Attention-related EEG markers in adult ADHD.

Abstract:

:ADHD status affects both bottom-up sensory processing and top-down attentional selection, impairing professional and social functioning. The objective of the study was to investigate the functional mechanisms of attention deficits in adult ADHD by examining the electrophysiological activities associated with bottom-up attentional cueing (temporal and spatial orienting of attention) and top-down control (conflict resolution). Continuous EEG was recorded in 21 adult ADHD patients (40.05±9.5 years) and 20 healthy adults (25.5±4 years) during performance of the Attention Network Test (ANT). We examined the cue and target-related P1, N1 and P3 components as well as the contingent negative variation (CNV) developing between cue and target. Oscillatory responses were analyzed in the alpha (8-13Hz) and beta (14-19Hz) frequency bands. ADHD patients performed similarly to controls but showed reduced P3 amplitude, larger early CNV decrementing over time, reduced preparatory activation in both alpha and beta bands, as well as flattened target-related posterior alpha and beta responses. As compared to controls, the inverted CNV pattern suggested peculiar preparatory processing in ADHD patients. The singular pattern of target-related beta response indicated increased inhibitory processes in the case of easier task resolution and more generally, the lack of association between conflict resolution speed and beta activity supported alternative executive processing in ADHD patients. Overall, the reduced activation of the functional networks devoted to bottom-up and top-down attention suggests that adult ADHD patients engage reduced cortical resources in this composite task, compatible with the cortical hypoarousal model.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

Hasler R,Perroud N,Meziane HB,Herrmann F,Prada P,Giannakopoulos P,Deiber MP

doi

10.1016/j.neuropsychologia.2016.05.008

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

120-133

eissn

0028-3932

issn

1873-3514

pii

S0028-3932(16)30159-2

journal_volume

87

pub_type

杂志文章
  • The representational-hierarchical view of amnesia: translation from animal to human.

    abstract::Animal research has, in our opinion, made an invaluable contribution to our understanding of human amnesia. In this article we summarise our and others' work in this area, focusing on a new view of amnesia we refer to as the representational-hierarchical view. According to this view-and in contrast to the prevailing p...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2010.02.026

    authors: Saksida LM,Bussey TJ

    更新日期:2010-07-01 00:00:00

  • Reaching movements may reveal the distorted topography of spatial representations after neglect.

    abstract::It has been proposed that patients with spatial neglect fail to respond appropriately toward stimuli opposite their brain lesion because they have an impairment of directing attention. However, a disorder of 'intention' - or movement initiation - has also been demonstrated in this condition. Recently, the paths of neg...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(99)00083-4

    authors: Jackson SR,Newport R,Husain M,Harvey M,Hindle JV

    更新日期:2000-01-01 00:00:00

  • Neural mechanisms involved in the detection of our first name: a combined ERPs and PET study.

    abstract::In everyday social interactions, hearing our own first name captures our attention and gives rise to a sense of self-awareness, since it is one of the most socially self related stimulus. In the present study, we combined ERPs and PET scan methods to explore the cerebral mechanisms underlying the detection of our own ...

    journal_title:Neuropsychologia

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.neuropsychologia.2004.07.002

    authors: Perrin F,Maquet P,Peigneux P,Ruby P,Degueldre C,Balteau E,Del Fiore G,Moonen G,Luxen A,Laureys S

    更新日期:2005-01-01 00:00:00

  • Material-dependent and material-independent selection processes in the frontal and parietal lobes: an event-related fMRI investigation of response competition.

    abstract::The present study used the flanker task [Percept. Psychophys. 16 (1974) 143] to identify neural structures that support response selection processes, and to determine which of these structures respond differently depending on the type of stimulus material associated with the response. Participants performed two versio...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(03)00040-x

    authors: Hazeltine E,Bunge SA,Scanlon MD,Gabrieli JD

    更新日期:2003-01-01 00:00:00

  • Understanding retrosplenial amnesia: insights from animal studies.

    abstract::Bilateral damage in the posterior cingulate region can induce anterograde amnesia. Identifying the potential contributions of the various areas within this heterogeneous region has, however, largely depended on animal research. Within the posterior cingulate region the retrosplenial cortex stands out by virtue of its ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章,评审

    doi:10.1016/j.neuropsychologia.2009.09.030

    authors: Aggleton JP

    更新日期:2010-07-01 00:00:00

  • Attentional blink in patients with multiple sclerosis.

