Cartilage Health in Knees Treated with Metal Resurfacing Implants or Untreated Focal Cartilage Lesions: A Preclinical Study in Sheep.

abstract：:The objective of this study was to characterize magnetic resonance imaging (MRI) findings and correlate with clinical results in patients who underwent autologous chondrocyte implantation (ACI) of osteochondral lesions of the talus (OLT). METHODS:Twenty-four grafts were evaluated at a mean 65.8 months after ACI for O...

journal_title：Cartilage

authors： Chan KW,Ferkel RD,Kern B,Chan SS,Applegate GR

更新日期：2018-01-01 00:00:00

abstract：:Various systematic reviews have recently shown that intra-articular platelet-rich plasma (IA-PRP) can lead to symptomatic relief of knee osteoarthritis for up to 12 months. There exist limited data on its use in small joints, such as the trapeziometacarpal joint (TMJ) or carpometacarpal joint (CMCJ) of the thumb. A pr...

journal_title：Cartilage

authors： Malahias MA,Roumeliotis L,Nikolaou VS,Chronopoulos E,Sourlas I,Babis GC

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is an incurable joint disease characterized by pronounced pain. MicroRNAs constitute epigenetic mechanisms that may affect OA progression by contributing to changes in chondrocyte phenotype. This study investigates for the first time whether there is a link between miRNA-1 (miR-1) and OA p...

journal_title：Cartilage

authors： Yang Y,Wang Y,Jia H,Li B,Xing D,Li JJ

更新日期：2020-11-20 00:00:00

abstract：OBJECTIVE:To compare the histological and immunohistochemical characteristics of matrix-assisted chondrocyte implantation (MACI) grafts between patients with revision surgery and patients with total joint arthroplasty. METHODS:Biopsies of MACI grafts from patients with revision and total joint arthroplasty. The graft ...

journal_title：Cartilage

authors： Beck A,Wood D,Vertullo CJ,Ebert J,Janes G,Sullivan M,Zheng MH

更新日期：2019-12-02 00:00:00

abstract：OBJECTIVE:Treatments for steroid-induced osteonecrosis of the knee remains challenging, and there has not been sufficient evidence to support joint preservation surgery. This study evaluated long-term outcomes of osteochondral autologous transplantation (OAT) for steroid-induced osteonecrosis of the knee. DESIGN:This ...

journal_title：Cartilage

authors： Nishitani K,Nakagawa Y,Kobayashi M,Nakamura S,Mukai S,Kuriyama S,Matsuda S

更新日期：2020-09-10 00:00:00

abstract：:Articular cartilage injuries of the knee and ankle are common, and a number of different methods have been developed in an attempt to improve their repair. Clinically, there are 2 distinct aims of cartilage repair: 1) restoration of joint function and 2) prevention or at least delay of the onset of osteoarthritis. The...

journal_title：Cartilage

authors： McIlwraith CW,Fortier LA,Frisbie DD,Nixon AJ

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:Traumatic impacts on the articular joint surface in vitro are known to lead to degeneration of the cartilage. The main objective of this study was to develop a spring-loaded impact device that can be used to deliver traumatic impacts of consistent magnitude and rate and to find whether impacts cause catabolic...

journal_title：Cartilage

authors： Alexander PG,Song Y,Taboas JM,Chen FH,Melvin GM,Manner PA,Tuan RS

更新日期：2013-01-01 00:00:00

abstract：:Objective To identify if the time of day and pre-imaging exercise matter while performing T2* mapping of hip joint cartilage at 3 T. Design Nine asymptomatic healthy volunteers (mean age 27.4 ± 4.0 years) with no obvious morphological evidence of cartilage damage were enrolled. The MRI protocol included a double-echo ...

journal_title：Cartilage

authors： Hesper T,Hosalkar HS,Schleich C,Antoch G,Welsch GH,Krauspe R,Zilkens C,Bittersohl B

更新日期：2017-10-01 00:00:00

abstract：:This study addressed difficulties in evaluating osteoarthritis (OA) progression in species with thin cartilage. Feasibility of using short, nonequilibrium contrast-enhanced micro-computed tomography (CE-μCT) to evaluate the physical and biochemical properties of cartilage was investigated. A preliminary in vitro study...

journal_title：Cartilage

authors： Flynn C,Hurtig M,Linden AZ

更新日期：2020-05-26 00:00:00

abstract：:Three-dimensional (3D) bioprinting techniques can be used for the fabrication of personalized, regenerative constructs for tissue repair. The current article provides insight into the potential and opportunities of 3D bioprinting for the fabrication of cartilage regenerative constructs. Although 3D printing is already...

