Abstract:
OBJECTIVES:To review the contribution of the Nurses' Health Studies (NHS and NHS II) in addressing hypotheses regarding risk factors for and consequences of obesity. METHODS:Narrative review of the publications of the NHS and NHS II between 1976 and 2016. RESULTS:Long-term NHS research has shown that weight gain and being overweight or obese are important risk factors for type 2 diabetes, cardiovascular diseases, certain types of cancers, and premature death. The cohorts have elucidated the role of dietary and lifestyle factors in obesity, especially sugar-sweetened beverages, poor diet quality, physical inactivity, prolonged screen time, short sleep duration or shift work, and built environment characteristics. Genome-wide association and gene-lifestyle interaction studies have shown that genetic factors predispose individuals to obesity but that such susceptibility can be attenuated by healthy lifestyle choices. This research has contributed to evolving clinical and public health guidelines on the importance of limiting weight gain through healthy dietary and lifestyle behaviors. CONCLUSIONS:The NHS cohorts have contributed to our understanding of the risk factors for and consequences of obesity and made a lasting impact on clinical and public health guidelines on obesity prevention.
journal_name
Am J Public Healthjournal_title
American journal of public healthauthors
Hruby A,Manson JE,Qi L,Malik VS,Rimm EB,Sun Q,Willett WC,Hu FBdoi
10.2105/AJPH.2016.303326subject
Has Abstractpub_date
2016-09-01 00:00:00pages
1656-62issue
9eissn
0090-0036issn
1541-0048journal_volume
106pub_type
杂志文章,评审abstract:OBJECTIVES:We assessed whether living in counties with Title X clinics and increased use of long-acting reversible contraception (LARC) in Colorado are associated with decreased risk of adverse birth outcomes. METHODS:We linked Title X clinic counties to the Colorado birth data set by using the mother's county of resi...
journal_title:American journal of public health
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journal_title:American journal of public health
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