    abstract::The attentional blink (AB), characterized as a failure to detect a second target following correct identification of a previous target in a rapid serial visual presentation (RSVP), has become a useful measure for investigation of the temporal dynamics of attention. In our previous work, we proposed a two-stage concurr...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2010.10.032

    authors: Kavcic V,Scheid E

    更新日期:2011-02-01 00:00:00

  • The PCSK6 gene is associated with handedness, the autism spectrum, and magical ideation in a non-clinical population.

    abstract::Common polymorphisms in the gene PCSK6, whose protein product mediates the development of brain and body asymmetry through the NODAL pathway, have recently been associated with handedness in three studies, making it a key candidate gene for understanding the developmental and expression of human lateralization. We tes...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2016.02.020

    authors: Robinson KJ,Hurd PL,Read S,Crespi BJ

    更新日期:2016-04-01 00:00:00

  • Dissociable prefrontal networks for cognitive and affective theory of mind: a lesion study.

    abstract::The underlying mechanisms and neuroanatomical correlates of theory of mind (ToM), the ability to make inferences on others' mental states, remain largely unknown. While numerous studies have implicated the ventromedial (VM) frontal lobes in ToM, recent findings have questioned the role of the prefrontal cortex. We des...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2007.05.021

    authors: Shamay-Tsoory SG,Aharon-Peretz J

    更新日期:2007-10-01 00:00:00

  • Differential-handed response to verbal and visual spatial stimuli: evidence of specialized hemispheric processing following callosotomy.

    abstract::Left- and right-hand responses were studied in a patient who had undergone complete corpus callosotomy to examine selective hemispheric processing employing free-field stimuli. Tests of verbal and visual spatial processing were presented, and multiple choice performances were obtained using both left and right hands. ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(89)90005-5

    authors: Loring DW,Meador KJ,Lee GP

    更新日期:1989-01-01 00:00:00

  • The effect of goal-subgoal conflict on planning ability after frontal- and temporal-lobe lesions in humans.

    abstract::Twenty-one patients with unilateral prefrontal cortical neurosurgical lesions (11 left and 10 right) and 38 patients with unilateral temporal lobectomy (19 left and 19 right) were compared to 44 matched control subjects on their performance on the 3-D Computerized Tower of Hanoi (3-D CTOH) test. The problems were spli...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(97)00009-2

    authors: Morris RG,Miotto EC,Feigenbaum JD,Bullock P,Polkey CE

    更新日期:1997-08-01 00:00:00

  • Differences in semantic category priming in the left and right cerebral hemispheres under automatic and controlled processing conditions.

    abstract::The contribution of each cerebral hemisphere to the generation of semantic category meanings at automatic and strategic levels of processing was investigated in a priming experiment where prime and target words were independently projected to the left or right visual fields (LVF or RVF). Non-associated category exempl...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(98)00156-0

    authors: Collins M

    更新日期:1999-08-01 00:00:00

  • The multiple-lemma representation of Italian compound nouns: a single case study of deep dyslexia.

    abstract::It is not clear how compound words are represented within the influential framework of the lemma-lexeme theory. Theoretically, compounds could be structured through a multiple lemma architecture, in which the lemma nodes of both the compound and its constituents are involved in lexical processing. If this were the cas...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2012.01.021

    authors: Marelli M,Aggujaro S,Molteni F,Luzzatti C

    更新日期:2012-04-01 00:00:00

  • Hemispheric asymmetries in bilinguals: tongue similarity affects lateralization of second language.

    abstract::It is known that the left hemisphere of the human brain is critical in understanding and producing spoken language, but it remains a topic of great interest determining the cerebral lateralization of multiple languages. The aim of this study is to examine the effects of similarity between languages on hemispheric asym...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2013.03.016

    authors: D'Anselmo A,Reiterer S,Zuccarini F,Tommasi L,Brancucci A

    更新日期:2013-06-01 00:00:00

  • Vision and cognition in Alzheimer's disease.

