Abstract:
INTRODUCTION:OnabotulinumtoxinA (OnabotA) is indicated for headache prophylaxis in patients with chronic migraine. However, there is some controversy about what is the minimum effective dose for treating chronic migraine patients. AIM:To determine the optimal dose of OnabotA for the prophylactic treatment of patients with chronic migraine. DEVELOPMENT:We performed a literature review of the randomized, double blind, placebo-controlled studies that have evaluated the safety and efficacy of OnabotA as headache prophylactic treatment in migraine patients. In the studies conducted before the PREEMPT clinical programme, a variety of dose ranges and infiltration paradigms were used. Initial phase II studies of OnabotA in chronic daily headache showed that those patients treated with 150 U had significant mean reductions from baseline in headache frequency compared with placebo, and this benefit was not observed for patients treated with 75 U. The experience from previous studies allowed to define an injection paradigm and dose range (155-195 U) that was used in the PREEMPT clinical trials. PREEMPT studies demonstrate that OnabotA is a safe an effective prophylactic treatment for chronic migraine. CONCLUSIONS:Available evidence to date supports that the optimal dose for the treatment of chronic migraine patients is the use of at least 150 U of OnabotA, that should be administered according to the PREEMPT injection paradigm. TITLE:Realmente es beneficioso usar las dosis de OnabotulinumtoxinA del estudio PREEMPT? :Introduccion. La OnabotulinumtoxinA (OnabotA) esta indicada para el tratamiento preventivo de los pacientes con diagnostico de migraña cronica. Existe cierta controversia acerca de cual es la dosis minima eficaz de OnabotA. Objetivo. Determinar cual es la dosis mas adecuada de OnabotA para el tratamiento de la migraña cronica. Desarrollo. Se revisan los estudios controlados frente a placebo, que han evaluado la eficacia y seguridad de OnabotA para el tratamiento de la migraña, prestando especial atencion a las dosis de toxina utilizadas. En los diferentes ensayos clinicos llevados a cabo antes del año 2010 se utilizaron distintos protocolos de infiltracion. La experiencia obtenida de los estudios previos permitio definir un protocolo de infiltracion que se utilizo en el programa PREEMPT, y que demostro que el tratamiento con OnabotA es seguro y eficaz en pacientes con migraña cronica. La dosis elegida en los ensayos PREEMPT 1 y 2 fue de 155-195 U, al observarse en los estudios en fase II que la dosis de 75 U no era eficaz y que la utilizacion de 150-200 U aumentaba la eficacia sin incrementar los efectos adversos. Ademas de la dosis, el paradigma de inyeccion PREEMPT tambien establece de manera detallada los puntos de inyeccion y la metodologia de infiltracion. Conclusiones. La evidencia cientifica disponible hasta la fecha sustenta que la dosis mas adecuada para el tratamiento de la migraña cronica es la utilizacion de al menos 150 U de OnabotA, y que la infiltracion debe realizarse con la metodologia definida en el paradigma de inyeccion PREEMPT.
journal_name
Rev Neuroljournal_title
Revista de neurologiaauthors
Irimia P,Esteve-Belloch P,Murie-Fernandez M,Martinez-Vila Esubject
Has Abstractpub_date
2014-03-10 00:00:00pages
S13-9eissn
0210-0010issn
1576-6578pii
rn2014024journal_volume
58 Suppl 2pub_type
杂志文章,评审abstract:INTRODUCTION:Human beings are characterised by the specialisation of certain functions, such as language or the ability to walk. We have achieved this capacity thanks to the development of multiple connections among different areas of the central and peripheral nervous system, together with adaptation of the musculoske...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2009-01-23 00:00:00
abstract:AIM:To describe the main physiopathological mechanisms of obstructive sleep apnea syndrome (OSAS) associated with the development of stroke. DEVELOPMENT:Sleep breathing disorders have a high prevalence in the healthy population, among them, the OSAS is the most recognized. This syndrome has been associated with vascul...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.6906.2019061
更新日期:2019-09-16 00:00:00
abstract:INTRODUCTION:We describe a series of 10 children with intracranial hypertension complicating fulminant hepatic failure submitted to intracranial pressure (ICP) monitoring for intensive care and transplantation management. PATIENTS AND METHODS:Information from pediatrics patients acute liver failure admitted to our hos...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2009-02-01 00:00:00
abstract:INTRODUCTION:Most patients with Parkinson's disease have cognitive and behavior disorders during the course of their illness. OBJECTIVE:In this study we consider practical aspects of the treatment of patients with Parkinson's disease who have such problems. DEVELOPMENT:Better understanding of both normal and abnormal...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:1999-07-16 00:00:00
