringing a need for reliable methods to assess the risk of combined exposure to multiple chemicals. Per- and polyfl...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2013.05.009
更新日期:2013-09-01 00:00:00
abstract::Information on arsenic (As) speciation in solid materials is critical for many environmental studies concerned with As stability and/or mobility in natural As-impacted soils and mining or industrial sites contaminated by As. The investigation of these systems has provided evidence for a number of secondary As minerals...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2009.07.004
更新日期:2009-11-01 00:00:00
abstract::The presence of selected volatile organic compounds (VOCs) including aromatic, aliphatic compounds and low molecular weight carbonyls, and a target set of phthalates were investigated in the interior of 23 used private cars during the summer and winter. VOC concentrations often exceeded levels typically found in resid...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2009.07.016
更新日期:2009-11-01 00:00:00
abstract:BACKGROUND:Several mechanisms are suspected to underlie adverse birth outcomes among mothers exposed to air pollutants, including inflammation, direct toxic effects on fetuses and the placenta, displacement of the oxygen-hemoglobin dissociation curve, and formation of DNA adducts. OBJECTIVE:To systematically review th...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2010.10.009
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:Although antibiotic use during early life has been demonstrated to be related to the altered adipogenesis in later life, limited data are available for the effect of antibiotic exposure in school children on adiposity from various sources, including from the use or contaminated food or drinking water. OBJEC...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2016.02.005
更新日期:2016-04-01 00:00:00
abstract::Methylmercury (MeHg) is a neurotoxicant known to affect the developing fetal brain as a sensitive target organ. As most mercury (Hg) in blood is MeHg, total mercury (THg) levels in blood are used to estimate the body burden of MeHg. The nutrients selenium (Se), vitamin E, and docosahexaenoic acid (DHA) are protective ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2017.11.001
更新日期:2018-02-01 00:00:00
abstract::A rapid and simple analytical method for the determination of organochlorines, such as polychlorinated biphenyls (PCBs) and selected organochlorinated pesticides (OCPs) and organobromines, such as polybrominated diphenyl ethers (PBDEs), in sediment samples was optimised using CRM 536 (PCBs in freshwater sediment). The...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2004.08.009
更新日期:2005-04-01 00:00:00
abstract::The content, behaviour and significance of heavy metals in composted waste materials is important from two potentially conflicting aspects of environmental legislation in terms of: (a) defining end-of-waste criteria and increasing recycling of composted residuals on land and (b) protecting soil quality by preventing c...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2008.06.009
更新日期:2009-01-01 00:00:00
abstract::The EU directives on air quality force member states to inform the public on the status of the ambient air quality. The Internet is commonly used for this purpose and often air quality is being presented as an index ranging from good to bad. A review of existing websites and air quality indices shows that the way air ...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2007.12.011
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Reactive oxygen species (ROS) arise as a result from, and are essential in, numerous cellular processes. ROS, however, are highly reactive and if left unneutralised by endogenous antioxidant systems, can result in extensive cellular damage and/or pathogenesis. In addition, exposure to a wide range of environ...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2019.105138
更新日期:2019-12-01 00:00:00
abstract::Endocrine-disrupting chemicals (EDCs) have received significant concern, since they ubiquitously exist in the environment and are able to induce adverse health effects on human and wildlife. Increasing evidence shows that the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR), members of the steroid ...
journal_title:Environment international
pub_type: 杂志文章,评审
doi:10.1016/j.envint.2019.105133
更新日期:2019-12-01 00:00:00
abstract::Three regulated halogenated flame retardants (HFRs), i.e., polybrominated diphenyl ethers (PBDEs), polybrominated biphenyls (PBBs) and hexabromocyclododecanes (HBCDs), and several alternative HFRs (AHFRs) including Dechlorane Plus (DP), decabromodiphenyl ethane (DBDPE), and 1,2-bis(2,4,6-tribromophenoxy) ethane (BTBPE...
journal_title:Environment international
pub_type: 杂志文章
doi:10.1016/j.envint.2012.04.006
更新日期:2012-09-15 00:00:00