Coinfections of Zika and Chikungunya Viruses in Bahia, Brazil, Identified by Metagenomic Next-Generation Sequencing.

Abstract:

:Metagenomic next-generation sequencing (mNGS) of samples from 15 patients with documented Zika virus (ZIKV) infection in Bahia, Brazil, from April 2015 to January 2016 identified coinfections with chikungunya virus (CHIKV) in 2 of 15 ZIKV-positive cases by PCR (13.3%). While generally nonspecific, the clinical presentation corresponding to these two CHIKV/ZIKV coinfections reflected infection by the virus present at a higher titer. Aside from CHIKV and ZIKV, coinfections of other viral pathogens were not detected. The mNGS approach is promising for differential diagnosis of acute febrile illness and identification of coinfections, although targeted arbovirus screening may be sufficient in the current ZIKV outbreak setting.

journal_name

J Clin Microbiol

authors

Sardi SI,Somasekar S,Naccache SN,Bandeira AC,Tauro LB,Campos GS,Chiu CY

doi

10.1128/JCM.00877-16

subject

Has Abstract

pub_date

2016-09-01 00:00:00

pages

2348-53

issue

9

eissn

0095-1137

issn

1098-660X

pii

JCM.00877-16

journal_volume

54

pub_type

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