    abstract::Alzheimer's disease (AD) is known to affect visual pathways, but potential concomitant effects on vision and cognitive performance are not well understood. We studied 43 individuals with AD of mild severity and 22 individuals without dementia on a battery of tests designed to measure multiple aspects of basic and high...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(00)00023-3

    authors: Rizzo M,Anderson SW,Dawson J,Nawrot M

    更新日期:2000-01-01 00:00:00

  • Age-related differences in processing irrelevant information: evidence from event-related potentials.

    abstract::Ignoring irrelevant information becomes more difficult with increasing age. The present cross-sectional study addressed this issue by investigating age-related differences in the ability to withhold a response to non-target stimuli. Fourteen young (20-34 years) and 14 elderly (60-80 years) participants performed two g...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2008.10.018

    authors: Vallesi A,Stuss DT,McIntosh AR,Picton TW

    更新日期:2009-01-01 00:00:00

  • Are planum temporale and sylvian fissure asymmetries directly related? A MRI study in great apes.

    abstract::In humans and great apes, both the planum temporale (PT-part of Wernicke's area) and the sylvian fissure (SF) in the left cerebral hemisphere have been consistently shown to be larger than the corresponding structures in the right hemisphere. The greater length of the SF in the left hemisphere is commonly thought to b...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(02)00288-9

    authors: Cantalupo C,Pilcher DL,Hopkins WD

    更新日期:2003-01-01 00:00:00

  • Higher intraindividual variability is associated with more forgetting and dedifferentiated memory functions in old age.

    abstract::Intraindividual trial-to-trial reaction time (RT) variability is commonly found to be higher in clinical populations or life periods that are associated with impaired cognition. In the present study, higher within-person trial-to-trial RT variability in a perceptual speed task is related to more forgetting and dediffe...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2011.03.013

    authors: Papenberg G,Bäckman L,Chicherio C,Nagel IE,Heekeren HR,Lindenberger U,Li SC

    更新日期:2011-06-01 00:00:00

  • Selective transfer of visual working memory training on Chinese character learning.

    abstract::Previous research has shown a systematic relationship between phonological working memory capacity and second language proficiency for alphabetic languages. However, little is known about the impact of working memory processes on second language learning in a non-alphabetic language such as Mandarin Chinese. Due to th...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2013.10.017

    authors: Opitz B,Schneiders JA,Krick CM,Mecklinger A

    更新日期:2014-01-01 00:00:00

  • Activation of Broca's area during the production of spoken and signed language: a combined cytoarchitectonic mapping and PET analysis.

    abstract::Broca's area in the inferior frontal gyrus consists of two cytoarchitectonically defined regions-Brodmann areas (BA) 44 and 45. Combining probabilistic maps of these two areas with functional neuroimaging data obtained using PET, it is shown that BA45, not BA44, is activated by both speech and signing during the produ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(03)00125-8

    authors: Horwitz B,Amunts K,Bhattacharyya R,Patkin D,Jeffries K,Zilles K,Braun AR

    更新日期:2003-01-01 00:00:00

  • Reflective lateral eye movements: individual styles, cognitive and lateralization effects.

    abstract::The direction of gaze shifts following verbal and spatial questions was recorded by direct observation in two separate sessions in 80 right-handed Ss. Ocular events were stable over the sessions, and some Ss were classified reliably as lateral, vertical or bidirectional eye movers. No effect for type of question was f...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(88)90007-3

    authors: De Gennaro L,Violani C

    更新日期:1988-01-01 00:00:00

  • Bilateral visual cross-integration by human forebrain commissurotomy subjects.

    abstract::Four forebrain commissurotomized patients were compared with one partially commissurotomized control subjects on their ability to cross-compare simultaneously flashed bilateral visual stimuli (colors, schematic faces, numbers, letters, patterns) as same or different, or to name the two stimuli. Two of the four patient...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(84)90059-9

    authors: Johnson LE

    更新日期:1984-01-01 00:00:00

  • Visuomotor priming by pictures of hand postures: perspective matters.

