Abstract:
:Severe rhabdomyolysis following an influenza B infection developed in a previously well 13-year-old girl. There was no history of trauma. Her course was complicated by episodes of severe hyperkalemia, hypocalcemia, hyperphosphatemia, and myoglobinuria. Renal failure, hypertension, and life-threatening arrhythmias developed; she died. Muscle biopsy revealed that this girl had carnitine palmityl transferase deficiency. An asymptomatic sister was demonstrated to have the same disorder. Although carnitine palmityl transferase deficiency is usually associated with mild bouts of rhabdomyolysis that become apparent only in adulthood, severe forms of this disorder may be seen in children. Life-threatening rhabdomyolysis and myoglobinuria may follow any infection associated with decreased intake. If carnitine palmityl transferase deficiency is diagnosed in a proband, other siblings should be evaluated so that proper preventative measures can be undertaken to help prevent the development of symptoms in susceptible individuals who have not been recognized to have the disease.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Kelly KJ,Garland JS,Tang TT,Shug AL,Chusid MJsubject
Has Abstractpub_date
1989-08-01 00:00:00pages
312-6issue
2eissn
0031-4005issn
1098-4275journal_volume
84pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:To investigate the role of objective and perceived knowledge about condoms in adolescent males' condom use at first intercourse. METHODS:A longitudinal analysis was conducted of data from a nationally representative sample of 404 virgin male adolescents who were aged 15 to 17 years at wave 1 and reported bec...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-0139
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:This study's aim was to elicit the perspectives of minority parents on their expectations of pediatric health care providers as a source of advice on "raising their child" and whether they would seek advice from these providers. A secondary aim was to demonstrate the value of qualitative methods for assessing...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2604
更新日期:2006-09-01 00:00:00
abstract::In Norway, a national consensus-based guideline used to address thresholds for offering life support at extreme preterm birth was issued in 1998. Since then, therapeutic advances may have changed attitudes and expectations to treatment, both within the medical community and the public, and there are concerns that syst...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2018-0478E
更新日期:2018-09-01 00:00:00
abstract::Pediatricians should be familiar with the principles of antenatal diagnosis and how they should be applied to specific problems in genetic counseling, diagnosis, and management in clinical practice. At the same time, pediatricians should be familiar with the resources for the new technology available to them in their ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-06-01 00:00:00
abstract::A rare complication of infection with the Epstein-Barr virus is the development of hemophagocytic lymphohistiocytosis. Although most cases of Epstein-Barr virus-induced hemophagocytic lymphohistiocytosis develop in immunocompetent individuals, the rare immunodeficiency X-linked lymphoproliferative disease is often unm...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1534
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Childhood asthma prevalence doubled from 1980 to 1995 and then increased more slowly from 2001 to 2010. During this second period, racial disparities increased. More recent trends remain to be described. METHODS:We analyzed current asthma prevalence using 2001-2013 National Health Interview Survey data for ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-2354
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this work was to examine factors related to perceived impact of early intervention on children with disabilities and their families. METHODS:A nationally representative sample of approximately 2100 parents completed a 40-minute telephone interview near their child's third birthday. Structural ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-2775
更新日期:2007-10-01 00:00:00
abstract::Three infants with infant botulism are presented to illustrate how atypical, early, and severe features may obscure or delay diagnosis. Two boys aged 6 weeks and 20 days, respectively, presented with rapid deterioration after brief periods of poor feeding, one with an apparent life-threatening event at home and the ot...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0297
更新日期:2005-09-01 00:00:00
abstract::A 6-week-old girl with congenital melanoma of the skin is reported and the literature is reviewed. We believe this to be the first case of congenital melanoma in a black infant who had no underlying giant melanocytic nevus. Because of the significant relationship between the early treatment and prognosis of malignant ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-06-01 00:00:00
abstract::Partial nasal obstruction in preterm infants increases the airway resistance. In spite of this, nasal feeding tubes are often used, if only because oral tubes are difficult to secure. A palatal appliance has been devised that maintains the position of oroenteric feeding tube(s) and is not associated with local complic...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1984-09-01 00:00:00
abstract:OBJECTIVE:Our goal was to evaluate the diagnosis and treatment of infants with persistent regurgitation who were referred to a pediatric gastroenterology service. METHODS:The records of 64 infants with persistent regurgitation and without any neurodevelopmental abnormalities, underlying illness, or cigarette smoke exp...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1146
更新日期:2007-11-01 00:00:00
abstract::We describe here the case of an adolescent who developed eosinophilic hepatitis during treatment for attention-deficit/hyperactivity disorder with lisdexamfetamine dimesylate (Vyvanse [Shire US Inc, Wayne, PA]). A 14-year-old boy presented to his primary care provider with abdominal pain and worsening jaundice. A diag...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-1835
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Current federal regulations of potentially carcinogenic environmental chemicals are based on the assumption that risks for humans can be extrapolated from the effects of chronic high-dose exposure of rodents. It is assumed that all chemicals induce cancer by a genotoxic mechanism (direct interaction with DNA)...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1993-09-01 00:00:00
