BMP2 Is Required for Postnatal Maintenance of Osteochondral Tissues of the Temporomandibular Joint.

abstract：OBJECTIVE:To evaluate clinical, functional, and radiographic outcomes of patients who underwent bipolar osteochondral allograft transplantation (OCAT) of the patellofemoral joint (PFJ). DESIGN:Prospectively collected data on 18 knees who underwent fresh osteochondral allograft transplantation of the patella and trochl...

journal_title：Cartilage

authors： Mirzayan R,Charles MD,Batech M,Suh BD,DeWitt D

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:To compare the progression of biochemical biomarkers of osteoarthritis (OA), knee pain, and function between nonobese patients (NON), obese patients without depression (OBESE), and obese patients with comorbid depression (O + D). DESIGN:Utilizing the FNIH OA Biomarkers Consortium dataset, we categorized knee...

journal_title：Cartilage

authors： Jacobs CA,Vranceanu AM,Thompson KL,Lattermann C

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To assess the continued effectiveness and safety of Gel-200 following observation and open-label retreatment in an extension protocol following a randomized, double-blind, phosphate buffered saline (PBS)-controlled trial (initial treatment trial). DESIGN:Patients who completed initial blinded treatment were ...

journal_title：Cartilage

authors： Strand V,Baraf HS,Lavin PT,Lim S,Hosokawa H

更新日期：2012-10-01 00:00:00

abstract：:Nucleofection of chondrocytes has been shown to be an adequate method of transfection. Using Amaxa's nucleofection system, transfection efficiencies up to 89% were achievable for vector (pmaxGFP) and 98% for siRNA (siGLO) into passaged chondrocytes. However, such methods rely on costly commercial kits with proprietary...

journal_title：Cartilage

authors： Parreno J,Delve E,Andrejevic K,Paez-Parent S,Wu PH,Kandel R

更新日期：2016-01-01 00:00:00

abstract：:Postoperative rehabilitation programs following articular cartilage repair procedures will vary greatly among patients and need to be individualized based on the nature of the lesion, the unique characteristics of the patient, and the type and detail of each surgical procedure. These programs are based on knowledge of...

journal_title：Cartilage

authors： Wilk KE,Macrina LC,Reinold MM

更新日期：2010-04-01 00:00:00

abstract：:This study addressed difficulties in evaluating osteoarthritis (OA) progression in species with thin cartilage. Feasibility of using short, nonequilibrium contrast-enhanced micro-computed tomography (CE-μCT) to evaluate the physical and biochemical properties of cartilage was investigated. A preliminary in vitro study...

journal_title：Cartilage

authors： Flynn C,Hurtig M,Linden AZ

更新日期：2020-05-26 00:00:00

abstract：:Joint injuries are very common in the athletic population, especially professional soccer players, with an incidence of 10 to 35.5 injuries per 1000 hours. Most soccer-related joint injuries occur in the lower extremities, with 16% to 46% occurring in the knee and 17% to 40% occurring in the ankle. Because of the limi...

journal_title：Cartilage

authors： Lee HH,Chu CR

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:Treatments for steroid-induced osteonecrosis of the knee remains challenging, and there has not been sufficient evidence to support joint preservation surgery. This study evaluated long-term outcomes of osteochondral autologous transplantation (OAT) for steroid-induced osteonecrosis of the knee. DESIGN:This ...

journal_title：Cartilage

authors： Nishitani K,Nakagawa Y,Kobayashi M,Nakamura S,Mukai S,Kuriyama S,Matsuda S

更新日期：2020-09-10 00:00:00

abstract：:Articular cartilage injuries, and corresponding surgical procedures, are occurring with increasing frequency as identified by a review of recent surgical trends. Concerns have grown in recent years regarding the longevity of results following microfracture, with a shift toward cartilage restoration procedures in recen...

journal_title：Cartilage

authors： Degen RM,Tetreault D,Mahony GT,Williams RJ

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis is a painful, chronic joint disease affecting man and animals with no known curative therapies. Palliative nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but they cause adverse side effects prompting the search for safer alternatives. To address this need, we evaluated the anti...

journal_title：Cartilage

authors： Grzanna MW,Secor EJ,Fortuno LV,Au AY,Frondoza CG

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:To determine if lubricin was present in the surface layer of repair cartilage formed after autologous chondrocyte implantation (ACI). DESIGN:Forty-three biopsies of repair tissue were taken from patients who had been treated with ACI 8 to 68 months previously (mean of 18.0 ± 14.4 months); 30 had flaps of per...

