Inhibition of KLF5-Myo9b-RhoA Pathway-Mediated Podosome Formation in Macrophages Ameliorates Abdominal Aortic Aneurysm.

abstract：RATIONALE:The development of the cardiac outflow tract (OFT) and great vessels is a complex process that involves coordinated regulation of multiple progenitor cell populations. Among these populations, neural crest cells make important contributions to OFT formation and aortic arch remodeling. Although numerous signal...

journal_title：Circulation research

authors： Singh N,Trivedi CM,Lu M,Mullican SE,Lazar MA,Epstein JA

更新日期：2011-11-11 00:00:00

abstract：RATIONALE:Congenital heart disease (CHD) is among the most common birth defects. Most cases are of unknown pathogenesis. OBJECTIVE:To determine the contribution of de novo copy number variants (CNVs) in the pathogenesis of sporadic CHD. METHODS AND RESULTS:We studied 538 CHD trios using genome-wide dense single nucle...

journal_title：Circulation research

authors： Glessner JT,Bick AG,Ito K,Homsy J,Rodriguez-Murillo L,Fromer M,Mazaika E,Vardarajan B,Italia M,Leipzig J,DePalma SR,Golhar R,Sanders SJ,Yamrom B,Ronemus M,Iossifov I,Willsey AJ,State MW,Kaltman JR,White PS,Shen Y

更新日期：2014-10-24 00:00:00

abstract：:We have recently demonstrated that endogenous erythropoietin (Epo)/Epo receptor (EpoR) system plays an important protective role in hypoxia-induced pulmonary hypertension. However, it remains to be examined whether vascular EpoR system contributes to angiogenesis in response to ischemia. We examined angiogenesis in Ep...

journal_title：Circulation research

authors： Nakano M,Satoh K,Fukumoto Y,Ito Y,Kagaya Y,Ishii N,Sugamura K,Shimokawa H

更新日期：2007-03-16 00:00:00

abstract：:A specific difference-spectrophotometric method was used to measure nitric oxide (NO) release into the coronary effluent perfusate of isolated, constant-flow-perfused guinea pig hearts. Authentic NO applied into the coronary circulation decreased vascular resistance dose dependently and enhanced coronary release of cy...

journal_title：Circulation research

authors： Kelm M,Schrader J

更新日期：1990-06-01 00:00:00

abstract：:Hibernating myocardium, characterized by reductions in flow and function at rest, has limited contractile reserve in response to increases in external workload. We hypothesized that this attenuation of function reflects an adaptive downregulation that prevents the development of metabolic evidence of ischemia during s...

journal_title：Circulation research

authors： Fallavollita JA,Malm BJ,Canty JM Jr

更新日期：2003-01-10 00:00:00

abstract：:The extracellular pH (pHo) and intracellular pH (pHi) were simultaneously measured with H(+)-sensitive microelectrodes in the rabbit papillary muscle during normal arterial perfusion and no-flow ischemia. The preparation was kept in an artificial gaseous atmosphere (N2 and CO2 during ischemia) without a surrounding fl...

journal_title：Circulation research

authors： Yan GX,Kléber AG

更新日期：1992-08-01 00:00:00

abstract：:We determined whether local bradykinin production modulates cardiac adrenergic activity. Depolarization of guinea pig heart sympathetic nerve endings (synaptosomes) with 1 to 100 mmol/L K+ caused the release of endogenous norepinephrine (10% to 50% above basal level). This release was exocytotic, because it depended o...

journal_title：Circulation research

authors： Seyedi N,Win T,Lander HM,Levi R

更新日期：1997-11-01 00:00:00

abstract：RATIONALE:Cardiac resynchronization therapy (CRT) is an effective clinical treatment for heart failure patients with conduction delay, impaired contraction, and energetics. Our recent studies have revealed that mitochondrial posttranslational modifications (PTM) may contribute to its benefits, motivating the present st...

journal_title：Circulation research

authors： Wang SB,Foster DB,Rucker J,O'Rourke B,Kass DA,Van Eyk JE

更新日期：2011-09-16 00:00:00

abstract：:The red cell membrane is a permeability barrier that limits the equilibration of a variety of solutes between red cell and plasma water. We utilized the multiple indicator dilution technique to investigate the effect of this barrier on the exchange in the liver of a group of tracer substances that are not removed in n...

journal_title：Circulation research

authors： Goresky CA,Bach GG,Nadeau BE

更新日期：1975-02-01 00:00:00

abstract：:Many cell types undergo apoptosis under conditions of ischemia. Little is known, however, about the molecular pathways that mediate this response. A cellular and biochemical approach to elucidate such signaling pathways was undertaken in primary cultures of cardiac myocytes, a cell type that is especially sensitive to...

journal_title：Circulation research

authors： Bialik S,Cryns VL,Drincic A,Miyata S,Wollowick AL,Srinivasan A,Kitsis RN

