[Disseminated intravascular coagulation (DIG) with massive hyperfibrinolysis in metastatic uterine cancer. Observations on the effects on the coagulopathy of various treatments (a case report)].

Abstract:

:We report on a 64-year-old patient with a recurrent endometrial carcinoma which was associated with disseminated intravascular coagulation (DIC) and excessive hyperfibrinolysis. The patient presented with severe bleeding due to hypofibrinogenemia. Fibrin degradation products were excessively elevated and there were also increased levels of activation markers of coagulation. Free plasmin was demonstrated in the circulation and alpha 2-antiplasmin was almost completely depleted. No increase in t-PA or u-PA level was demonstrated. Antifibrinolytic treatment led to a decrease of fibrin degradation products, but to an increase of activation markers of coagulation and was not associated with an increase of fibrinogen. Combination chemotherapy led to a rapid decrease of activation markers of coagulation and a sustained increase of fibrinogen. The beneficial effects on DIC/hyperfibrinolysis occurred despite the absence of any measurable effect of chemotherapy on the tumour. The patient finally died due to progression of the tumour, but without recurrence of the DIC/hyperfibrinolysis.

journal_name

Wien Klin Wochenschr

authors

Weltermann A,Mitterbauer GJ,Mitterbauer M,Hattey E,Speiser W,Gisslinger H,Knöbl P,Eichinger S

subject

Has Abstract

pub_date

1998-01-30 00:00:00

pages

53-7

issue

2

eissn

0043-5325

issn

1613-7671

journal_volume

110

pub_type

杂志文章
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    doi:

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    doi:

    authors: Grünberger J,Linzmayer L,Gathmann P,Saletu B

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    doi:

    authors: Pichler M,Kleinberger G,Kotzaurek R,Pall H,Szeless S

    更新日期:1976-01-23 00:00:00

  • [The development of infants subjected to aided respiration in the newborn period (author's transl)].

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    doi:

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  • [Haemodialysis in children (author's transl)].

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    journal_title:Wiener klinische Wochenschrift

    pub_type: 杂志文章

    doi:

    authors: Wolf A,Balzar E,Pinggera WF,Stummvoll HK

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  • [Infiltration pattern of immunocompetent lymphocytes in the tissue of malignant non-Hodgkin's lymphoma: relationship to histological and clinical parameters].

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    doi:

    authors: Gattringer C,Radaszkiewicz T,Greil R,Pfaller W,Huber H

    更新日期:1985-03-01 00:00:00

  • [The use of lasers in medicine with special reference to dermatology].

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    doi:

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  • [Malformations and abnormality of the sex ration after hormone treatment in mice (author's transl)].

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    doi:

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  • [Reduced lung function parameters after physical exertion in Austrian Alps in ozone concentrations below the legal warning limit].

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  • [Diagnostic value of ultrasonography in aneurysm of the abdominal aorta (author's transl)].

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  • [Simple renal cysts and hypertension].

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  • [Peroxisomal diseases--oxygen and free radicals].

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  • Spinal subdural hematoma following lumbar decompressive surgery: a report of two cases.

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    doi:

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    doi:

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  • [Bronchial asthmatic disease associated with tobacco dust--an occupational lung disease?].

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  • COVID-19: a primer for healthcare providers.

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    doi:

    authors: Wuketich S,Zwintz E

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