journal_title：Cartilage

authors： Roberts S,Menage J,Flannery CR,Richardson JB

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Telomere length and telomerase activity are important indicators of cellular senescence and replicative ability. Loss of telomerase is associated with ageing and the development of osteoarthritis. Implantation of telomerase-positive cells, chondrocytes, or stem cells expressing a normal chondrocyte phenotype ...

journal_title：Cartilage

authors： Wilson B,Novakofski KD,Donocoff RS,Liang YX,Fortier LA

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:Excessive use of glucocorticoids (GCs) may cause adverse effects on the skeletal system in children. However, only a few studies have reported the effects of GCs on the epiphyseal cartilage. This study aimed to uncover the subsequent epiphyseal cartilage changes of immature femoral heads after excessive GC tr...

journal_title：Cartilage

authors： Jin S,Yang L,Meng C,He Y,Ma K,Huang W,Wang H

更新日期：2020-12-03 00:00:00

abstract：OBJECTIVE:To determine the optimal environmental conditions for chondrogenic differentiation of human adipose tissue-derived mesenchymal stromal/stem cells (AMSCs). In this investigation we specifically investigate the role of oxygen tension and 3-dimensional (3D) culture systems. DESIGN:Both AMSCs and primary human c...

journal_title：Cartilage

authors： Galeano-Garces C,Camilleri ET,Riester SM,Dudakovic A,Larson DR,Qu W,Smith J,Dietz AB,Im HJ,Krych AJ,Larson AN,Karperien M,van Wijnen AJ

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:A systematic review and meta-analysis of Autologous Matrix-Induced Chondrogenesis (AMIC®) outcomes for grade III/IV chondral and osteochondral lesions of the knee treated with Chondro-Gide®. DESIGN:Studies with a minimum follow-up of 1 year providing clinical results of AMIC repair in the knee were included ...

journal_title：Cartilage

authors： Steinwachs MR,Gille J,Volz M,Anders S,Jakob R,De Girolamo L,Volpi P,Schiavone-Panni A,Scheffler S,Reiss E,Wittmann U

更新日期：2019-09-11 00:00:00

abstract：OBJECTIVE:Ankle arthropathy is a frequent and invalidating manifestation of hemophilia. Arthrodesis is the gold standard surgical procedure in end-stage disease, with many drawbacks in young patients. Recent literature has shown increase interest in regenerative procedures in hemophilic arthropathy, which may be desira...

journal_title：Cartilage

authors： Buda R,Cavallo M,Castagnini F,Cenacchi A,Natali S,Vannini F,Giannini S

更新日期：2015-07-01 00:00:00

abstract：PURPOSE:This study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery. METHODS:This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Re...

journal_title：Cartilage

authors： Andrade R,Nunes J,Hinckel BB,Gruskay J,Vasta S,Bastos R,Oliveira JM,Reis RL,Gomoll AH,Espregueira-Mendes J

更新日期：2019-12-17 00:00:00

abstract：OBJECTIVE:Our aim is to explore the candidate pathogenesis genes and pathways of developmental dysplasia of hip (DDH). DESIGN:Proliferating primary chondrocytes from hip cartilage were used for total RNA extraction including 5 DDH patients and 5 neck of femur fracture (NOF) subjects. Genome-wide mRNA and microRNA (miR...

journal_title：Cartilage

authors： Cheng B,Jia Y,Wen Y,Hou W,Xu K,Liang C,Cheng S,Liu L,Chu X,Ye J,Yao Y,Zhang F,Xu P

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to fully characterize the mechanics of an in vivo impactor and correlate the mechanics with superficial cracking of articular surfaces. DESIGN:A spring-loaded impactor was used to apply energy-controlled impacts to the articular surfaces of neonatal bovine cartilage. The simul...

journal_title：Cartilage

authors： Bonnevie ED,Delco ML,Fortier LA,Alexander PG,Tuan RS,Bonassar LJ

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The current therapeutic strategy for posttraumatic osteoarthritis (PTOA) focuses on early intervention to attenuate disease progression, preserve joint function, and defer joint replacement timing. Sequential transcriptomic changes of articular cartilage in a rat model were investigated to explore the molecul...

