Convergent approaches for defining functional imaging endophenotypes in schizophrenia.

Abstract:

:In complex genetic disorders such as schizophrenia, endophenotypes have potential utility both in identifying risk genes and in illuminating pathophysiology. This is due to their presumed status as closer in the etiopathological pathway to the causative genes than is the currently defining clinical phenomenology of the illness and thus their simpler genetic architecture than that of the full syndrome. There, many genes conferring slight individual risk are additive or epistatic (interactive) with regard to cumulative schizophrenia risk. In addition the use of endophenotypes has encouraged a conceptual shift away from the exclusive study of categorical diagnoses in manifestly ill patients, towards the study of quantitative traits in patients, unaffected relatives and healthy controls. A more recently employed strategy is thus to study unaffected first-degree relatives of schizophrenia patients, who share some of the genetic diathesis without illness-related confounds that may themselves impact fMRI task performance. Consistent with the multiple biological abnormalities associated with the disorder, many candidate endophenotypes have been advanced for schizophrenia, including measures derived from structural brain imaging, EEG, sensorimotor integration, eye movements and cognitive performance (Allen et al., 2009), but recent data derived from quantitative functional brain imaging measures present additional attractive putative endophenotypes. We will review two major, conceptually different approaches that use fMRI in this context. One, the dominant paradigm, employs defined cognitive tasks on which schizophrenia patients perform poorly as "cognitive stress tests". The second uses very simple probes or "task-free" approaches where performance in patients and controls is equal. We explore the potential advantages and disadvantages of each method, the associated data analytic approaches and recent studies exploring their interface with the genetic risk architecture of schizophrenia.

journal_name

Front Hum Neurosci

authors

Pearlson GD,Calhoun VD

doi

10.3389/neuro.09.037.2009

subject

Has Abstract

pub_date

2009-11-24 00:00:00

pages

37

issn

1662-5161

journal_volume

3

pub_type

杂志文章
  • Non-invasive detection of high gamma band activity during motor imagery.

    abstract::High gamma oscillations (70-150 Hz; HG) are rapidly evolving, spatially localized neurophysiological signals that are believed to be the best representative signature of engaged neural populations. The HG band has been best characterized from invasive electrophysiological approaches such as electrocorticography becaus...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00817

    authors: Smith MM,Weaver KE,Grabowski TJ,Rao RP,Darvas F

    更新日期:2014-10-16 00:00:00

  • Anterior Cingulate Cortico-Hippocampal Dysconnectivity in Unaffected Relatives of Schizophrenia Patients: A Stochastic Dynamic Causal Modeling Study.

    abstract::Familial risk plays a significant role in the etiology of schizophrenia (SZ). Many studies using neuroimaging have demonstrated structural and functional alterations in relatives of SZ patients, with significant results found in diverse brain regions involving the anterior cingulate cortex (ACC), caudate, dorsolateral...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00383

    authors: Xi YB,Li C,Cui LB,Liu J,Guo F,Li L,Liu TT,Liu K,Chen G,Xi M,Wang HN,Yin H

    更新日期:2016-07-27 00:00:00

  • Cortical Neural Synchronization Underlies Primary Visual Consciousness of Qualia: Evidence from Event-Related Potentials.

    abstract::This article reviews three experiments on event-related potentials (ERPs) testing the hypothesis that primary visual consciousness (stimulus self-report) is related to enhanced cortical neural synchronization as a function of stimulus features. ERP peak latency and sources were compared between "seen" trials and "not ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2016.00310

    authors: Babiloni C,Marzano N,Soricelli A,Cordone S,Millán-Calenti JC,Del Percio C,Buján A

    更新日期:2016-06-30 00:00:00

  • Voluntary Out-of-Body Experience: An fMRI Study.

    abstract::The present single-case study examined functional brain imaging patterns in a participant that reported being able, at will, to produce somatosensory sensations that are experienced as her body moving outside the boundaries of her physical body all the while remaining aware of her unmoving physical body. We found that...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00070

    authors: Smith AM,Messier C

    更新日期:2014-02-10 00:00:00

  • Neck proprioception shapes body orientation and perception of motion.

    abstract::This review article deals with some effects of neck muscle proprioception on human balance, gait trajectory, subjective straight-ahead (SSA), and self-motion perception. These effects are easily observed during neck muscle vibration, a strong stimulus for the spindle primary afferent fibers. We first remind the early ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2014.00895

    authors: Pettorossi VE,Schieppati M

    更新日期:2014-11-04 00:00:00

  • Contributions of Sensory Coding and Attentional Control to Individual Differences in Performance in Spatial Auditory Selective Attention Tasks.

