Abstract:
:Purpose. To determine the 5-year success rate of the "all-inside" technique of arthroscopic meniscus suture and collagen membrane wrapping along with bone marrow blood injection, to evaluate the progression of degenerative changes and the impact of simultaneous anteriro cruciate ligament (ACL) reconstruction. Methods. Fifty-four consecutive patients with complex meniscal tears were treated with the previously described technique. The subjective scores (International Knee Documentation Committee 2000, Lysholm, EQ-5D-5L) and Barret clinical criteria of meniscal healing were recorded. Magnetic resonance images (MRIs) were assessed at 2 and 5 years postoperatively, using the Whole-Organ Magnetic Resonance Imaging Score (WORMS) criteria. Kaplan-Meier survival analyses were performed in order to assess the survivorship after the index procedure. Thirty-nine patients were divided into 2 groups: group A-isolated meniscus repair and group B-meniscus repair with concurrent ACL reconstruction. Results. Fifty-four patients were treated and 44 were available for analysis. There was a statistically significant improvement in subjective scores and clinical assessment between the preoperative, 2-year follow-up, and 5-year follow-up time points. EQ-5D-5L utility value was 0.9 ± 1 at final follow-up. The WORMS osteoarthritis severity grade had increased from 6.9 ± 5.0 points at the 2-year follow-up to 11.1 ± 9.6 points at the 5-year follow-up (P < 0.001). There was a significant difference between the groups after 60 months. The overall survival rate at final follow-up was 88%. Conclusions. The treatment option evaluated in this study has shown very good mid-term clinical and MRI-based outcomes as well as a favorable survival rate. Simultaneous ACL reconstruction is likely a factor for osteoarthritis progression.
journal_name
Cartilagejournal_title
Cartilageauthors
Ciemniewska-Gorzela K,Bąkowski P,Naczk J,Jakob R,Piontek Tdoi
10.1177/1947603520924762subject
Has Abstractpub_date
2020-06-01 00:00:00pages
1947603520924762eissn
1947-6035issn
1947-6043pub_type
杂志文章相关文献
Cartilage文献大全abstract:BACKGROUND:Full-depth cartilage lesions do not heal and the long-term clinical outcome is uncertain. In the symptomatic middle-aged (35-60 years) patient, treatment with metal implants has been proposed. However, the cartilage health surrounding these implants has not been thoroughly studied. Our objective was to evalu...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603517720260
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:Describe the local morphological response of the articular-epiphyseal cartilage complex to surgical stab incision in the distal femur of foals, with emphasis on the relationship between growth cartilage injury, enchondral ossification, and repair. DESIGN:Nine foals were induced into general anesthesia at the...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603513480024
更新日期:2013-07-01 00:00:00
abstract::Postoperative rehabilitation programs following articular cartilage repair procedures will vary greatly among patients and need to be individualized based on the nature of the lesion, the unique characteristics of the patient, and the type and detail of each surgical procedure. These programs are based on knowledge of...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603510366029
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:Hyaluronic acid-transglutaminase (HA-TG) is an enzymatically crosslinkable adhesive hydrogel with chondrogenic properties demonstrated in vitro and in an ectopic mouse model. In this study, we investigated the feasibility of using HA-TG in a collagen scaffold to treat chondral lesions in an ovine model, to ev...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603521989417
更新日期:2021-01-29 00:00:00
abstract:OBJECTIVE:TNIIIA2 is a peptide of the extracellular matrix glycoprotein tenascin-C. We evaluated whether intra-articular injection of TNIIIA2 could prevent articular cartilage degeneration without inducing synovitis in an osteoarthritis mice model. DESIGN:Ten micrograms per milliliter of TNIIIA2 were injected into the...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520912300
更新日期:2020-03-23 00:00:00
abstract:OBJECTIVE:Treatments for steroid-induced osteonecrosis of the knee remains challenging, and there has not been sufficient evidence to support joint preservation surgery. This study evaluated long-term outcomes of osteochondral autologous transplantation (OAT) for steroid-induced osteonecrosis of the knee. DESIGN:This ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520954489
更新日期:2020-09-10 00:00:00
