Abstract:
Purpose:Soft tissue sarcoma (STS) is rare but aggressive neoplasm. Interstitial brachytherapy (ISBT) alone or combined with external beam radiotherapy (EBRT) as post-operative treatment improves loco-regional (LRC) and distant control. Material and methods:Out of twenty-nine non-metastatic STS (lower limb 64%) patients (median age 37 yrs), treated with surgery and post-operative ISBT during February 2011 - December 2016, 27 patients with > 6 months follow-up were analyzed. Spindle cell sarcoma was the commonest (24%) histology. Eleven patients (44%) received EBRT (45-50 Gy), where ISBT was used as boost (16-20 Gy). Fourteen patients (56%) received ISBT alone (4 Gy per fractio). Treatment was done with a 60 Cobalt (60Co) source high-dose-rate system. Results:With a median follow-up of 20 months (17-51 months), LRC rate was 85.7% (with EBRT 90.5% and ISBT 83.2% alone). Median disease-free survival (DFS) was 39.7 ±3.9 months (32-47.2 months). Median loco-regional failure-free survival (LRRFS) was 43.8 ±3.6 months (36.8-50.9 months). Distant failure-free survival (DFFS) was 18 months (15.5-26.6 months). Overall survival was 42.4 ±3.4 months (35.7-48.1 months). Tumor grade was a significant factor for DFFS. Total radiation dose (including EBRT) has significant influence on DFS and LRRFS. 14.8% patients developed ≥ grade 2 late toxicity (skin atrophy, hypo-pigmentation, and telangiectasia). Conclusions:Combination of surgery and ISBT with/out EBRT improves local and distant control with acceptable late toxicities. 60Co-based ISBT is safe and gives a good outcome.
journal_name
J Contemp Brachytherapyjournal_title
Journal of contemporary brachytherapyauthors
Manir KS,Basu A,Choudhury KB,Basu S,Ghosh K,Gangopadhyay Sdoi
10.5114/jcb.2018.78994subject
Has Abstractpub_date
2018-10-01 00:00:00pages
431-438issue
5eissn
1689-832Xissn
2081-2841pii
33986journal_volume
10pub_type
杂志文章abstract::Over the last twenty years major software and hardware developments in brachytherapy treatment planning, intraoperative navigation and dose delivery have been made. Image-guided brachytherapy has emerged as the ultimate conformal radiation therapy, allowing precise dose deposition on small volumes under direct image v...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
doi:10.5114/jcb.2010.16920
更新日期:2010-09-01 00:00:00
abstract:Purpose:To report the results of INTERACTS (INTErventional Radiotherapy ACtive Teaching School) consensus conference on sarcoma interventional radiotherapy (brachytherapy). Material and methods:An international board of multidisciplinary experts was invited to a consensus conference on the state-of-the-art of sarcoma ...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
doi:10.5114/jcb.2020.98120
更新日期:2020-08-01 00:00:00
abstract:Purpose:Permanent seed implant cesium-131 (131Cs) brachytherapy provides highly localized radiation for patients with recurrent head and neck cancer (HNC), who may be ineligible for external beam radiation therapy due to a high-risk of toxicity. As carotid blowout is a concern in the setting of re-irradiation, a dose t...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2019.86298
更新日期:2019-06-01 00:00:00
abstract:Purpose:Increased complexity of interventional radiotherapy (brachytherapy - BT) treatment planning and quality control procedures has led to the need of a specific training. However, the details of the features of BT learning objectives and their distribution in the training paths of the Italian Radiation Oncology Sch...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
doi:10.5114/jcb.2019.83137
更新日期:2019-02-01 00:00:00
abstract:Purpose:To quantify the reduction of relative displacement between the implanted intracavitary applicator and the patient bony anatomy, due to the use of a hover transport system during the patient transports between the imaging table and the treatment table. Material and methods:The displacement of the applicator ins...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2018.73755
更新日期:2018-02-01 00:00:00
abstract:PURPOSE:To report the treatment effect of image-guided high-dose-rate (HDR) interstitial brachytherapy for refractory recurrence of papillary thyroid cancer (PTC). CASE REPORT:This 66-year-old female presented with recurrence 5 years after thyroidectomy for PTC. Despite external irradiation and radioactive (131)I, the...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2016.59127
更新日期:2016-04-01 00:00:00
abstract:PURPOSE:A report of preliminary results and toxicity profiles using image-guided brachytherapy (IGBT) combined with whole pelvic intensity-modulated radiation therapy (WP-IMRT) for locally advanced cervical cancer. MATERIAL AND METHODS:Fifteen patients with locally advanced cervical cancer were enrolled into the study...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2013.34338
