TNIIIA2, The Peptide of Tenascin-C, as a Candidate for Preventing Articular Cartilage Degeneration.

abstract：OBJECTIVE:The current therapeutic strategy for posttraumatic osteoarthritis (PTOA) focuses on early intervention to attenuate disease progression, preserve joint function, and defer joint replacement timing. Sequential transcriptomic changes of articular cartilage in a rat model were investigated to explore the molecul...

journal_title：Cartilage

authors： Liu CC,Lee HC,Peng YS,Tseng AH,Wu JL,Tsai WY,Wong CS,Su LJ

更新日期：2019-05-20 00:00:00

abstract：PURPOSE:This study aimed to systematically analyze the postoperative clinical, functional, and imaging outcomes, complications, reoperations, and failures following patellofemoral cartilage restoration surgery. METHODS:This review was conducted according to the guidelines of Preferred Reporting Items for Systematic Re...

journal_title：Cartilage

authors： Andrade R,Nunes J,Hinckel BB,Gruskay J,Vasta S,Bastos R,Oliveira JM,Reis RL,Gomoll AH,Espregueira-Mendes J

更新日期：2019-12-17 00:00:00

abstract：OBJECTIVE:To assess the clinical outcome of patients treated with autologous chondrocyte implantation using ChondroCelect in daily practice. METHODS:The study is a cross-sectional analysis of an open-label, noninterventional cohort. The setting was a compassionate use program, involving 43 orthopaedic centers in 7 Eur...

journal_title：Cartilage

authors： Vanlauwe J,Huylebroek J,Van Der Bauwhede J,Saris D,Veeckman G,Bobic V,Victor J,Almqvist KF,Verdonk P,Fortems Y,Van Lommel N,Haazen L

更新日期：2012-04-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis (OA) is an incurable joint disease characterized by pronounced pain. MicroRNAs constitute epigenetic mechanisms that may affect OA progression by contributing to changes in chondrocyte phenotype. This study investigates for the first time whether there is a link between miRNA-1 (miR-1) and OA p...

journal_title：Cartilage

authors： Yang Y,Wang Y,Jia H,Li B,Xing D,Li JJ

更新日期：2020-11-20 00:00:00

abstract：OBJECTIVE:We have recently shown that mesenchymal stem cells (MSCs) embedded in a hyaluronic acid (HA) hydrogel and exposed to chondrogenic factors (transforming growth factor-β3 [TGF-β3]) produce a cartilage-like tissue in vitro. The current objective was to determine if these same factors could be combined immediatel...

journal_title：Cartilage

authors： Fisher MB,Belkin NS,Milby AH,Henning EA,Söegaard N,Kim M,Pfeifer C,Saxena V,Dodge GR,Burdick JA,Schaer TP,Steinberg DR,Mauck RL

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Hyaluronic acid-transglutaminase (HA-TG) is an enzymatically crosslinkable adhesive hydrogel with chondrogenic properties demonstrated in vitro and in an ectopic mouse model. In this study, we investigated the feasibility of using HA-TG in a collagen scaffold to treat chondral lesions in an ovine model, to ev...

journal_title：Cartilage

authors： Levinson C,Cavalli E,von Rechenberg B,Zenobi-Wong M,Darwiche SE

更新日期：2021-01-29 00:00:00

abstract：OBJECTIVE:The purpose of this article is to report on a distinctive pattern of linear femoral head chondral lesions that were observed in 7 patients who underwent hip arthroscopy for the treatment of mixed-type femoroacetabular impingement (FAI). DESIGN:Between 2010 and 2012, 702 patients were treated with hip arthros...

journal_title：Cartilage

authors： Philippon MJ,Goljan P,Devitt BM,Peixoto LP

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Asp...

journal_title：Cartilage

authors： Desando G,Bartolotti I,Vannini F,Cavallo C,Castagnini F,Buda R,Giannini S,Mosca M,Mariani E,Grigolo B

更新日期：2017-01-01 00:00:00

abstract：:Nucleofection of chondrocytes has been shown to be an adequate method of transfection. Using Amaxa's nucleofection system, transfection efficiencies up to 89% were achievable for vector (pmaxGFP) and 98% for siRNA (siGLO) into passaged chondrocytes. However, such methods rely on costly commercial kits with proprietary...

journal_title：Cartilage

authors： Parreno J,Delve E,Andrejevic K,Paez-Parent S,Wu PH,Kandel R

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To determine if lubricin was present in the surface layer of repair cartilage formed after autologous chondrocyte implantation (ACI). DESIGN:Forty-three biopsies of repair tissue were taken from patients who had been treated with ACI 8 to 68 months previously (mean of 18.0 ± 14.4 months); 30 had flaps of per...

