Neurologic Complications Caused by Epstein-Barr Virus in Pediatric Patients.

Abstract:

:We retrospectively analyzed the medical documentation of 194 children infected with Epstein-Barr virus. The diagnosis was based on clinical symptoms and the presence of the viral capsid antigen IgM antibody. Patients with severe neurologic complications also underwent neurologic examination, magnetic resonance imaging (MRI), and electroencephalography (EEG). There were 2 peaks in incidence of infection; the first one in young children aged 1 to 5 years represented 62.0% of cases. The second peak (24.6% of patients) occurred in teenagers. Febrile seizures were confirmed in 3.1% of affected children younger than 5 years and headaches in 24.2% patients, mostly older children. Ten children presented severe, neurologic complications: meningoencephalitis, acute encephalitis, acute cerebellitis, transverse myelitis, and myeloradiculitis. Our study identified a variety of Epstein-Barr virus-related neurologic complications. Epstein-Barr virus should be routinely tested for when a child presents with an apparent neuroinfection as it is a common pathogen that can induce a wide variety of signs and symptoms.

journal_name

J Child Neurol

authors

Mazur-Melewska K,Breńska I,Jończyk-Potoczna K,Kemnitz P,Pieczonka-Ruszkowska I,Mania A,Służewski W,Figlerowicz M

doi

10.1177/0883073815613563

subject

Has Abstract

pub_date

2016-05-01 00:00:00

pages

700-8

issue

6

eissn

0883-0738

issn

1708-8283

pii

0883073815613563

journal_volume

31

pub_type

杂志文章
  • High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial.

    abstract::This is the first study to evaluate the efficacy of riboflavin for migraine prophylaxis in children. This was a randomized, double-blind study of riboflavin (200 mg daily) versus placebo in 48 children. The primary efficacy measure was the number of patients achieving a 50% or greater reduction in the number of migrai...

    journal_title:Journal of child neurology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1177/0883073808318053

    authors: MacLennan SC,Wade FM,Forrest KM,Ratanayake PD,Fagan E,Antony J

    更新日期:2008-11-01 00:00:00

  • Ornithine transcarbamylase deficiency presenting with acute reversible cortical blindness.

    abstract::Acute focal neurologic deficits are a rare but known presentation of ornithine transcarbamylase deficiency, particularly in females. We describe here a 6-year-old girl with newly diagnosed ornithine transcarbamylase deficiency who presents with an episode of acute cortical blindness lasting for 72 hours in the absence...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073814535490

    authors: Prasun P,Altinok D,Misra VK

    更新日期:2015-05-01 00:00:00

  • Clinical predictors of computed tomography in epileptic children.

    abstract::The purpose of this study was to determine which clinical characteristics correlated with abnormal computed tomographic (CT) scans in epileptic children. Thirty variables were examined. Of these, four variables (presence of inherited or congenital disease, focal motor findings, developmental delay, and early onset of ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307388600100210

    authors: Koprowski C,Clancy R

    更新日期:1986-04-01 00:00:00

  • Epilepsy treatment in Rett syndrome.

    abstract::Rett syndrome is a neurodevelopmental disorder predominately affecting females. The majority of patients have epilepsy in the early stages of the disease. This study evaluates the clinical course of epilepsy and the effect of antiepileptic drug treatment in Rett syndrome using retrospective data analysis. Epilepsy was...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073811408422

    authors: Krajnc N,Župančič N,Oražem J

    更新日期:2011-11-01 00:00:00

  • Outcome measures in pediatric neurology: why do we need them?

    abstract::Outcome measures should include the patient's values and preferences (from the patient's perspective) in addition to performance ratings and physiologic states. Outcome measures can assess relationships between services and interventions and their end results, can clarify which therapies are worth providing and which ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307380001501201

    authors: Ronen GM,Rosenbaum MP,Streiner DL

    更新日期:2000-12-01 00:00:00

  • Effects of youth football on selected clinical measures of neurologic function: a pilot study.

