[The status of large vessels in overweight and obesity according to ultrasound findings].

Abstract:

AIM:To investigate the impact of overweight and obesity on the structure and function of large arteries in apparently healthy individuals; to estimate the magnitude of atherosclerotic lesions of the vessels. MATERIALS AND METHODS:Sixty-one apparently healthy individuals with varying weights were randomly examined. All the examinees were divided into 3 groups according to their body mass index (BMI) and blood pressure (BP). They all underwent ultrasonography of the brachiocephalic arteries at the extracranial level, as well as the abdominal aorta and femoral arteries. RESULTS:The overweight and obese persons have increased diameters and thickness of the intima-media complex of the common carotid arteries and aorta. These changes are maximally pronounced in obesity in conjunction with high normal BP (systolic BP, 130-139 mm Hg; diastolic BP, 85-89 mm Hg). At the same time, there is a reduction in blood flow velocities and an increase in arterial wall stiffness. More marked structural and functional changes are observed in persons with abdominal obesity. The femoral artery belonging to muscular ones exhibited no structural changes, but displayed reduced blood flow velocities in obesity concurrent with high normal BP. In all the groups, the spread of atherosclerotic plaques is equal; the latter are recorded in one third of the examinees. However, the degree and incidence of vascular atherosclerosis are higher in overweight and obesity concurrent with high normal BP. CONCLUSION:The overweight and obese persons without cardiovascular diseases were found to have eccentric remodeling of elastic and muscular-and-elastic vessels: the carotid arteries and aorta in conjunction with increased intima-media thickness, reduced blood flow velocities, and atherosclerotic vascular changes. These changes are most pronounced in the obese persons with high normal BP. In all the groups, atherosclerotic changes are encountered mainly in the brachiocephalic arteries at the extracranial level. :Цель исследования. Изучить влияние избыточной массы тела и ожирения на структурно-функциональное состояние крупных артерий у практически здоровых лиц. Оценить выраженность атеросклеротического поражения сосудов. Материалы и методы. Обследовали 61 практически здорового человека с различной массой тела методом случайной выборки. Всех испытуемых разделили на 3 группы в зависимости от индекса массы тела (ИМТ) и величины артериального давления (АД). Всем обследованным проводили ультразвуковое исследование плечеголовных (брахиоцефальных) артерий на экстракраниальном уровне, а также брюшного отдела аорты, бедренных артерий. Результаты. У лиц с избыточной массой тела и ожирением увеличены диаметры и толщина комплекса интима-медиа (ТИМ) общих сонных артерий и аорты. Эти изменения максимально выражены при ожирении в сочетании с высоким нормальным АД (систолическое АД 130-139 мм рт.ст., диастолическое АД 85-89 мм рт.ст.). Одновременно с этим наблюдается снижение скоростей кровотока, увеличивается жесткость артериальной стенки. Более выраженные структурно-функциональные изменения наблюдались у лиц с абдоминальным типом ожирения. В бедренной артерии, относящейся к артериям мышечного типа, структурные изменения не выявлены, имеется снижение скоростей кровотока при сочетании ожирения и высокого нормального АД. Распространенность атеросклеротических бляшек во всех группах одинакова, бляшки регистрировались у 1/3 обследованных. Однако при сочетании избыточной массы тела и ожирения с высоким нормальным АД выраженность и распространенность атеросклероза сосудов больше. Заключение. У лиц с избыточной массой тела и ожирением, не имеющих сердечно-сосудистых заболеваний, выявлено эксцентрическое ремоделирование сосудов эластического и мышечно-эластического типов: сонных артерий и аорты в сочетании с увеличением ТИМ, снижением скоростей кровотока и атеросклеротическими изменениями сосудов. У лиц с высоким нормальным АД и ожирением эти изменения наиболее выражены. Атеросклеротические изменения встречаются во всех группах, преимущественно в брахиоцефальных артериях на экстракраниальном уровне.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Khovaeva YB,Batalova AA,Golovskoy BV,Gerasimova АV

doi

10.17116/terarkh201688429-34

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

29-34

issue

4

eissn

0040-3660

issn

2309-5342

journal_volume

88

pub_type

杂志文章
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    authors: Tulenbaev MZh,Adibaev OA,Satbekov ZhS,Akanov AA,Kaĭrbekov AK

    更新日期:1987-01-01 00:00:00

  • [Prevalence of arterial hypertension and efficacy of long-term multifactor prophylaxis in some regions of Russia].

    abstract:AIM:To study prevalence of arterial hypertension (AH) in relation to gender, age, profession, risk factors (RF), RF combination; efficacy of active long-term multifactor prevention among the employees of industrial enterprises in some regions of Russia. MATERIAL AND METHODS:14000 males and 20969 females from industria...