abstract:OBJECTIVE:To evaluate a simple, relatively inexpensive method using the fluid bed to provide high-intensity double-surface (HIDS) phototherapy and to confirm that the method described is more effective than conventional phototherapy (CPT) in the treatment of neonatal hyperbilirubinemia. DESIGN:Prospective controlled s...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1995-06-01 00:00:00
abstract:BACKGROUND:After licensure of the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States in 2000, the incidence of pediatric pneumococcal meningitis decreased significantly. However, cases continue to occur. It is unknown whether meningitis due to PCV7 and non-PCV7 serotypes causes similar morbidity and mo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0621
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To describe potential patient safety events for hospitalized children, examine associated factors, and explore impacts of safety events. METHODS:The newly released Patient Safety Indicators (PSIs), developed by researchers at the Agency for Healthcare Research and Quality to identify potential in-hospital pa...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.6.1741
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to assess and compare the usefulness, helpfulness, and stress associated with reviewing a previously adapted advance care planning guide, My Thoughts, My Wishes, My Voice, in comparison with the widely used adult document Five Wishes by adolescents and young adults (AYAs) livin...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-0663
更新日期:2012-11-01 00:00:00
abstract::An overview is presented of the major methods of contraception available to the sexually active adolescent. Emphasis is given to the combined birth control pill, while the literature describing absolute and relative contraindications to oral contraception is reviewed. It is noted that adolescents with chronic illness ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1980-01-01 00:00:00
abstract::Autism spectrum disorders are not rare; many primary care pediatricians care for several children with autism spectrum disorders. Pediatricians play an important role in early recognition of autism spectrum disorders, because they usually are the first point of contact for parents. Parents are now much more aware of t...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2007-2361
更新日期:2007-11-01 00:00:00
abstract:BACKGROUND:New biomarkers like procalcitonin and C-reactive protein may help design an accurate decision support tool used to identify children with pleocytosis at low or high risk of bacterial meningitis. Our objective was to develop and validate a score (that we call the meningitis score for emergencies [MSE]) to dis...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-1126
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Increased morbidity and mortality from lower respiratory tract infection (LRTI) has been suggested in HIV-exposed uninfected (HEU) children; however, the contribution of respiratory viruses is unclear. We studied the epidemiology of LRTI hospitalization in HIV-unexposed uninfected (HUU) and HEU infants aged ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-3272
更新日期:2016-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Family-centered rounds (FCRs) have become standard of care, despite the limited evaluation of FCRs' benefits or interventions to support high-quality FCR delivery. This work examines the impact of the FCR checklist intervention, a checklist and associated provider training, on performance of F...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2016-1688
更新日期:2017-05-01 00:00:00
abstract::We describe here the case of a boy who presented 2 days after birth with purpura fulminans on his feet and scalp. Laboratory investigations revealed signs of disseminated intravascular coagulation. An underlying coagulation disorder was suspected, and therapy with recombinant tissue plasminogen activator, fresh-frozen...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2009-2913
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:It has been proposed that infection by group A beta-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms. OBJECTIVE:To examine the temporal relationship between newly acquired GAB...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.113.6.e578
更新日期:2004-06-01 00:00:00
abstract::The frequency and severity of 17 side effects presumably associated with stimulant medication were assessed during a rigorous, triple-blind, placebo-controlled, crossover evaluation of methylphenidate, 0.3 and 0.5 mg/kg twice a day, in 83 children with attention deficit hyperactivity disorder. Side effects were rated ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1990-08-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence and characteristics of fetal alcohol spectrum disorders (FASD) among first grade students (6- to 7-year-olds) in a representative Midwestern US community. METHODS:From a consented sample of 70.5% of all first graders enrolled in public and private schools, an oversample of small ...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2013-3319
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To assess patterns of morbidity and associated factors in late infancy and early childhood among human immunodeficiency virus (HIV)-infected and -uninfected African children. DESIGN:Prospective study. SETTING:The Queen Elizabeth Central Hospital, Blantyre, Malawi. PARTICIPANTS:Children with known HIV statu...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.6.e77
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVES:Ataxia-telangiectasia (AT) is a rare, autosomal recessive neurodegenerative disorder in which the diagnosis is obvious when ataxia and telangiectasia are both present. However, the diagnosis can be made upon the onset of ataxia and before the appearance of telangiectasia if confirmed by laboratory tests. Ear...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.1.98
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:Late-onset sepsis (occurring after 3 days of age) is an important problem in very low birth weight (VLBW) infants. To determine the current incidence of late-onset sepsis, risk factors for disease, and the impact of late-onset sepsis on subsequent hospital course, we evaluated a cohort of 6956 VLBW (401-1500 ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.110.2.285
更新日期:2002-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Although home visiting programs have been documented to improve parenting in high-risk families, their effectiveness is diminished when parents disengage from programs. Cellular phones offer an approach to promoting parent engagement and enhancing parenting outcomes. Our objective was to exami...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2013-1021Q
更新日期:2013-11-01 00:00:00