Abstract:
:A sensitive, specific, high-performance liquid chromatographic procedure was developed for the measurement of plasma tiflamizole levels. Acidic plasma samples were extracted with three volumes of ether. The ether extracts were combined and evaporated to dryness. The residue was dissolved in acetonitrile, washed with hexane, and the acetonitrile was evaporated to dryness. The residue was dissolved in 0.5 mL of mobile phase consisting of acetonitrile and 0.007 M pH 3 sodium phosphate buffer (70:30, v/v) and then chromatographed on a octadecylsilane bonded microparticulate silica column. The assay is specific, precise, accurate, and can measure 10 ng of tiflamizole in 5 mL of plasma. The method was applied to human pharmacokinetic studies.
journal_name
J Pharm Scijournal_title
Journal of pharmaceutical sciencesauthors
Rakestraw DC,Whitney CC Jrdoi
10.1002/jps.2600731245subject
Has Abstractpub_date
1984-12-01 00:00:00pages
1829-30issue
12eissn
0022-3549issn
1520-6017pii
S0022-3549(15)46465-2journal_volume
73pub_type
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