Abstract:
Purpose:To evaluate clinical outcomes in patients with localized prostate cancer (LPC) treated with 3D conformal high-dose-rate (HDR) brachytherapy (BT) as monotherapy. Material and methods:From March 2004 to November 2017, 277 men with LPC underwent 3D conformal HDR-BT as monotherapy, with a temporary implant. The dose prescription was: 38 Gy in 4 fractions (149 patients), 27 Gy in 2 fractions (41 patients), and 19-20 Gy in a single fraction (87 patients). Biochemical progression-free survival (bPFS), progression-free survival (PFS), and cancer-specific survival (CSS) were calculated. Acute and late genitourinary (GU) and gastrointestinal (GI) toxicity assessment were performed using Common Terminology Criteria for Adverse Events v5.0. Results:The mean age was 67 (range, 47-81) years. Overall, 145 patients were low-risk, 116 intermediate-risk, and 16 high-risk prostate cancer. After a median follow-up of six years (range, 6-160 months), bPFS, PFS, and CSS were 81%, 96%, and 97%, respectively. Dose prescription, initial prostate specific antigen (iPSA) ≥ 9,5 ng/ml, and high-risk disease resulted in prognostic factors regarding bPFS. Only G2-G3 acute or late GI and GU toxicities were observed. Conclusions:HDR-BT as monotherapy is a valid and safe treatment modality for localized prostate cancer. After a long follow-up, patients receiving 19-20 Gy in a single fraction had a lower biochemical control rate compared to patients receiving 38 Gy in 4 fractions or 27 Gy in 2 fractions. Randomized prospective trials with a longer follow-up are necessary to confirm our results, and define total doses and dose per fraction for HDR-BT in patients with LPC.
journal_name
J Contemp Brachytherapyjournal_title
Journal of contemporary brachytherapyauthors
Soatti CP,Delishaj D,D'Amico R,Frigerio C,Fumagalli IC,Bonsignore F,Sangalli G,Declich F,Arcangeli S,Ardizzoia A,Colombo Adoi
10.5114/jcb.2020.101685subject
Has Abstractpub_date
2020-12-01 00:00:00pages
533-539issue
6eissn
1689-832Xissn
2081-2841pii
42674journal_volume
12pub_type
杂志文章abstract:Purpose:We present a case report of treatment using interstitial and surface high-dose-rate (HDR) brachytherapy for cutaneous squamous cell carcinoma (SCC) involving the interspace of the third and fourth digits. The patient refused two-ray amputation and the lesion was not amenable for external beam radiation therapy ...
journal_title:Journal of contemporary brachytherapy
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abstract:Purpose:Increased complexity of interventional radiotherapy (brachytherapy - BT) treatment planning and quality control procedures has led to the need of a specific training. However, the details of the features of BT learning objectives and their distribution in the training paths of the Italian Radiation Oncology Sch...
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journal_title:Journal of contemporary brachytherapy
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doi:10.5114/jcb.2013.39210
更新日期:2013-12-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
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abstract::In order to improve oncologic outcomes in radiotherapy treatments of patients with unresectable pelvic sidewall recurrences of uterine cervical cancer, we combined high-dose-rate interstitial brachytherapy (HDR-ISBT) with newly tested hypoxic radiosensitizer Kochi oxydol-radiation therapy for unresectable carcinomas (...
journal_title:Journal of contemporary brachytherapy
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doi:10.5114/jcb.2020.101695
更新日期:2020-12-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2012.29365
更新日期:2012-06-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2015.51853
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:
更新日期:2009-06-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
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journal_title:Journal of contemporary brachytherapy
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2011.26472
更新日期:2011-12-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2017.69807
更新日期:2017-08-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:
更新日期:2009-03-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
doi:10.5114/jcb.2014.42023
更新日期:2014-03-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
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更新日期:2015-01-01 00:00:00
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章,评审
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
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journal_title:Journal of contemporary brachytherapy
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journal_title:Journal of contemporary brachytherapy
pub_type: 杂志文章
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journal_title:Journal of contemporary brachytherapy
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journal_title:Journal of contemporary brachytherapy
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journal_title:Journal of contemporary brachytherapy
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journal_title:Journal of contemporary brachytherapy
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abstract::The aim of this study is to report an uncommon case of nasal keloid treated with adaptive image-guided high-dose-rate (HDR) intracavitary brachytherapy. A 34-year-old female presented with nasal keloid after facial trauma was treated with scar resection and HDR intracavitary brachytherapy with a customized eccentric a...
journal_title:Journal of contemporary brachytherapy
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