Abstract:
INTRODUCTION:With the globalization of Chagas disease, unexperienced health care providers may have difficulties in identifying which patients should be examined for this condition. This study aimed to develop and validate a diagnostic clinical prediction model for chronic Chagas disease. METHODS:This diagnostic cohort study included consecutive volunteers suspected to have chronic Chagas disease. The clinical information was blindly compared to serological tests results, and a logistic regression model was fit and validated. RESULTS:The development cohort included 602 patients, and the validation cohort included 138 patients. The Chagas disease prevalence was 19.9%. Sex, age, referral from blood bank, history of living in a rural area, recognizing the kissing bug, systemic hypertension, number of siblings with Chagas disease, number of relatives with a history of stroke, ECG with low voltage, anterosuperior divisional block, pathologic Q wave, right bundle branch block, and any kind of extrasystole were included in the final model. Calibration and discrimination in the development and validation cohorts (ROC AUC 0.904 and 0.912, respectively) were good. Sensitivity and specificity analyses showed that specificity reaches at least 95% above the predicted 43% risk, while sensitivity is at least 95% below the predicted 7% risk. Net benefit decision curves favor the model across all thresholds. CONCLUSIONS:A nomogram and an online calculator (available at http://shiny.ipec.fiocruz.br:3838/pedrobrasil/chronic_chagas_disease_prediction/) were developed to aid in individual risk estimation.
journal_name
Rev Soc Bras Med Tropjournal_title
Revista da Sociedade Brasileira de Medicina Tropicalauthors
Brasil PE,Xavier SS,Holanda MT,Hasslocher-Moreno AM,Braga JUdoi
10.1590/0037-8682-0196-2016subject
Has Abstractpub_date
2016-05-01 00:00:00pages
329-40issue
3eissn
0037-8682issn
1678-9849pii
S0037-86822016000300329journal_volume
49pub_type
杂志文章abstract::Saprophytic fungi are being increasingly recognized as etiologic agents of mycoses in immunosuppressed patients. We report a case of subcutaneous infiltration by Aureobasidium pullulans, likely due to traumatic inoculation, in a neutropenic patient during chemotherapy for chronic lymphocytic leukemia. The patient was ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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doi:10.1590/s0037-86822006000300007
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abstract:INTRODUCTION:The present study shows a descriptive analysis of triatomine occurrence and its natural Trypanosoma infection rates in the state of Pernambuco, Brazil, between 2006 and 2007. METHODS:Entomological data for the species, such as specimens captured in both intra and peridomiciles and natural infection index,...
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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abstract::The activity of azole fungicides for agronomical use (epoxiconazole, difenoconazole and cyproconazole) was evaluated in comparison with the therapeutic antifungal agent fluconazole, on 23 environmental samples of Cryptococcus neoformans var neoformans isolated from pigeon feces that were collected from farms with agri...
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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abstract::By morphological and morphometric analyses of serial sections the occurrence of T. cruzi nests in the central vein and in the parenchyma of adrenal glands, in the left ventricular wall and in the inferior vena cava wall in chronic Chagasic patients was studied. Of 36 cases 50% showed parasites in the adrenal central v...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821991000200002
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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doi:10.1590/s0037-86821991000300004
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821991000400008
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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更新日期:2007-03-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
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abstract::Considered as an American tegumentary leishmaniasis (ATL) endemic area, Ribeira Valley, in the south region of São Paulo State, presented 929 notified cases in the last 15 years. Aiming to identify the phlebotomine fauna, captures were performed fortnightly in the rural area of Pedro de Toledo County during one year, ...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
doi:10.1590/s0037-86821998000500002
更新日期:1998-09-01 00:00:00
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journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
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更新日期:2020-02-07 00:00:00
abstract:INTRODUCTION::This study aimed to evaluate a new commercial kit, Kit SIRE Nitratase-PlastLabor, for testing the drug susceptibility of clinical Mycobacterium tuberculosis isolates. METHODS::The accuracy of the Kit SIRE Nitratase was evaluated by examining the susceptibility (streptomycin, isoniazid, rifampicin, and et...
journal_title:Revista da Sociedade Brasileira de Medicina Tropical
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00