The role of a defunctioning stoma for colonic and perianal Crohn's disease in the biological era.

Abstract:

OBJECTIVE:A defunctioning stoma is a therapeutic option for colonic or perianal Crohn's disease. In the pre-biologic era the response rate to defunctioning in our unit was high (86%), but intestinal continuity was only restored in 11-20%. Few data exist on the outcome of defunctioning since the widespread introduction of biologicals. MATERIAL AND METHODS:All patients undergoing a defunctioning stoma for colonic/perianal Crohn's disease since 2003-2011 were identified from a prospective database. Indications for surgery, medical therapy, response to defunctioning and long-term clinical outcome were recorded. Successful restoration of continuity was defined as no stoma at last follow up. RESULTS:Seventy-six patients were defunctioned (57 with biologicals) and at last follow up, 20 (27%) had continuity restored. Early clinical response rate (<3 months) was 15/76 (20%) and overall response 31/76 (41%). Complex anal fistulae/stenosis were associated with a very low chance of restoring continuity (10% and 0%, respectively), while colitis was associated with a higher chance of restoring continuity (48%). Endoscopic or histological improvement in colitis after defunctioning was associated with a higher rate of restoring continuity (10/16, 63%) compared to no such improvement (4/15, 27%, p = 0.05). Those failing biologics had similar chance of restoration as those not receiving biologics, 15/57 (26%) and 5/19 (26%), respectively. CONCLUSION:Overall response to colonic defunctioning was 41%. Successful restoration of continuity occurred in 27%, but 48% in the absence of perianal disease. Response is appreciably less in the pre-biologic era, so patient and physician expectations need to be managed appropriately.

journal_name

Scand J Gastroenterol

authors

Martí-Gallostra M,Myrelid P,Mortensen N,Keshav S,Travis SP,George B

doi

10.1080/00365521.2016.1205127

subject

Has Abstract

pub_date

2017-03-01 00:00:00

pages

251-256

issue

3

eissn

0036-5521

issn

1502-7708

journal_volume

52

pub_type

杂志文章
  • X-ray examination and/or endoscopy in the diagnosis of gastroduodenal ulcer and cancer.

    abstract::The diagnostic value of barium meal and endoscopy for the diagnosis of gastric ulcer and cancer was studied in 173 unselected patients with upper abdominal dyspepsia. The predictive value of both positive and negative results was higher for endoscopy than for barium meal. This was also found in earlier studies compris...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.3109/00365528009181429

    authors: Kiil J,Andersen D

    更新日期:1980-01-01 00:00:00

  • Relationship between local and total bone mineral content after gastric surgery.

    abstract::We compared the total body bone mineral mass (TBBM), assessed by the dual-photon technique, with the local bone mineral mass (BMC), measured by single-photon absorptiometry, in 27 ulcus patients treated by either gastric resection or parietal cell vagotomy. Except for raised concentrations of serum alkaline phosphatas...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Nilas L,Gotfredsen A,Christiansen C

    更新日期:1984-07-01 00:00:00

  • Solitary bile duct hamartoma of the liver.

    abstract::Bile duct hamartomas, also known as von Meyenburg complexes, are benign liver malformations which usually present as multiple small nodules scattered in both lobes of the liver. We report a unique case of bile duct hamartoma. An asymptomatic 30-year-old man who had a solitary cystic lesion underwent partial hepatectom...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520510023387

    authors: Kobayashi A,Takahashi S,Hasebe T,Konishi M,Nakagohri T,Gotohda N,Kinoshita T

    更新日期:2005-11-01 00:00:00

  • Fatty acid patterns of serum triglycerides and subcutaneous adipose tissues after ileal bypass in obesity.

    abstract::A group of 9 obese subjects with a mean body weight of 140 kg was treated for their obesity with a jejuno-ileal intestinal shunt. During the first post-operative year their mean body weight decreased to 100 kg. Fatty acid patterns of triglycerides inserum and subcutaneous adipose tissue were studied at intervals durin...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Kallner A,Hallberg D,Backman L

    更新日期:1975-01-01 00:00:00

  • Gastric parietal, chief, and G-cell densities in chronic renal failure.

    abstract::We calculated morphometrically the amount of antral gastrin-producing (G) cells and body parietal and chief cells in gastric biopsy specimens from 30 undialysed patients with chronic renal failure (CRF) and from sex- and age-matched controls. The CRF patients had raised fasting serum gastrin levels, whereas these were...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529108998586

    authors: Paronen I,Ala-Kaila K,Rantala I,Kainulainen H,Karvonen AL

    更新日期:1991-07-01 00:00:00

  • Pouch emptying of solid foods after gastroplasty for morbid obesity.

