Malnutrition Is Associated with Protection from Rotavirus Diarrhea: Evidence from a Longitudinal Birth Cohort Study in Bangladesh.

Abstract:

:Rotavirus is a leading cause of dehydrating diarrhea and death among infants and children globally, particularly in communities of the developing world. While numerous studies have described the complex relationships among infectious diarrhea, growth faltering, and poverty, the impact of nutritional status on susceptibility to rotavirus diarrhea is not well understood. In a longitudinal study conducted over the first 3 years of life among 626 slum-dwelling infants enrolled at birth in Dhaka, Bangladesh, we observed that common measures of healthy growth and development were positively associated with a risk of symptomatic rotavirus infection. This finding runs counter to the idea that improving childhood nutrition will implicitly decrease the incidence of symptomatic infection by enteric pathogens. As childhood nutrition improves worldwide, rotavirus infection may remain a public health challenge, making universal vaccination of even greater importance.

journal_name

J Clin Microbiol

authors

Verkerke H,Sobuz S,Ma JZ,Petri SE,Reichman D,Qadri F,Rahman M,Haque R,Petri WA Jr

doi

10.1128/JCM.00916-16

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

2568-74

issue

10

eissn

0095-1137

issn

1098-660X

pii

JCM.00916-16

journal_volume

54

pub_type

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