    abstract::Listeners with normal hearing thresholds (NHTs) differ in their ability to steer attention to whatever sound source is important. This ability depends on top-down executive control, which modulates the sensory representation of sound in the cortex. Yet, this sensory representation also depends on the coding fidelity o...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00530

    authors: Dai L,Shinn-Cunningham BG

    更新日期:2016-10-20 00:00:00

  • Differential development of the ventral visual cortex extends through adolescence.

    abstract::The ventral temporal cortex (VTC) in humans includes functionally defined regions that preferentially respond to objects, faces, and places. Recent developmental studies suggest that the face selective region in the fusiform gyrus ('fusiform face area', FFA) undergoes a prolonged development involving substantial incr...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/neuro.09.080.2009

    authors: Golarai G,Liberman A,Yoon JM,Grill-Spector K

    更新日期:2010-02-22 00:00:00

  • Disruption of the brain-derived neurotrophic factor (BDNF) immunoreactivity in the human Kölliker-Fuse nucleus in victims of unexplained fetal and infant death.

    abstract::Experimental studies have demonstrated that the neurotrophin brain-derived neutrophic factor (BDNF) is required for the appropriate development of the central respiratory network, a neuronal complex in the brainstem of vital importance to sustaining life. The pontine Kölliker-Fuse nucleus (KFN) is a fundamental compon...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00648

    authors: Lavezzi AM,Corna MF,Matturri L

    更新日期:2014-09-04 00:00:00

  • Cognitive control signals in posterior cingulate cortex.

    abstract::Efficiently shifting between tasks is a central function of cognitive control. The role of the default network - a constellation of areas with high baseline activity that declines during task performance - in cognitive control remains poorly understood. We hypothesized that task switching demands cognitive control to ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00223

    authors: Hayden BY,Smith DV,Platt ML

    更新日期:2010-12-06 00:00:00

  • Cerebellar contributions to visuomotor adaptation and motor sequence learning: an ALE meta-analysis.

    abstract::Cerebellar contributions to motor learning are well-documented. For example, under some conditions, patients with cerebellar damage are impaired at visuomotor adaptation and at acquiring new action sequences. Moreover, cerebellar activation has been observed in functional MRI (fMRI) investigations of various motor lea...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00027

    authors: Bernard JA,Seidler RD

    更新日期:2013-02-07 00:00:00

  • A review of visual perspective taking in autism spectrum disorder.

    abstract::Impairments in social cognition are a key symptom of autism spectrum disorder (ASD). People with autism have great difficulty with understanding the beliefs and desires of other people. In recent years literature has begun to examine the link between impairments in social cognition and abilities which demand the use o...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章,评审

    doi:10.3389/fnhum.2013.00652

    authors: Pearson A,Ropar D,de C Hamilton AF

    更新日期:2013-10-08 00:00:00

  • Relationship of the Acoustic Startle Response and Its Modulation to Adaptive and Maladaptive Behaviors in Typically Developing Children and Those With Autism Spectrum Disorders: A Pilot Study.

    abstract::Background: Autism spectrum disorder (ASD) is associated with persistent impairments in adaptive functioning across multiple domains of daily life. Thus, investigation of the biological background of both adaptive and maladaptive behaviors may shed light on developing effective interventions for improving social adapt...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00005

    authors: Ebishima K,Takahashi H,Stickley A,Nakahachi T,Sumiyoshi T,Kamio Y

    更新日期:2019-01-22 00:00:00

  • Interpreting Prefrontal Recruitment During Walking After Stroke: Influence of Individual Differences in Mobility and Cognitive Function.

    abstract::Background: Functional near-infrared spectroscopy (fNIRS) is a valuable neuroimaging approach for studying cortical contributions to walking function. Recruitment of prefrontal cortex during walking has been a particular area of focus in the literature. The present study investigated whether task-related change in pre...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00194

    authors: Chatterjee SA,Fox EJ,Daly JJ,Rose DK,Wu SS,Christou EA,Hawkins KA,Otzel DM,Butera KA,Skinner JW,Clark DJ

    更新日期:2019-06-18 00:00:00

  • Pre-stimulus Alpha Oscillations and Inter-subject Variability of Motor Evoked Potentials in Single- and Paired-Pulse TMS Paradigms.

