Abstract:
:Attention Deficit Hyperactivity Disorder (ADHD) is associated with altered cerebellar volume and cerebellum is associated with cognitive performance. However there are mixed results regarding the cerebellar volume in young patients with ADHD. To clarify the size and direction of this effect, we conducted the analysis on the large public database of brain images. The aim of this study was to confirm that cerebellar volume in ADHD is smaller than in control subjects in currently the largest publicly available cohort of ADHD subjects.We applied cross-sectional case control study design by comparing 286 ADHD patients (61 female) with age and gender matched control subjects. Volumetric measurements of cerebellum were obtained using automated segmentation with FreeSurfer 5.1. Statistical analysis was performed in R-CRAN statistical environment. Patients with ADHD had significantly smaller total cerebellar volumes (134.5±17.11cm3 vs.138.90±15.32 cm3). The effect was present in both females and males (males 136.9±14.37 cm3 vs. 141.20±14.75 cm3; females 125.7±12.34 cm3 vs. 131.20±15.03 cm3). Age was positively and significantly associated with the cerebellar volumes. These results indicate either delayed or disrupted cerebellar development possibly contributing to ADHD pathophysiology.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Wyciszkiewicz A,Pawlak MA,Krawiec Kdoi
10.1177/0883073816678550subject
Has Abstractpub_date
2017-02-01 00:00:00pages
215-221issue
2eissn
0883-0738issn
1708-8283pii
0883073816678550journal_volume
32pub_type
杂志文章,多中心研究abstract::The aim of this study was to clarify the relationship between neurologic findings and outcome of patients with West syndrome, focusing on the popliteal angle. The complete neurologic examination, including an assessment of the popliteal angle and muscle tone, was performed on 45 patients with West syndrome. A tight po...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738060210101801
更新日期:2006-10-01 00:00:00
abstract:BACKGROUND:Metagenomic next-generation sequencing offers an unbiased approach to identifying viral pathogens in cerebrospinal fluid of patients with meningoencephalitis of unknown etiology. METHODS:In an 11-month case series, we investigated the use of cerebrospinal fluid metagenomic next-generation sequencing to diag...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820972232
更新日期:2020-11-18 00:00:00
abstract:AIM:To investigate etiology and prognostic significance of pontine tegmentum lesions accompanying a cluster of acute flaccid myelitis. METHOD:We retrospectively examined patients from 6 centers in Turkey who manifested encephalitis or myelitis associated with dorsal pontine lesions on magnetic resonance imaging (MRI) ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820911737
更新日期:2020-07-01 00:00:00
abstract::Torticollis refers to a twisting of the head and neck caused by a shortened sternocleidomastoid muscle, tipping the head toward the shortened muscle, while rotating the chin in the opposite direction. Torticollis is seen at all ages, from newborns to adults. It can be congenital or postnatally acquired. In this review...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073812469294
更新日期:2013-03-01 00:00:00
abstract::From February 2006 to March 2008, 42 pregnant women homozygous for the 677CT-methylenetetrahydrofolate reductase (MTHFR) allele were recruited in our obstetrics service for pregnancy at risk. All had antithrombotic prophylaxis with low-dose aspirin and/or low-molecular-weight heparin, supplemented with folic acid. In ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073809344622
更新日期:2010-06-01 00:00:00
abstract::Twelve living patients (aged 19 months to 32 years) with aspartylglucosaminuria were examined by magnetic resonance imaging (MRI), and the magnetic resonance (MR) images of 16 health volunteers (aged 4 to 32 years) were used as controls. One patient was examined twice. Postmortem MRI and histopathologic analysis were ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389701200606
更新日期:1997-09-01 00:00:00
abstract::We assessed 10 youth football players (13.4 ± 0.7 y) immediately before and after their season to explore the effects of football participation on selected clinical measures of neurologic function. Postseason postural stability in a closed-eye condition was improved compared to preseason (P = .017). Neurocognitive tes...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813509887
更新日期:2014-12-01 00:00:00
abstract::Multiple sclerosis onset in youth is increasingly recognized. A systematic review was conducted to assess incidence and prevalence of pediatric-onset multiple sclerosis, focusing on occurrence by age subgroups and disease course. A literature search for the period 1965-2018 was carried out, selecting population-based ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073819845827