    abstract::We assessed 10 youth football players (13.4 ± 0.7 y) immediately before and after their season to explore the effects of football participation on selected clinical measures of neurologic function. Postseason postural stability in a closed-eye condition was improved compared to preseason (P = .017). Neurocognitive tes...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073813509887

    authors: Munce TA,Dorman JC,Odney TO,Thompson PA,Valentine VD,Bergeron MF

    更新日期:2014-12-01 00:00:00

  • The cavum septi pellucidi in term and preterm newborn infants.

    abstract::We reviewed cranial sonographic studies done on 108 normal newborn infants to determine the prevalence and variability in size of the cavum septi pellucidi (CSP). Infants were classified according to gestational age by 2-week intervals. At 24 weeks, only four normal scans were identified. Between 26 and 34 weeks, ten ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389200700106

    authors: Mott SH,Bodensteiner JB,Allan WC

    更新日期:1992-01-01 00:00:00

  • Effects of postnatal dexamethasone exposure on the developmental outcome of premature infants.

    abstract::Extremely low birth weight premature infants are at risk for poor neurodevelopmental outcome. Postnatal dexamethasone has often been used in premature infants to prevent or treat bronchopulmonary dysplasia, and this drug is thought by some to affect neurodevelopmental outcome. We retrospectively examined the effect of...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073807309232

    authors: Needelman H,Evans M,Roberts H,Sweney M,Bodensteiner JB

    更新日期:2008-04-01 00:00:00

  • Four-month-old infant with focal segmental glomerulosclerosis and mitochondrial DNA deletion.

    abstract::Mitochondrial cytopathies are a group of heterogeneous disorders characterized by multisystem involvement. Renal involvement in mitochondrial cytopathies is usually manifested as tubular dysfunction owing to impaired energy metabolism; however, a few cases with glomerular changes have also been reported. Herein we rep...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738050200011304

    authors: Unal S,Kalkanoğlu HS,Kocaefe C,Gucer S,Ozen S,Turanli G,Coskun T

    更新日期:2005-01-01 00:00:00

  • Advancing the medical management of epilepsy: disease modification and pharmacogenetics.

    abstract::Despite the recent development of new antiepilepsy drugs, a significant number of children are still unable to achieve seizure freedom without side effects. Understanding the factors behind individual variability in antiepilepsy drug tolerability and dose response and incorporating these factors into a treatment plan ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/08830738020170011301

    authors: Glauser TA

    更新日期:2002-01-01 00:00:00

  • Unusual manifestations of pediatric neuromyelitis optica.

    abstract::Neuromyelitis optica is a rare, severe idiopathic disease that predominantly involves optic nerves and spinal cord. Main clinical features of neuromyelitis optica are visual loss, paraparesis or tetraparesis, sensory loss, and sphincter dysfunction. A 13-year-old girl with vision loss and behavioral change was admitte...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073812448837

    authors: Yavuz H,Kiresi D

    更新日期:2013-05-01 00:00:00

  • Epilepsy, intelligence, and psychiatric disorders in patients with cerebellar hypoplasia.

    abstract::The cerebellum is involved in motor and cognitive functions and behavior. Its role in controlling epileptic seizures has been demonstrated in the literature. Genetic factors can enhance epilepsy susceptibility when the cerebellum is damaged. We examined the occurrence and features of epilepsy, intelligence, and psychi...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738030180011001

    authors: Parmeggiani A,Posar A,Scaduto MC,Chiodo S,Giovanardi-Rossi P

    更新日期:2003-01-01 00:00:00

  • Clinical features and magnetic resonance imaging in congenital and childhood stroke.

    abstract::Fifty-three (5%) of 1064 consecutively imaged children showed an arterial vascular pattern on magnetic resonance images, accounting for 12% of all abnormal studies. Signal abnormalities on T2-weighted scans persisted years after the clinical stroke occurrence. Ipsilateral atrophy of the pons or midbrain was found in 2...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389100600311

    authors: Smith CD,Baumann RJ

    更新日期:1991-07-01 00:00:00

  • Birth-related upper brachial plexus injuries in infants: operative and nonoperative approaches.

