Clinical and Basic Science of Cartilage Injury and Arthritis in the Football (Soccer) Athlete.

abstract：OBJECTIVE:To evaluate the effect of intra-articular injection of autologous micronized adipose tissue (MAT) with ankle arthroscopic debridement in patients with advanced-stage posttraumatic osteoarthritis (PTOA) of ankle. DESIGN:A retrospective cohort study investigating patients treated with arthroscopic debridement ...

journal_title：Cartilage

authors： Shimozono Y,Dankert JF,Kennedy JG

更新日期：2020-08-06 00:00:00

abstract：OBJECTIVE:Our aim is to explore the candidate pathogenesis genes and pathways of developmental dysplasia of hip (DDH). DESIGN:Proliferating primary chondrocytes from hip cartilage were used for total RNA extraction including 5 DDH patients and 5 neck of femur fracture (NOF) subjects. Genome-wide mRNA and microRNA (miR...

journal_title：Cartilage

authors： Cheng B,Jia Y,Wen Y,Hou W,Xu K,Liang C,Cheng S,Liu L,Chu X,Ye J,Yao Y,Zhang F,Xu P

更新日期：2021-02-01 00:00:00

abstract：:Because of poor regenerative capabilities of cartilage, reconstruction of similar rigidity and flexibility is difficult, challenging, and restricted. The aim of the present investigation was to develop cost-effective acellular xenogeneic biomaterial as cartilage substitution. Two novel biometrics have been developed u...

journal_title：Cartilage

authors： Das P,Rajesh K,Lalzawmliana V,Bavya Devi K,Basak P,Lahiri D,Kundu B,Roy M,Nandi SK

更新日期：2019-06-19 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is an incurable joint disease characterized by pronounced pain. MicroRNAs constitute epigenetic mechanisms that may affect OA progression by contributing to changes in chondrocyte phenotype. This study investigates for the first time whether there is a link between miRNA-1 (miR-1) and OA p...

journal_title：Cartilage

authors： Yang Y,Wang Y,Jia H,Li B,Xing D,Li JJ

更新日期：2020-11-20 00:00:00

abstract：OBJECTIVE:To assess the clinical outcome of patients treated with autologous chondrocyte implantation using ChondroCelect in daily practice. METHODS:The study is a cross-sectional analysis of an open-label, noninterventional cohort. The setting was a compassionate use program, involving 43 orthopaedic centers in 7 Eur...

journal_title：Cartilage

authors： Vanlauwe J,Huylebroek J,Van Der Bauwhede J,Saris D,Veeckman G,Bobic V,Victor J,Almqvist KF,Verdonk P,Fortems Y,Van Lommel N,Haazen L

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of accelerated compared with traditional postoperative weightbearing (WB) rehabilitation following matrix-induced autologous chondrocyte implantation (MACI) of the knee, using MRI. METHODS:A randomized controlled study design was used to assess MRI-based outcomes of MACI gra...

journal_title：Cartilage

authors： Ebert JR,Fallon M,Robertson WB,Lloyd DG,Zheng MH,Wood DJ,Ackland T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:ADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motif) zinc metalloproteinases are important during the synthesis and breakdown of cartilage extracellular matrix. ADAMTS-12 is up-regulated during in vitro chondrogenesis and embryonic limb development; however, the regulation of ADAMTS-1...

journal_title：Cartilage

authors： Hong E,Yik J,Amanatullah DF,Di Cesare PE,Haudenschild DR

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:There are limited data on bone dimension and cartilage thickness of the distal humeral articular surface. This study aimed to evaluate sex- and age-related bone dimension and cartilage thickness differences and assess the effect of cartilage thickness on distal humeral shape. DESIGN:Elbow magnetic resonance ...

journal_title：Cartilage

authors： Misir A,Gunay AE,Oguzkaya S,Uzun E,Kizkapan TB,Yildiz KI,Ozcamdalli M

更新日期：2020-02-10 00:00:00

abstract：:Articular cartilage injuries, and corresponding surgical procedures, are occurring with increasing frequency as identified by a review of recent surgical trends. Concerns have grown in recent years regarding the longevity of results following microfracture, with a shift toward cartilage restoration procedures in recen...

journal_title：Cartilage

authors： Degen RM,Tetreault D,Mahony GT,Williams RJ

更新日期：2016-10-01 00:00:00

abstract：OBJECTIVE:Treatments for steroid-induced osteonecrosis of the knee remains challenging, and there has not been sufficient evidence to support joint preservation surgery. This study evaluated long-term outcomes of osteochondral autologous transplantation (OAT) for steroid-induced osteonecrosis of the knee. DESIGN:This ...

journal_title：Cartilage

authors： Nishitani K,Nakagawa Y,Kobayashi M,Nakamura S,Mukai S,Kuriyama S,Matsuda S

