Elevated Circulating hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b in Type 2 Diabetes Mellitus with Diarrhea-Predominant Irritable Bowel Syndrome.

Abstract:

:Background and Aims. Although the differential expression of microRNA (miRNA) genes has been identified in many diseases, little information exists concerning the miRNA expression profile in type 2 diabetes mellitus (T2DM) with diarrhea-predominant irritable bowel syndrome (D-IBS). Therefore, the specific expression of miRNAs in diabetes with D-IBS is identified in the study. Materials and Methods. 201 patients with IBS and 220 matched healthy controls were included in the study. Microarray technology and real-time reverse transcriptase-polymerase chain reaction analysis (RT-PCR) were taken to examine the miRNA expression profiles of T2DM patients with diarrhea-predominant irritable bowel syndrome (D-IBS) compared with patients with T2DM, patients with D-IBS, and control subjects. Results. We have found that 35 miRNAs were differentially expressed in T2DM with D-IBS, in which three representative miRNAs, hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b, were found to be significantly elevated in T2DM with D-IBS by RT-PCR. Conclusions. Our study has indicated that hsa-miR-106b, hsa-miR-26a, and hsa-miR-29b were elevated in T2DM with D-IBS, which may be the potential biomarkers of T2DM with D-IBS. To obtain a better understanding of the biological functions of these miRNAs in T2DM with D-IBS, functional annotation analysis suggested that the MAPK pathway may be responsible for T2DM with D-IBS.

authors

Tao W,Dong X,Kong G,Fang P,Huang X,Bo P

doi

10.1155/2016/9256209

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

9256209

eissn

1687-6121

issn

1687-630X

journal_volume

2016

pub_type

杂志文章
  • The Methylation Status and Expression of Epstein-Barr Virus Early Genes BARF1 and BHRF1 in Epstein-Barr Virus-Associated Gastric Carcinomas.

    abstract::Epstein-Barr virus (EBV) is an important DNA virus which establishes latent infection in human malignancies. Expression of EBV-encoded genes in the associated tumors is strongly modulated by promoter CpG methylation of EBV genome. This study aimed to explore the methylation status of the promoters of EBV BamHI-A right...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/3804146

    authors: Li J,Liu W,Che K,Zhang Y,Zhao Z,Luo B

    更新日期:2017-01-01 00:00:00

  • Synergic Interaction of Rifaximin and Mutaflor (Escherichia coli Nissle 1917) in the Treatment of Acetic Acid-Induced Colitis in Rats.

    abstract::Background. Inflammatory bowel disease results from the dysregulation of immune response to environmental and microbial agents in genetically susceptible individuals. The aim of the present study was to examine the effect of rifaximin and/or Mutaflor (Escherichia coli Nissle 1917, EcN) administration on the healing of...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2016/3126280

    authors: Dembiński A,Warzecha Z,Ceranowicz P,Dembiński M,Cieszkowski J,Gosiewski T,Bulanda M,Kuśnierz-Cabala B,Gałązka K,Konturek PC

    更新日期:2016-01-01 00:00:00

  • Helicobacter pylori-Induced Chronic Gastritis and Assessing Risks for Gastric Cancer.

    abstract::Chronic gastritis is an inflammation of the gastric mucosa and has multiple etiologies. Here we discuss the pathological alterations induced by Helicobacter pylori (HP) leading to chronic gastritis and the epigenetic bases underlying these changes. We review the histology of the normal gastric mucosa and overview the ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/393015

    authors: Carrasco G,Corvalan AH

    更新日期:2013-01-01 00:00:00

  • Small intestinal tumours.

    abstract::Objective. Balloon enteroscopy (BE) and capsule enteroscopy (CE) are enteroscopy methods that allow examination and treatment of the small bowel. Before the CE and BE era, the small intestine was difficult to access for investigation. Small intestinal tumours are infrequent conditions, but about half of them are malig...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2013/702536

    authors: Kopáčová M,Rejchrt S,Bureš J,Tachecí I

    更新日期:2013-01-01 00:00:00

  • Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity.