journal_title：Cartilage

authors： Roberts S,Menage J,Flannery CR,Richardson JB

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To assess the safety and efficacy of accelerated compared with traditional postoperative weightbearing (WB) rehabilitation following matrix-induced autologous chondrocyte implantation (MACI) of the knee, using MRI. METHODS:A randomized controlled study design was used to assess MRI-based outcomes of MACI gra...

journal_title：Cartilage

authors： Ebert JR,Fallon M,Robertson WB,Lloyd DG,Zheng MH,Wood DJ,Ackland T

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVE:Excessive use of glucocorticoids (GCs) may cause adverse effects on the skeletal system in children. However, only a few studies have reported the effects of GCs on the epiphyseal cartilage. This study aimed to uncover the subsequent epiphyseal cartilage changes of immature femoral heads after excessive GC tr...

journal_title：Cartilage

authors： Jin S,Yang L,Meng C,He Y,Ma K,Huang W,Wang H

更新日期：2020-12-03 00:00:00

abstract：OBJECTIVE:To assess the continued effectiveness and safety of Gel-200 following observation and open-label retreatment in an extension protocol following a randomized, double-blind, phosphate buffered saline (PBS)-controlled trial (initial treatment trial). DESIGN:Patients who completed initial blinded treatment were ...

journal_title：Cartilage

authors： Strand V,Baraf HS,Lavin PT,Lim S,Hosokawa H

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:Cartilage health is thought to be dependent on the relationship between mechanics, structure, and metabolism, rather than these individual components in isolation. Due to sex differences in cartilage health, there is need to determine if the relationships between these cartilage components separately for male...

journal_title：Cartilage

authors： Harkey MS,Blackburn JT,Hackney AC,Lewek MD,Schmitz RJ,Pietrosimone B

更新日期：2020-09-19 00:00:00

abstract：:The objective was to evaluate short-term outcomes of patients of more than 60 years old, who underwent arthroscopic treatment for femoroacetabular impingement (FAI). The study design was a nonrandomized controlled clinical trial; this was a prospective study in 15 patients (15 hips) over 60 years old. Inclusion criter...

journal_title：Cartilage

authors： Mardones RM,Nemtala F,Tomic A

更新日期：2010-07-01 00:00:00

abstract：:The concept of using gene transfer strategies for cartilage repair originates from the idea of transferring genes encoding therapeutic factors into the repair tissue, resulting in a temporarily and spatially defined delivery of therapeutic molecules to sites of cartilage damage. This review focuses on the potential be...

journal_title：Cartilage

authors： Madry H,Orth P,Cucchiarini M

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVE:The identification of early-stage osteoarthritis (OA) is crucial for the deceleration of its progression; however, no reliable biomarker is available for this purpose. The current study aimed to determine the role of serum calprotectin in the detection of early-stage knee OA. DESIGN:In a case-control study, ...

journal_title：Cartilage

authors： Safa A,Bagherifard A,Hadi Al-Baseesee H,Amini Kadijani A,Yahyazadeh H,Azizi M,Akbari A,Mirzaei A

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:Osteoarthritis is a painful, chronic joint disease affecting man and animals with no known curative therapies. Palliative nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but they cause adverse side effects prompting the search for safer alternatives. To address this need, we evaluated the anti...

journal_title：Cartilage

authors： Grzanna MW,Secor EJ,Fortuno LV,Au AY,Frondoza CG

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Bone morphogenetic protein 2 (BMP2) plays important roles in cartilage growth and development. Paradoxically, elevated levels of BMP2 leads to hypertrophic differentiation and osteoarthritis of cartilage. We examined the in vivo loss of BMP2 in cells expressing aggrecan of the mandibular condyle and knee. DE...

journal_title：Cartilage

authors： O'Brien MH,Dutra EH,Mehta S,Chen PJ,Yadav S

更新日期：2020-12-14 00:00:00

abstract：BACKGROUND:Osteochondral allograft (OCA) transplantation is an increasingly common treatment for patients with symptomatic focal chondral lesions of the knee. There has been increasing interest in determining predictive factors to maximize patient benefit after this operation. The aim of the present study is to evaluat...

journal_title：Cartilage

authors： Owusu-Akyaw KA,Bido J,Warner T,Rodeo SA,Williams RJ

更新日期：2020-09-17 00:00:00

abstract：:Articular cartilage injuries of the knee and ankle are common, and a number of different methods have been developed in an attempt to improve their repair. Clinically, there are 2 distinct aims of cartilage repair: 1) restoration of joint function and 2) prevention or at least delay of the onset of osteoarthritis. The...

