Acute Delamination of Commercially Available Decellularized Osteochondral Allograft Plugs: A Report of Two Cases.

abstract：OBJECTIVE:Recent studies have implicated the cyclin dependent kinase inhibitor, p21, in enhanced tissue regeneration observed in MRL/MpJ "super-healer" mice. Specifically, p21 is downregulated in MRL cells and similar ear hole closure to MRL mice has been observed in p21-/- mice. However, the direct implications of p21...

journal_title：Cartilage

authors： Jablonski CL,Besler BA,Ali J,Krawetz RJ

更新日期：2019-09-26 00:00:00

abstract：:Objective The aim of this study was to evaluate the chondroprotective effect of chemically decellularized meniscal allografts transplanted into the knee joints of adult merino sheep. Methods Lateral sheep meniscal allografts were chemically processed by a multistep method to yield acellular, sterile grafts. The grafts...

journal_title：Cartilage

authors： Gelse K,Körber L,Schöne M,Raum K,Koch P,Pachowsky M,Welsch G,Breiter R

更新日期：2017-04-01 00:00:00

abstract：:Introduction Articular cartilage is made up of hyaline tissue embodying chondrocytes, which arise from mesenchymal stromal cells (MSCs) and specialized extracellular matrix. Despite possessing resident progenitors in and around the joint primed for chondrogenesis, cartilage has limited intrinsic capacity of repair and...

journal_title：Cartilage

authors： Vinod E,Boopalan PRJVC,Sathishkumar S

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this study was to compare results of osteochondral fractures (OCF) after first-time lateral patella dislocation, when either refixation or debridement was performed in a mid- to long-term follow-up and to analyze redislocation and reintervention rates. DESIGN:Fifty-three consecutive patients w...

journal_title：Cartilage

authors： Gesslein M,Merkl C,Bail HJ,Krutsch V,Biber R,Schuster P

更新日期：2019-11-13 00:00:00

abstract：OBJECTIVE:TNIIIA2 is a peptide of the extracellular matrix glycoprotein tenascin-C. We evaluated whether intra-articular injection of TNIIIA2 could prevent articular cartilage degeneration without inducing synovitis in an osteoarthritis mice model. DESIGN:Ten micrograms per milliliter of TNIIIA2 were injected into the...

journal_title：Cartilage

authors： Hattori T,Hasegawa M,Unno H,Iino T,Fukai F,Yoshida T,Sudo A

更新日期：2020-03-23 00:00:00

abstract：BACKGROUND:Full-depth cartilage lesions do not heal and the long-term clinical outcome is uncertain. In the symptomatic middle-aged (35-60 years) patient, treatment with metal implants has been proposed. However, the cartilage health surrounding these implants has not been thoroughly studied. Our objective was to evalu...

journal_title：Cartilage

authors： Martinez-Carranza N,Hultenby K,Lagerstedt AS,Schupbach P,Berg HE

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Our aim is to explore the candidate pathogenesis genes and pathways of developmental dysplasia of hip (DDH). DESIGN:Proliferating primary chondrocytes from hip cartilage were used for total RNA extraction including 5 DDH patients and 5 neck of femur fracture (NOF) subjects. Genome-wide mRNA and microRNA (miR...

journal_title：Cartilage

authors： Cheng B,Jia Y,Wen Y,Hou W,Xu K,Liang C,Cheng S,Liu L,Chu X,Ye J,Yao Y,Zhang F,Xu P

更新日期：2021-02-01 00:00:00

abstract：:Various systematic reviews have recently shown that intra-articular platelet-rich plasma (IA-PRP) can lead to symptomatic relief of knee osteoarthritis for up to 12 months. There exist limited data on its use in small joints, such as the trapeziometacarpal joint (TMJ) or carpometacarpal joint (CMCJ) of the thumb. A pr...

journal_title：Cartilage

authors： Malahias MA,Roumeliotis L,Nikolaou VS,Chronopoulos E,Sourlas I,Babis GC

更新日期：2021-01-01 00:00:00

abstract：:Introduction Autologous osteochondral transplantation (AOT) is a treatment for osteochondral lesions with known concerns, including histological degradation of the graft and poor cartilage integration. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have been described has having the potential to improve results. ...

journal_title：Cartilage

authors： Smyth NA,Ross KA,Haleem AM,Hannon CP,Murawski CD,Do HT,Kennedy JG

更新日期：2018-07-01 00:00:00

abstract：:Purpose. To determine the 5-year success rate of the "all-inside" technique of arthroscopic meniscus suture and collagen membrane wrapping along with bone marrow blood injection, to evaluate the progression of degenerative changes and the impact of simultaneous anteriro cruciate ligament (ACL) reconstruction. Methods....

