Osteochondral Allograft Transplantation and Opening Wedge Tibial Osteotomy: Clinical Results of a Combined Single Procedure.

abstract：:Objective The aim of this study was to evaluate the chondroprotective effect of chemically decellularized meniscal allografts transplanted into the knee joints of adult merino sheep. Methods Lateral sheep meniscal allografts were chemically processed by a multistep method to yield acellular, sterile grafts. The grafts...

journal_title：Cartilage

authors： Gelse K,Körber L,Schöne M,Raum K,Koch P,Pachowsky M,Welsch G,Breiter R

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Full-depth cartilage lesions do not heal and the long-term clinical outcome is uncertain. In the symptomatic middle-aged (35-60 years) patient, treatment with metal implants has been proposed. However, the cartilage health surrounding these implants has not been thoroughly studied. Our objective was to evalu...

journal_title：Cartilage

authors： Martinez-Carranza N,Hultenby K,Lagerstedt AS,Schupbach P,Berg HE

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Asp...

journal_title：Cartilage

authors： Desando G,Bartolotti I,Vannini F,Cavallo C,Castagnini F,Buda R,Giannini S,Mosca M,Mariani E,Grigolo B

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:This study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery. METHODS:This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Re...

journal_title：Cartilage

authors： Andrade R,Nunes J,Hinckel BB,Gruskay J,Vasta S,Bastos R,Oliveira JM,Reis RL,Gomoll AH,Espregueira-Mendes J

更新日期：2019-12-17 00:00:00

abstract：OBJECTIVE:Our aim was to compare T2 with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the hip and assess the reproducibility and effect of joint unloading on T2 mapping. DESIGN:Ten individuals at high risk of developing hip osteoarthritis (SibKids) underwent contemporaneous T2 mappi...

journal_title：Cartilage

authors： Fernquest S,Palmer A,Gammer B,Hirons E,Kendrick B,Taylor A,De Berker H,Bangerter N,Carr A,Glyn-Jones S

更新日期：2019-04-11 00:00:00

abstract：OBJECTIVE:To compare the progression of biochemical biomarkers of osteoarthritis (OA), knee pain, and function between nonobese patients (NON), obese patients without depression (OBESE), and obese patients with comorbid depression (O + D). DESIGN:Utilizing the FNIH OA Biomarkers Consortium dataset, we categorized knee...

journal_title：Cartilage

authors： Jacobs CA,Vranceanu AM,Thompson KL,Lattermann C

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Focal cartilage lesions in the knee joint have limited capacity to heal. Current animal experiments show that incisions of the deep zone of a cartilage allograft allow acceptable integration for the graft. QUESTIONS/PURPOSES:We performed this clinical study to determine (1) if the multiply incised cartilage...

journal_title：Cartilage

authors： Bardos T,Vancsodi J,Farkas B,Fazekas A,Nagy SA,Bogner P,Vermes C,Than P

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:Hyaluronic acid-transglutaminase (HA-TG) is an enzymatically crosslinkable adhesive hydrogel with chondrogenic properties demonstrated in vitro and in an ectopic mouse model. In this study, we investigated the feasibility of using HA-TG in a collagen scaffold to treat chondral lesions in an ovine model, to ev...

journal_title：Cartilage

authors： Levinson C,Cavalli E,von Rechenberg B,Zenobi-Wong M,Darwiche SE

更新日期：2021-01-29 00:00:00

abstract：:Purpose. To determine the 5-year success rate of the "all-inside" technique of arthroscopic meniscus suture and collagen membrane wrapping along with bone marrow blood injection, to evaluate the progression of degenerative changes and the impact of simultaneous anteriro cruciate ligament (ACL) reconstruction. Methods....

journal_title：Cartilage

authors： Ciemniewska-Gorzela K,Bąkowski P,Naczk J,Jakob R,Piontek T

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVE:Bone morphogenetic protein 2 (BMP2) plays important roles in cartilage growth and development. Paradoxically, elevated levels of BMP2 leads to hypertrophic differentiation and osteoarthritis of cartilage. We examined the in vivo loss of BMP2 in cells expressing aggrecan of the mandibular condyle and knee. DE...

journal_title：Cartilage

authors： O'Brien MH,Dutra EH,Mehta S,Chen PJ,Yadav S

更新日期：2020-12-14 00:00:00

abstract：OBJECTIVE:Telomere length and telomerase activity are important indicators of cellular senescence and replicative ability. Loss of telomerase is associated with ageing and the development of osteoarthritis. Implantation of telomerase-positive cells, chondrocytes, or stem cells expressing a normal chondrocyte phenotype ...