journal_title：Cartilage

authors： McIlwraith CW,Fortier LA,Frisbie DD,Nixon AJ

更新日期：2011-10-01 00:00:00

abstract：OBJECTIVE:To compare the histological and immunohistochemical characteristics of matrix-assisted chondrocyte implantation (MACI) grafts between patients with revision surgery and patients with total joint arthroplasty. METHODS:Biopsies of MACI grafts from patients with revision and total joint arthroplasty. The graft ...

journal_title：Cartilage

authors： Beck A,Wood D,Vertullo CJ,Ebert J,Janes G,Sullivan M,Zheng MH

更新日期：2019-12-02 00:00:00

abstract：OBJECTIVE:Our aim is to explore the candidate pathogenesis genes and pathways of developmental dysplasia of hip (DDH). DESIGN:Proliferating primary chondrocytes from hip cartilage were used for total RNA extraction including 5 DDH patients and 5 neck of femur fracture (NOF) subjects. Genome-wide mRNA and microRNA (miR...

journal_title：Cartilage

authors： Cheng B,Jia Y,Wen Y,Hou W,Xu K,Liang C,Cheng S,Liu L,Chu X,Ye J,Yao Y,Zhang F,Xu P

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Accurate arthroscopic evaluation of cartilage lesions could significantly improve the outcome of repair surgery. In this study, we investigated for the first time the potential of intra-articular ultrasound as an arthroscopic tool for grading cartilage defects in the human shoulder joint in vivo and compared ...

journal_title：Cartilage

authors： Puhakka J,Afara IO,Paatela T,Sormaala MJ,Timonen MA,Virén T,Jurvelin JS,Töyräs J,Kiviranta I

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Telomere length and telomerase activity are important indicators of cellular senescence and replicative ability. Loss of telomerase is associated with ageing and the development of osteoarthritis. Implantation of telomerase-positive cells, chondrocytes, or stem cells expressing a normal chondrocyte phenotype ...

journal_title：Cartilage

authors： Wilson B,Novakofski KD,Donocoff RS,Liang YX,Fortier LA

更新日期：2014-10-01 00:00:00

abstract：:Because of poor regenerative capabilities of cartilage, reconstruction of similar rigidity and flexibility is difficult, challenging, and restricted. The aim of the present investigation was to develop cost-effective acellular xenogeneic biomaterial as cartilage substitution. Two novel biometrics have been developed u...

journal_title：Cartilage

authors： Das P,Rajesh K,Lalzawmliana V,Bavya Devi K,Basak P,Lahiri D,Kundu B,Roy M,Nandi SK

更新日期：2019-06-19 00:00:00

abstract：:Objective To evaluate the outcome of patients who have undergone simultaneous osteotomy and osteochondral allograft (OCA) transplantation. Our hypothesis is that use of high tibial osteotomy and fresh OCA in a combined procedure is safe and effective without increasing morbidity in comparison to OCA alone. Design A ca...

journal_title：Cartilage

authors： Hsu AC,Tirico LEP,Lin AG,Pulido PA,Bugbee WD

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:Recent studies have implicated the cyclin dependent kinase inhibitor, p21, in enhanced tissue regeneration observed in MRL/MpJ "super-healer" mice. Specifically, p21 is downregulated in MRL cells and similar ear hole closure to MRL mice has been observed in p21-/- mice. However, the direct implications of p21...

journal_title：Cartilage

authors： Jablonski CL,Besler BA,Ali J,Krawetz RJ

更新日期：2019-09-26 00:00:00

abstract：OBJECTIVE:The objective of this study was to fully characterize the mechanics of an in vivo impactor and correlate the mechanics with superficial cracking of articular surfaces. DESIGN:A spring-loaded impactor was used to apply energy-controlled impacts to the articular surfaces of neonatal bovine cartilage. The simul...

journal_title：Cartilage

authors： Bonnevie ED,Delco ML,Fortier LA,Alexander PG,Tuan RS,Bonassar LJ

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Describe the local morphological response of the articular-epiphyseal cartilage complex to surgical stab incision in the distal femur of foals, with emphasis on the relationship between growth cartilage injury, enchondral ossification, and repair. DESIGN:Nine foals were induced into general anesthesia at the...

journal_title：Cartilage

authors： Olstad K,Hendrickson EH,Ekman S,Carlson CS,Dolvik NI

更新日期：2013-07-01 00:00:00