更新日期:2013-03-01 00:00:00
abstract:PURPOSE:Intracavitary brachytherapy (ICB) is a widely used technique in the treatment of cervical cancer. In our Institute, we use different reconstructive methods in the conventional planning procedure. The main aim of this study was to compare these methods using critical organ doses obtained in various treatment pla...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2010.19498
更新日期:2010-12-01 00:00:00
abstract:PURPOSE:To report on preliminary results of a prospective study on MRI-assisted cervix cancer brachytherapy pre-planning. MATERIAL AND METHODS:In six locally advanced cervix cancer patients, five days before the first brachytherapy fraction, tandem & ring applicator was inserted under para-cervical anaesthesia, MRI pe...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:
更新日期:2009-10-01 00:00:00
abstract:PURPOSE:To study the safety and efficacy of high-dose-rate interstitial brachytherapy (HDRIBT) in patients with liver metastases (LM). MATERIAL AND METHODS:Between 2009 and 2011, 10 patients with 12 metastatic lesions in the liver were enrolled in this prospective trial. All patients had either refused surgery or foun...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2013.36175
更新日期:2013-06-01 00:00:00
abstract:Purpose:To compare post-implant dosimetrics between intraoperatively built custom-linked (IBCL) seeds and loose seeds (LS) at 24 hours and 1 month by sector analysis, and to evaluate the effect of IBCL seeds with regard to change in dosimetric parameters, in patients with prostate cancer treated with brachytherapy. Ma...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2020.98110
更新日期:2020-08-01 00:00:00
abstract:PURPOSE:Dose coverage is crucial for successful treatment in mono-brachytherapy. Since few and very high dose fractions are used, there is an important balance between dwell positioning outside the clinical target volume (CTV) and possible damage on adjacent normal tissue. The purpose of this study was to evaluate the ...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2014.45586
更新日期:2014-10-01 00:00:00
abstract:PURPOSE:To evaluate the treatment outcomes with high-dose-rate (HDR) interstitial brachytherapy (HDR-BRT) in head and neck cancers (HNC). MATERIAL AND METHODS:Fifty-eight patients with HNC as per American Joint Committee on Cancer (AJCC) TNM staging criteria were analyzed retrospectively between 2008 and 2015. Forty-t...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2017.67147
更新日期:2017-04-01 00:00:00
abstract:PURPOSE:During intracavitary brachytherapy (ICBT) for cervical cancer, the choice of applicator system remains rather arbitrary. However, as the applicator geometry may play an important role in dose distribution, thereby improving the therapeutic ratio, this study was conducted to compare the Manchester-style and Flet...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2012.32555
更新日期:2012-12-01 00:00:00
abstract:Purpose:Inadequate procedural training is of increasing concern in resident training, especially in prostate brachytherapy (PB). Transperineal rectal spacer placement (TRSP) requires many of the same proficiencies as PB. This work describes the assessment of teaching techniques focusing on developing critical competenc...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2019.90984
更新日期:2019-12-01 00:00:00
abstract:Purpose:Graphical optimization (GO) and inverse planning simulated annealing (IPSA) are the main treatment planning optimization techniques used in patients undergoing 3D brachytherapy treatment. This study aims to compare the dosimetric difference of plans optimized by GO and IPSA in cervical cancer brachytherapy. Ma...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2019.87145
更新日期:2019-08-01 00:00:00
abstract:Purpose:The aim of this study was to compare short-term oncologic outcomes and toxicity of focal or partial low-dose-rate brachytherapy (focal/partial LDR-BT) with whole gland low-dose-rate brachytherapy (whole LDR-BT) in localized prostate cancer patients. Material and methods:Medical records of eligible patients who...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2020.100374
更新日期:2020-10-01 00:00:00
abstract::The aim of this study is to report the use of ruthenium brachytherapy as an adjunctive treatment in the management of an intraocular extension of the conjunctival squamous cell carcinoma (SCC). In 2013, a 73-year-old man presented with a tumor blocking the angle and infiltrating corneal endothelium. The patient was tr...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2018.75603
更新日期:2018-04-01 00:00:00
abstract:Purpose:To compare the cervical cancer treatment outcome and toxicities between two different institutions. Material and methods:We analysed the clinical outcome of cervical cancer patients treated at two different centres from January 2015 to December 2016. Centre A treated 72 patients by external beam radiotherapy (...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2019.88582