    abstract::To obtain information on possible determinants of weight loss after horizontal gastroplasty, pouch emptying was prospectively investigated in 27 morbidly obese patients. A scintigraphic method was used. Examinations were carried out every 6 months until 2 years after surgery. Pouch emptying was described by means of d...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509089272

    authors: Andersen T,Pedersen BH,Henriksen JH,Uhrenholdt A

    更新日期:1985-12-01 00:00:00

  • Outpatient management of acute uncomplicated diverticulitis results in health-care cost savings.

    abstract:PURPOSE:Outpatient management without antibiotics has been shown to be safe for selected patients diagnosed with acute uncomplicated diverticulitis (AUD). The aim of this study was to evaluate the impact on admissions, complication rates and health-care costs of the policy of outpatient treatment without using antibiot...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2018.1448887

    authors: Isacson D,Andreasson K,Nikberg M,Smedh K,Chabok A

    更新日期:2018-04-01 00:00:00

  • Fructo-oligosaccharides and fibre in enteral nutrition has a beneficial influence on microbiota and gastrointestinal quality of life.

    abstract:OBJECTIVE:Intestinal microbiota is important in health and disease. The aim of this study was to evaluate the effect of fructo-oligosaccharides (FOS) and fibre-enriched tube feeding on quality of life and intestinal microbiota (faecal Bifidobacteria). MATERIAL AND METHODS:Nineteen out of 59 home-living, tube-feeding-d...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/00365520902839675

    authors: Wierdsma NJ,van Bodegraven AA,Uitdehaag BM,Arjaans W,Savelkoul PH,Kruizenga HM,van Bokhorst-de van der Schueren MA

    更新日期:2009-01-01 00:00:00

  • Epidemiology of pancreatic cancer in Norway: trends in incidence, basis of diagnosis and survival 1965-2007.

    abstract:OBJECTIVE:Pancreatic cancer is the second most frequent gastrointestinal cancer in the Western world. Few reports on concomitant trends in pancreatic cancer incidence, diagnosis, mortality and survival exist at the national level. This study provides a baseline overview of the temporal patterns in these four indicators...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365520903358899

    authors: Søreide K,Aagnes B,Møller B,Westgaard A,Bray F

    更新日期:2010-01-01 00:00:00

  • Immune-mediated liver damage in chronic hepatitis C.

    abstract::Although the exact mechanisms inducing the hepatic injury in chronic hepatitis C infection are still not completely elucidated, the evidence of a direct cytopathic viral effect is sparse. The overall majority of experimental studies and clinical observations among patients instead favour immune-mediated hepatocellular...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,评审

    doi:10.3109/00365529509096301

    authors: Wejstål R

    更新日期:1995-07-01 00:00:00

  • The association between non-ulcer dyspepsia and other gastrointestinal disorders.

    abstract::Non-ulcer dyspepsia (NUD) is defined as dyspepsia in which investigation shows no evidence of focal gastroduodenal disease or oesophagitis. The aim of the present study was to determine the proportion of NUD patients with other identifiable diseases. We interviewed 327 consecutive patients who had at least 1 month of ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528509088842

    authors: Talley NJ,Piper DW

    更新日期:1985-09-01 00:00:00

  • Effects of posture on the physiology of gastric emptying: a magnetic resonance imaging study.

    abstract:OBJECTIVE:Gastric contents empty from the stomach despite frequent changes in body position. The mechanism that maintains gastric emptying independent of position is poorly understood. The aim of this study was to determine the effects of body position on gastric emptying and motor function. MATERIAL AND METHODS:Twelv...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520600610451

    authors: Steingoetter A,Fox M,Treier R,Weishaupt D,Marincek B,Boesiger P,Fried M,Schwizer W

    更新日期:2006-10-01 00:00:00

  • Cephalic phase of pancreatic-polypeptide secretion studied by sham feeding in man.

    abstract::The effect of sham feeding on pancreatic-polypeptide (PP) secretion was studied in 26 duodenal ulcer (DU) patients and in 8 healthy subjects. Modified sham feeding (MSF) by the 'chew and spit' technique induced a rapid increase in plasma concentrations of PP both in DU patients, 56 (2-138) pmol/l, and in the healthy s...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527909179889

    authors: Schwartz TW,Stenquist B,Olbe L

    更新日期:1979-01-01 00:00:00

  • Safety and efficacy of precut needle-knife fistulotomy.

    abstract::OBJECTIVE. Although precut is considered an useful alternative when standard methods of biliary access have failed, there is some controversy about it's safety. The study aim was to evaluate the effectiveness of needle-knife fistulotomy (NKF) after a difficult biliary cannulation and whether common bile duct (CBD) dia...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2014.898085

    authors: Lopes L,Dinis-Ribeiro M,Rolanda C

    更新日期:2014-06-01 00:00:00

  • Hydrogen peroxide stimulates phospholipase A2-mediated arachidonic acid release in cultured intestinal epithelial cells (INT 407).