journal_title：Cartilage

authors： Mouser VHM,Levato R,Bonassar LJ,D'Lima DD,Grande DA,Klein TJ,Saris DBF,Zenobi-Wong M,Gawlitta D,Malda J

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To evaluate clinical, functional, and radiographic outcomes of patients who underwent bipolar osteochondral allograft transplantation (OCAT) of the patellofemoral joint (PFJ). DESIGN:Prospectively collected data on 18 knees who underwent fresh osteochondral allograft transplantation of the patella and trochl...

journal_title：Cartilage

authors： Mirzayan R,Charles MD,Batech M,Suh BD,DeWitt D

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:TNIIIA2 is a peptide of the extracellular matrix glycoprotein tenascin-C. We evaluated whether intra-articular injection of TNIIIA2 could prevent articular cartilage degeneration without inducing synovitis in an osteoarthritis mice model. DESIGN:Ten micrograms per milliliter of TNIIIA2 were injected into the...

journal_title：Cartilage

authors： Hattori T,Hasegawa M,Unno H,Iino T,Fukai F,Yoshida T,Sudo A

更新日期：2020-03-23 00:00:00

abstract：OBJECTIVE:Accurate arthroscopic evaluation of cartilage lesions could significantly improve the outcome of repair surgery. In this study, we investigated for the first time the potential of intra-articular ultrasound as an arthroscopic tool for grading cartilage defects in the human shoulder joint in vivo and compared ...

journal_title：Cartilage

authors： Puhakka J,Afara IO,Paatela T,Sormaala MJ,Timonen MA,Virén T,Jurvelin JS,Töyräs J,Kiviranta I

更新日期：2016-07-01 00:00:00

abstract：:Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication qual...

journal_title：Cartilage

authors： Frehner F,Benthien JP

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of accelerated compared with traditional postoperative weightbearing (WB) rehabilitation following matrix-induced autologous chondrocyte implantation (MACI) of the knee, using MRI. METHODS:A randomized controlled study design was used to assess MRI-based outcomes of MACI gra...

journal_title：Cartilage

authors： Ebert JR,Fallon M,Robertson WB,Lloyd DG,Zheng MH,Wood DJ,Ackland T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Cartilage health is thought to be dependent on the relationship between mechanics, structure, and metabolism, rather than these individual components in isolation. Due to sex differences in cartilage health, there is need to determine if the relationships between these cartilage components separately for male...

journal_title：Cartilage

authors： Harkey MS,Blackburn JT,Hackney AC,Lewek MD,Schmitz RJ,Pietrosimone B

更新日期：2020-09-19 00:00:00

abstract：OBJECTIVE:The identification of early-stage osteoarthritis (OA) is crucial for the deceleration of its progression; however, no reliable biomarker is available for this purpose. The current study aimed to determine the role of serum calprotectin in the detection of early-stage knee OA. DESIGN:In a case-control study, ...

journal_title：Cartilage

authors： Safa A,Bagherifard A,Hadi Al-Baseesee H,Amini Kadijani A,Yahyazadeh H,Azizi M,Akbari A,Mirzaei A

更新日期：2020-10-01 00:00:00

abstract：PURPOSE:Patients with isolated medial compartment osteoarthritis and varus deformity may undergo high tibial osteotomy (HTO) to reduce the contact pressure in the medial compartment. The purpose of this investigation is (1) examine the timeline of return to work (RTW) following HTO and (2) evaluate RTW stratified by oc...

journal_title：Cartilage

authors： Agarwalla A,Christian DR,Liu JN,Garcia GH,Redondo ML,Yanke AB,Cole BJ

更新日期：2019-06-10 00:00:00

abstract：OBJECTIVE:We sought to determine whether rates of postoperative arthrofibrosis following tibial tuberosity osteotomy (TTO) with complete mobilization of the fragment (TTO-HD) are comparable to TTOs where the hinge remained intact (TTO-HI). DESIGN:Patients who underwent TTO with concomitant cartilage repair procedure b...

journal_title：Cartilage

authors： Merkely G,Ackermann J,Sheehy E,Gomoll AH

更新日期：2020-10-23 00:00:00

abstract：:Objective To test different fixation methods of a 3-dimensionally woven poly(ϵ-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model. Methods Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared ...

journal_title：Cartilage

authors： Friedman JM,Sennett ML,Bonadio MB,Orji KO,Neuwirth AL,Keah N,Carey JL,Moutos FT,Estes BT,Guilak F,Madry H,Mauck RL,Dodge GR

