Fatal rhabdomyolysis following influenza infection in a girl with familial carnitine palmityl transferase deficiency.

Abstract:

:Severe rhabdomyolysis following an influenza B infection developed in a previously well 13-year-old girl. There was no history of trauma. Her course was complicated by episodes of severe hyperkalemia, hypocalcemia, hyperphosphatemia, and myoglobinuria. Renal failure, hypertension, and life-threatening arrhythmias developed; she died. Muscle biopsy revealed that this girl had carnitine palmityl transferase deficiency. An asymptomatic sister was demonstrated to have the same disorder. Although carnitine palmityl transferase deficiency is usually associated with mild bouts of rhabdomyolysis that become apparent only in adulthood, severe forms of this disorder may be seen in children. Life-threatening rhabdomyolysis and myoglobinuria may follow any infection associated with decreased intake. If carnitine palmityl transferase deficiency is diagnosed in a proband, other siblings should be evaluated so that proper preventative measures can be undertaken to help prevent the development of symptoms in susceptible individuals who have not been recognized to have the disease.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Kelly KJ,Garland JS,Tang TT,Shug AL,Chusid MJ

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

312-6

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

84

pub_type

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