Abstract:
BACKGROUND:Focal cartilage lesions in the knee joint have limited capacity to heal. Current animal experiments show that incisions of the deep zone of a cartilage allograft allow acceptable integration for the graft. QUESTIONS/PURPOSES:We performed this clinical study to determine (1) if the multiply incised cartilage graft is surgically applicable for focal cartilage lesions, (2) whether this allograft has a potential to integrate to the repair site, and (3) if patients show clinical improvement. PATIENTS AND METHODS:Seven patients with 8 chondral lesions were enrolled into the study. Symptomatic lesions between 2 and 8 cm(2) were accepted. Additional injuries were allowed but were addressed simultaneously. Grafts were tailored to match and the deep zone of the cartilage was multiply incised to augment the basal integration before securing in place. Rigorous postoperative physiotherapy followed. At 12 and 24 months the patients' satisfaction were measured and serial magnetic resonance imaging (MRI) was performed in 6 patients. RESULTS:Following the implantations no adverse reaction occurred. MRI evaluation postoperatively showed the graft in place in 5 out of 6 patients. In 1 patient, MRI suggested partial delamination at 1 year and graft degeneration at 2 years. Short Form-36 health survey and the Lysholm knee score demonstrated a significant improvement in the first year; however, by 2 years there was a noticeable drop in the scores. Conclusions. Multiply incised pure chondral allograft used for cartilage repair appears to be a relatively safe method. Further studies are necessary to assess its potential in cartilage repair before its clinical use.
journal_name
Cartilagejournal_title
Cartilageauthors
Bardos T,Vancsodi J,Farkas B,Fazekas A,Nagy SA,Bogner P,Vermes C,Than Pdoi
10.1177/1947603514563596subject
Has Abstractpub_date
2015-04-01 00:00:00pages
73-81issue
2eissn
1947-6035issn
1947-6043pii
10.1177_1947603514563596journal_volume
6pub_type
杂志文章相关文献
Cartilage文献大全abstract:PURPOSE:Patients with isolated medial compartment osteoarthritis and varus deformity may undergo high tibial osteotomy (HTO) to reduce the contact pressure in the medial compartment. The purpose of this investigation is (1) examine the timeline of return to work (RTW) following HTO and (2) evaluate RTW stratified by oc...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603519852417
更新日期:2019-06-10 00:00:00
abstract:OBJECTIVE:Ankle arthropathy is a frequent and invalidating manifestation of hemophilia. Arthrodesis is the gold standard surgical procedure in end-stage disease, with many drawbacks in young patients. Recent literature has shown increase interest in regenerative procedures in hemophilic arthropathy, which may be desira...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603515574286
更新日期:2015-07-01 00:00:00
abstract::Objective To measure and identify the determinants of the outcomes after hip/knee arthroplasty (HA/KA) in patients with osteoarthritis during the first postsurgical year. Design In this prospective observational study, we evaluated the preoperative and postoperative (3, 6, and 12 months) outcomes of 626 patients who u...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603517743000
更新日期:2018-04-01 00:00:00
abstract::INTRODUCTION: The zone of calcified cartilage (ZCC) anchors articular cartilage (AC) to subchondral bone through a layer of intermediate stiffness. The regulation and functional consequences of cartilage calcification may vary with depth from the articular surface. The hypothesis of this study was that the in vitro ca...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603510369552
更新日期:2010-10-01 00:00:00
abstract::Objective This study is a literature review from 2010 to 2014 concerning the quality of evidence in clinical trials about microfracture in attempt to repair articular cartilage. We have decided to focus on microfracturing, since this seems to be the best documented technique. Interest in evaluation of publication qual...
