miRNA-503 Promotes Tumor Progression and Is Associated with Early Recurrence and Poor Prognosis in Human Colorectal Cancer.

abstract：:Aromatase inhibitor (AI) is widely used as an endocrine treatment in postmenopausal patients with hormone receptor-positive breast cancer. To identify useful prognostic factors for patients with metastatic breast cancer treated with AI therapy, we investigated the association between several hormone receptor-related f...

journal_title：Oncology

authors： Motomura K,Ishitobi M,Komoike Y,Koyama H,Nagase H,Inaji H,Noguchi S

更新日期：2010-01-01 00:00:00

abstract：:Ifosfamide is relatively well tolerated but it can be associated occasionally with life-threatening complications such as arrhythmias and heart failure, severe encephalopathy and hemorrhagic cystitis. Mesna administration can control the urothelial toxicity of ifosfamide, but it is without effect on the other complica...

journal_title：Oncology

authors： Klastersky J

更新日期：2003-01-01 00:00:00

abstract：:To assess the prognostic value of pretreatment serum neuron-specific enolase (NSE) in nonsmall cell lung cancer (NSCLC), levels were measured in 84 NSCLC patients, 40 healthy controls, and 20 patients with benign pulmonary diseases. NSE concentration was higher in NSCLC (11.7 +/- 10.8 ng/ml) (mean +/- SD; median = 9.7...

journal_title：Oncology

authors： Diez M,Torres A,Ortega L,Maestro M,Hernando F,Gomez A,Picardo A,Granell J,Balibrea JL

更新日期：1993-03-01 00:00:00

abstract：:The immunodepressive effect of a single, carcinogenic dose of dimethylnitrosamine was tested in a potent model of renal cancer induction using two antigens which differ in their cellular processing. Responsiveness to sheep red blood cells (SRBC), an antigen requiring the collaboration of both thymus-dependent (T) and ...

journal_title：Oncology

authors： Hard GC

更新日期：1981-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemoradiotherapy (nCRT) followed by total mesorectal excision surgery is a standard treatment for locally advanced rectal cancer (LARC). Tumor-infiltrating lymphocytes (TILs) have been reported to be associated with tumor response; however, this remains to be established. We previously reported ...

journal_title：Oncology

authors： Miyakita H,Sadahiro S,Suzuki T,Chan LF,Ogimi T,Okada K,Yamamoto S,Kajiwara H

更新日期：2020-01-01 00:00:00

abstract：:In order to assess the feasibility of a sequential hormonal treatment after tamoxifen failure, 24 postmenopausal advanced breast cancer patients (median age 60 years; ECOG PS < or = 1) were treated with formestane (4-hydroxyandrostenedione) 250 mg i.m. fortnightly; 19 patients were estrogen receptor-positive. The site...

journal_title：Oncology

authors： Noberasco C,Bajetta E,Zilembo N,Di Leo A,Cappuzzo F,Bartoli C,Bono A,Bichisao E

更新日期：1995-11-01 00:00:00

abstract：:Oxaliplatin-based chemotherapy is an effective first-line treatment option for patients with metastatic colorectal cancer (mCRC), which, in combination with targeted therapies and a sequential treatment approach using all active agents, has extended median overall survival to 2 years and beyond. Prolonged survival bri...

journal_title：Oncology

authors： Grothey A

更新日期：2010-01-01 00:00:00

abstract：:Patients with polycythemia vera (PV) experience shortened survival, increased risk of thromboembolic and hemorrhagic events, and burdensome symptoms. For all patients with PV, treatment with aspirin and hematocrit control with phlebotomy are recommended. In addition, patients with high-risk status or poor hematocrit c...

journal_title：Oncology

authors： Gerds AT,Dao KH

更新日期：2017-01-01 00:00:00

abstract：:Oral cancer is the eleventh most common cancer globally, with well-established major risk factors of tobacco, areca nut, alcohol, and high-risk human papillomavirus (HR-HPV) types 16 and 18. HR-HPV16/18 are the etiologic agents of cervical cancers and a proportion of oropharyngeal cancers. HPV-associated oropharyngeal...

journal_title：Oncology

authors： Yete S,D'Souza W,Saranath D

更新日期：2018-01-01 00:00:00

abstract：UNLABELLED:The outlook for patients with testicular germ cell cancer was dramatically improved by the introduction of cisplatin. Well-known side effects of cisplatin (nausea, vomiting, nephrotoxicity, myelosuppression) can be managed with preventive methods. The long life expectancy after this therapy draws attention t...

journal_title：Oncology

authors： Biró K,Baki M,Büki B,Noszek L,Jókúti L

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer. PATIENTS AND METHODS:Forty-eight patients were enrolled in this study. Patients received an alternating regimen of 4 cycles of mFOLF...

journal_title：Oncology

authors： Oki E,Emi Y,Akagi Y,Tokunaga S,Sadanaga N,Tanaka T,Ogata Y,Saeki H,Kakeji Y,Baba H,Nishimaki T,Natsugoe S,Shirouzu K,Maehara Y,Kyushu Study Group of Clinical Cancer.

