Attachment, Neurobiology, and Mentalizing along the Psychosis Continuum.

Abstract:

:In this review article, we outline the evidence linking attachment adversity to psychosis, from the premorbid stages of the disorder to its clinical forms. To better understand the neurobiological mechanisms through which insecure attachment may contribute to psychosis, we identify at least five neurobiological pathways linking attachment to risk for developing psychosis. Besides its well documented influence on the hypothalamic-pituary-adrenal (HPA) axis, insecure attachment may also contribute to neurodevelopmental risk through the dopaminergic and oxytonergic systems, as well as bear influence on neuroinflammation and oxidative stress responses. We further consider the neuroscientific and behavioral studies that underpin mentalization as a suite of processes potentially moderating the risk to transition to psychotic disorders. In particular, mentalization may help the individual compensate for endophenotypical impairments in the integration of sensory and metacognitive information. We propose a model where embodied mentalization would lie at the core of a protective, resilience response mitigating the adverse and potentially pathological influence of the neurodevelopmental cascade of risk for psychosis.

journal_name

Front Hum Neurosci

authors

Debbané M,Salaminios G,Luyten P,Badoud D,Armando M,Solida Tozzi A,Fonagy P,Brent BK

doi

10.3389/fnhum.2016.00406

subject

Has Abstract

pub_date

2016-08-22 00:00:00

pages

406

issn

1662-5161

journal_volume

10

pub_type

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