journal_title：Cartilage

authors： Ciemniewska-Gorzela K,Bąkowski P,Naczk J,Jakob R,Piontek T

更新日期：2020-06-01 00:00:00

abstract：:The objective of this study was to characterize magnetic resonance imaging (MRI) findings and correlate with clinical results in patients who underwent autologous chondrocyte implantation (ACI) of osteochondral lesions of the talus (OLT). METHODS:Twenty-four grafts were evaluated at a mean 65.8 months after ACI for O...

journal_title：Cartilage

authors： Chan KW,Ferkel RD,Kern B,Chan SS,Applegate GR

更新日期：2018-01-01 00:00:00

abstract：:The concept of using gene transfer strategies for cartilage repair originates from the idea of transferring genes encoding therapeutic factors into the repair tissue, resulting in a temporarily and spatially defined delivery of therapeutic molecules to sites of cartilage damage. This review focuses on the potential be...

journal_title：Cartilage

authors： Madry H,Orth P,Cucchiarini M

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:Bone morphogenetic protein 2 (BMP2) plays important roles in cartilage growth and development. Paradoxically, elevated levels of BMP2 leads to hypertrophic differentiation and osteoarthritis of cartilage. We examined the in vivo loss of BMP2 in cells expressing aggrecan of the mandibular condyle and knee. DE...

journal_title：Cartilage

authors： O'Brien MH,Dutra EH,Mehta S,Chen PJ,Yadav S

更新日期：2020-12-14 00:00:00

abstract：OBJECTIVE:The objective of this study was to fully characterize the mechanics of an in vivo impactor and correlate the mechanics with superficial cracking of articular surfaces. DESIGN:A spring-loaded impactor was used to apply energy-controlled impacts to the articular surfaces of neonatal bovine cartilage. The simul...

journal_title：Cartilage

authors： Bonnevie ED,Delco ML,Fortier LA,Alexander PG,Tuan RS,Bonassar LJ

更新日期：2015-10-01 00:00:00

abstract：:Objective To measure and identify the determinants of the outcomes after hip/knee arthroplasty (HA/KA) in patients with osteoarthritis during the first postsurgical year. Design In this prospective observational study, we evaluated the preoperative and postoperative (3, 6, and 12 months) outcomes of 626 patients who u...

journal_title：Cartilage

authors： Neuprez A,Neuprez AH,Kaux JF,Kurth W,Daniel C,Thirion T,Huskin JP,Gillet P,Bruyère O,Reginster JY

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of intra-articular injection of autologous micronized adipose tissue (MAT) with ankle arthroscopic debridement in patients with advanced-stage posttraumatic osteoarthritis (PTOA) of ankle. DESIGN:A retrospective cohort study investigating patients treated with arthroscopic debridement ...

journal_title：Cartilage

authors： Shimozono Y,Dankert JF,Kennedy JG

更新日期：2020-08-06 00:00:00

abstract：OBJECTIVE:Treatments for steroid-induced osteonecrosis of the knee remains challenging, and there has not been sufficient evidence to support joint preservation surgery. This study evaluated long-term outcomes of osteochondral autologous transplantation (OAT) for steroid-induced osteonecrosis of the knee. DESIGN:This ...

journal_title：Cartilage

authors： Nishitani K,Nakagawa Y,Kobayashi M,Nakamura S,Mukai S,Kuriyama S,Matsuda S

更新日期：2020-09-10 00:00:00

abstract：OBJECTIVE:Hyaluronic acid-transglutaminase (HA-TG) is an enzymatically crosslinkable adhesive hydrogel with chondrogenic properties demonstrated in vitro and in an ectopic mouse model. In this study, we investigated the feasibility of using HA-TG in a collagen scaffold to treat chondral lesions in an ovine model, to ev...

journal_title：Cartilage

authors： Levinson C,Cavalli E,von Rechenberg B,Zenobi-Wong M,Darwiche SE

更新日期：2021-01-29 00:00:00

abstract：:Objective To identify if the time of day and pre-imaging exercise matter while performing T2* mapping of hip joint cartilage at 3 T. Design Nine asymptomatic healthy volunteers (mean age 27.4 ± 4.0 years) with no obvious morphological evidence of cartilage damage were enrolled. The MRI protocol included a double-echo ...

journal_title：Cartilage

authors： Hesper T,Hosalkar HS,Schleich C,Antoch G,Welsch GH,Krauspe R,Zilkens C,Bittersohl B

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:The purpose of this article is to report on a distinctive pattern of linear femoral head chondral lesions that were observed in 7 patients who underwent hip arthroscopy for the treatment of mixed-type femoroacetabular impingement (FAI). DESIGN:Between 2010 and 2012, 702 patients were treated with hip arthros...

