Abstract:
:An automated potentiometric procedure was used for studying in vitro dissolution kinetics of acidic drugs. Theoretical considerations indicated that the pH-stat method could be used to establish approximate sink conditions or, possibly, a perfect sink. Data obtained from dissolution studies using the pH-stat method were compared with data obtained from known sink and nonsink conditions. These comparisons indicated that the pH-stat method can be used to establish a sink condition for dissolution studies. The effective diffusion layer thicknesses for benzoic and salicylic acids dissolving in water were determined, and a theoretical dissolution rate was calculated utilizing these values. The close agreement between the experimental dissolution rates obtained under pH-stat conditions and theoretical dissolution rates indicated that perfect sink conditions were established under the experimental conditions used.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Underwood FL,Cadwallader DEdoi
10.1002/jps.2600670837subject
Has Abstractpub_date
1978-08-01 00:00:00pages
1163-7issue
8eissn
0022-3549issn
1520-6017pii
S0022-3549(15)42168-9journal_volume
67pub_type
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