更新日期:2019-10-01 00:00:00
abstract::Two boys, aged 7 and 12 years, with nondominant (right) hemispheric acquired vascular lesions and left visual-field disturbances had right spatial constructional disabilities, contralateral to that which would be expected. These unusual disturbances may represent the previously unreported phenomena of ipsilateral negl...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389400900109
更新日期:1994-01-01 00:00:00
abstract::Pediatric headache patients often experience significant sleep disturbance, which may be a risk factor for poor physical, academic, and emotional functioning, including increased anxiety/fear. The current retrospective cohort study of a clinical sample of youth with persistent headache aimed to examine the impact of s...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073819887597
更新日期:2020-03-01 00:00:00
abstract::A 3 1/2-year-old boy presented with megaloblastic anemia and recurrent episodes of severe lactic acidosis and coma. At age 4 years, he developed sepsis and died; postmortem examination failed to show any gross abnormality in any tissue. Biochemical analysis of muscle showed decreased activities for all respiratory cha...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380401900403
更新日期:2004-04-01 00:00:00
abstract::Cardiomyopathy is a leading cause of death in patients with Duchenne muscular dystrophy. Congestive heart failure is often sub-clinical and unrecognized as a result of the severe physical limitations of this patient population. We report the case of a 16-year-old boy with Duchenne muscular dystrophy who demonstrated n...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200031401
更新日期:2005-03-01 00:00:00
abstract::We report 10 years' follow-up of the previously described family with a novel mutation of the KCNA1 gene. The family consisted of 3 affected boys (first seen at ages 3, 11, and 12) and their affected mother and asymptomatic father and sister. They clinically presented with diffuse myokymia, muscle cramps, and lower li...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812457461
更新日期:2013-11-01 00:00:00
abstract::The neuronal ceroid lipofuscinoses represent a group of disorders characterized by neurodegeneration and intracellular accumulation of an auto-fluorescent lipopigment (ceroid lipofuscin). Together, they represent the most prevalent class of childhood neurodegenerative disease. The neuronal ceroid lipofuscinoses encomp...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073813494268
更新日期:2013-09-01 00:00:00
abstract::Subacute sclerosing panencephalitis is an almost universally fatal late complication of measles infection for which there is no established treatment. We report a patient with subacute sclerosing panencephalitis who was bed-bound and ataxic and had a left hemiparesis and frequent myoclonus. He was started on a new reg...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380201700911
更新日期:2002-09-01 00:00:00
abstract::Development of acylcarnitine and amino acid profiling using tandem mass spectrometry, and its application for use with dried blood specimens collected on filter-paper cards, has introduced an innovative new technology for detecting inborn errors of fatty acid, organic acid, and amino acid metabolism. From November 1, ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073899014001021
更新日期:1999-11-01 00:00:00
abstract::Homocystinuria represents a group of hereditary metabolic disorders characterized by an accumulation of homocysteine in the serum and an increased excretion of homocysteine in the urine. The infantile form is severe: the main clinical findings are neurologic signs, associated with hematological signs and bone alterati...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073809336877
更新日期:2010-03-01 00:00:00
abstract::We retrospectively analyzed the medical documentation of 194 children infected with Epstein-Barr virus. The diagnosis was based on clinical symptoms and the presence of the viral capsid antigen IgM antibody. Patients with severe neurologic complications also underwent neurologic examination, magnetic resonance imaging...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073815613563
更新日期:2016-05-01 00:00:00
abstract::Children with autistic spectrum disorder are known to have histopathological abnormalities in the cerebellum. Diffusion tensor imaging has been utilized to study abnormalities in connectivity and microintegrity in brains of such children. A region of interest approach was adopted to study cerebellar outflow and inflow...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073809358765