    abstract::The mechanisms by which hydrogen peroxide and, for comparison, 4-beta-phorbol-12-myristate-13-acetate (PMA) stimulate release of radiolabeled arachidonic acid (14C-AA) in cultured intestinal epithelial cells (INT 407) were investigated. Both hydrogen peroxide and PMA caused a rapid (3 min) and dose-related intracellul...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529109025037

    authors: Gustafson C,Lindahl M,Tagesson C

    更新日期:1991-03-01 00:00:00

  • Endoscopic manometry of the sphincter of Oddi and the pancreatic and biliary ducts in patients with chronic pancreatitis.

    abstract::Sphincter of Oddi activity and the common bile duct (CBD) and pancreatic duct (PD) pressures were measured by means of endoscopic manometry in 15 patients (11 men and 4 women aged 18-77 (median, 40) years) with various degrees of chronic pancreatitis. Eleven of the 15 patients studied had an abnormal manometric patter...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529409090461

    authors: Vestergaard H,Kruse A,Rokkjaer M,Frøbert O,Thommesen P,Funch-Jensen P

    更新日期:1994-02-01 00:00:00

  • Evaluation of preoperative prognostic factors in patients with resectable pancreatic ductal adenocarcinoma.

    abstract::Objective: Upfront surgery is the standard treatment for resectable pancreatic ductal adenocarcinomas (R-PDACs); however, these tumors often recur. We investigated the factors governing recurrence and prognosis in patients with R-PDAC. Methods: We analyzed 359 patients who underwent upfront surgery for R-PDAC between ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365521.2019.1624816

    authors: Izumo W,Higuchi R,Furukawa T,Yazawa T,Uemura S,Shiihara M,Yamamoto M

    更新日期:2019-06-01 00:00:00

  • The incidence and result of radiological examination of the stomach using a barium meal.

    abstract::In 1964 1.6-1.8% of the population in Copenhagen County - with a population of approx. 500,000 - were referred for a radiological examination of the stomach. The incidence, the same in both sexes, increased with increasing age, being 1% at the age of 20 years and 3-4% at the age of 70 years. The probability of demonst...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Bonnevie O

    更新日期:1976-01-01 00:00:00

  • Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers.

    abstract:OBJECTIVE:Enterotoxigenic Escherichia coli (ETEC) is the leading cause of travelers' diarrhea. The aim of this study was to investigate the ability of a powdered extract of hyperimmune bovine colostrum to protect against diarrhea in volunteers challenged with ETEC. MATERIALS AND METHODS:Tablets were manufactured from ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,随机对照试验

    doi:10.3109/00365521.2011.574726

    authors: Otto W,Najnigier B,Stelmasiak T,Robins-Browne RM

    更新日期:2011-07-01 00:00:00

  • Managing dyspepsia in the young adult patient: effects of different tests for Helicobacter pylori in a "test-and-scope" approach.

    abstract:AIM:To evaluate how different methods for the detection of Helicobacter pylori influence on a "test, score and scope" decision approach in young dyspeptic patients. RESULTS:Complete data from 341 patients (52.2% males) were analyzed. One hundred and ten (32%) were H. pylori-positive by definition. The rapid serology t...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365521.2013.800988

    authors: Valle PC,Breckan RK,Mortensen L,Amin A,Kildahl-Andersen O,Paulssen EJ

    更新日期:2013-08-01 00:00:00

  • Calcium malabsorption and absence of bone decalcination following intestinal shunt operation for obesity. A comparison of two types of operation.

    abstract::Calcium absorption was studied in 23 patients before and one year after intestinal shunt operation for obesity. It decreased from 23 to 12% (p less than 0.02) after surgery, when the jejunum/ileum ratio was 36cm/12cm [type I], and only from 19 to 16% (p greater than 0.05), when the ratio was 12cm/36cm [type III]. It i...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365527809179810

    authors: Danö P,Christiansen C

    更新日期:1978-01-01 00:00:00

  • Food-stimulated gastroesophageal sphincter pressure in patients with abnormal duodenal loop compared with controls.

    abstract::The gastroesophageal sphincter pressure (GESP) was studied before, during, and after food intake in nine patients with abnormal duodenal loop (AD), six patients with a normal duodenum (controls), and seven healthy volunteers. In normal and control subjects a significant increase in GESP was observed during food intake...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528109182007

    authors: Funch-Jensen P,Oster MJ,Thommesen P

    更新日期:1981-01-01 00:00:00

  • Delayed mid-ileal perforation secondary to acute-on-chronic ischaemia after a diagnostic colonoscopy.