更新日期：2013-01-01 00:00:00

abstract：:Malignant fibrous histiocytoma (MFH), the most common soft-tissue sarcoma, consists mainly of two different cell populations: histiocytelike and fibroblastlike cells. It has been suggested to contain a large amount of reactive histiocytes and fibroblasts hard to distinguish from the tumor cells. In this study, the clo...

journal_title：Oncology

authors： Fujita MQ,Hashida N,Shin M,Nakanishi H,Yoshihara W,Aozasa K

更新日期：1998-11-01 00:00:00

abstract：:To improve our understanding of the basic biological mechanisms of Hürthle cell tumours (HCT), proliferative activity in 20 HCT was determined by Ag-NOR (nucleolar organiser regions) counting and by immunohistochemical markers proliferating cell nuclear antigen (PCNA) and MIB-1. Ten surgically removed Hürthle cell ade...

journal_title：Oncology

authors： Cör A

更新日期：1999-07-01 00:00:00

abstract：:The relative risk of breast cancer incidence and tumor promotion associated with psychotropic drug consumption was evaluated in 151 patients with newly diagnosed neoplasms and 151 hospital controls. No significantly altered risk of breast cancer was found in association with the use of diazepam, chlordiazepoxide, anti...

journal_title：Oncology

authors： Wallace RB,Sherman BM,Bean JA

更新日期：1982-01-01 00:00:00

abstract：:We conducted a prospective multicenter phase II trial of patients with borderline resectable pancreatic carcinoma to investigate the efficacy of neoadjuvant nab-paclitaxel plus gemcitabine therapy on overall survival (OS). The clinical trial primarily evaluated OS time from the first day of protocol therapy as a prima...

journal_title：Oncology

authors： Okada KI,Shimokawa T,Hirono S,Kawai M,Sho M,Satoi S,Matsumoto I,Eguchi H,Murakami Y,Yamada S,Doi M,Yamaue H,NAC-GA investigators.

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Postoperative management of patients with pancreatic adenocarcinoma (PA) is controversial. METHODS:The aim of this pilot study was to assess the feasibility of postoperative combination chemotherapy followed by radiotherapy in patients aged 18-70 years with a histological diagnosis of PA, and Karnofsky perf...

journal_title：Oncology

authors： Reni M,Passoni P,Bonetto E,Balzano G,Panucci MG,Zerbi A,Ronzoni M,Staudacher C,Villa E,Di Carlo V

更新日期：2005-01-01 00:00:00

abstract：:Intratumoral metabolism and synthesis of estrogens are considered to play very important roles in the pathogenesis and development of various sex steroid-dependent neoplasms including breast and endometrial carcinoma. 17 beta-Hydroxysteroid dehydrogenase (17 beta-HSD) isozymes catalyze the interconversion of estradiol...

journal_title：Oncology

authors： Sasano H,Suzuki T,Takeyama J,Utsunomiya H,Ito K,Ariga N,Moriya T

更新日期：2000-01-01 00:00:00

abstract：:To establish appropriate indications for endoscopic treatment of submucosal invasive gastric carcinoma, we investigated clinicopathologic features and proliferating cell nuclear antigen (PCNA) expression at the deepest invasive portion of 192 differentiated submucosal invasive gastric carcinomas that had been surgical...

journal_title：Oncology

authors： Nishida T,Tanaka S,Haruma K,Yoshihara M,Sumii K,Kajiyama G

更新日期：1995-07-01 00:00:00

abstract：:A cultured cell line (SHIN-3) derived from a human ovarian serous cystadenocarcinoma which consistently produces two tumor markers, CA-125 and tissue polypeptide antigen (TPA) was established. After 1 week of culture of 1 x 10(5) cells, high levels of tumor marker were observed (the total CA-125 release was 1,500 U an...

journal_title：Oncology

authors： Imai S,Kiyozuka Y,Maeda H,Noda T,Hosick HL

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Sorafenib, a multitargeted tyrosine kinase inhibitor, is now the treatment of choice for systemic therapy of patients with advanced hepatocellular carcinoma (HCC). Herein, we present the clinical characteristics and outcomes of patients with advanced HCC who were treated with sorafenib. METHODS:Data of 201 ...