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To compare the progression of biochemical biomarkers of osteoarthritis (OA), knee pain, and function between nonobese patients (NON), obese patients without depression (OBESE), and obese patients with comorbid depression (O + D). DESIGN:Utilizing the FNIH OA Biomarkers Consortium dataset, we categorized knee...

journal_title：Cartilage

authors： Jacobs CA,Vranceanu AM,Thompson KL,Lattermann C

更新日期：2020-01-01 00:00:00

abstract：:Articular cartilage injuries, and corresponding surgical procedures, are occurring with increasing frequency as identified by a review of recent surgical trends. Concerns have grown in recent years regarding the longevity of results following microfracture, with a shift toward cartilage restoration procedures in recen...

journal_title：Cartilage

authors： Degen RM,Tetreault D,Mahony GT,Williams RJ

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Ankle arthropathy is a frequent and invalidating manifestation of hemophilia. Arthrodesis is the gold standard surgical procedure in end-stage disease, with many drawbacks in young patients. Recent literature has shown increase interest in regenerative procedures in hemophilic arthropathy, which may be desira...

journal_title：Cartilage

authors： Buda R,Cavallo M,Castagnini F,Cenacchi A,Natali S,Vannini F,Giannini S

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Describe the local morphological response of the articular-epiphyseal cartilage complex to surgical stab incision in the distal femur of foals, with emphasis on the relationship between growth cartilage injury, enchondral ossification, and repair. DESIGN:Nine foals were induced into general anesthesia at the...

journal_title：Cartilage

authors： Olstad K,Hendrickson EH,Ekman S,Carlson CS,Dolvik NI

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Osteochondral allograft (OCA) transplantation is an increasingly common treatment for patients with symptomatic focal chondral lesions of the knee. There has been increasing interest in determining predictive factors to maximize patient benefit after this operation. The aim of the present study is to evaluat...

journal_title：Cartilage

authors： Owusu-Akyaw KA,Bido J,Warner T,Rodeo SA,Williams RJ

更新日期：2020-09-17 00:00:00

abstract：OBJECTIVE:To evaluate the effect of intra-articular injection of autologous micronized adipose tissue (MAT) with ankle arthroscopic debridement in patients with advanced-stage posttraumatic osteoarthritis (PTOA) of ankle. DESIGN:A retrospective cohort study investigating patients treated with arthroscopic debridement ...

journal_title：Cartilage

authors： Shimozono Y,Dankert JF,Kennedy JG

更新日期：2020-08-06 00:00:00

abstract：OBJECTIVE:Our aim is to explore the candidate pathogenesis genes and pathways of developmental dysplasia of hip (DDH). DESIGN:Proliferating primary chondrocytes from hip cartilage were used for total RNA extraction including 5 DDH patients and 5 neck of femur fracture (NOF) subjects. Genome-wide mRNA and microRNA (miR...

journal_title：Cartilage

authors： Cheng B,Jia Y,Wen Y,Hou W,Xu K,Liang C,Cheng S,Liu L,Chu X,Ye J,Yao Y,Zhang F,Xu P

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:The current therapeutic strategy for posttraumatic osteoarthritis (PTOA) focuses on early intervention to attenuate disease progression, preserve joint function, and defer joint replacement timing. Sequential transcriptomic changes of articular cartilage in a rat model were investigated to explore the molecul...

journal_title：Cartilage

authors： Liu CC,Lee HC,Peng YS,Tseng AH,Wu JL,Tsai WY,Wong CS,Su LJ

更新日期：2019-05-20 00:00:00

abstract：OBJECTIVE:Both selenium (Se) deficiency and mycotoxin T2 lead to epiphyseal plate lesions, similar to Kashin-Beck disease (KBD). However, regulation of selenoproteins synthesis mediated by SECISBP2, in response to these 2 environmental factors, remained unclear. The present study proposed to explore the mechanism behin...

journal_title：Cartilage

authors： Sun J,Min Z,Zhao W,Hussain S,Zhao Y,Guo D,Zhang F,Guo Y,Sun M,Huang H,Han Y,Zhong N,Xu P,Lu S

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:The purpose of this systematic review and meta-analysis was to evaluate the effect of electromagnetic field treatment on the symptoms of knee osteoarthritis (OA). In addition, the influence of the type of control group and other covariates have been investigated to identify the sources of heterogeneity in the...

journal_title：Cartilage

authors： Viganò M,Perucca Orfei C,Ragni E,Colombini A,de Girolamo L

更新日期：2020-06-08 00:00:00