Incides of lipid peroxidation in patients with hypercholesterolemia and hypertriglyceridemia.

Abstract:

:Peroxidation of lipoproteins has received attention recently in connection with its possible initiation and propagation of atherosclerosis. We studied indices of lipid peroxidation in plasma of 30 patients with either hypercholesterolemia or both hypercholesterolemia and hypertriglyceridemia, and compared them with those of 19 healthy subjects. In the patients lipid hydroperoxides measured both iodometrically and as thiobarbituric acid-reactive substances (TBA-RS) were significantly increased, while concentrations of thiol groups remained unchanged. There was no correlation between concentrations of hydroperoxides and TBA-RS, possibly because the two methods assessed different breakdown products of lipid peroxidation. Lipid hydroperoxide levels, but not those of TBA-RS were correlated with LDL-cholesterol and triglyceride levels. In 6 patients administration of vitamin E at a daily dosage of 300 mg for 4 to 6 weeks depressed elevated hydroperoxides by 33%, and TBA-RS by 44% on average.

journal_name

Wien Klin Wochenschr

authors

Domagała B,Hartwich J,Szczeklik A

subject

Has Abstract

pub_date

1989-06-09 00:00:00

pages

425-8

issue

12

eissn

0043-5325

issn

1613-7671

journal_volume

101

pub_type

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