    abstract::Advances in intraoperative neuroelectrodiagnostic testing and microneurosurgical techniques have made it possible to accurately explore the brachial plexus of neonates. Since 1987, we have followed 250 infants with birth-related brachial plexus injuries, and successful operations have been completed on more than 70 in...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389400900202

    authors: Laurent JP,Lee RT

    更新日期:1994-04-01 00:00:00

  • Risk factors and imaging characteristics of childhood stroke in china.

    abstract::There are scarce reports of childhood stroke from China. Our objective was to describe the clinical spectrum, risk factors, and imaging characteristics of childhood stroke in China. Using a hospital discharge database, children with stroke who were first admitted from 2002 to 2011 were retrospectively enrolled. We ide...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073814538667

    authors: Deng Y,Wang Y,Yang W,Yu Y,Xu J,Wang Y,Gao B

    更新日期:2015-03-01 00:00:00

  • Genetic susceptibility to neurodevelopmental disorders.

    abstract::A large body of evidence suggests that genetic factors influence liability to many common neurodevelopmental disorders. Examples include Tourette syndrome, attention-deficit hyperactivity disorder, autism, and dyslexia. Characterization of the genetic component of susceptibility to these conditions at a molecular leve...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,评审

    doi:10.1177/088307389901400310

    authors: Ryan SG

    更新日期:1999-03-01 00:00:00

  • Pica and the elephant's ear.

    abstract::This is a case report of an otherwise healthy 2-year-old boy with a history of pica, associated with iron deficiency anemia. This boy was referred to our department for a neurologic evaluation because of an acute episode of sialorrhea, difficulty in speaking, dysphagia, and repeated swallowing movements. An uncertain ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738020170111705

    authors: Mihailidou H,Galanakis E,Paspalaki P,Borgia P,Mantzouranis E

    更新日期:2002-11-01 00:00:00

  • Speed-Accuracy Trade-Off in a Trajectory-Constrained Self-Feeding Task: A Quantitative Index of Unsuppressed Motor Noise in Children With Dystonia.

    abstract::Motor speed and accuracy are both affected in childhood dystonia. Thus, deriving a speed-accuracy function is an important metric for assessing motor impairments in dystonia. Previous work in dystonia studied the speed-accuracy trade-off during point-to-point tasks. To achieve a more relevant measurement of functional...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073815578526

    authors: Lunardini F,Bertucco M,Casellato C,Bhanpuri N,Pedrocchi A,Sanger TD

    更新日期:2015-10-01 00:00:00

  • Myalgia and cramps: dystrophinopathy with wide-ranging laboratory findings.

    abstract::We present 12 cases of males with myalgia and cramps and a normal muscle strength examination. All the patients had muscle dystrophin values consistent with Becker muscular dystrophy. Five of the patients had a normal electromyogram, and five had normal light microscopic muscle biopsy results. Of particular note, four...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/088307389601100105

    authors: Samaha FJ,Quinlan JG

    更新日期:1996-01-01 00:00:00

  • Acute pseudotumoral hemicerebellitis in a child: a rare and distinct entity?

    abstract::A pseudotumoral presentation of acute hemicerebellitis is rare in pediatric age. The authors report a new single case study of a 7-year-old child with pseudotumoral unilateral cerebellitis mimicking an intracranial tumor, which clinically presented itself with signs of intracranial hypertension and mild contralateral ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073814545114

    authors: Alberini E,Vellante V,Zennaro F,Calligaris L,Barbi E,Carrozzi M,Devescovi R

    更新日期:2015-03-01 00:00:00

  • Considerations for the treatment of infantile neuronal ceroid lipofuscinosis (infantile Batten disease).