更新日期:2019-10-01 00:00:00
abstract:PURPOSE:Radiotherapy for breast cancer includes different techniques and methods. The purpose of this study is to compare dosimetric calculations using TG-43 dose formalism and Varian Acuros™ BV (GBBS) dose calculation algorithm for interstitial implant of breast using metal catheters in high-dose-rate (HDR) brachyther...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2015.54052
更新日期:2015-08-01 00:00:00
abstract:Purpose:To evaluate the impact of supplemental external beam radiation therapy (EBRT) prior to permanent prostate brachytherapy on long term urinary, bowel, and erectile function. Material and methods:Patient administered urinary, bowel, and erectile quality of life (QoL) instrument were obtained prior to treatment an...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2017.70763
更新日期:2017-10-01 00:00:00
abstract:Purpose:The aim of this study was to propose an index for evaluating dosimetric impact of inter-observer target delineation variability in brachytherapy. Material and methods:The coverage with dosimetric concordance index (CDCI) is expressed as CDCIcommon and CDCIpair. The CDCIcommon is the mean coverage of target vol...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2020.94309
更新日期:2020-04-01 00:00:00
abstract::In order to improve oncologic outcomes in radiotherapy treatments of patients with unresectable pelvic sidewall recurrences of uterine cervical cancer, we combined high-dose-rate interstitial brachytherapy (HDR-ISBT) with newly tested hypoxic radiosensitizer Kochi oxydol-radiation therapy for unresectable carcinomas (...
journal_title:Journal of contemporary brachytherapy
pub_type:
doi:10.5114/jcb.2020.101695
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To retrospectively compare the potential dosimetric advantages of a multichannel vaginal applicator vs. a single channel one in intracavitary vaginal high-dose-rate (HDR) brachytherapy after hysterectomy, and evaluate the dosimetric advantage of fractional re-planning. MATERIAL AND METHODS:We randomly selected...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2014.47816
更新日期:2015-01-01 00:00:00
abstract:Purpose:Cervical cancer is the most common gynecological cancer in India. Uniform protocol-based treatment is important for achieving optimal outcomes. We undertook a survey to investigate patterns of care with special regard to patterns of care in cervical cancer brachytherapy in India. Material and methods:A 17-ques...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2019.90448
更新日期:2019-12-01 00:00:00
abstract:Purpose:This research aims to evaluate the effectiveness and safety of a robot-assisted 3D personalized template in 125I seed brachytherapy of thoracoabdominal tumors. Material and methods:Forty-three patients with different tumors were involved in this research between 2013 and 2015. They were all eligible to 125I se...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2018.77957
更新日期:2018-08-01 00:00:00
abstract::Paediatric malignancies are relatively rare, with an annual frequency of 13-14 in 100 000 children up to 15 years, and account for less than 1% of all cancer in developed countries. Paediatric tumours are generally managed with a multi-modality treatment programme that includes surgery, chemotherapy, and external beam...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
doi:10.5114/jcb.2010.14407
更新日期:2010-06-01 00:00:00
abstract::High-dose-rate endorectal brachytherapy (HDREBT) is an image guided brachytherapy treatment for patients with rectal cancer. It is based on tumor imaging with magnetic resonance in particular, which is used to choose eligible patients and improve tumor visualization. Treatment planning is performed using 3D CT simulat...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
doi:10.5114/jcb.2015.51402
更新日期:2015-04-01 00:00:00
abstract:PURPOSE:Groupe Européen de Curiethérapie (GEC) and European Society for Radiotherapy & Oncology (ESTRO) has proposed a rectal dose constraint of the most exposed 2-cc volume (D2cc of ≤ 75 Gy EQD2α/β = 3) during external-beam plus high-dose-rate brachytherapy (HDR-BT) in localized prostate cancer patients. This study ai...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2016.61738
更新日期:2016-08-01 00:00:00
abstract:Purpose:Perineal template-based interstitial gynecologic brachytherapy (ISBT) treatments are evaluated to determine whether adaptive inter-fraction re-planning is beneficial and necessary to meet the treatment aims of the American Brachytherapy Society (ABS) consensus guidelines for interstitial brachytherapy. Adherenc...
journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2019.84420
更新日期:2019-04-01 00:00:00