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    doi:

    authors: Tozhiev MS,Khvan YE,Shestov DB,Tadzhiev FS,Vorob'ev AM,Ochilova RKh,Terebov AA,Avdeeva GP,Bondarenko VV,Tepliakov VCh

    更新日期:2007-01-01 00:00:00

  • [Use of immunoglobulin for treating patients with nonspecific ulcerative colitis].

    abstract::The therapeutic effect of human immunoglobulins was assessed in 29 patients with nonspecific ulcerative colitis, as was their influence on intestinal flora. A 5 to 15 ml dose of immunoglobulin was administered intramuscularly every other day, 3 injections altogether. The clinical and endoscopic effect of treatment was...

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    doi:

    authors: Khalif IL,Kirkin BV,Glad'ko IA,Korshunov VM,Pinegin BV

    更新日期:1986-01-01 00:00:00

  • [Variability of the hypolipidemic action of simvastatin and fluvastatin in patients with primary hyperlipoproteinemia].

    abstract:AIM:To reveal the metabolic parameters of lipoproteins (L), which determine the benefits of hypolipidemic effects of simvastatin (S) and fluvastatin (F); to trace changes in the activity of lecithin-cholesterol acyltransferase (LCA) and cholesterol (C) ester transfer (CET) from high density lipoproteins to very low den...

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    doi:

    authors: Tvorogova MG,Susekov AV,Semenova OA,Kukharchuk VV,Titov VN

    更新日期:1998-01-01 00:00:00

  • [Local radiotherapy in combined treatment of rheumatoid arthritis].

    abstract:AIM:To study efficiency in rheumatoid arthritis (RA) of local radiotherapy methods: radionuclide synovectomy (RS), x-ray therapy (XRT) and local gamma-therapy (LGT) proposed by the authors. MATERIAL AND METHODS:175 patients with RA received local radiotherapy on the knee joints. The patients were divided into three gr...

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    doi:

    authors: Marusenko IM,Ignat'ev VK,Zdorov AE

    更新日期:2001-01-01 00:00:00

  • [Reverse diffusion of hydrogen ions and its correlation with acid secretion and proliferative activity of gastric mucosal epithelium in patients with variants of chronic gastritis and peptic ulcer].

    abstract::Eighty-one patients with chronic gastritis and 124 patients with peptic ulcer were examined. It was discovered that in chronic gastritis, the concomitant gastritis included, in patients with peptic ulcer, the degree of enhancement of reverse diffusion of hydrogen ions depended on the intensity of atrophy of the fundal...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Geller LI,Alekseenko SA

    更新日期:1984-01-01 00:00:00

  • [Non-Hodgkin's lymphomas of the spleen and their pathomorphosis following splenectomy].

    abstract::Clinico-morphological correlations in non-Hodgkin's splenic lymphomas (NHL) have shown that a clinical course and hematological symptoms of splenic NHL correlate with a morphological variant of disease. Blast forms have a more aggressive course. Data on the clinical pathomorphosis of splenic NHL after splenectomy sugg...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Korchmaru IF,Iakovleva IA

    更新日期:1987-01-01 00:00:00

  • [Nitric-oxidergic mechanisms in the regulation of the bronchi and their significance in the pathogenesis of bronchial asthma].

    abstract:AIM:Assessment of NO-synthase (NOS) activity in bronchial asthma (BA) basing on cytochemical identification and quantitation of NADPN-diaphorase. MATERIALS AND METHODS:Operative samples from 12 BA patients and biopsies from 8 patients free of bronchial inflammation or obstruction. Experimental data on control and BA r...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Nevzorova VA,Eliseeva EV,Zuga MV,Protopopova MIu,Gel'tser BI

    更新日期:1998-01-01 00:00:00

  • [Clinical significance of disorders of local defense in nonspecific lung diseases].

    abstract::A study was made of the humoral (IgA, G, M, lysozyme and lactoferrin) and cellular links (phagocytic activity of alveolar macrophages) of pulmonary local defence as well as sputum adhesion in 177 patients with chronic nonspecific pulmonary diseases (80 patients with chronic obstructive bronchitis, 54 patients with pyo...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Dvoretsiiĭ LI,Didkovskiĭ NA,Charlyev G

    更新日期:1986-01-01 00:00:00

  • [The problems in optimizing the delivery of general therapeutic care at the regional level during the transition to compulsory medical insurance].

    abstract::The authors hold that perfection of local therapeutic service in present-day situation when insurance principles are introduced in medical care may be achieved through design of medico-economic standards of guaranteed minimum of medical aid for each citizen of Russian Federation. This approach allows accurate estimati...