abstract:INTRODUCTION AND MATERIAL:Nine brains belonging to early onset Alzheimer disease (E280A-PS1 mutation) affected individuals from Antioquia, Colombia, were analyzed by neuropathological standard techniques. All individuals were ascertained from genealogies descendents from a common ancestor that shows a dominant autosomi...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-07-01 00:00:00
abstract:INTRODUCTION:Cultural manifestations are frequently used as a source of descriptors in the field of the health sciences. The story of Odysseus (Ulysses) is one of the oldest and most influential works of world literature and has given rise to many subsequent creations, with strong roots in popular culture. AIMS:To con...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:10.33588/rn.7103.2020187
更新日期:2020-08-01 00:00:00
abstract:INTRODUCTION:Mental retardation (MR) is a clinical condition that may be due to a large variety of causes, the most important of which are those of a genetic origin, owing to the repercussions they can have on the family. There are more than one thousand types of MR with a genetic origin, and they are not usually found...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2006-01-07 00:00:00
abstract:INTRODUCTION:Thymectomy is a surgical procedure which is generally accepted for treatment of myasthenia gravis. OBJECTIVE:To describe the long-term evolution of 217 myasthenic patients who had had thymectomies in the Hospital Clinico Quirurgico Hermanos Ameijeiras in La Habana, Cuba. PATIENTS AND METHODS:We determine...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-05-01 00:00:00
abstract:INTRODUCTION:Parkinson's disease (PD) is a common neurodegenerative disease which begins in adulthood. Its incidence in Mexico is estimated to be 40-50 cases per 100,000 inhabitants/year and is the fourth reason for medical care in the National Institute of Neurology and Neurosurgery. The protein alpha-synuclein, SNCA,...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2016-10-16 00:00:00
abstract::Several predispocitional and genetic factors are thought to be involved in the etiology of Alzheimer s disease (AD). Except for age, there is no consensus among researchers about the factors that can best predict AD. Some studies have found that, older women, cerebrovascular risk factors (hypertension, ischemic heart ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-07-16 00:00:00
abstract::We report four young women with Takayasu's arteritis who developed an ischemic stroke. In three of these patients, this complication heralded the onset of the disease. Three patients also had seizures. In all cases, the diagnosis was suspected on the basis of an abnormal cardiovascular examination showing absent carot...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::The term 'acute myelopathies'--referred to a spinal cord dysfunction--represent a heterogeneous group of disorders with distinct etiologies, clinical and radiologic features, and prognoses. The objective of this review is to discuss the non-traumatic acute myelopathies. Acute myelopathy can be due to several causes as...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2013-09-06 00:00:00
abstract:INTRODUCTION:Colloid cysts are intracranial lesions with an estimated incidence of three individuals per million people per year. They are benign tumours in the anterosuperior portion of the third ventricle. The normal flow of cerebrospinal fluid may be interrupted by a large cyst that obstructs the foramen of Monro. T...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2003-05-01 00:00:00
abstract:INTRODUCTION:Attention deficit disorder with or without hyperactivity (ADHD) is characterised by the patients' inability to pay attention in non selective activities, hyperactivity that is difficult to inhibit, impulsiveness with failure to control their reactions and an unstable personality, which gives rise to diffic...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-03-16 00:00:00
abstract:INTRODUCTION:The efficiency of Cambridge Cognitive Examination' (CAMCOG) is analyzed as a tool to detect dementias in epidemiological studies. PATIENTS AND METHODS:The data were obtained from subjects who enrolled the second phase on a door-to-door field epidemiological study. The tool used was the 'Cambridge Mental D...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-02-16 00:00:00
abstract:AIM:To identify the clinical features that predict a favourable response to onabotulinumtoxinA (OnabotA) treatment in patients with refractory migraine. PATIENTS AND METHODS:Retrospective analysis of patients with refractory migraine who underwent at least two pericranial injections of OnabotA between 2008 and 2012. P...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2014-03-16 00:00:00
abstract:OBJECTIVE:To review all the neurosurgical techniques currently used for the relief of pain. DEVELOPMENT:The techniques described range from the classical operations causing lesions, such as neurotomy, rhizotomy, cordotomy, mesencephalotomy, thalamotomy, hypothalamotomy, cingulectomy, leukotomy and hypophysectomy, to t...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2000-03-16 00:00:00