更新日期：2020-09-10 00:00:00

abstract：OBJECTIVE:Cartilage health is thought to be dependent on the relationship between mechanics, structure, and metabolism, rather than these individual components in isolation. Due to sex differences in cartilage health, there is need to determine if the relationships between these cartilage components separately for male...

journal_title：Cartilage

authors： Harkey MS,Blackburn JT,Hackney AC,Lewek MD,Schmitz RJ,Pietrosimone B

更新日期：2020-09-19 00:00:00

abstract：OBJECTIVE:To evaluate clinical, functional, and radiographic outcomes of patients who underwent bipolar osteochondral allograft transplantation (OCAT) of the patellofemoral joint (PFJ). DESIGN:Prospectively collected data on 18 knees who underwent fresh osteochondral allograft transplantation of the patella and trochl...

journal_title：Cartilage

authors： Mirzayan R,Charles MD,Batech M,Suh BD,DeWitt D

更新日期：2020-10-01 00:00:00

abstract：:Nucleofection of chondrocytes has been shown to be an adequate method of transfection. Using Amaxa's nucleofection system, transfection efficiencies up to 89% were achievable for vector (pmaxGFP) and 98% for siRNA (siGLO) into passaged chondrocytes. However, such methods rely on costly commercial kits with proprietary...

journal_title：Cartilage

authors： Parreno J,Delve E,Andrejevic K,Paez-Parent S,Wu PH,Kandel R

更新日期：2016-01-01 00:00:00

abstract：:Objective To identify if the time of day and pre-imaging exercise matter while performing T2* mapping of hip joint cartilage at 3 T. Design Nine asymptomatic healthy volunteers (mean age 27.4 ± 4.0 years) with no obvious morphological evidence of cartilage damage were enrolled. The MRI protocol included a double-echo ...

journal_title：Cartilage

authors： Hesper T,Hosalkar HS,Schleich C,Antoch G,Welsch GH,Krauspe R,Zilkens C,Bittersohl B

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:We have developed an ultrapurified low endotoxin alginate (UPLE alginate), which can drastically reduce endotoxin levels. Our purposes were to examine the effects of UPLE alginate administration on osteoarthritis (OA) progression and to determine the adequate molecular weight of the UPLE alginate for therapeu...

journal_title：Cartilage

authors： Igarashi T,Iwasaki N,Kawamura D,Tsukuda Y,Kasahara Y,Todoh M,Tadano S,Minami A

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:TNIIIA2 is a peptide of the extracellular matrix glycoprotein tenascin-C. We evaluated whether intra-articular injection of TNIIIA2 could prevent articular cartilage degeneration without inducing synovitis in an osteoarthritis mice model. DESIGN:Ten micrograms per milliliter of TNIIIA2 were injected into the...

journal_title：Cartilage

authors： Hattori T,Hasegawa M,Unno H,Iino T,Fukai F,Yoshida T,Sudo A

更新日期：2020-03-23 00:00:00

abstract：:Objective The aim of this study was to evaluate the chondroprotective effect of chemically decellularized meniscal allografts transplanted into the knee joints of adult merino sheep. Methods Lateral sheep meniscal allografts were chemically processed by a multistep method to yield acellular, sterile grafts. The grafts...

journal_title：Cartilage

authors： Gelse K,Körber L,Schöne M,Raum K,Koch P,Pachowsky M,Welsch G,Breiter R

更新日期：2017-04-01 00:00:00

abstract：OBJECTIVE:To determine if lubricin was present in the surface layer of repair cartilage formed after autologous chondrocyte implantation (ACI). DESIGN:Forty-three biopsies of repair tissue were taken from patients who had been treated with ACI 8 to 68 months previously (mean of 18.0 ± 14.4 months); 30 had flaps of per...

journal_title：Cartilage

authors： Roberts S,Menage J,Flannery CR,Richardson JB

更新日期：2010-10-01 00:00:00

abstract：:Postoperative rehabilitation programs following articular cartilage repair procedures will vary greatly among patients and need to be individualized based on the nature of the lesion, the unique characteristics of the patient, and the type and detail of each surgical procedure. These programs are based on knowledge of...

journal_title：Cartilage

authors： Wilk KE,Macrina LC,Reinold MM

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND:Full-depth cartilage lesions do not heal and the long-term clinical outcome is uncertain. In the symptomatic middle-aged (35-60 years) patient, treatment with metal implants has been proposed. However, the cartilage health surrounding these implants has not been thoroughly studied. Our objective was to evalu...

journal_title：Cartilage

authors： Martinez-Carranza N,Hultenby K,Lagerstedt AS,Schupbach P,Berg HE

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:To compare the histological and immunohistochemical characteristics of matrix-assisted chondrocyte implantation (MACI) grafts between patients with revision surgery and patients with total joint arthroplasty. METHODS:Biopsies of MACI grafts from patients with revision and total joint arthroplasty. The graft ...