    abstract:Objective:Fucosterol is derived from the brown alga Eisenia bicyclis and has various biological activities, including antioxidant, anticancer, and antidiabetic properties. The aim of this study was to investigate the protective effects of fucosterol pretreatment on Concanavalin A- (ConA-) induced acute liver injury in ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/2824139

    authors: Mo W,Wang C,Li J,Chen K,Xia Y,Li S,Xu L,Lu X,Wang W,Guo C

    更新日期:2018-07-17 00:00:00

  • Clinical Significance of Peripheral Blood T Lymphocyte Subsets in Helicobacter pylori-Infected Patients.

    abstract::Background. Helicobacter pylori chronically colonizes gastric/duodenal mucosa and induces gastroduodenal disease and vigorous humoral and cellular immune responses. Methods. In order to clarify the immunological changes induced by this infection, we determined the percentage and, as indicated, ratios of the following ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/819842

    authors: Satoh Y,Ogawara H,Kawamura O,Kusano M,Murakami H

    更新日期:2012-01-01 00:00:00

  • Sustained Clinical Efficacy and Mucosal Healing of Thiopurine Maintenance Treatment in Ulcerative Colitis: A Real-Life Study.

    abstract:Background and Aims:Thiopurines are commonly used for treating ulcerative colitis (UC), despite the fact that controlled evidence supporting their efficacy is limited. The aim of this study was to evaluate the long-term outcome of thiopurines as maintenance therapy in a large cohort of UC patients. Methods:All UC pati...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/4195968

    authors: Pugliese D,Aratari A,Festa S,Ferraro PM,Monterubbianesi R,Guidi L,Scribano ML,Papi C,Armuzzi A

    更新日期:2018-10-03 00:00:00

  • Recurrent posterior strokes in inflammatory bowel disease patients.

    abstract::Objective. To describe the stroke characteristics of patients with a history of inflammatory bowel disease (IBD). Background. A hypercoagulable state associated with IBD has been frequently implicated as a risk factor for ischemic stroke. Variable mechanisms and infrequent occurrence limit prospective clinical researc...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2015/672460

    authors: Shaban A,Hymel B,Chavez-Keatts M,Karlitz JJ,Martin-Schild S

    更新日期:2015-01-01 00:00:00

  • A Meta-Analysis of the Efficacy of Prokinetic Agents against Glycemic Control.

    abstract:Background:Prokinetic agents are used in diabetic gastroparesis patients to improve gastric emptying and upper gastrointestinal (GI) symptoms. However, the efficacy of prokinetic agents against glycemic control is questionable. Therefore, we conducted a systemic review and meta-analysis to determine the efficacy of pro...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2019/3014973

    authors: Kim YJ,Chung WC,Lee SJ

    更新日期:2019-09-09 00:00:00

  • Variability in Prevalence of Helicobacter pylori Strains Resistant to Clarithromycin and Levofloxacin in Southern Poland.

    abstract::Background. An increasing resistance of Helicobacter pylori strains to antimicrobial agents is the serious therapeutic problem. The aim of this study was to compare the primary and secondary resistance of H. pylori strains isolated between 2006-2008 (data published) and 2009-2011 to clarithromycin and levofloxacin. Ma...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/418010

    authors: Karczewska E,Klesiewicz K,Skiba I,Wojtas-Bonior I,Sito E,Czajecki K,Zwolińska-Wcisło M,Budak A

    更新日期:2012-01-01 00:00:00

  • Development of probiotic candidate in combination with essential oils from medicinal plant and their effect on enteric pathogens: a review.

    abstract::Medicinal plants and probiotics both have very high potential in terms of their antimicrobial activity against antibiotic-resistant enteric pathogens. The probiotics being enteric microorganism do not have any parasitic effect on human beings. They have been an integral part of daily food for centuries. They have been...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/457150

    authors: Shipradeep,Karmakar S,Sahay Khare R,Ojha S,Kundu K,Kundu S

    更新日期:2012-01-01 00:00:00

  • Initial Development and Validation of a Transition Readiness Scale for Adolescents with Inflammatory Bowel Disease.

