Abstract:
:The changes in renal function produced by endogenous synthesis of prostaglandins by the kidney were evaluated by infusing sodium arachidonate, the prescursor of the prostaglandins, into one renal artery of the dog. These changes were compared with those produced by similar infusions on performed prostaglandin (PG) E2 and F2alpha.PGE2given at 0.01-0.3 mug/kg min--1 produced dose-related increases in urine flow, sodium and potassium excretion, free water clearance, and renal blood flow. The glomerular filtration rage increased only at the lowest dose and the calculated filtration fraction fell. Arachidonic acid at 1.0-30.0 mug/kg min--1 similarly produced dose-related increases in electrolyte excretion, but the increase in renal blood flow was much less than that produced by PGE2 and there were no changes in glomerular filtration rate, filtration fraction, or free water clearances. PGF2alpha had essentially no effects at infusion rates of 0.03-1.0 mug/kg min--1. All renal effects of arachidonic acid were inhibited by simultaneous infusions of an inhibitor of prostaglandin synthetase, 5, 8, 11,14-eicosatetraynoic acid (20:4). None of the effects produced by PGE2 were inhibited by 20:4. These results indicate that enhanced endogenous renal prostaglandin synthesis, which can be produced by arachidonate infusion, results in significant alterations of renal function. This finding strengthens the hypothesis that renal prostaglandins formed in vivo have physiological importance as regulators of renal function.
journal_name
Circ Resjournal_title
Circulation researchauthors
Tannenbaum J,Splawinski JA,Oates JA,Nies ASdoi
10.1161/01.res.36.1.197subject
Has Abstractpub_date
1975-01-01 00:00:00pages
197-203issue
1eissn
0009-7330issn
1524-4571journal_volume
36pub_type
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更新日期:2006-08-18 00:00:00
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更新日期:2007-07-20 00:00:00
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pub_type: 杂志文章
doi:10.1161/01.res.85.11.1000
更新日期:1999-11-26 00:00:00
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更新日期:2014-02-28 00:00:00
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pub_type: 杂志文章,收录出版
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更新日期:1981-02-01 00:00:00
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更新日期:2004-02-20 00:00:00
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更新日期:1990-09-01 00:00:00
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更新日期:2020-05-22 00:00:00
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更新日期:2015-03-13 00:00:00
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更新日期:2020-07-03 00:00:00
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更新日期:2000-10-27 00:00:00
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更新日期:1977-11-01 00:00:00
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更新日期:2012-04-13 00:00:00