Abstract:
PURPOSE:The incidence of non-melanoma skin cancer (NMSC) has been increasing over the past 30 years. Basal cell carcinoma and squamous cell carcinoma are the two most common subtypes of NMSC. The aim of this study was to estimate tumour control, toxicity, and aesthetic events in elderly patients treated with high-dose-rate (HDR) brachytherapy (BT) using Valencia applicator. MATERIAL AND METHODS:From January 2012 to May 2015, 57 lesions in 39 elderly eligible patients were enrolled. All the lesions had a diameter ≤ 25 mm (median: 12.5 mm) and a depth ≤ 4 mm. The appropriate Valencia applicator, 2 or 3 cm in diameter was used. The prescribed dose was 40 Gy in 8 fractions (5 Gy/fraction) in 48 lesions (group A), and 50 Gy in 10 fractions (5 Gy/fraction) in 9 lesions (group B), delivered 2/3 times a week. The biological effective dose (BED) was 60 Gy and 75 Gy, respectively. RESULTS:After median follow-up of 12 months, 96.25% lesions showed a complete response and only two cases presented partial remission. Radiation Therapy Oncology Group - European Organization for Research and Treatment of Cancer (RTOG/EORTC) G 1-2 acute toxicities were observed in 63.2% of the lesions: 56.3% in group A and 77.7% in group B. Late G1-G2 toxicities was observed in 19.3% of the lesions: 18.8% in group A and 22.2% in group B, respectively. No G3 or higher acute or late toxicities occurred. In 86% of the lesions, an excellent cosmetic result was observed (87.5% in group A and 77.8% in group B). Six lesions had a good cosmetic outcome and only 2.3% presented a fair cosmetic impact. CONCLUSIONS:The treatment of NMSC with HDR-BT using Valencia surface applicator is effective with excellent and good cosmetics results in elderly patients. The hypofractionated course appears effective and no statistical differences were observed between the two groups analysed.
journal_name
J Contemp Brachytherapyjournal_title
Journal of contemporary brachytherapyauthors
Delishaj D,Laliscia C,Manfredi B,Ursino S,Pasqualetti F,Lombardo E,Perrone F,Morganti R,Paiar F,Fabrini MGdoi
10.5114/jcb.2015.55746subject
Has Abstractpub_date
2015-12-01 00:00:00pages
437-44issue
6eissn
1689-832Xissn
2081-2841pii
26157journal_volume
7pub_type
杂志文章abstract::Over the last twenty years major software and hardware developments in brachytherapy treatment planning, intraoperative navigation and dose delivery have been made. Image-guided brachytherapy has emerged as the ultimate conformal radiation therapy, allowing precise dose deposition on small volumes under direct image v...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
doi:10.5114/jcb.2010.16920
更新日期:2010-09-01 00:00:00
abstract:Purpose:To compare post-implant dosimetrics between intraoperatively built custom-linked (IBCL) seeds and loose seeds (LS) at 24 hours and 1 month by sector analysis, and to evaluate the effect of IBCL seeds with regard to change in dosimetric parameters, in patients with prostate cancer treated with brachytherapy. Ma...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2020.98110
更新日期:2020-08-01 00:00:00
abstract:Purpose:To evaluate dose-volume relationships of target volume and critical structures in computed tomography (CT) image-based brachytherapy for head and neck cancer. Material and methods:Thirty-seven patients with mobile tongue, floor of mouth, and base of tongue cancer treated with brachytherapy (post-operative alon...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2017.72581
更新日期:2017-12-01 00:00:00
abstract:PURPOSE:Groupe Européen de Curiethérapie (GEC) and European Society for Radiotherapy & Oncology (ESTRO) has proposed a rectal dose constraint of the most exposed 2-cc volume (D2cc of ≤ 75 Gy EQD2α/β = 3) during external-beam plus high-dose-rate brachytherapy (HDR-BT) in localized prostate cancer patients. This study ai...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2016.61738
更新日期:2016-08-01 00:00:00
abstract:PURPOSE:The standard primary treatment for soft tissue sarcoma (STS) is a wide surgical resection, preceded or followed by radiotherapy. Purpose of this retrospective study was to assess the efficacy of perioperative brachytherapy (BRT) plus postoperative external beam radiation therapy (EBRT) in patients with intermed...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2017.68215
更新日期:2017-06-01 00:00:00
abstract:Purpose:Skin cancers are the most common human malignancy with increasing incidence. Currently, surgery is standard of care treatment for non-melanoma skin cancers. However, brachytherapy is a growing modality in the management of skin cancers. Therefore, we aimed to assess the outcome of patients with non-melanoma ski...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2018.75596
更新日期:2018-04-01 00:00:00
abstract:Purpose:Soft tissue sarcoma (STS) is rare but aggressive neoplasm. Interstitial brachytherapy (ISBT) alone or combined with external beam radiotherapy (EBRT) as post-operative treatment improves loco-regional (LRC) and distant control. Material and methods:Out of twenty-nine non-metastatic STS (lower limb 64%) patient...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2018.78994