更新日期：1999-09-03 00:00:00

abstract：:Left ventricular (LV) remodeling after experimental myocardial infarction (MI) is associated with hypertrophy of noninfarcted myocardium and electrophysiological alterations. We have recently shown that post-MI hypertrophied LV myocytes have prolonged action potential duration (APD) and generate triggered activity fro...

journal_title：Circulation research

authors： Gidh-Jain M,Huang B,Jain P,el-Sherif N

更新日期：1996-10-01 00:00:00

abstract：:Aldose reductase (AR), a member of the aldo-keto reductase superfamily, has been shown to metabolize toxic aldehydes generated by lipid peroxidation, suggesting that it may serve as an antioxidant defense. To investigate its role in the late phase of ischemic preconditioning (PC), conscious rabbits underwent 6 cycles ...

journal_title：Circulation research

authors： Shinmura K,Bolli R,Liu SQ,Tang XL,Kodani E,Xuan YT,Srivastava S,Bhatnagar A

更新日期：2002-08-09 00:00:00

abstract：:The changes in renal function produced by endogenous synthesis of prostaglandins by the kidney were evaluated by infusing sodium arachidonate, the prescursor of the prostaglandins, into one renal artery of the dog. These changes were compared with those produced by similar infusions on performed prostaglandin (PG) E2 ...

journal_title：Circulation research

authors： Tannenbaum J,Splawinski JA,Oates JA,Nies AS

更新日期：1975-01-01 00:00:00

abstract：RATIONALE:Natural killer (NK) cells are lymphocytes of the innate immune system that play specialized and niche-specific roles in distinct organs. OBJECTIVE:We investigated the possible function of NK cells in the pathogenesis of congestive heart failure after myocardial infarction. METHODS AND RESULTS:Depletion of N...

journal_title：Circulation research

authors： Yan X,Hegab AE,Endo J,Anzai A,Matsuhashi T,Katsumata Y,Ito K,Yamamoto T,Betsuyaku T,Shinmura K,Shen W,Vivier E,Fukuda K,Sano M

更新日期：2014-02-14 00:00:00

abstract：RATIONALE:Activated nuclear factor (NF)-κB signaling in the vascular endothelium promotes the initiation and progression of atherosclerosis. Targeting endothelial NF-κB may provide a novel strategy to limit chronic inflammation. OBJECTIVE:To examine the role of microRNA-181b (miR-181b) in endothelial NF-κB signaling a...

journal_title：Circulation research

authors： Sun X,He S,Wara AKM,Icli B,Shvartz E,Tesmenitsky Y,Belkin N,Li D,Blackwell TS,Sukhova GK,Croce K,Feinberg MW

更新日期：2014-01-03 00:00:00

abstract：:The mechanical properties of mammalian ventricular cardiac muscle have been studied in the presence and in the absence of an intact endocardial surface. Isotonic and isometric twitch contractions were obtained from papillary muscles of the right ventricle of cat at 29 degrees and 37 degrees C, at different extracellul...

journal_title：Circulation research

authors： Brutsaert DL,Meulemans AL,Sipido KR,Sys SU

更新日期：1988-02-01 00:00:00

abstract：:We investigated whether the heart, like other mammalian organs, possesses internal clocks, and, if so, whether pressure overload-induced hypertrophy alters the clock mechanism. Clock genes are intrinsically maintained, as shown by rhythmic changes even in single cells. Clocks are believed to confer a selective advanta...

journal_title：Circulation research

authors： Young ME,Razeghi P,Taegtmeyer H

更新日期：2001-06-08 00:00:00

abstract：:To see how serotonin affects filtration from lung vessels, we measured vascular pressures, lung lymph flow, lung lymph and blood plasma protein concentrations, arterial blood gases, cardiac output, and lung water content in unanesthetized sheep before and during intravenous serotonin infusions and compared serotonin e...

journal_title：Circulation research

authors： Brigham KL,Owen PJ

更新日期：1975-06-01 00:00:00

abstract：:Heme oxygenase (HO)-1 is a protective antioxidant enzyme that prevents cardiomyocyte apoptosis, for instance, during progressive cardiomyopathy. Here we identify a fundamental aspect of the HO-1 protection mechanism by demonstrating that HO-1 activity in mouse heart stimulates the bigenomic mitochondrial biogenesis pr...

journal_title：Circulation research

authors： Piantadosi CA,Carraway MS,Babiker A,Suliman HB

更新日期：2008-11-21 00:00:00

abstract：:Mammalian cardiomyocytes irreversibly lose their capacity to proliferate soon after birth, yet the underlying mechanisms have been unclear. Cyclin D1 and its partner, cyclin-dependent kinase 4 (CDK4), are important for promoting the G1-to-S phase progression via phosphorylation of the retinoblastoma (Rb) protein. Mito...

journal_title：Circulation research

authors： Tamamori-Adachi M,Ito H,Sumrejkanchanakij P,Adachi S,Hiroe M,Shimizu M,Kawauchi J,Sunamori M,Marumo F,Kitajima S,Ikeda MA