    abstract::Inter- and intra-subject variability of the motor evoked potentials (MEPs) to TMS is a well-known phenomenon. Although a possible link between this variability and ongoing brain oscillations was demonstrated, the results of the studies are not consistent with each other. Exploring this topic further is important since...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00504

    authors: Iscan Z,Nazarova M,Fedele T,Blagovechtchenski E,Nikulin VV

    更新日期:2016-10-07 00:00:00

  • Modulatory Effects of Motor State During Paired Associative Stimulation on Motor Cortex Excitability and Motor Skill Learning.

    abstract::Repeated pairing of electrical stimulation of a peripheral nerve with transcranial magnetic stimulation (TMS) over the primary motor cortex (M1) representation for a target muscle can induce neuroplastic adaptations in the human brain related to motor learning. The extent to which the motor state during this form of p...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00008

    authors: Palmer JA,Halter A,Gray W,Wolf SL,Borich MR

    更新日期:2019-01-29 00:00:00

  • Tool Embodiment: The Tool's Output Must Match the User's Input.

    abstract::The embodiment of tools and rubber hands is believed to involve the modification of two separate body representations: the body schema and the body image, respectively. It is thought that tools extend the capabilities of the body's action schema, whereas prosthetics like rubber hands are incorporated into the body ima...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2018.00537

    authors: Weser V,Proffitt DR

    更新日期:2019-01-11 00:00:00

  • Facial Attractiveness of Chinese College Students With Different Sexual Orientation and Sex Roles.

    abstract::Facial attractiveness refers to a positive and joyful emotional experience induced by the face of a target person and the extent to which other people are driven to be close to their wishes. Since the 1970s, face attractiveness has gradually emerged in western psychological research, but most of the studies were confi...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2019.00132

    authors: Hou J,Sui L,Jiang X,Han C,Chen Q

    更新日期:2019-04-30 00:00:00

  • Sex Differences in Categorical Adaptation for Faces and Chinese Characters during Early Perceptual Processing.

    abstract::Previous event-related potential studies support sex differences in the N170 response during face and word processing; however, it remains unclear whether N170 categorical adaptation for faces and words is different between women and men. Using an adaptation paradigm, in which an adaptor and subsequent test stimulus a...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00656

    authors: Zhu C,Ma X,Ji L,Chen S,Cao X

    更新日期:2018-01-12 00:00:00

  • Staying cool when things get hot: emotion regulation modulates neural mechanisms of memory encoding.

    abstract::During times of emotional stress, individuals often engage in emotion regulation to reduce the experiential and physiological impact of negative emotions. Interestingly, emotion regulation strategies also influence memory encoding of the event. Cognitive reappraisal is associated with enhanced memory while expressive ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2010.00230

    authors: Hayes JP,Morey RA,Petty CM,Seth S,Smoski MJ,McCarthy G,Labar KS

    更新日期:2010-12-22 00:00:00

  • Cortical responses to salient nociceptive and not nociceptive stimuli in vegetative and minimal conscious state.

    abstract:AIMS:Questions regarding perception of pain in non-communicating patients and the management of pain continue to raise controversy both at a clinical and ethical level. The aim of this study was to examine the cortical response to salient visual, acoustic, somatosensory electric non-nociceptive and nociceptive laser st...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00017

    authors: de Tommaso M,Navarro J,Lanzillotti C,Ricci K,Buonocunto F,Livrea P,Lancioni GE

    更新日期:2015-01-29 00:00:00

  • Corrigendum: Spatial task context makes short-latency reaches prone to induced Roelofs illusion.

    abstract::[This corrects the article on p. 673 in vol. 8, PMID: 25221500.]. ...

    journal_title:Frontiers in human neuroscience

    pub_type: 已发布勘误

    doi:10.3389/fnhum.2014.00923

    authors: Taghizadeh B,Gail A

    更新日期:2014-11-14 00:00:00

  • Methodological Problems With Online Concussion Testing.

    abstract::Reaction time testing is widely used in online computerized concussion assessments, and most concussion studies utilizing the metric have demonstrated varying degrees of difference between concussed and non-concussed individuals. The problem with most of these online concussion assessments is that they predominantly r...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2020.509091

    authors: Holden J,Francisco E,Tommerdahl A,Lensch R,Kirsch B,Zai L,Pearce AJ,Favorov OV,Dennis RG,Tommerdahl M

    更新日期:2020-10-01 00:00:00

  • What we talk about when we talk about the default mode network.