    abstract::Perforation occurring at a remote site of the bowel after diagnostic colonoscopy is rare. A 61-year-old man presenting with bloody diarrhoea underwent colonoscopy. A dynamic ileus developed in less than 1 day, and mid-ileal perforation occurred 7 days after the procedure. It is suggested that high air pressure during ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/003655298750027065

    authors: Chau TN,Ng C,Lau LK,Lai ST,Yuen H

    更新日期:1998-09-01 00:00:00

  • Nephrotic syndrome in ulcerative colitis.

    abstract::Complicating disorders in various organs outside the intestinal tract are common in ulcerative colitis. This report deals with the occurrence of nephrotic syndrome in two patients with long-standing ulcerative colitis. In the patient studied in most detail, 2 episodes have taken place, the first developing into uremia...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:

    authors: Stokke KT,Teisberg PA,Myhre E,Hovig T,Flatmark A,Gjone E

    更新日期:1976-01-01 00:00:00

  • Chronic non-A, non-B hepatitis. A long-term follow-up study in 49 patients.

    abstract::Forty-nine patients with biopsy-verified chronic non-A, non-B hepatitis (NANBH) of both percutaneously transmitted and sporadic types were followed up for up to 20 years (mean, 62 months +/- 44 months). Drug addicts were not included. Twenty-four patients had chronic persistent hepatitis (CPH), and 25 had chronic acti...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365528708991968

    authors: Wejstål R,Lindberg J,Lundin P,Norkrans G

    更新日期:1987-11-01 00:00:00

  • Percutaneous ethanol injection in the treatment of hepatocellular carcinoma. A multicenter survey of evaluation practices and complication rates.

    abstract:BACKGROUND:Percutaneous ethanol injection (PEI) has become a widely used procedure in the treatment of hepatocellular carcinoma (HCC). However, the criteria for selecting patients are not standardized, and little information is available about the complications of the procedure. METHODS:A questionnaire was sent to 11 ...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529709002998

    authors: Di Stasi M,Buscarini L,Livraghi T,Giorgio A,Salmi A,De Sio I,Brunello F,Solmi L,Caturelli E,Magnolfi F,Caremani M,Filice C

    更新日期:1997-11-01 00:00:00

  • Peripheral bone mineral content in patients with fatty liver and hepatic cirrhosis.

    abstract::The aim of our study was to determine peripheral bone mineral content (BMC) and serum osteocalcin (OC) levels in two groups of patients with fatty liver and hepatic cirrhosis as compared with a control group comprising healthy subjects. Group I consisted of 18 male patients (mean age, 51 years) with hepatic steatosis,...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.3109/00365529009095508

    authors: Resch H,Pietschmann P,Krexner E,Woloszczuk W,Willvonseder R

    更新日期:1990-04-01 00:00:00

  • Helicobacter pylori CagA-positive strains affect oxygen free radicals generation by gastric mucosa.

    abstract:BACKGROUND:Helicobacter pylori plays a key role in production of reactive oxygen metabolites (ROMs). However, the importance of virulent CagA-positive H. pylori strains remains to be determined. The aim of this study was to assess ROMs production in gastric biopsies of patients infected by H. pylori. Results were corre...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 临床试验,杂志文章

    doi:10.1080/003655201750074474

    authors: Danese S,Cremonini F,Armuzzi A,Candelli M,Papa A,Ojetti V,Pastorelli A,Di Caro S,Zannoni G,De Sole P,Gasbarrini G,Gasbarrini A

    更新日期:2001-03-01 00:00:00

  • Quantitative measurement of nitric oxide and hydrogen peroxide in Helicobacter pylori-infected Mongolian gerbils in vivo.

    abstract:OBJECTIVE:Peroxynitrite formation, as reflected by nitrotyrosine expression, is low in Helicobacter pylori-infected Mongolian gerbils despite pronounced expression of radical-forming enzymes. The aim of the present study was to investigate in vivo whether H. pylori inhibits either one or both of the nitro- and oxyradic...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章

    doi:10.1080/00365520701288306

    authors: Elfvin A,Edebo A,Bölin I,Fändriks L

    更新日期:2007-10-01 00:00:00

  • A single vial is enough in the absence of endoscopic suspected intestinal metaplasia - less is more!

    abstract::Background: For the correct staging of chronic atrophic gastritis (AG) and gastric intestinal metaplasia (GIM) at least 4 biopsies are recommended: 2 from the antrum/incisura and 2 from the body sent in two different vials. As virtual chromoendoscopy with narrow-band-imaging (NBI) is valid both in the diagnosis and st...

    journal_title:Scandinavian journal of gastroenterology

    pub_type: 杂志文章,多中心研究

    doi:10.1080/00365521.2019.1613443

    authors: Castro R,Esposito G,Libânio D,Afonso L,Annibale B,Dinis-Ribeiro M,Pimentel-Nunes P

    更新日期:2019-05-01 00:00:00