journal_title：Oncology

authors： Baek KK,Kim JH,Uhm JE,Park SH,Lee J,Park JO,Park YS,Kang WK,Lim HY

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Serrated adenoma (SA) consists of glands both with intraluminal projection of tall columnar cells, which resemble the terminally differentiated cells in the surface epithelium, and with concave short cells, which resemble progenitor crypt cells of the colon. The aim of this study was to clarify the relationsh...

journal_title：Oncology

authors： Jiao YF,Nakamura S,Sugai T,Yamada N,Habano W

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:Previous data showed that distant metastatic breast cancer (MBC) might be curable in up to 3% of the cases in selected patients, mostly young, with good performance status and with low-volume metastatic disease, mainly by an aggressive multidisciplinary approach including aggressive combination chemotherapy ...

journal_title：Oncology

authors： Güth U,Elfgen C,Montagna G,Schmid SM

更新日期：2019-01-01 00:00:00

abstract：:Methyl-CCNU (NSC-95441) was administered to patients with malignant melanoma in a split dose schedule. Nausea and vomiting were eliminated as clinical problems during therapy. Response rate to the drug seemed somewhat lower than the average of three previously reported disease-oriented phase II trials, though the diff...

journal_title：Oncology

authors： Wittes RE,Hong WK,Gatchell L,Krakoff IH,Golbey RB

更新日期：1977-01-01 00:00:00

abstract：:67Ga-subtraction scan was found to be useful and a promising new method for the pre-treatment evaluation of the patient with Hodgkin's disease or non-Hodgkin's lymphoma. The scan appeared to be most accurate in the neck, chest, and axillary regions. It appears to offer a means of increasing the accuracy of evaluating ...

journal_title：Oncology

authors： Krolikiewicz H,Maruyama Y,Deland FH,Beihn RM,Hafner T,Utley JF

更新日期：1977-01-01 00:00:00

abstract：:Nontumor-bearing C3H/He mice were splenectomized and intravenously inoculated 7 days later with Streptococcus pneumoniae, Pseudomonas aeruginosa, or Escherichia coli. The survival rate was reduced by splenectomy in the animals inoculated with S. pneumoniae, but did not change in those inoculated with P. aeruginosa or ...

journal_title：Oncology

authors： Ando T,Motokawa I,Sakurai K,Ohmura Y,Matsunaga K,Fujii T,Yoshikumi C,Taguchi T

更新日期：1988-01-01 00:00:00

abstract：BACKGROUND:It is unclear for whom new anti-human epidermal growth factor receptor 2 (anti-HER2) agents, such as pertuzumab and T-DM1, should be considered. We investigated prognostic factors before neoadjuvant chemotherapy (NAC) among HER2-positive invasive breast cancer patients and those after NAC among patients who ...

journal_title：Oncology

authors： Fujita N,Enomoto Y,Inakami K,Yanagisawa T,Iguchi C,Aono T,Nomura T,Yamamoto H,Kasugai T,Shiba E

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the outcomes of gemcitabine-treated patients with inoperable biliary tract cancers. METHODS:We conducted a retrospective study of consecutively treated 22 inoperable biliary tract cancer patients with gemcitabine (500-1,000 mg/m(2) on days 1, 8, 15 every 4 weeks) as f...

journal_title：Oncology

authors： Kiba T,Nishimura T,Matsumoto S,Hatano E,Mori A,Yasumi S,Doi R,Ikai I,Kitano T,Nishimura T,Yoshikawa K,Ishiguro H,Yanagihara K,Doi E,Teramukai S,Fukushima M

更新日期：2006-01-01 00:00:00

abstract：:Gastrointestinal stem cells have the capacity for long-term self-replication and the ability to give rise to all other epithelial cell lineages. These properties make them essential since they maintain tissue homeostasis by regulating cell turnover depending on the current demand. However, they are also important play...

journal_title：Oncology

authors： Schier S,Wright NA

更新日期：2005-01-01 00:00:00

abstract：:The activity of deoxycytidylate aminohydrolase, a pivotal enzyme for pyrimidine biosynthesis in mammalian tissue, is 100x greater in the Novikoff hepatoma harvested from the intraperitoneal cavity than in the same tumor excised from either subcutaneous or intramuscular sites. The increased enzyme activity in the intra...

journal_title：Oncology

authors： Sheid B

更新日期：1990-01-01 00:00:00

abstract：BACKGROUND:Recent data suggest that capecitabine may have little efficacy in women with metastatic triple negative breast cancer (TNT). We have therefore retrospectively analysed capecitabine outcome in the TN subgroup of patients with locally advanced or metastatic breast cancer treated in our unit. PATIENTS AND METH...

journal_title：Oncology

authors： Kotsori AA,Dolly S,Sheri A,Parton M,Shaunak N,Ashley S,Walsh G,Johnston S,Smith IE

更新日期：2010-01-01 00:00:00