    abstract::The default mode network (DMN) has been widely defined as a set of brain regions that are engaged when people are in a "resting state" (left to themselves in a scanner, with no explicit task instruction). The network emerged as a scientific object in the early twenty-first century, and in just over a decade has become...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2014.00619

    authors: Callard F,Margulies DS

    更新日期:2014-08-25 00:00:00

  • Alterations of Resting-State Static and Dynamic Functional Connectivity of the Dorsolateral Prefrontal Cortex in Subjects with Internet Gaming Disorder.

    abstract::Internet gaming disorder (IGD), a major behavior disorder, has gained increasing attention. Recent studies indicate altered resting-state static functional connectivity (FC) of the dorsolateral prefrontal cortex (DLPFC) in subjects with IGD. Whereas static FC often provides information on functional changes in subject...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2018.00041

    authors: Han X,Wu X,Wang Y,Sun Y,Ding W,Cao M,Du Y,Lin F,Zhou Y

    更新日期:2018-02-06 00:00:00

  • Expansion of Perceptual Body Maps Near - But Not Across - The Wrist.

    abstract::Perceiving the external spatial location of touch requires that tactile information about the stimulus location on the skin be integrated with proprioceptive information about the location of the body in external space, a process called tactile spatial remapping. Recent results have suggested that this process relies ...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2017.00111

    authors: Longo MR

    更新日期:2017-03-07 00:00:00

  • Bimanual non-congruent actions in motor neglect syndrome: a combined behavioral/fMRI study.

    abstract::In Motor Neglect (MN) syndrome, a specific impairment in non-congruent bimanual movements has been described. In the present case-control study, we investigated the neuro-functional correlates of this behavioral deficit. Two right-brain-damaged (RBD) patients, one with (MN+) and one without (MN-) MN, were evaluated by...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2015.00541

    authors: Garbarini F,Turella L,Rabuffetti M,Cantagallo A,Piedimonte A,Fainardi E,Berti A,Fadiga L

    更新日期:2015-10-06 00:00:00

  • Imaging the neural mechanisms of TMS neglect-like bias in healthy volunteers with the interleaved TMS/fMRI technique: preliminary evidence.

    abstract::Applying a precisely timed pulse of transcranial magnetic stimulation (TMS) over the right posterior parietal cortex (PPC) can produce temporary visuo-spatial neglect-like effects. Although the TMS is applied over PPC, it is not clear what other brain regions are involved. We applied TMS within a functional magnetic r...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00326

    authors: Ricci R,Salatino A,Li X,Funk AP,Logan SL,Mu Q,Johnson KA,Bohning DE,George MS

    更新日期:2012-12-17 00:00:00

  • Neurophysiologic Correlates of Post-stroke Mood and Emotional Control.

    abstract:OBJECTIVE:Emotional disturbance is a common complication of stroke significantly affecting functional recovery and quality of life. Identifying relevant neurophysiologic markers associated with post-stroke emotional disturbance may lead to a better understanding of this disabling condition, guiding the diagnosis, devel...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2016.00428

    authors: Doruk D,Simis M,Imamura M,Brunoni AR,Morales-Quezada L,Anghinah R,Fregni F,Battistella LR

    更新日期:2016-08-30 00:00:00

  • "You can't kid a kidder": association between production and detection of deception in an interactive deception task.

    abstract::Both the ability to deceive others, and the ability to detect deception, has long been proposed to confer an evolutionary advantage. Deception detection has been studied extensively, and the finding that typical individuals fare little better than chance in detecting deception is one of the more robust in the behavior...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2012.00087

    authors: Wright GR,Berry CJ,Bird G

    更新日期:2012-04-17 00:00:00

  • Characterizing aging in the human brainstem using quantitative multimodal MRI analysis.

    abstract::Aging is ubiquitous to the human condition. The MRI correlates of healthy aging have been extensively investigated using a range of modalities, including volumetric MRI, quantitative MRI (qMRI), and diffusion tensor imaging. Despite this, the reported brainstem related changes remain sparse. This is, in part, due to t...

    journal_title:Frontiers in human neuroscience

    pub_type: 杂志文章

    doi:10.3389/fnhum.2013.00462

    authors: Lambert C,Chowdhury R,Fitzgerald TH,Fleming SM,Lutti A,Hutton C,Draganski B,Frackowiak R,Ashburner J

    更新日期:2013-08-20 00:00:00