    journal_title:Terapevticheskii arkhiv

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    doi:

    authors: Riabov SI,Poliakov IV,Lind VA,Petukhova VV,Andreeva EN,Kaiukov IG,Ermakov IuA,Dobronravov VA,Rumiantsev ASh

    更新日期:1996-01-01 00:00:00

  • [The specific features of pancreatic incretory dysfunction in chronic pancreatitis].

    abstract:AIM:To reveal the specific features of pancreatogenic diabetes mellitus (DM) and to discuss the principles of its medical therapy. SUBJECTS AND METHODS:Sixty-six patients (55 men and 11 women) aged 30 to 65 years with chronic pancreatitis (CP) were examined. The disease was accompanied with pancreatic calcification an...

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    doi:

    authors: Vinokurova LV,Shuliat'ev IS,Drozdov VN,Berezina OI,Varvanina GG,Nevmerzhitskiĭ VI

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  • [Comparative efficacy of combined therapy with preductal and amino acid composition in elderly patients with coronary heart disease and class II-III angina].

    abstract:AIM:A comparative analysis of effectiveness of combined therapy including trimetazidine (preductal) and composition of amino acids (glutamic acid, glycin and cystein) in elderly patients with coronary heart disease and angina of functional class II-III (FC II-III). MATERIALS AND METHODS:60 patients (47 females and 13 ...

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Zaslavskaia RM,Kelimberdieva ES,Komissarova IA,Teĭblium MM,Goncharov LF,Goncharova ZF,Akhmetov KZh

    更新日期:1999-01-01 00:00:00

  • [Rheumatoid arthritis: achievements and unresolved issues].

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  • [A multicenter evaluation of efficacy and tolerance in the local treatment with dolgit cream of patients with osteoarthrosis].

    abstract::A 2-week clinical trial of cream dolgit efficacy and tolerance in 76 patients with primary osteoarthritis in 8 rheumatological centers showed this preparation to reduce local pain syndrome in 70.1%, palpation pain sensitivity in 79.2%, joint swelling in 75.5% of patients. Unwanted reactions in the form of skin itch at...

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    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Nasonova VA,Murav'ev IuV,Nasonov EL,Lebedeva VV,Tsvetkova ES,Chichasova NV,Badokin VV,Lesniak OM,Demin AA,Baranova EIa

    更新日期:1995-01-01 00:00:00

  • [Meloxicam: the golden mean of nonsteroidal anti-inflammatory drugs].

    abstract::Nonsteroidal anti-inflammatory drugs (NSAIDs) are most commonly used to treat acute and chronic pain in locomotor system (LMS) diseases. However, their administration may be accompanied by the development of dangerous complications as organic and functional disorders of the cardiovascular system (CVS) and gastrointest...

    journal_title:Terapevticheskii arkhiv

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    doi:

    authors: Karateev AE

    更新日期:2014-01-01 00:00:00

  • [HLA antigens in systemic lupus erythematosus patients].

    abstract::A study was made of the rate of HLA system antigens in 75 patients with different clinical versions and immuno-pathological manifestations of systemic lupus erythematosus (SLE). A total of 350 normal subjects comprised the control group. During SLE, a high rate of DNW3, B8 and AI antigens was revealed. Associative rel...

    journal_title:Terapevticheskii arkhiv

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    doi:

    authors: Matveĭkov GP,Levin VI,Dosin IuM,Kaliia ES,Semenov GV

    更新日期:1984-01-01 00:00:00

  • [Effectiveness of differential diagnosis of benign and malignant ulcers at endoscopy].

    abstract:AIM:Assessment of efficacy of differential diagnosis between benign and malignant lesions in gastric mucosa by means of endoscopy. MATERIALS AND METHODS:Morphological verdicts upon investigation of operative specimens were compared to findings at preoperative duodenofibrogastroscopy with spot biopsy in 326 patients op...

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    authors: Gurin NN,Logunov KV

    更新日期:1998-01-01 00:00:00

  • [Acarbose (glucobai) effects on lipid metabolism in patients with non-insulin dependent diabetes mellitus].

    abstract:AIM:To investigate the effect of acarbose, intestinal alpha-glucosidase inhibitor, on lipid metabolism in patients with non-insulin-dependent diabetes mellitus (NIDDM). MATERIAL AND METHODS:Glucobai was given for 6 months in a dose 300 mg/day to 63 NIDDM patients aged 40-69 years. The examination covered indices of gl...