    abstract::Observing hand postures interacts with the preparation of similar actions. This may be due to motor encoding of the observed displays and/or to enhanced visual processing induced by motor planning. We studied the effects of the observer's perspective on motor representation, using a visuomotor priming task with simple...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/s0028-3932(02)00319-6

    authors: Vogt S,Taylor P,Hopkins B

    更新日期:2003-01-01 00:00:00

  • Is there a positive bias in false recognition? Evidence from confabulating amnesia patients.

    abstract::Although there is some evidence for a positive emotional bias in the content of confabulations in brain damaged patients, findings have been inconsistent. The present study used the semantic-associates procedure to induce false recall and false recognition in order to examine whether a positive bias would be found in ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2015.08.002

    authors: Alkathiri NH,Morris RG,Kopelman MD

    更新日期:2015-10-01 00:00:00

  • The innate sense of the body develops to become a public affair by 2-3 years.

    abstract::Infants from birth do express a sense of their own body as a differentiated entity among other entities in the world, an entity that is situated, physically bounded, organized, and agent in the environment. Quickly however, this implicit sense of self develops to become explicit, conceptual, and more importantly, publ...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2009.11.021

    authors: Rochat P

    更新日期:2010-02-01 00:00:00

  • Laterality and unilateral deafness: Patients with congenital right ear deafness do not develop atypical language dominance.

    abstract::Auditory speech perception, speech production and reading lateralize to the left hemisphere in the majority of healthy right-handers. In this study, we investigated to what extent sensory input underlies the side of language dominance. We measured the lateralization of the three core subprocesses of language in patien...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2015.10.032

    authors: Van der Haegen L,Acke F,Vingerhoets G,Dhooge I,De Leenheer E,Cai Q,Brysbaert M

    更新日期:2016-12-01 00:00:00

  • Risk for depression is associated with neural biases in emotional categorisation.

    abstract::Negative biases in emotional processing are a major characteristic of depression. Recent research has shown that such negative biases are evident in high risk individuals even in the absence of personal history of depression, suggesting that they may serve as key vulnerability markers of depression. However, the neura...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2008.05.030

    authors: Chan SW,Harmer CJ,Goodwin GM,Norbury R

    更新日期:2008-10-01 00:00:00

  • Improving language without words: first evidence from aphasia.

    abstract::The pervasiveness of word-finding difficulties in aphasia has motivated several theories regarding management of the deficit and its effectiveness. Recently, the hypothesis was advanced that instead of simply accompanying speech gestures participate in language production by increasing the semantic activation of words...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2010.09.025

    authors: Marangolo P,Bonifazi S,Tomaiuolo F,Craighero L,Coccia M,Altoè G,Provinciali L,Cantagallo A

    更新日期:2010-11-01 00:00:00

  • Cluster analysis reveals at least three, and possibly five distinct handedness groups.

    abstract::Multivariate techniques have used data from hand preference questionnaires to group hand preference items, but no attempt has been made to date to use multivariate analyses to group individuals in terms of handedness groups. This study analyzed the responses of 645 subjects on the Waterloo 60-item handedness questionn...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/0028-3932(92)90110-8

    authors: Peters M,Murphy K

    更新日期:1992-04-01 00:00:00

  • Heterotopagnosia: When I point at parts of your body.

    abstract::Heterotopagnosia is the acquired inability of brain-lesioned patients to point at someone else's body parts when prompted. The cognitive basis of this disorder is unclear. It might result from a biological function deficit critical for communication in human beings; alternatively, it could result from the disruption o...

    journal_title:Neuropsychologia

    pub_type: 杂志文章

    doi:10.1016/j.neuropsychologia.2009.02.016

    authors: Cleret de Langavant L,Trinkler I,Cesaro P,Bachoud-Lévi AC

    更新日期:2009-06-01 00:00:00

  • Location and function of the human frontal eye-field: a selective review.

    abstract::The location and possible function of the human frontal eye-field (FEF) were evaluated by reviewing results of cerebral blood-flow (CBF) and lesion studies. A remarkable consistency was found regarding the rostro-caudal (Y: from -6 to 1 mm) and dorso-ventral (Z: from 44 to 51 mm) location of the FEF, as defined by the...

    journal_title:Neuropsychologia

    pub_type: 杂志文章,评审

    doi:10.1016/0028-3932(95)00134-4

    authors: Paus T

    更新日期:1996-06-01 00:00:00