journal_title：Cartilage

authors： Philippon MJ,Goljan P,Devitt BM,Peixoto LP

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Our aim was to compare T2 with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the hip and assess the reproducibility and effect of joint unloading on T2 mapping. DESIGN:Ten individuals at high risk of developing hip osteoarthritis (SibKids) underwent contemporaneous T2 mappi...

journal_title：Cartilage

authors： Fernquest S,Palmer A,Gammer B,Hirons E,Kendrick B,Taylor A,De Berker H,Bangerter N,Carr A,Glyn-Jones S

更新日期：2019-04-11 00:00:00

abstract：OBJECTIVE:Cartilage health is thought to be dependent on the relationship between mechanics, structure, and metabolism, rather than these individual components in isolation. Due to sex differences in cartilage health, there is need to determine if the relationships between these cartilage components separately for male...

journal_title：Cartilage

authors： Harkey MS,Blackburn JT,Hackney AC,Lewek MD,Schmitz RJ,Pietrosimone B

更新日期：2020-09-19 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of accelerated compared with traditional postoperative weightbearing (WB) rehabilitation following matrix-induced autologous chondrocyte implantation (MACI) of the knee, using MRI. METHODS:A randomized controlled study design was used to assess MRI-based outcomes of MACI gra...

journal_title：Cartilage

authors： Ebert JR,Fallon M,Robertson WB,Lloyd DG,Zheng MH,Wood DJ,Ackland T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:To compare the histological and immunohistochemical characteristics of matrix-assisted chondrocyte implantation (MACI) grafts between patients with revision surgery and patients with total joint arthroplasty. METHODS:Biopsies of MACI grafts from patients with revision and total joint arthroplasty. The graft ...

journal_title：Cartilage

authors： Beck A,Wood D,Vertullo CJ,Ebert J,Janes G,Sullivan M,Zheng MH

更新日期：2019-12-02 00:00:00

abstract：OBJECTIVE:To assess the clinical outcome of patients treated with autologous chondrocyte implantation using ChondroCelect in daily practice. METHODS:The study is a cross-sectional analysis of an open-label, noninterventional cohort. The setting was a compassionate use program, involving 43 orthopaedic centers in 7 Eur...

journal_title：Cartilage

authors： Vanlauwe J,Huylebroek J,Van Der Bauwhede J,Saris D,Veeckman G,Bobic V,Victor J,Almqvist KF,Verdonk P,Fortems Y,Van Lommel N,Haazen L

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Describe the local morphological response of the articular-epiphyseal cartilage complex to surgical stab incision in the distal femur of foals, with emphasis on the relationship between growth cartilage injury, enchondral ossification, and repair. DESIGN:Nine foals were induced into general anesthesia at the...

journal_title：Cartilage

authors： Olstad K,Hendrickson EH,Ekman S,Carlson CS,Dolvik NI

更新日期：2013-07-01 00:00:00

abstract：:Joint injuries are very common in the athletic population, especially professional soccer players, with an incidence of 10 to 35.5 injuries per 1000 hours. Most soccer-related joint injuries occur in the lower extremities, with 16% to 46% occurring in the knee and 17% to 40% occurring in the ankle. Because of the limi...

journal_title：Cartilage

authors： Lee HH,Chu CR

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:To determine if lubricin was present in the surface layer of repair cartilage formed after autologous chondrocyte implantation (ACI). DESIGN:Forty-three biopsies of repair tissue were taken from patients who had been treated with ACI 8 to 68 months previously (mean of 18.0 ± 14.4 months); 30 had flaps of per...

journal_title：Cartilage

authors： Roberts S,Menage J,Flannery CR,Richardson JB

更新日期：2010-10-01 00:00:00

abstract：:Nucleofection of chondrocytes has been shown to be an adequate method of transfection. Using Amaxa's nucleofection system, transfection efficiencies up to 89% were achievable for vector (pmaxGFP) and 98% for siRNA (siGLO) into passaged chondrocytes. However, such methods rely on costly commercial kits with proprietary...

journal_title：Cartilage

authors： Parreno J,Delve E,Andrejevic K,Paez-Parent S,Wu PH,Kandel R

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:We sought to determine whether rates of postoperative arthrofibrosis following tibial tuberosity osteotomy (TTO) with complete mobilization of the fragment (TTO-HD) are comparable to TTOs where the hinge remained intact (TTO-HI). DESIGN:Patients who underwent TTO with concomitant cartilage repair procedure b...

journal_title：Cartilage

authors： Merkely G,Ackermann J,Sheehy E,Gomoll AH

更新日期：2020-10-23 00:00:00