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    更新日期:2000-01-01 00:00:00

  • [The problem of secondary immunodeficiencies in patients with chronic bronchitis].

    abstract::The paper concerns the problem of secondary immunodeficiency (SID) in chronic bronchitis (CB) patients. Clinical and laboratory criteria of SID are suggested with clinical illustrations covering 57 cases. SID was diagnosed in 80.7% of the examinees and was associated with reduced quantitative and functional parameters...

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    authors: Shirinskiĭ VS,Sennikova IuA

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  • [The clinical, hemodynamic and hormonal-metabolic effects of the calcium-antagonist treatment of middle-aged and elderly patients with IHD at the polyclinic stage of rehabilitation].

    abstract::160 presenile and senile CHD patients received calcium antagonists nifedipine, verapamil, diltiazem. The highest antianginal effect occurred after a course of verapamil with special effect in those functionally compromised. Rheoencephalographic picture was dependent on the initial functional class of the patient and o...

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    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Pimenov LT,Ezhov AV,Churshin AD,Dudarev MV

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  • [Possibility of complex medicamental and endovascular treatment of pulmonary hypertension in Takayasu arteritis with predominant pulmonary arteries' lesion].

    abstract::Takayasu arteritis (TA) is a systemic vasculitis with predominatly lesions of aorta and its large branches. In some cases pulmonary arteries (PA) are involved in the pathological inflammatory process and lead to the formation of pulmonary hypertension and significantly worse the prognosis. Timely development of lesion...

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    pub_type: 杂志文章

    doi:10.26442/00403660.2020.05.000623

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  • [The effect of plasmapheresis on the function of the calcium-regulating systems in patients with rheumatoid arthritis].

    abstract::As many as 87 patients with rheumatoid arthritis were examined for changes in the status of the calcium-regulating systems under the influence of therapy. The multimodality treatment of 57 of the patients included discrete plasmapheresis, which allowed the attainment of an earlier and more marked beneficial clinicolab...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Trusov VV,Bazhenov VN,Odnopozov II

    更新日期:1991-01-01 00:00:00

  • [A cytokine status in chronic alcoholic and biliary pancreatitis].

    abstract:AIM:To determine characteristics of a cytokine status in chronic pancreatitis (CP) depending on etiological factor, stage of the disease, complications, therapy. Material and methods. 72 patients had chronic alcoholic pancreatitis (CAP), 38 patients--chronic biliary pancreatitis (CBP). Control group consisted of 20 hea...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Vinokurova LV,Zhivaeva NS,Tsaregorodtseva TM,Serova TI

    更新日期:2006-01-01 00:00:00

  • [Orthostatic hypotension in primary amyloidosis].

    abstract::Proceeding from clinicoanatomical observation of a 50-year-old man, the authors discuss the pathogenesis of arterial hypotension developing in generalized amyloidosis with severe affection of the cardiovascular and nervous system, and the adrenal glands. ...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Lapin VV,Baĭkov VV,Kodzaev IuK,Amineva KhK

    更新日期:1988-01-01 00:00:00

  • [Current approaches to treating of patients with multiple myeloma with renal failure: Questions and proofs].

    abstract::Renal failure (RF) is detected in 20-30% of patients at the onset of multiple myeloma (MM), in 50% of patients during its progression. The advent of new, highly effective agents has considerably expanded the possibilities of treatment in MM patients. Unfortunately, patients with RF, especially those with severe RF, we...

    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章,评审

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    authors: Rekhtina IG,Mendeleeva LP

    更新日期:2017-01-01 00:00:00

  • [Correlations between electrophysiological myocardial remodeling and parameters of free radical oxidation in patients with various forms of ischemic heart disease].

    abstract:AIM:To investigate potentialities of a novel biochemical test assessing oxidative resistance of plasma as a marker of ischemic damage to the myocardium and to study this marker correlation with high-performance ECG parameters reflecting electrophysiological remodeling of the myocardium in patients with ischemic heart d...

    journal_title:Terapevticheskii arkhiv

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    doi:

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  • [Successful use of long-term follow-up in patients with chronic myeloid leukemia with a deep molecular response at reduced doses of 2nd generation tyrosine kinase inhibitors: clinical cases and literature review].

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  • Clinical, Virusological and Immunological characteristics of hospitalised HIV-infected patients.

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  • [The concurrence of kidney and liver dysfunctions in decompensated heart failure].

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    authors: Villevalde SV,Kobalava ZD,Solovyeva AЕ,Moiseev VS

    更新日期:2016-01-01 00:00:00

  • [The role of the renin-angiotensin system in the pathogenesis of nephrotic syndrome].

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    journal_title:Terapevticheskii arkhiv

    pub_type: 杂志文章

    doi:

    authors: Kutyrina IM,Klepikov PV,Tareeva IE

    更新日期:1988-01-01 00:00:00