abstract:OBJECTIVE:Bone morphogenetic protein 2 (BMP2) plays important roles in cartilage growth and development. Paradoxically, elevated levels of BMP2 leads to hypertrophic differentiation and osteoarthritis of cartilage. We examined the in vivo loss of BMP2 in cells expressing aggrecan of the mandibular condyle and knee. DE...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520980158
更新日期:2020-12-14 00:00:00
abstract:BACKGROUND:Osteochondral allograft (OCA) transplantation is an increasingly common treatment for patients with symptomatic focal chondral lesions of the knee. There has been increasing interest in determining predictive factors to maximize patient benefit after this operation. The aim of the present study is to evaluat...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520958132
更新日期:2020-09-17 00:00:00
abstract::Nucleofection of chondrocytes has been shown to be an adequate method of transfection. Using Amaxa's nucleofection system, transfection efficiencies up to 89% were achievable for vector (pmaxGFP) and 98% for siRNA (siGLO) into passaged chondrocytes. However, such methods rely on costly commercial kits with proprietary...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603515609399
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of intra-articular injection of autologous micronized adipose tissue (MAT) with ankle arthroscopic debridement in patients with advanced-stage posttraumatic osteoarthritis (PTOA) of ankle. DESIGN:A retrospective cohort study investigating patients treated with arthroscopic debridement ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520946364
更新日期:2020-08-06 00:00:00
abstract::Various systematic reviews have recently shown that intra-articular platelet-rich plasma (IA-PRP) can lead to symptomatic relief of knee osteoarthritis for up to 12 months. There exist limited data on its use in small joints, such as the trapeziometacarpal joint (TMJ) or carpometacarpal joint (CMCJ) of the thumb. A pr...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603518805230
更新日期:2021-01-01 00:00:00
abstract:BACKGROUND:Focal cartilage lesions in the knee joint have limited capacity to heal. Current animal experiments show that incisions of the deep zone of a cartilage allograft allow acceptable integration for the graft. QUESTIONS/PURPOSES:We performed this clinical study to determine (1) if the multiply incised cartilage...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603514563596
更新日期:2015-04-01 00:00:00
abstract:OBJECTIVE:Ankle arthropathy is a frequent and invalidating manifestation of hemophilia. Arthrodesis is the gold standard surgical procedure in end-stage disease, with many drawbacks in young patients. Recent literature has shown increase interest in regenerative procedures in hemophilic arthropathy, which may be desira...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603515574286
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:Recent studies have implicated the cyclin dependent kinase inhibitor, p21, in enhanced tissue regeneration observed in MRL/MpJ "super-healer" mice. Specifically, p21 is downregulated in MRL cells and similar ear hole closure to MRL mice has been observed in p21-/- mice. However, the direct implications of p21...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603519876348
更新日期:2019-09-26 00:00:00
abstract::Objective To evaluate the outcome of patients who have undergone simultaneous osteotomy and osteochondral allograft (OCA) transplantation. Our hypothesis is that use of high tibial osteotomy and fresh OCA in a combined procedure is safe and effective without increasing morbidity in comparison to OCA alone. Design A ca...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603517710307
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:To determine the optimal environmental conditions for chondrogenic differentiation of human adipose tissue-derived mesenchymal stromal/stem cells (AMSCs). In this investigation we specifically investigate the role of oxygen tension and 3-dimensional (3D) culture systems. DESIGN:Both AMSCs and primary human c...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603516659344
更新日期:2017-07-01 00:00:00
abstract:OBJECTIVE:Telomere length and telomerase activity are important indicators of cellular senescence and replicative ability. Loss of telomerase is associated with ageing and the development of osteoarthritis. Implantation of telomerase-positive cells, chondrocytes, or stem cells expressing a normal chondrocyte phenotype ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603514537518
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To assess the continued effectiveness and safety of Gel-200 following observation and open-label retreatment in an extension protocol following a randomized, double-blind, phosphate buffered saline (PBS)-controlled trial (initial treatment trial). DESIGN:Patients who completed initial blinded treatment were ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603512451024