journal_title:Cartilage
pub_type: 杂志文章,评审
doi:10.1177/1947603517700956
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:The low regenerative potential of cartilage contributed to the development of different cell therapies aimed to improve the clinical outcome in young patients with Osteochondral Lesions of the Talus (OLT). This study is designed to assess the regenerative potential of autologous matrix-induced Bone Marrow Asp...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603516642573
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVE:We sought to determine whether rates of postoperative arthrofibrosis following tibial tuberosity osteotomy (TTO) with complete mobilization of the fragment (TTO-HD) are comparable to TTOs where the hinge remained intact (TTO-HI). DESIGN:Patients who underwent TTO with concomitant cartilage repair procedure b...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520968209
更新日期:2020-10-23 00:00:00
abstract:OBJECTIVE:Treatments for steroid-induced osteonecrosis of the knee remains challenging, and there has not been sufficient evidence to support joint preservation surgery. This study evaluated long-term outcomes of osteochondral autologous transplantation (OAT) for steroid-induced osteonecrosis of the knee. DESIGN:This ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520954489
更新日期:2020-09-10 00:00:00
abstract:OBJECTIVE:Osteoarthritis (OA) is an incurable joint disease characterized by pronounced pain. MicroRNAs constitute epigenetic mechanisms that may affect OA progression by contributing to changes in chondrocyte phenotype. This study investigates for the first time whether there is a link between miRNA-1 (miR-1) and OA p...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520973255
更新日期:2020-11-20 00:00:00
abstract:OBJECTIVE:Bone morphogenetic protein 2 (BMP2) plays important roles in cartilage growth and development. Paradoxically, elevated levels of BMP2 leads to hypertrophic differentiation and osteoarthritis of cartilage. We examined the in vivo loss of BMP2 in cells expressing aggrecan of the mandibular condyle and knee. DE...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520980158
更新日期:2020-12-14 00:00:00
abstract::Postoperative rehabilitation programs following articular cartilage repair procedures will vary greatly among patients and need to be individualized based on the nature of the lesion, the unique characteristics of the patient, and the type and detail of each surgical procedure. These programs are based on knowledge of...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603510366029
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to fully characterize the mechanics of an in vivo impactor and correlate the mechanics with superficial cracking of articular surfaces. DESIGN:A spring-loaded impactor was used to apply energy-controlled impacts to the articular surfaces of neonatal bovine cartilage. The simul...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603515595071
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:The identification of early-stage osteoarthritis (OA) is crucial for the deceleration of its progression; however, no reliable biomarker is available for this purpose. The current study aimed to determine the role of serum calprotectin in the detection of early-stage knee OA. DESIGN:In a case-control study, ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520961161
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:We have developed an ultrapurified low endotoxin alginate (UPLE alginate), which can drastically reduce endotoxin levels. Our purposes were to examine the effects of UPLE alginate administration on osteoarthritis (OA) progression and to determine the adequate molecular weight of the UPLE alginate for therapeu...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603511418959
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:To assess the safety and efficacy of accelerated compared with traditional postoperative weightbearing (WB) rehabilitation following matrix-induced autologous chondrocyte implantation (MACI) of the knee, using MRI. METHODS:A randomized controlled study design was used to assess MRI-based outcomes of MACI gra...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603510380902
更新日期:2011-01-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to compare results of osteochondral fractures (OCF) after first-time lateral patella dislocation, when either refixation or debridement was performed in a mid- to long-term follow-up and to analyze redislocation and reintervention rates. DESIGN:Fifty-three consecutive patients w...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603519886637
更新日期:2019-11-13 00:00:00
abstract:OBJECTIVE:To compare the histological and immunohistochemical characteristics of matrix-assisted chondrocyte implantation (MACI) grafts between patients with revision surgery and patients with total joint arthroplasty. METHODS:Biopsies of MACI grafts from patients with revision and total joint arthroplasty. The graft ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603519890754
更新日期:2019-12-02 00:00:00
abstract::Purpose. To determine the 5-year success rate of the "all-inside" technique of arthroscopic meniscus suture and collagen membrane wrapping along with bone marrow blood injection, to evaluate the progression of degenerative changes and the impact of simultaneous anteriro cruciate ligament (ACL) reconstruction. Methods....