journal_title：Cartilage

authors： Liu CC,Lee HC,Peng YS,Tseng AH,Wu JL,Tsai WY,Wong CS,Su LJ

更新日期：2019-05-20 00:00:00

abstract：OBJECTIVE:To assess the clinical outcome of patients treated with autologous chondrocyte implantation using ChondroCelect in daily practice. METHODS:The study is a cross-sectional analysis of an open-label, noninterventional cohort. The setting was a compassionate use program, involving 43 orthopaedic centers in 7 Eur...

journal_title：Cartilage

authors： Vanlauwe J,Huylebroek J,Van Der Bauwhede J,Saris D,Veeckman G,Bobic V,Victor J,Almqvist KF,Verdonk P,Fortems Y,Van Lommel N,Haazen L

更新日期：2012-04-01 00:00:00

abstract：:Objective The aim of this study was to evaluate the chondroprotective effect of chemically decellularized meniscal allografts transplanted into the knee joints of adult merino sheep. Methods Lateral sheep meniscal allografts were chemically processed by a multistep method to yield acellular, sterile grafts. The grafts...

journal_title：Cartilage

authors： Gelse K,Körber L,Schöne M,Raum K,Koch P,Pachowsky M,Welsch G,Breiter R

更新日期：2017-04-01 00:00:00

abstract：:Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the world's population living longer, the prevalence of OA is expected to increase dramatically in t...

journal_title：Cartilage

authors： Christiansen BA,Bhatti S,Goudarzi R,Emami S

更新日期：2015-01-01 00:00:00

abstract：:Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication qual...

journal_title：Cartilage

authors： Frehner F,Benthien JP

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Our aim was to compare T2 with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the hip and assess the reproducibility and effect of joint unloading on T2 mapping. DESIGN:Ten individuals at high risk of developing hip osteoarthritis (SibKids) underwent contemporaneous T2 mappi...

journal_title：Cartilage

authors： Fernquest S,Palmer A,Gammer B,Hirons E,Kendrick B,Taylor A,De Berker H,Bangerter N,Carr A,Glyn-Jones S

更新日期：2019-04-11 00:00:00

abstract：BACKGROUND:Osteochondral allograft (OCA) transplantation is an increasingly common treatment for patients with symptomatic focal chondral lesions of the knee. There has been increasing interest in determining predictive factors to maximize patient benefit after this operation. The aim of the present study is to evaluat...

journal_title：Cartilage

authors： Owusu-Akyaw KA,Bido J,Warner T,Rodeo SA,Williams RJ

更新日期：2020-09-17 00:00:00

abstract：BACKGROUND:Focal cartilage lesions in the knee joint have limited capacity to heal. Current animal experiments show that incisions of the deep zone of a cartilage allograft allow acceptable integration for the graft. QUESTIONS/PURPOSES:We performed this clinical study to determine (1) if the multiply incised cartilage...

journal_title：Cartilage

authors： Bardos T,Vancsodi J,Farkas B,Fazekas A,Nagy SA,Bogner P,Vermes C,Than P

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:We have recently shown that mesenchymal stem cells (MSCs) embedded in a hyaluronic acid (HA) hydrogel and exposed to chondrogenic factors (transforming growth factor-β3 [TGF-β3]) produce a cartilage-like tissue in vitro. The current objective was to determine if these same factors could be combined immediatel...

journal_title：Cartilage

authors： Fisher MB,Belkin NS,Milby AH,Henning EA,Söegaard N,Kim M,Pfeifer C,Saxena V,Dodge GR,Burdick JA,Schaer TP,Steinberg DR,Mauck RL

更新日期：2016-04-01 00:00:00

abstract：:Objective To measure and identify the determinants of the outcomes after hip/knee arthroplasty (HA/KA) in patients with osteoarthritis during the first postsurgical year. Design In this prospective observational study, we evaluated the preoperative and postoperative (3, 6, and 12 months) outcomes of 626 patients who u...

journal_title：Cartilage

authors： Neuprez A,Neuprez AH,Kaux JF,Kurth W,Daniel C,Thirion T,Huskin JP,Gillet P,Bruyère O,Reginster JY

更新日期：2018-04-01 00:00:00

abstract：:INTRODUCTION: The zone of calcified cartilage (ZCC) anchors articular cartilage (AC) to subchondral bone through a layer of intermediate stiffness. The regulation and functional consequences of cartilage calcification may vary with depth from the articular surface. The hypothesis of this study was that the in vitro ca...

journal_title：Cartilage

authors： Hwang J,Kyubwa EM,Bae WC,Bugbee WD,Masuda K,Sah RL

更新日期：2010-10-01 00:00:00