abstract:INTRODUCTION AND AIMS:Parasomnias have been little studied in prepubertal age children. When it happens often they can alter the continuity of the sleep and reduce the value restorer of this affecting the academic functioning and daytime behavioural in younger children. We study the total frequency of the parasomnias, ...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2007-07-01 00:00:00
abstract:INTRODUCTION:Hyperekplexia is a disease characterized by an exaggerated startle reflex in front of minimal tactile and/or acoustic stimuli, that usually goes with high muscular tone, except when the patient is sleep. When the patient grows, high muscular tone decreases and then appear sudden hypertonic episodes that ma...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract:INTRODUCTION:Between 5 and 48% of the patients with Behçet s disease have neurological abnormalities. In children, meningoencephalitis as an initial manifestation of the disease is not frequent. CASE REPORT:We present a four years old girl with a Behçet s disease. When she was six months of age, during an hospitalizat...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::Different therapeutic models have been presented with which to treat the condition of attention deficit hyperactivity disorder (ADHD) and the scientific literature speaks of the benefits linked to multimodal approaches. The National Institute of Mental Health report grants combined treatments an essential role. Throug...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2004-02-01 00:00:00
abstract:INTRODUCTION:Diverse evidences have shown that the process of natural aging causes a decline in different cognitive functions, including among them the attentional process. AIM:To determine how the healthy aging affects to the different attentional networks. SUBJECTS AND METHODS:Two groups: young subjects (32.5 ± 9.7...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2011-01-01 00:00:00
abstract:INTRODUCTION:Optic neuritis is rare in childhood. Frequently (35-52% of all cases depending on the series) they have, during their clinical course, foci of demyelination leading to the clinical picture of multiple sclerosis (MS). Since 1993, the optic neuritis study group has recommended treatment with high doses of co...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:1999-05-01 00:00:00
abstract:INTRODUCTION:The possibility of diagnosing carotid stenosis and carrying out surgery without arteriography has increased with the use of different diagnostic methods. The eco-Doppler has been shown to be a useful method, although it requires previous individualised validation. OBJECTIVE:We aim to validate our Vascular...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-09-01 00:00:00
abstract:INTRODUCTION:In the evaluation of stenoses of the extracranial internal carotid artery (ICA), there are studies that suggest that magnetic resonance angiography (MRA) can be a substitute for conventional arteriography (CA), although it seems it has a tendency to overestimate the degree of stenosis. No similar compariso...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2003-10-16 00:00:00
abstract:INTRODUCTION:Stroke is a serious but potentially reversible entity. Reducing the time of care in the acute phase is essential to limit morbidity and mortality. The evaluation of the performances in stroke care is essential because it allows identify opportunities for improvement. AIM:To understand and analyze the dete...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2016-02-16 00:00:00
abstract:INTRODUCTION:Eosinophil infiltration of skeletal muscle is rare, but often no etiological factor can be identified and these are isolated eosinophilic myositis. They may be associated with parasite infections or drugs, or be features of rare systemic disorders of hypereosinophilia, such as the myalgia eosinophilia synd...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2001-11-16 00:00:00
abstract:INTRODUCTION AND OBJECTIVE:The treatment of non traumatic intra cerebral haemorrhage is one of the therapeutic challenges at the present time. In spite of present day technology and advances in understanding its physiopathology, the prognosis is the same as it was fifteen years ago. We review the surgical treatments us...
journal_title:Revista de neurologia
pub_type: 杂志文章,评审
doi:
更新日期:2001-06-01 00:00:00
abstract:INTRODUCTION:Scientific cooperation is essential for the advance of science. Bibliometrics and social network analysis offer evaluation indicators to analyse collaboration in scientific papers. The aim of this study is to characterize scientific collaboration patterns in Revista de Neurología between 2002 and 2006. MA...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2008-06-01 00:00:00
abstract:INTRODUCTION:Depression is a state of mind often associated with Parkinson's disease, which is not correlated with the stage of the disease or the response to treatment with L-dopa. It has been suggested that patients with right-sided Parkinsonism have more depression than those with left-sided. OBJECTIVE:To assess wh...
journal_title:Revista de neurologia
pub_type: 杂志文章
doi:
更新日期:2000-12-16 00:00:00