    abstract:Background and Aims:To date, there are no validated measures in IBD to assess the level of preparedness for transition into adult health care. The purpose of this study was to develop and assess the reliability and validity of a "Transition Readiness" (TR) measure for adolescents with IBD, as well as to evaluate the le...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/5062105

    authors: Hammerman O,Bayatra A,Turner D,Levine A,Shamir R,Assa A,Wilschanski M,Bachner YG,Israeli E

    更新日期:2019-06-18 00:00:00

  • Impact of Body Mass Index on Surgical and Oncological Outcomes in Laparoscopic Total Mesorectal Excision for Locally Advanced Rectal Cancer after Neoadjuvant 5-Fluorouracil-Based Chemoradiotherapy.

    abstract:Aims:To evaluate the impact of body mass index (BMI) on the surgical outcome of laparoscopic total mesorectal excision (laTME) for locally advanced rectal cancer (LARC, clinically staged as UICC stage II/III) after neoadjuvant chemoradiotherapy (nCRT). Methods:312 LARC patients undergoing laTME after nCRT were divided...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/1509140

    authors: Sun Y,Chi P

    更新日期:2017-01-01 00:00:00

  • A Downmodulated MicroRNA Profiling in Patients with Gastric Cancer.

    abstract::Objective. Here, we aim to investigate the microRNA (miR) profiling in human gastric cancer (GC). Methods. Tumoral and matched peritumoral gastric specimens were collected from 12 GC patients who underwent routine surgery. A high-throughput miR sequencing method was applied to detect the aberrantly expressed miRs in a...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/1526981

    authors: Zhang T,Liu C,Huang S,Ma Y,Fang J,Chen Y

    更新日期:2017-01-01 00:00:00

  • Health-Related Quality of Life among Patients with Hepatitis C Virus Infection: A Cross-Sectional Study in Jianping County of Liaoning Province, China.

    abstract:Background:Patients with chronic liver disease (CLD) have extrahepatic manifestations and impaired health-related quality of life (HRQOL), and hepatitis C virus (HCV) infection is a leading cause of CLD, cirrhosis, and hepatocellular carcinoma (HCC). This study is aimed at assessing HRQOL in patients with HCV infection...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/6716103

    authors: Zhang H,Ren R,Liu J,Mao Y,Pan G,Men K,Ma L

    更新日期:2020-01-07 00:00:00

  • Safety of laparoscopic colorectal surgery in a low-volume setting: review of early and late outcome.

    abstract::Background. There is increasing evidence suggesting that the laparoscopic technique is the treatment of choice for large bowel resection, including for malignancy. The purpose of the study was to assess whether general surgeons, with particular skills in advanced laparoscopy, can adequately provide safe laparoscopic c...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2014/581523

    authors: Gandy RC,Berney CR

    更新日期:2014-01-01 00:00:00

  • Thromboelastography in Patients with Inflammatory Bowel Disease.

    abstract:Purpose:Patients with inflammatory bowel disease (IBD) frequently suffer from venous thromboembolic events, and the risk of thromboembolism increases along with disease activity. This study was conducted to discover novel thrombophilic markers using thromboelastography (TEG) and to evaluate the relation between the pre...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/3245657

    authors: Shen Y,Shi L,Zhang J,Zhu H,Yao Y,Liu Z,Zou X,Zhang X

    更新日期:2020-05-20 00:00:00

  • Regulators of Actin Dynamics in Gastrointestinal Tract Tumors.