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to fully characterize the mechanics of an in vivo impactor and correlate the mechanics with superficial cracking of articular surfaces. DESIGN:A spring-loaded impactor was used to apply energy-controlled impacts to the articular surfaces of neonatal bovine cartilage. The simul...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603515595071
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:We sought to determine whether rates of postoperative arthrofibrosis following tibial tuberosity osteotomy (TTO) with complete mobilization of the fragment (TTO-HD) are comparable to TTOs where the hinge remained intact (TTO-HI). DESIGN:Patients who underwent TTO with concomitant cartilage repair procedure b...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520968209
更新日期:2020-10-23 00:00:00
abstract:OBJECTIVE:Excessive use of glucocorticoids (GCs) may cause adverse effects on the skeletal system in children. However, only a few studies have reported the effects of GCs on the epiphyseal cartilage. This study aimed to uncover the subsequent epiphyseal cartilage changes of immature femoral heads after excessive GC tr...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520978574
更新日期:2020-12-03 00:00:00
abstract:OBJECTIVE:The identification of early-stage osteoarthritis (OA) is crucial for the deceleration of its progression; however, no reliable biomarker is available for this purpose. The current study aimed to determine the role of serum calprotectin in the detection of early-stage knee OA. DESIGN:In a case-control study, ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520961161
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Accurate arthroscopic evaluation of cartilage lesions could significantly improve the outcome of repair surgery. In this study, we investigated for the first time the potential of intra-articular ultrasound as an arthroscopic tool for grading cartilage defects in the human shoulder joint in vivo and compared ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603515617280
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:There are limited data on bone dimension and cartilage thickness of the distal humeral articular surface. This study aimed to evaluate sex- and age-related bone dimension and cartilage thickness differences and assess the effect of cartilage thickness on distal humeral shape. DESIGN:Elbow magnetic resonance ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520903780
更新日期:2020-02-10 00:00:00
abstract::Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication qual...
journal_title:Cartilage
pub_type: 杂志文章,评审
doi:10.1177/1947603517700956
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:Articular cartilage is incapable of effective repair following injury or during osteoarthritis. While there have been developments in cartilage repair technologies, there is a need to advance biologically relevant models for preclinical testing of biomaterial and regenerative therapies. This study describes c...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520934534
更新日期:2020-06-21 00:00:00
abstract:OBJECTIVE:Our aim is to explore the candidate pathogenesis genes and pathways of developmental dysplasia of hip (DDH). DESIGN:Proliferating primary chondrocytes from hip cartilage were used for total RNA extraction including 5 DDH patients and 5 neck of femur fracture (NOF) subjects. Genome-wide mRNA and microRNA (miR...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603521990859
更新日期:2021-02-01 00:00:00
abstract:OBJECTIVE:We have recently shown that mesenchymal stem cells (MSCs) embedded in a hyaluronic acid (HA) hydrogel and exposed to chondrogenic factors (transforming growth factor-β3 [TGF-β3]) produce a cartilage-like tissue in vitro. The current objective was to determine if these same factors could be combined immediatel...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603515623030
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Our aim was to compare T2 with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the hip and assess the reproducibility and effect of joint unloading on T2 mapping. DESIGN:Ten individuals at high risk of developing hip osteoarthritis (SibKids) underwent contemporaneous T2 mappi...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603519841670
更新日期:2019-04-11 00:00:00
abstract:OBJECTIVE:Osteoarthritis (OA) is an incurable joint disease characterized by pronounced pain. MicroRNAs constitute epigenetic mechanisms that may affect OA progression by contributing to changes in chondrocyte phenotype. This study investigates for the first time whether there is a link between miRNA-1 (miR-1) and OA p...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520973255
更新日期:2020-11-20 00:00:00