Abstract:
INTRODUCTION:Skull base metastases (SBM) are an infrequent and late type of cancer progression that are associated to poor prognosis. Its clinical manifestations may be grouped in five clinical syndromes and radiotherapy is its more frequent treatment. Because of the improvement in imaging tests and the close follow up of cancer patients, SBM can be diagnosed incidentally. In this group the best option of treatment has not been established. AIM:To analyze the clinical features and outcomes of patients with SBM diagnosed incidentally. PATIENTS AND METHODS:Between January 2012 and December 2015, 31 patients with diagnoses of SBM from solid primary tumor were reviewed. RESULTS:SBM were diagnosed due to skull base syndromes (n = 24) or incidentally (n = 7). Symptomatic patients were treated with radiotherapy. Patients diagnosed incidentally remained without symptoms of craneal base involvement during the follow up, although they frequently had other types of intracranial progression. A statistically significant difference in survival was observed between symptomatic and asymptomatic patients (p = 0.001). CONCLUSIONS:The incidentally diagnosed SBM were frequently associated to other types of intracranial progression, limiting the options of treatment. TITLE:Metastasis asintomaticas de la base craneal: evolucion clinica y alternativas terapeuticas. :Introduccion. Las metastasis sintomaticas de la base craneal (MBC) son una progresion infrecuente, tardia y de mal pronostico en pacientes con tumores solidos. Sus manifestaciones clinicas pueden agruparse en cinco sindromes caracteristicos, y su tratamiento mas frecuente es la radioterapia. Gracias a los progresos tecnologicos en las pruebas de imagen y al seguimiento estrecho de los pacientes con cancer, las MBC pueden diagnosticarse incidentalmente. En este subgrupo no se conoce la evolucion clinica ni se ha establecido la mejor modalidad de tratamiento. Objetivo. Analizar las caracteristicas clinicas y la evolucion de los pacientes diagnosticados incidentalmente de MBC. Pacientes y metodos. Entre enero de 2012 y diciembre de 2015, 31 pacientes con una neoplasia solida diagnosticados de MBC fueron valorados por nuestro servicio. Resultados. Las MBC se diagnosticaron por la presencia de un sindrome de base craneal (n = 24) o incidentalmente (n = 7). Los pacientes sintomaticos fueron tratados con radioterapia. Todos los pacientes diagnosticados incidentalmente permanecieron sin sintomas relacionados con la afectacion de la base craneal hasta la fecha del fallecimiento, aunque frecuentemente presentaron de forma concomitante otros tipos de progresion intracraneal de mal pronostico. Se observo una diferencia estadisticamente significativa en la supervivencia a favor de los pacientes sintomaticos (p = 0,001). Conclusiones. Las MBC diagnosticadas incidentalmente se asociaron frecuentemente a otros tipos de progresion intracraneal, limitando las opciones terapeuticas.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Vargas A,Paulazo C,Oleaga L,Verger Esubject
Has Abstractpub_date
2017-03-01 00:00:00pages
201-204issue
5eissn
0210-0010issn
1576-6578pii
rn2016329journal_volume
64pub_type
杂志文章abstract:INTRODUCTION:In the early stages of their development, children acquire the skills and knowledge that provide them with the foundations on which they will later add what they learn at school, including skills such as reading, writing and mathematics. The presence of learning difficulties at the infantile stage can affe...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-02-13 00:00:00
abstract:INTRODUCTION:Human beings are characterised by the specialisation of certain functions, such as language or the ability to walk. We have achieved this capacity thanks to the development of multiple connections among different areas of the central and peripheral nervous system, together with adaptation of the musculoske...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
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更新日期:2009-01-23 00:00:00
abstract:TITLE:Parálisis súbita de la supraversión de la mirada en una niña de 9 años. : ...