    abstract::Reorganization of the actin cytoskeleton underlies cell migration in a wide variety of physiological and pathological processes, such as embryonic development, wound healing, and tumor cell invasion. It has been shown that actin assembly and disassembly are precisely regulated by intracellular signaling cascades that ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/930157

    authors: Steinestel K,Wardelmann E,Hartmann W,Grünewald I

    更新日期:2015-01-01 00:00:00

  • 2017 Update on Ovarian Cancer Peritoneal Carcinomatosis Multimodal-Treatment Considerations.

    abstract::Ovarian cancer peritoneal carcinomatosis requires a multimodal-treatment approach. Current treatment considerations are analyzed in this update and include the management of recurrent malignant ascites and the understanding of its pathophysiology, the role of peritoneal washing cytology in detecting peritoneal metasta...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2018/5284814

    authors: Halkia E,Chrelias G,Chrelias C,Esquivel J

    更新日期:2018-04-05 00:00:00

  • Robot-Assisted versus Laparoscopic-Assisted Gastrectomy among Gastric Cancer Patients: A Retrospective Short-Term Analysis from a Single Institution in China.

    abstract:Background:The da Vinci robotic system was considered an effectively alternative treatment option for early gastric cancer patients in recent years. The aim of our study was to evaluate the safety and feasibility of robot-assisted gastrectomy in our center. Methods:This study included 33 patients who underwent robot-a...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2019/9059176

    authors: Sun LF,Liu K,Su XS,Wei X,Chen XL,Zhang WH,Chen XZ,Yang K,Zhou ZG,Hu JK

    更新日期:2019-10-23 00:00:00

  • Correlation between Endosonographic and Doppler Ultrasound Features of Portal Hypertension in Patients with Cirrhosis.

    abstract::Purpose. Endoscopic ultrasound (EUS) permits the detailed visualization of clinically significant features of portal hypertension; however, it is an invasive procedure that is not widely available. The aim of this cross-sectional study was to determine whether a correlation exists between the features of portal hypert...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/395345

    authors: Wiechowska-Kozłowska A,Zasada K,Milkiewicz M,Milkiewicz P

    更新日期:2012-01-01 00:00:00

  • Methanolic Extract of Distemonanthus benthamianus (Caesalpiniaceae) Stem Bark Suppresses Ethanol/Indomethacin-Induced Chronic Gastric Injury in Rats.

    abstract::Distemonanthus benthamianus (Caesalpiniaceae) is a plant from the Cameroon pharmacopoeia very widely used in the treatment of many pathologies among which are gastrointestinal disorders. The main purpose of this study was to assess the healing properties of gastric ulcer from the methanolic extract of Distemonanthus b...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2020/8180323

    authors: Matah Marte VM,Ateufack G,Mbiantcha M,Atsamo AD,Adjouzem CF,Djuichou Nguemnang SF,Tsafack EG,Yousseu Nana W,Madjo Kouam YK,Ngoufack Azanze E

    更新日期:2020-11-28 00:00:00

  • Immunohistochemical Markers as Predictors of Histopathologic Response and Prognosis in Rectal Cancer Treated with Preoperative Adjuvant Therapy: State of the Art.

    abstract::We explain the state of the art of the immunohistochemical markers of response in rectal cancers treated with neoadjuvant medical therapies and its implication with prognosis. Neoadjuvant chemoradiotherapy is widely used to improve the outcome of patients with locally advanced rectal cancer, and the evaluation of the ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/2808235

    authors: Del Gobbo A,Ferrero S

    更新日期:2017-01-01 00:00:00

  • Analysis of KRAS Mutations of Exon 2 Codons 12 and 13 by SNaPshot Analysis in Comparison to Common DNA Sequencing.

    abstract::Due to the call for fast KRAS mutation status analysis for treatment of patients with monoclonal antibodies for metastatic colorectal cancer, sensitive, economic, and easily feasible methods are required. Under this aspect, the sensitivity and specificity of the SNaPshot analysis in comparison to the commonly used DNA...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2010/789363

    authors: Zinsky R,Bölükbas S,Bartsch H,Schirren J,Fisseler-Eckhoff A

    更新日期:2010-01-01 00:00:00

  • Peripheral signals mediate the beneficial effects of gastric surgery in obesity.