journal_title：Cartilage

authors： Wilson B,Novakofski KD,Donocoff RS,Liang YX,Fortier LA

更新日期：2014-10-01 00:00:00

abstract：OBJECTIVE:The current therapeutic strategy for posttraumatic osteoarthritis (PTOA) focuses on early intervention to attenuate disease progression, preserve joint function, and defer joint replacement timing. Sequential transcriptomic changes of articular cartilage in a rat model were investigated to explore the molecul...

journal_title：Cartilage

authors： Liu CC,Lee HC,Peng YS,Tseng AH,Wu JL,Tsai WY,Wong CS,Su LJ

更新日期：2019-05-20 00:00:00

abstract：OBJECTIVE:To determine if lubricin was present in the surface layer of repair cartilage formed after autologous chondrocyte implantation (ACI). DESIGN:Forty-three biopsies of repair tissue were taken from patients who had been treated with ACI 8 to 68 months previously (mean of 18.0 ± 14.4 months); 30 had flaps of per...

journal_title：Cartilage

authors： Roberts S,Menage J,Flannery CR,Richardson JB

更新日期：2010-10-01 00:00:00

abstract：:Introduction Autologous osteochondral transplantation (AOT) is a treatment for osteochondral lesions with known concerns, including histological degradation of the graft and poor cartilage integration. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have been described has having the potential to improve results. ...

journal_title：Cartilage

authors： Smyth NA,Ross KA,Haleem AM,Hannon CP,Murawski CD,Do HT,Kennedy JG

更新日期：2018-07-01 00:00:00

abstract：:Three-dimensional (3D) bioprinting techniques can be used for the fabrication of personalized, regenerative constructs for tissue repair. The current article provides insight into the potential and opportunities of 3D bioprinting for the fabrication of cartilage regenerative constructs. Although 3D printing is already...

journal_title：Cartilage

authors： Mouser VHM,Levato R,Bonassar LJ,D'Lima DD,Grande DA,Klein TJ,Saris DBF,Zenobi-Wong M,Gawlitta D,Malda J

更新日期：2017-10-01 00:00:00

abstract：:Nucleofection of chondrocytes has been shown to be an adequate method of transfection. Using Amaxa's nucleofection system, transfection efficiencies up to 89% were achievable for vector (pmaxGFP) and 98% for siRNA (siGLO) into passaged chondrocytes. However, such methods rely on costly commercial kits with proprietary...

journal_title：Cartilage

authors： Parreno J,Delve E,Andrejevic K,Paez-Parent S,Wu PH,Kandel R

更新日期：2016-01-01 00:00:00

abstract：:Articular cartilage injuries, and corresponding surgical procedures, are occurring with increasing frequency as identified by a review of recent surgical trends. Concerns have grown in recent years regarding the longevity of results following microfracture, with a shift toward cartilage restoration procedures in recen...

journal_title：Cartilage

authors： Degen RM,Tetreault D,Mahony GT,Williams RJ

更新日期：2016-10-01 00:00:00

abstract：:Objective To test different fixation methods of a 3-dimensionally woven poly(ϵ-caprolactone) (PCL) scaffold within chondral defects of a weightbearing large animal model. Methods Full thickness chondral defects were made in the femoral condyles of 15 adult male Yucatan mini-pigs. Two surgical approaches were compared ...

journal_title：Cartilage

authors： Friedman JM,Sennett ML,Bonadio MB,Orji KO,Neuwirth AL,Keah N,Carey JL,Moutos FT,Estes BT,Guilak F,Madry H,Mauck RL,Dodge GR

更新日期：2018-10-01 00:00:00

abstract：:Osteoarthritis (OA) is a painful and life-altering disease that severely limits the daily activity of millions of Americans, and is one of the most common causes of disability in the world. With obesity on the rise and the world's population living longer, the prevalence of OA is expected to increase dramatically in t...

journal_title：Cartilage

authors： Christiansen BA,Bhatti S,Goudarzi R,Emami S

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:Excessive use of glucocorticoids (GCs) may cause adverse effects on the skeletal system in children. However, only a few studies have reported the effects of GCs on the epiphyseal cartilage. This study aimed to uncover the subsequent epiphyseal cartilage changes of immature femoral heads after excessive GC tr...