journal_title：Cartilage

authors： Beck A,Wood D,Vertullo CJ,Ebert J,Janes G,Sullivan M,Zheng MH

更新日期：2019-12-02 00:00:00

abstract：OBJECTIVE:We have recently shown that mesenchymal stem cells (MSCs) embedded in a hyaluronic acid (HA) hydrogel and exposed to chondrogenic factors (transforming growth factor-β3 [TGF-β3]) produce a cartilage-like tissue in vitro. The current objective was to determine if these same factors could be combined immediatel...

journal_title：Cartilage

authors： Fisher MB,Belkin NS,Milby AH,Henning EA,Söegaard N,Kim M,Pfeifer C,Saxena V,Dodge GR,Burdick JA,Schaer TP,Steinberg DR,Mauck RL

更新日期：2016-04-01 00:00:00

abstract：:Objective To evaluate the outcome of patients who have undergone simultaneous osteotomy and osteochondral allograft (OCA) transplantation. Our hypothesis is that use of high tibial osteotomy and fresh OCA in a combined procedure is safe and effective without increasing morbidity in comparison to OCA alone. Design A ca...

journal_title：Cartilage

authors： Hsu AC,Tirico LEP,Lin AG,Pulido PA,Bugbee WD

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Our aim was to compare T2 with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the hip and assess the reproducibility and effect of joint unloading on T2 mapping. DESIGN:Ten individuals at high risk of developing hip osteoarthritis (SibKids) underwent contemporaneous T2 mappi...

journal_title：Cartilage

authors： Fernquest S,Palmer A,Gammer B,Hirons E,Kendrick B,Taylor A,De Berker H,Bangerter N,Carr A,Glyn-Jones S

更新日期：2019-04-11 00:00:00

abstract：OBJECTIVE:The objective of this study was to assess the effect of granulocyte colony-stimulating factor (G-CSF) on osteochondral defect repair in the rat knee. DESIGN:Twenty-six 12-week-old male Lewis rats were randomly divided into 2 groups. From day 0 to day 4, the G-CSF group received glycosylated G-CSF, and the co...

journal_title：Cartilage

authors： Okano T,Mera H,Itokazu M,Okabe T,Koike T,Nakamura H,Wakitani S

更新日期：2014-04-01 00:00:00

abstract：:The objective of this study was to characterize magnetic resonance imaging (MRI) findings and correlate with clinical results in patients who underwent autologous chondrocyte implantation (ACI) of osteochondral lesions of the talus (OLT). METHODS:Twenty-four grafts were evaluated at a mean 65.8 months after ACI for O...

journal_title：Cartilage

authors： Chan KW,Ferkel RD,Kern B,Chan SS,Applegate GR

更新日期：2018-01-01 00:00:00

abstract：:The concept of using gene transfer strategies for cartilage repair originates from the idea of transferring genes encoding therapeutic factors into the repair tissue, resulting in a temporarily and spatially defined delivery of therapeutic molecules to sites of cartilage damage. This review focuses on the potential be...

journal_title：Cartilage

authors： Madry H,Orth P,Cucchiarini M

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:To assess the continued effectiveness and safety of Gel-200 following observation and open-label retreatment in an extension protocol following a randomized, double-blind, phosphate buffered saline (PBS)-controlled trial (initial treatment trial). DESIGN:Patients who completed initial blinded treatment were ...

journal_title：Cartilage

authors： Strand V,Baraf HS,Lavin PT,Lim S,Hosokawa H

更新日期：2012-10-01 00:00:00

abstract：:Various systematic reviews have recently shown that intra-articular platelet-rich plasma (IA-PRP) can lead to symptomatic relief of knee osteoarthritis for up to 12 months. There exist limited data on its use in small joints, such as the trapeziometacarpal joint (TMJ) or carpometacarpal joint (CMCJ) of the thumb. A pr...

journal_title：Cartilage

authors： Malahias MA,Roumeliotis L,Nikolaou VS,Chronopoulos E,Sourlas I,Babis GC

更新日期：2021-01-01 00:00:00

abstract：OBJECTIVE:To determine the optimal environmental conditions for chondrogenic differentiation of human adipose tissue-derived mesenchymal stromal/stem cells (AMSCs). In this investigation we specifically investigate the role of oxygen tension and 3-dimensional (3D) culture systems. DESIGN:Both AMSCs and primary human c...

journal_title：Cartilage

authors： Galeano-Garces C,Camilleri ET,Riester SM,Dudakovic A,Larson DR,Qu W,Smith J,Dietz AB,Im HJ,Krych AJ,Larson AN,Karperien M,van Wijnen AJ

更新日期：2017-07-01 00:00:00