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Comparison of two reference systems for biomarker data analysis in a freshwater biomonitoring context.

Abstract：

:The usefulness of fish biomarkers for freshwater biomonitoring is now well recognized, but they still pose several questions to ecotoxicology researchers. The present study, designed to assess the effects of a small city located in an agricultural river basin watershed on sticklebacks living in an adjacent river, underlines the importance of reference selection. Two reference systems were used to analyse responses of a set of biomarkers, including biotransformation enzymes, oxidative stress parameters, neurotoxicity and endocrine disruption end-points, measured in wild sticklebacks electrofished in a contaminated stream. The results showed that the investigated urban pressure disturbed CYP3A activity but also induced hepatic lipoperoxidation and circulating vitellogenine but this result is strongly influenced by the selected reference system. This work therefore demonstrates the need for further research to identify a robust reference system for stickleback biomarker analysis.

journal_name

Environ Int

journal_title

Environment international

authors

Sanchez W,Piccini B,Maillot-Maréchal E,Porcher JM

doi

10.1016/j.envint.2010.02.006

subject

Has Abstract

pub_date

2010-05-01 00:00:00

pages

377-382

issue

4

eissn

0160-4120

issn

1873-6750

pii

S0160-4120(10)00027-9

journal_volume

36

pub_type

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