Abstract：
:Occupational medical surveillance is highly desirable in manufacturing facilities where exposure to chemicals is significant. The insecticide fipronil is generally considered safe for humans but with increasing use, exposure to fipronil is of concern. Identification of urinary metabolites of fipronil may allow development of affordable, cheap and rapid procedures for human exposure evaluation. In this study we developed a fast and easy approach for synthesis of hydroxy-fipronil, a potential urinary metabolite of fipronil. This standard was used to develop a sensitive analytical LC-MS/MS method with a limit of quantification (LOQ) of 0.4ng/mL. Fipronil sulfone, a known metabolite, and hydroxy-fipronil were quantified in urine samples from rats treated with a fipronil containing diet. Fipronil sulfone concentration centered around 20ng/mL, while the concentration of hydroxy-fipronil was dose-dependent ranging in 10-10,000ng/mL and thus being a more sensitive marker of fipronil exposure. A fipronil immunoassay with cross-reactivity to hydroxy-fipronil showed a good correlation in signal intensity with LC-MS data. It was also used to demonstrate the applicability of the method for sample screening in the evaluation of exposure levels.
journal_name
Environ Intjournal_title
Environment internationalauthors
Vasylieva N,Barnych B,Wan D,El-Sheikh EA,Nguyen HM,Wulff H,McMahen R,Strynar M,Gee SJ,Hammock BDdoi
10.1016/j.envint.2017.03.012subject
Has Abstractpub_date
2017-06-01 00:00:00pages
91-98eissn
0160-4120issn
1873-6750pii
S0160-4120(17)30044-2journal_volume
103pub_type
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