Abstract:
OBJECTIVE:Post-traumatic stress disorder (PTSD) is a common psychiatric disorder, which may accelerate aging. Many study have investigated the association between telomeres length and PTSD, but results from published studies are contradictory. Therefore, Meta-analysis approaches were conducted to give more precise estimate of relationship between telomere length and PTSD. METHOD:We systematically reviewed the databases of PUBMED, PsycINFO, Medline(Ovid SP) and EMBASE for all articles on the association between telomere length and PTSD. Data were summarized by using random-effects in the meta-analysis. The heterogeneity among studies were examined by using Cochrane's Q statistic and I-squared. RESULTS:Five eligible studies containing 3851 participants were included in our meta-analysis. Shorten telomere length was significantly associated with PTSD with mean difference of -0.19( 95% CI: -0.27, -0.01; P<0.001) with I-square of 96%. The results from subgroup analysis demonstrated that shorter telomere length was significantly associated with PTSD across all gender groups, with mean difference of -0.15( 95% CI: -0.29, -0.01; P=0.04) for female, mean difference of -0.17( 95% CI: -0.19, -0.15; P<0.001) for male. Meanwhile, shorten telomere length was significantly associated with sexual assault(mean difference =-0.15, 95% CI: -0.29, -0.01), childhood trauma (mean difference =-0.08, 95% CI: -0.19, -0.07), but not combat (mean difference =-0.39, 95% CI: -0.83, 0.05). CONCLUSION:Compared to the individuals without PTSD, individuals with PTSD have shorter telomere length, which has implications for early intervention and timely treatment to prevent future adverse health outcomes.
journal_name
J Affect Disordjournal_title
Journal of affective disordersauthors
Li X,Wang J,Zhou J,Huang P,Li Jdoi
10.1016/j.jad.2017.03.048subject
Has Abstractpub_date
2017-08-15 00:00:00pages
322-326eissn
0165-0327issn
1573-2517pii
S0165-0327(16)31762-1journal_volume
218pub_type
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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journal_title:Journal of affective disorders
pub_type: 杂志文章,随机对照试验
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2019.01.053
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journal_title:Journal of affective disorders
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2011-08-01 00:00:00
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doi:10.1016/j.jad.2014.11.028
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2009.07.016
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doi:10.1016/s0165-0327(02)00338-5
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pub_type: 杂志文章
doi:10.1016/j.jad.2007.05.015
更新日期:2008-01-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.07.063
更新日期:2018-11-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2020.04.060
更新日期:2020-08-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2018.02.092
更新日期:2018-07-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章,评审
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.10.037
更新日期:2013-05-01 00:00:00
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journal_title:Journal of affective disorders
pub_type: 杂志文章
doi:10.1016/j.jad.2012.04.035
更新日期:2012-12-15 00:00:00