更新日期:2010-10-01 00:00:00
abstract::Six girls between 2 years 9 months and 15 years of age with Rett syndrome were thoroughly investigated. Blood ammonia levels varied between 42 and 123 mumol/L, and serum lactate concentration was slightly elevated in two girls. Electroencephalograms showed a dysrhythmic pattern during wakefulness; during drowsiness an...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389000500311
更新日期:1990-07-01 00:00:00
abstract::Acquired toxoplasmosis, although relatively common in children, is usually asymptomatic but can also be clinically manifested by a benign and self-limited infectious mononucleosis-like syndrome. Neurological complications are very rare in immunocompetent children. The authors report a 5-year-old boy who presented with...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073810370480
更新日期:2010-12-01 00:00:00
abstract::An infant newly diagnosed with propionic acidemic coma was managed successfully with total parenteral nutrition (TPN) and continuous infusion of insulin. The urinary excretion of 3-hydroxypropionic acid was reduced to 3% of the admission value in 4 days, gradually decreasing to 1.5% in 16 days. The treatment did not p...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738920070011411
更新日期:1992-04-01 00:00:00
abstract::Five patients with palatal tics and Gilles de la Tourette syndrome have been previously reported. Little is known about the characteristics of palatal tics given that there are so few reports. On one hand, palatal tics may be rare. Alternatively, they may be less well recognized than repetitive eye blinking or sniffin...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814546687
更新日期:2015-08-01 00:00:00
abstract::Congenital adrenal hyperplasia could provide a promising model for the study of the effects of hormones on cognition. The aim of this study was to assess sexual dimorphic abilities related to oral language, spatial abilities, and verbal fluency and to determine the existence of learning disabilities in 11 congenital g...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808315618
更新日期:2008-08-01 00:00:00
abstract::Acute necrotizing encephalopathy is a novel disease entity, proposed by Mizuguchi et al in 1995, that shows a characteristic selective and symmetric involvement of the thalamus, brain stem, and cerebellum. It usually leaves sequelae. The etiology of acute necrotizing encephalopathy is unknown. We describe here six pat...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389901400407
更新日期:1999-04-01 00:00:00
abstract::The goal of the research was to point out the importance of early prespeech therapy for babies suffering from at-birth-acquired unilateral or bilateral lesion in the prespeech period of development. On the basis of existing studies and experience in the field, a protocol and methodology for the observation of the phon...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章
doi:10.1177/0883073807299970
更新日期:2007-01-01 00:00:00
abstract::Using diffusion tensor imaging tractography and color-coded anisotropy map quantification, we investigated asymmetry of the arcuate fasciculus to determine language laterality in children and compared it with the Wada test. Arcuate fasciculus volume and fractional anisotropy were measured after tractography. We also q...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811409225
更新日期:2011-12-01 00:00:00
abstract::The voltage-sensitive calcium channel probe 125I-omega-GVIA conotoxin has been shown to be a developmental marker in whole brain preparations of Swiss Webster mice. The present study looks more carefully at regional dissections of the mouse brain (cerebrum, cerebellum, and brain stem) at postnatal day 8 and postnatal ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389400900120
更新日期:1994-01-01 00:00:00
abstract::Movement disorders, a common problem in children with neurologic impairment, are receiving increasing clinical attention. The differences in movement disorders between adults and children are striking; presentation is frequently insidious and may be characterized by mild hypotonia. The clinical manifestations of extra...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073803018001S0601
更新日期:2003-09-01 00:00:00
abstract::After obtaining familial informed consent, between January 1996 and July 1997, 173 children (5 to 15 years old) with sickle cell disease were enrolled in a prospective multicenter study using blood screening, transcranial Doppler ultrasonography (n = 143), cerebral magnetic resonance imaging (n = 144), and neuropsycho...
journal_title:Journal of child neurology
pub_type: 杂志文章,多中心研究
doi:10.1177/088307380001500510
更新日期:2000-05-01 00:00:00