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:To study the safety and efficacy of high-dose-rate interstitial brachytherapy (HDRIBT) in patients with liver metastases (LM). MATERIAL AND METHODS:Between 2009 and 2011, 10 patients with 12 metastatic lesions in the liver were enrolled in this prospective trial. All patients had either refused surgery or foun...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2013.36175
更新日期:2013-06-01 00:00:00
abstract::The aim of this study is to report an uncommon case of nasal keloid treated with adaptive image-guided high-dose-rate (HDR) intracavitary brachytherapy. A 34-year-old female presented with nasal keloid after facial trauma was treated with scar resection and HDR intracavitary brachytherapy with a customized eccentric a...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2018.76838
更新日期:2018-06-01 00:00:00
abstract::In a field dominated by external beam radiation therapy (EBRT), both the therapeutic and technical possibilities of brachytherapy (BT) are underrated, shadowed by protons and intensity modulated radiotherapy. Decreasing expertise and indications, as well as increasing lack of specific BT training for radiation therapy...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2015.56769
更新日期:2015-12-01 00:00:00
abstract:Purpose:To present a small series of cases, in which single-fraction image-guided high-dose-rate (HDR) brachytherapy was provided as palliative treatment for inoperable head and neck cancer cases. Material and methods:We used this technique to treat 3 patients with symptomatic head and neck cancer (tongue cancer, ging...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2020.96870
更新日期:2020-06-01 00:00:00
abstract::The aim of this study is to report the use of ruthenium brachytherapy as an adjunctive treatment in the management of an intraocular extension of the conjunctival squamous cell carcinoma (SCC). In 2013, a 73-year-old man presented with a tumor blocking the angle and infiltrating corneal endothelium. The patient was tr...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2018.75603
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:The aim of this work was to determine dose distributions for high-energy brachytherapy sources at spatial locations not included in the radial dose function gL(r) and 2D anisotropy function F(r,θ) table entries for radial distance r and polar angle θ. The objectives of this study are as follows: 1) to evaluate ...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2010.13715
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:This study investigates the distortion of geometry of catheters and anatomy in acquired U/S images, caused by utilizing various stand-off materials for covering a transrectal bi-planar ultrasound probe in HDR and LDR prostate brachytherapy, biopsy and other interventional procedures. Furthermore, an evaluation ...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2011.26472
更新日期:2011-12-01 00:00:00
abstract:PURPOSE:To evaluate the treatment outcomes with high-dose-rate (HDR) interstitial brachytherapy (HDR-BRT) in head and neck cancers (HNC). MATERIAL AND METHODS:Fifty-eight patients with HNC as per American Joint Committee on Cancer (AJCC) TNM staging criteria were analyzed retrospectively between 2008 and 2015. Forty-t...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2017.67147
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:To report the treatment effect of interstitial brachytherapy for abdominal wall metastases of ovarian cancer. MATERIAL AND METHODS:The patient is a 44-year-old female with a diagnosis of stage IA ovarian cancer. After surgery and two cycles of chemotherapy with paclitaxel and carboplatin, the patient noticed d...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2015.48574
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:While there are several reports of prostate multisector dosimetry data obtained from CT or MRI scans performed at intervals ranging from 14-70 days after prostate brachytherapy (PB), there are no reports on multisector dosimetry performed in the immediate post-implant period. This study was undertaken to determ...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2014.42023
更新日期:2014-03-01 00:00:00
abstract:Purpose:The aim of this study was to compare short-term oncologic outcomes and toxicity of focal or partial low-dose-rate brachytherapy (focal/partial LDR-BT) with whole gland low-dose-rate brachytherapy (whole LDR-BT) in localized prostate cancer patients. Material and methods:Medical records of eligible patients who...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2020.100374
更新日期:2020-10-01 00:00:00