journal_title：Cartilage

authors： Jin S,Yang L,Meng C,He Y,Ma K,Huang W,Wang H

更新日期：2020-12-03 00:00:00

abstract：:Objective To identify if the time of day and pre-imaging exercise matter while performing T2* mapping of hip joint cartilage at 3 T. Design Nine asymptomatic healthy volunteers (mean age 27.4 ± 4.0 years) with no obvious morphological evidence of cartilage damage were enrolled. The MRI protocol included a double-echo ...

journal_title：Cartilage

authors： Hesper T,Hosalkar HS,Schleich C,Antoch G,Welsch GH,Krauspe R,Zilkens C,Bittersohl B

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of intra-articular injection of autologous micronized adipose tissue (MAT) with ankle arthroscopic debridement in patients with advanced-stage posttraumatic osteoarthritis (PTOA) of ankle. DESIGN:A retrospective cohort study investigating patients treated with arthroscopic debridement ...

journal_title：Cartilage

authors： Shimozono Y,Dankert JF,Kennedy JG

更新日期：2020-08-06 00:00:00

abstract：OBJECTIVE:The objective of this study was to fully characterize the mechanics of an in vivo impactor and correlate the mechanics with superficial cracking of articular surfaces. DESIGN:A spring-loaded impactor was used to apply energy-controlled impacts to the articular surfaces of neonatal bovine cartilage. The simul...

journal_title：Cartilage

authors： Bonnevie ED,Delco ML,Fortier LA,Alexander PG,Tuan RS,Bonassar LJ

更新日期：2015-10-01 00:00:00

abstract：:Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication qual...

journal_title：Cartilage

authors： Frehner F,Benthien JP

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to assess the effect of granulocyte colony-stimulating factor (G-CSF) on osteochondral defect repair in the rat knee. DESIGN:Twenty-six 12-week-old male Lewis rats were randomly divided into 2 groups. From day 0 to day 4, the G-CSF group received glycosylated G-CSF, and the co...

journal_title：Cartilage

authors： Okano T,Mera H,Itokazu M,Okabe T,Koike T,Nakamura H,Wakitani S

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:The purpose of this article is to report on a distinctive pattern of linear femoral head chondral lesions that were observed in 7 patients who underwent hip arthroscopy for the treatment of mixed-type femoroacetabular impingement (FAI). DESIGN:Between 2010 and 2012, 702 patients were treated with hip arthros...

journal_title：Cartilage

authors： Philippon MJ,Goljan P,Devitt BM,Peixoto LP

更新日期：2014-01-01 00:00:00

abstract：:INTRODUCTION: The zone of calcified cartilage (ZCC) anchors articular cartilage (AC) to subchondral bone through a layer of intermediate stiffness. The regulation and functional consequences of cartilage calcification may vary with depth from the articular surface. The hypothesis of this study was that the in vitro ca...

journal_title：Cartilage

authors： Hwang J,Kyubwa EM,Bae WC,Bugbee WD,Masuda K,Sah RL

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:ADAMTS (a disintegrin and metalloproteinase with thrombospondin type-1 motif) zinc metalloproteinases are important during the synthesis and breakdown of cartilage extracellular matrix. ADAMTS-12 is up-regulated during in vitro chondrogenesis and embryonic limb development; however, the regulation of ADAMTS-1...

journal_title：Cartilage

authors： Hong E,Yik J,Amanatullah DF,Di Cesare PE,Haudenschild DR

更新日期：2013-04-01 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of accelerated compared with traditional postoperative weightbearing (WB) rehabilitation following matrix-induced autologous chondrocyte implantation (MACI) of the knee, using MRI. METHODS:A randomized controlled study design was used to assess MRI-based outcomes of MACI gra...

journal_title：Cartilage

authors： Ebert JR,Fallon M,Robertson WB,Lloyd DG,Zheng MH,Wood DJ,Ackland T

更新日期：2011-01-01 00:00:00

abstract：INTRODUCTION:Delamination of the chondral surface of an osteochondral allograft (OCA) from the underlying cancellous bone has been described as a mode of failure after implantation in the knee. Our hypothesis was that increased storage time of the OCA is associated with increased risk of graft delamination after implan...

journal_title：Cartilage

authors： Rauck RC,Wang D,Tao M,Williams RJ

更新日期：2019-10-01 00:00:00