    abstract::Obesity is nowadays a public health problem both in the industrialized world and developing countries. The different treatments to fight against obesity are not very successful with the exception of gastric surgery. The mechanism behind the achievement of this procedure remains unclear although the modifications in th...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2015/560938

    authors: Barja-Fernández S,Folgueira C,Castelao C,Leis R,Casanueva FF,Seoane LM

    更新日期:2015-01-01 00:00:00

  • Effects of Vonoprazan Compared with Esomeprazole on the Healing of Artificial Postendoscopic Submucosal Dissection Ulcers: A Prospective, Multicenter, Two-Arm, Randomized Controlled Trial.

    abstract:Background:Vonoprazan affords more clinical benefits than proton pump inhibitors (PPIs) during the healing of gastroduodenal ulcers. However, it remains controversial whether vonoprazan is more effective than PPIs when used to heal artificial ulcers arising after endoscopic submucosal dissection (ESD). Aim:This study ...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2018/1615092

    authors: Ishii Y,Yamada H,Sato T,Sue S,Kaneko H,Irie K,Sasaki T,Tamura T,Ikeda R,Fukuchi T,Kobayashi R,Makazu M,Sato C,Hirasawa K,Kondo M,Shibata W,Maeda S

    更新日期:2018-02-18 00:00:00

  • Establishment of a standardized liver fibrosis model with different pathological stages in rats.

    abstract::Objective. To establish a standardized animal model for liver fibrosis with the same assessment criteria for liver fibrosis studies that have been established on a unified platform. Methods. The standardized liver fibrosis model was established using Sprague-Dawley (SD) rats that either received an intraperitoneal inj...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2012/560345

    authors: Li L,Hu Z,Li W,Hu M,Ran J,Chen P,Sun Q

    更新日期:2012-01-01 00:00:00

  • Gut Microbiota in HIV Infection: Implication for Disease Progression and Management.

    abstract::Survival rates among HIV patients have significantly improved since the introduction of antiretroviral therapy (ART) in HIV management. However, persistent disease progression and clinical complications in virally suppressed individuals point to additional contributing factors other than HIV replication; microbial tra...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2014/803185

    authors: Nwosu FC,Avershina E,Wilson R,Rudi K

    更新日期:2014-01-01 00:00:00

  • Subthreshold Psychiatric Psychopathology in Functional Gastrointestinal Disorders: Can It Be the Bridge between Gastroenterology and Psychiatry?

    abstract:Background and Aims:Functional gastrointestinal disorders (FGDs) are multifactorial disorders of the gut-brain interaction. This study investigated the prevalence of Axis I and spectrum disorders in patients with FGD and established the link between FGDs and psychopathological dimensions. Methods:A total of 135 consec...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章

    doi:10.1155/2017/1953435

    authors: Stasi C,Nisita C,Cortopassi S,Corretti G,Gambaccini D,De Bortoli N,Fani B,Simonetti N,Ricchiuti A,Dell'Osso L,Marchi S,Bellini M

    更新日期:2017-01-01 00:00:00

  • The Differential Role of Human Cationic Trypsinogen (PRSS1) p.R122H Mutation in Hereditary and Nonhereditary Chronic Pancreatitis: A Systematic Review and Meta-Analysis.

    abstract:Background:Environmental factors and genetic mutations have been increasingly recognized as risk factors for chronic pancreatitis (CP). The PRSS1 p.R122H mutation was the first discovered to affect hereditary CP, with 80% penetrance. We performed here a systematic review and meta-analysis to evaluate the associations o...

    journal_title:Gastroenterology research and practice

    pub_type: 杂志文章,评审

    doi:10.1155/2017/9505460

    authors: Hu C,Wen L,Deng L,Zhang C,Lugea A,Su HY,Waldron RT,Pandol SJ,Xia Q

    更新日期:2017-01-01 00:00:00