abstract:PURPOSE:To explore patterns of time to failure in men receiving high doses of permanent seed brachytherapy with or without external beam radiation therapy as a function of risk status. MATERIAL AND METHODS:Two thousand two hundred and thirty four patients were treated with prostate brachytherapy with median follow up ...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2013.39210
更新日期:2013-12-01 00:00:00
abstract:PURPOSE:Three different techniques of low-dose-rate seed implantation for prostate cancer have been used since its use started in our hospital. The purpose of this study was to compare the results of the three different techniques. MATERIAL AND METHODS:The data of 305 prostate cancer patients who underwent low-dose-ra...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2015.48603
更新日期:2015-02-01 00:00:00
abstract:PURPOSE:To compare prostate contours on conventional stepping transverse image acquisitions with those on twister-based sagittal image acquisitions. MATERIAL AND METHODS:Twenty prostate cancer patients who were planned to have permanent interstitial prostate brachytherapy were prospectively accrued. A transrectal ultr...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2017.69807
更新日期:2017-08-01 00:00:00
abstract:PURPOSE:To outline the evolution of computerized brachytherapy treatment planning in the United States through a review of technological developments and clinical practice refinements. MATERIAL AND METHODS:A literature review was performed and interviews were conducted with six participants in the development of compu...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
doi:10.5114/jcb.2014.43131
更新日期:2014-06-01 00:00:00
abstract:Purpose:To evaluate clinical outcomes in patients with localized prostate cancer (LPC) treated with 3D conformal high-dose-rate (HDR) brachytherapy (BT) as monotherapy. Material and methods:From March 2004 to November 2017, 277 men with LPC underwent 3D conformal HDR-BT as monotherapy, with a temporary implant. The do...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2020.101685
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:During intracavitary brachytherapy (ICBT) for cervical cancer, the choice of applicator system remains rather arbitrary. However, as the applicator geometry may play an important role in dose distribution, thereby improving the therapeutic ratio, this study was conducted to compare the Manchester-style and Flet...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2012.32555
更新日期:2012-12-01 00:00:00
abstract:PURPOSE:To report the treatment effect of image-guided high-dose-rate (HDR) interstitial brachytherapy for refractory recurrence of papillary thyroid cancer (PTC). CASE REPORT:This 66-year-old female presented with recurrence 5 years after thyroidectomy for PTC. Despite external irradiation and radioactive (131)I, the...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2016.59127
更新日期:2016-04-01 00:00:00
abstract::A 33-year-old premenopausal multiparous woman with the history of septate uterus was referred to the hospital with menorrhagia and inter-menstrual bleeding occurring for the last 6 months. Work-up revealed a stage IIB cervical cancer. The patient underwent curative chemo/radiotherapy. The patient's septate uterus pres...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2017.70996
更新日期:2017-10-01 00:00:00
abstract:Purpose:To verify the accuracy and efficacy of three-dimensional printing individual template (3D-PIT) with computed tomography-magnetic resonance imaging (CT-MRI) fusion for radioactive iodine-125 (125I) seed implantation in high-grade brain gliomas. Material and methods:Between June 2017 and June 2018, 16 patients w...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2019.85729
更新日期:2019-06-01 00:00:00
abstract::In order to improve oncologic outcomes in radiotherapy treatments of patients with unresectable pelvic sidewall recurrences of uterine cervical cancer, we combined high-dose-rate interstitial brachytherapy (HDR-ISBT) with newly tested hypoxic radiosensitizer Kochi oxydol-radiation therapy for unresectable carcinomas (...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2020.101695
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To evaluate whether Co-60 is equivalent to Ir-192 for HDR cervical brachytherapy, through 3D-DVH dose comparisons in standard and optimised plans. Previous studies have only considered 2D dosimetry, point dose comparisons or identical loading. Typical treatment times and economics are considered. MATERIAL AND ...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2012.27952
更新日期:2012-03-01 00:00:00
abstract:Purpose:Artificial intelligence (AI) plays a central role in building decision supporting systems (DSS), and its application in healthcare is rapidly increasing. The aim of this study was to define the role of AI in healthcare, with main focus on radiation oncology (RO) and interventional radiotherapy (IRT, brachythera...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
doi:10.5114/jcb.2020.100384
更新日期:2020-10-01 00:00:00