journal_title:Revista de neurologia
pub_type: 信件
doi:10.33588/rn.7110.2020275
更新日期:2020-11-16 00:00:00
abstract::We present a family study of multiple cavernomatosis which affected a boy of six, his mother and two brothers. It was seen clinically as epileptic crises, focal neurological defects and frequent headaches. In our case, the condition started as a syndrome of intracranial hypertension with progressive headache and vomit...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract:AIMS:To review the fundamentals of occupational therapy (OT) and to present its possible contributions in the field of neurological rehabilitation. DEVELOPMENT:As its name suggests, OT is a form of treatment that makes use of occupations. Furthermore, occupation is a purpose itself, since OT seeks to adapt the individ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2002-08-16 00:00:00
abstract:INTRODUCTION:Neuronal ceroid lipofuscinosis (NCL), represents a group of inherited neurodegenerative disorders. Based on the age of the patient at onset, clinical course and ultrastructural morphology it has been identified three clinical types for the pediatric group: 1) Infantile NCL (INCL); 2) Late infantile NCL (LI...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The cognitive effects of the most commonly used antiepileptic drugs (AEDs) are reviewed, discussing both the absolute effects (the effects compared to no treatment) and the relative effects (the comparison of one AED with an other). The cognitive profile per AED is given, based on a literature database, consisting of ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2002-05-01 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:The paraneoplastic neurological syndromes are alterations associated with neoplasias. However, they are not caused by metastases or complications such as infections, vascular disorders, metabolic or nutritional alterations or secondary effect of treatment. The paraneoplastic syndromes are o...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-16 00:00:00
abstract:INTRODUCTION:An arterial gas embolism is defined as the presence of air in the arterial circulation. This is an extremely rare cause of stroke that has been described in a multitude of clinical scenarios, generally related to iatrogenic processes. A clinical case is reported in which the arterial gas embolism occurred ...
journal_title:Revista de neurologia
pub_type:
doi:10.33588/rn.6903.2019178
更新日期:2019-08-01 00:00:00
abstract:INTRODUCTION:Epilepsy and the epileptic syndromes are common neurological diseases and represent an important public health problem that has given rise to marked social and healthcare concerns. AIM:To analyse the changes in the consumption of antiepileptic drugs in the Basque Country Autonomous Community over a 13 yea...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-04-16 00:00:00
abstract:AIMS:To analyze the validity of the single deck 64-card Wisconsin Card Sorting Test (WCST-64) compared to the standard version (WCST-128), and to study the sensibility of both versions to identify changes over time in patients with traumatic brain injury (TBI). PATIENTS AND METHODS:The WCST was administered twice acro...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-02-01 00:00:00
abstract::Neuroinflammation is a key process in the neuropathogenesis of AIDS virus since as a result of the aberrant activation of the chemokine receptors (CXCR4, CX3CR1 and CR5) produces proinflammatory cytokine release by infected cells, increases microglial neurotoxicity and generates lipoperoxides and reactive oxygen speci...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2011-01-16 00:00:00
abstract:INTRODUCTION:Since the 1980s, in relation to the spread of AIDS, there has been an enormous increase in cryptococcosis, a mycotic disorder which usually affects the central nervous system (CNS). This disease is caused by Cryptococcus neoformans, a microorganism acquired by inhalation of bird excrement. This germ produc...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-05-16 00:00:00
abstract:INTRODUCTION:Scientific cooperation is essential for the advance of science. Bibliometrics and social network analysis offer evaluation indicators to analyse collaboration in scientific papers. The aim of this study is to characterize scientific collaboration patterns in Revista de Neurología between 2002 and 2006. MA...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract:AIM:To review the neurochemical features and therapeutic options for frontotemporal dementia (FTD). DEVELOPMENT:The main neurochemical alterations in FTD are the serotoninergic and dopamine depletion. In contrast with Alzheimer's and diffuse Lewy bodies disease, there are not significant alterations of the cholinergic...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-05-01 00:00:00
abstract:TITLE:Meningoencefalitis tuberculosa con quistes aracnoideos medulares y siringomielia aguda. ...