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520924762
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:Traumatic impacts on the articular joint surface in vitro are known to lead to degeneration of the cartilage. The main objective of this study was to develop a spring-loaded impact device that can be used to deliver traumatic impacts of consistent magnitude and rate and to find whether impacts cause catabolic...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603512455195
更新日期:2013-01-01 00:00:00
abstract::Objective The aim of this study was to evaluate the chondroprotective effect of chemically decellularized meniscal allografts transplanted into the knee joints of adult merino sheep. Methods Lateral sheep meniscal allografts were chemically processed by a multistep method to yield acellular, sterile grafts. The grafts...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603516646161
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Recent studies have implicated the cyclin dependent kinase inhibitor, p21, in enhanced tissue regeneration observed in MRL/MpJ "super-healer" mice. Specifically, p21 is downregulated in MRL cells and similar ear hole closure to MRL mice has been observed in p21-/- mice. However, the direct implications of p21...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603519876348
更新日期:2019-09-26 00:00:00
abstract:OBJECTIVE:The purpose of this systematic review and meta-analysis was to evaluate the effect of electromagnetic field treatment on the symptoms of knee osteoarthritis (OA). In addition, the influence of the type of control group and other covariates have been investigated to identify the sources of heterogeneity in the...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520931168
更新日期:2020-06-08 00:00:00
abstract::This study addressed difficulties in evaluating osteoarthritis (OA) progression in species with thin cartilage. Feasibility of using short, nonequilibrium contrast-enhanced micro-computed tomography (CE-μCT) to evaluate the physical and biochemical properties of cartilage was investigated. A preliminary in vitro study...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603520924748
更新日期:2020-05-26 00:00:00
abstract::Introduction Autologous osteochondral transplantation (AOT) is a treatment for osteochondral lesions with known concerns, including histological degradation of the graft and poor cartilage integration. Platelet-rich plasma (PRP) and hyaluronic acid (HA) have been described has having the potential to improve results. ...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603517690022
更新日期:2018-07-01 00:00:00
abstract:OBJECTIVE:Both selenium (Se) deficiency and mycotoxin T2 lead to epiphyseal plate lesions, similar to Kashin-Beck disease (KBD). However, regulation of selenoproteins synthesis mediated by SECISBP2, in response to these 2 environmental factors, remained unclear. The present study proposed to explore the mechanism behin...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603518809406
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:Hyaluronic acid-transglutaminase (HA-TG) is an enzymatically crosslinkable adhesive hydrogel with chondrogenic properties demonstrated in vitro and in an ectopic mouse model. In this study, we investigated the feasibility of using HA-TG in a collagen scaffold to treat chondral lesions in an ovine model, to ev...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603521989417
更新日期:2021-01-29 00:00:00
abstract:INTRODUCTION:Delamination of the chondral surface of an osteochondral allograft (OCA) from the underlying cancellous bone has been described as a mode of failure after implantation in the knee. Our hypothesis was that increased storage time of the OCA is associated with increased risk of graft delamination after implan...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603518777576
更新日期:2019-10-01 00:00:00
abstract::The concept of using gene transfer strategies for cartilage repair originates from the idea of transferring genes encoding therapeutic factors into the repair tissue, resulting in a temporarily and spatially defined delivery of therapeutic molecules to sites of cartilage damage. This review focuses on the potential be...
journal_title:Cartilage
pub_type: 杂志文章,评审
doi:10.1177/1947603510392914
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:Our aim was to compare T2 with delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) in the hip and assess the reproducibility and effect of joint unloading on T2 mapping. DESIGN:Ten individuals at high risk of developing hip osteoarthritis (SibKids) underwent contemporaneous T2 mappi...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603519841670
更新日期:2019-04-11 00:00:00
abstract:OBJECTIVE:To determine the optimal environmental conditions for chondrogenic differentiation of human adipose tissue-derived mesenchymal stromal/stem cells (AMSCs). In this investigation we specifically investigate the role of oxygen tension and 3-dimensional (3D) culture systems. DESIGN:Both AMSCs and primary human c...
journal_title:Cartilage
pub_type: 杂志文章
doi:10.1177/1947603516659344
更新日期:2017-07-01 00:00:00