更新日期：2003-01-10 00:00:00

abstract：:A plasma membrane preparation purified from guinea pig ventricles without the use of high concentrations of detergents or structure-disrupting salts was used to compare the mechanisms of controlling sodium, potassium-activated adenosinetriphosphatase (Na, K-ATPase) and adenylate cyclase activities. The basal ATPase ac...

journal_title：Circulation research

authors： Tada M,Kirchberger MA,Iorio JM,Katz AM

更新日期：1975-01-01 00:00:00

abstract：:Computer simulations and nonlinear dynamics have provided invaluable tools for illuminating the underlying mechanisms of cardiac arrhythmias. Here, we review how this approach has led to major insights into the mechanisms of spatially discordant alternans, a key arrhythmogenic factor predisposing the heart to re-entry...

journal_title：Circulation research

authors： Weiss JN,Karma A,Shiferaw Y,Chen PS,Garfinkel A,Qu Z

更新日期：2006-05-26 00:00:00

abstract：:Mitochondria play a key role in determining cell fate during exposure to stress. Their role during ischemia/reperfusion is particularly critical because of the conditions that promote both apoptosis by the mitochondrial pathway and necrosis by irreversible damage to mitochondria in association with mitochondrial perme...

journal_title：Circulation research

authors： Weiss JN,Korge P,Honda HM,Ping P

更新日期：2003-08-22 00:00:00

abstract：:Previous studies have suggested that intravenous infusion of arginine vasopressin (AVP) inhibits sympathetic nerve activity (SNA) in rabbits by its action at the brainstem. This study aimed to determine, first, whether this action of AVP depended on functioning baroreflex mechanisms. The second aim was to determine th...

journal_title：Circulation research

authors： Suzuki S,Takeshita A,Imaizumi T,Hirooka Y,Yoshida M,Ando S,Nakamura M

更新日期：1989-11-01 00:00:00

abstract：:The potential for heparin to enhance the training-induced increase in collateral-dependent blood flow to the distal hind-limb muscles was evaluated after bilateral femoral artery ligation in adult male rats (approximately 350 g). Rats received either saline (n = 34) or heparin (n = 36) injections and were kept sedenta...

journal_title：Circulation research

authors： Yang HT,Ogilvie RW,Terjung RL

更新日期：1995-03-01 00:00:00

abstract：:Experiments were designed to determine the contribution of endothelial cells to the heterogeneous behavior of the arterial and venous wall. Rings of canine femoral, pulmonary, saphenous, and splenic arteries and veins, with and without endothelium, were mounted for isometric tension recording in Krebs-Ringer bicarbona...

journal_title：Circulation research

authors： De Mey JG,Vanhoutte PM

更新日期：1982-10-01 00:00:00

abstract：:First-generation, E1-deleted adenoviral vectors (E1-AV) can transduce the vascular endothelium with high efficiency, but their use is limited by the resulting acute endothelial injury and the long-term development of intimal hyperplasia. To reduce the impact of viral proteins on the gene-modified cells, a second-gener...

journal_title：Circulation research

authors： Qian HS,Channon K,Neplioueva V,Wang Q,Finer M,Tsui L,George SE,McArthur J

更新日期：2001-05-11 00:00:00

abstract：RATIONALE:Patients with chronic kidney disease (CKD) develop hyperhomocysteinemia and have a higher cardiovascular mortality than those without hyperhomocysteinemia by 10-fold. OBJECTIVE:We investigated monocyte differentiation in human CKD and cardiovascular disease (CVD). METHODS AND RESULTS:We identified CD40 as a...

journal_title：Circulation research

authors： Yang J,Fang P,Yu D,Zhang L,Zhang D,Jiang X,Yang WY,Bottiglieri T,Kunapuli SP,Yu J,Choi ET,Ji Y,Yang X,Wang H

更新日期：2016-11-11 00:00:00

abstract：:The myocardium of the failing heart undergoes a number of structural alterations, most notably hypertrophy of cardiac myocytes and an increase in extracellular matrix proteins, often seen as primary fibrosis. Connective tissue growth factor (CTGF) is a key molecule in the process of fibrosis and therefore seems an att...

journal_title：Circulation research

authors： Duisters RF,Tijsen AJ,Schroen B,Leenders JJ,Lentink V,van der Made I,Herias V,van Leeuwen RE,Schellings MW,Barenbrug P,Maessen JG,Heymans S,Pinto YM,Creemers EE

更新日期：2009-01-30 00:00:00

abstract：:cAMP-dependent protein kinase is anchored to discrete cellular compartments by a family of proteins, the A-kinase anchor proteins (AKAPs). We have investigated in vivo and in vitro the biological effects of the expression of a prototypic member of the family, AKAP75, on smooth muscle cells. In vitro expression of AKAP...

journal_title：Circulation research

authors： Indolfi C,Stabile E,Coppola C,Gallo A,Perrino C,Allevato G,Cavuto L,Torella D,Di Lorenzo E,Troncone G,Feliciello A,Avvedimento E,Chiariello M

更新日期：2001-02-16 00:00:00