journal_title:Revista de neurologia
pub_type: 信件
doi:
更新日期:2017-10-16 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:The treatment of non traumatic intra cerebral haemorrhage is one of the therapeutic challenges at the present time. In spite of present day technology and advances in understanding its physiopathology, the prognosis is the same as it was fifteen years ago. We review the surgical treatments us...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2001-06-01 00:00:00
abstract::In the last years there is an increasing interest in the knowledge of vascular status in patients with acute stroke. Detection and localization of an artery occlusion is of great interest for an accurate prognosis and the selection of the most appropriate recanalizing therapy. Neurosonology is a useful diagnostic tool...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2013-01-01 00:00:00
abstract::Prenatal risk factors causing cerebral palsy (CP), here defined as a non-progressive motor abnormality of tone or posture, are much more numerous than once believed, when a great deal of brain injury was attributed to factors surrounding delivery. Scientific advances in genetics and biochemistry, as well as clinical t...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-08-01 00:00:00
abstract:INTRODUCTION:Tourette syndrome is a neurologic disorder characterized by involuntary vocal and motor tics. It affects around 1 to 2% of school-age children and is the most common movement disorder in paediatric age. Tics are involuntary or semivoluntary, sudden, brief, intermittent, repetitive movements (motor tics) or...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-23 00:00:00
abstract:INTRODUCTION:The new antiepileptic drugs should also be evaluated outside clinical trials. OBJECTIVE:To study the efficacy of treatment with lamotrigine in everyday neuropaediatric clinical practice. PATIENTS AND METHODS:We made a longitudinal study of all patients treated with lamotrigine in a hospital outpatients d...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-07-16 00:00:00
abstract:INTRODUCTION AND DEVELOPMENT:Face recognition requires a special type of processing that is different to that used to recognise objects. The right medial region of the fusiform gyrus displays a higher degree of activation when dealing with faces, which is why it is known as the fusiform face area, although the integrit...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2005-01-15 00:00:00
abstract:INTRODUCTION:Progressive cerebral polidystrophy or Alpers syndrome is a clinico-pathological picture, with no specific biological marker, characterized by involvement mainly of the cerebral grey matter and which shows clinically as a rapidly progressive encephalopathy with intractable seizures, usually myoclonic. The t...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-12-01 00:00:00
abstract:INTRODUCTION:Stroke is a recognized cause of disability among adults. However the impact that the deficits that occur after a moderate/severe stroke have on long-term disability, as well as the response of the resultant deficits to rehabilitation, are not completely understood. PATIENTS AND METHODS:A total of 396 pati...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2017-05-01 00:00:00
abstract:OBJECTIVE:To review the incidence and causes of the infections and metabolic diseases of the nervous system in patients with systemic neoplasias. DEVELOPMENT:Patients with immunodeficiency, particularly those with hematological neoplasias and persons treated with immunosuppressive drugs have a considerable tendency to...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-12-16 00:00:00
abstract:INTRODUCTION:OnabotulinumtoxinA (OnabotA) is indicated for headache prophylaxis in patients with chronic migraine. However, there is some controversy about what is the minimum effective dose for treating chronic migraine patients. AIM:To determine the optimal dose of OnabotA for the prophylactic treatment of patients ...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2014-03-10 00:00:00
abstract:INTRODUCTION:Over the last twenty years much work has been done to study the P300 in alcoholism. A systematically reduced amplitude, both in patients and in populations at risk (children of alcoholics) was found. Besides, studies on twins indicate that the waves of the evoked potentials are under genetic control. Furth...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-04-16 00:00:00
abstract:OBJECTIVE:To evaluate, using transcranial Doppler, changes in parameters in patients with cerebral hematoma, as compared with controls, for detection of possible regional hypoperfusion. PATIENTS AND METHODS:We studied 24 patients with cerebral hematomas and 15 healthy volunteers. The volume of the hematoma and the hyp...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-07-16 00:00:00
abstract::Asymptomatic carotid stenosis is a relatively frequent pathology, although when considering the possibility of managing it surgically, there is still an important amount of disagreement concerning the criteria to be taken into account. This study conducts a broad examination of the condition, from its concept and epid...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2012-09-01 00:00:00
abstract::Traffic accidents (TA) are, after heart disease, cancer and stroke, the fourth death cause among the general population. Although the number of AT caused by diseases-excluding alcoholism- seems to be reduced, interaction between organic pathology and functional ability increases the importance of this problem. This pa...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1995-03-01 00:00:00