    abstract::The infantile form of neuronal ceroid lipofuscinosis (ie, infantile Batten disease) is the most rapidly progressing type and is caused by an inherited deficiency in the lysosomal enzyme palmitoyl protein thioesterase 1. The absence of enzyme activity leads to progressive accumulation of autofluorescent material in man...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073813495960

    authors: Sands MS

    更新日期:2013-09-01 00:00:00

  • Impaired social behavior in children with benign childhood epilepsy with centrotemporal spikes.

    abstract::The aim of the present study was to assess the emotional and cognitive aspects of social cognition among patients with rolandic epilepsy. A computerized neuropsychological battery was used for cognitive evaluation. Affective and cognitive social cognition were evaluated using two computerized Theory of Mind tasks. Cog...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073811414420

    authors: Genizi J,Shamay-Tsoory SG,Shahar E,Yaniv S,Aharon-Perez J

    更新日期:2012-02-01 00:00:00

  • Reduced Penetrance of PRRT2 Mutation in a Chinese Family With Infantile Convulsion and Choreoathetosis Syndrome.

    abstract::Paroxysmal kinesigenic dyskinesia is a rare episodic movement disorder that can be isolated or associated with benign infantile seizures as part of choreoathetosis syndrome. Mutations in the PRRT2 gene have been recently identified as a cause of paroxysmal kinesigenic dyskinesia and infantile convulsion and choreoathe...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073814556887

    authors: Zhang LM,An Y,Pan G,Ding YF,Zhou YF,Yao YH,Wu BL,Zhou SZ

    更新日期:2015-09-01 00:00:00

  • Childhood Facial Palsy: Etiologic Factors and Clinical Findings, an Observational Retrospective Study.

    abstract::The purpose of this study was to determine the etiologic factors, clinical characteristics, seasonal distributions, family history, response to corticosteroid therapy, recurrence and residual paralysis rates, and factors affecting these in pediatric facial palsy. Patients aged <18 years diagnosed with acute peripheral...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073819865682

    authors: Hanci F,Türay S,Bayraktar Z,Kabakuş N

    更新日期:2019-12-01 00:00:00

  • Unilateral schizencephaly and contralateral polymicrogyria associated with umbilical cord mass.

    abstract::We report a 6-month-old boy with diffuse hypertonia and developmental delay who had unilateral separated-lip schizencephaly and contralateral polymicrogyria. The contralateral polymicrogyria was associated with an incomplete clefting in that hemisphere. An umbilical cord hamartoma is presumed to have caused hypoperfus...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/08830738030180031401

    authors: Hahn JS,Lewis AJ

    更新日期:2003-03-01 00:00:00

  • Migraine and cranial autonomic symptoms in children and adolescents: a clinical study.

    abstract::The frequency of cranial autonomic symptoms in children affected by primary headaches is uncertain. The aim of our study was to estimate the frequency of symptoms in pediatric headaches and correlate it with main migraine characteristics. A questionnaire investigating the presence of cranial autonomic symptoms was adm...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073814535494

    authors: Raieli V,Giordano G,Spitaleri C,Consolo F,Buffa D,Santangelo G,Savettieri G,Vanadia F,D'Amelio M

    更新日期:2015-02-01 00:00:00

  • Alexander Disease.

    abstract::Alexander disease is a leukodystrophy caused by dominant missense mutations in the gene encoding the glial fibrillary acidic protein. Individuals with this disorder often present with a typical neuroradiologic pattern including white matter abnormalities with brainstem involvement, selective contrast enhancement, and ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073816673263

    authors: Tavasoli A,Armangue T,Ho CY,Whitehead M,Bornhorst M,Rhee J,Hwang EI,Wells EM,Packer R,van der Knaap MS,Bugiani M,Vanderver A

    更新日期:2017-02-01 00:00:00

  • Executive function and cerebrovascular reactivity in pediatric hypertension.

    abstract::Primary hypertension is associated with decreased performance on neurocognitive testing and a blunted cerebrovascular reactivity to hypercapnia. Parents of 14 children with hypertension and prehypertension completed the Behavior Rating Inventory of Executive Functions. Children underwent 24-hour ambulatory blood press...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073813494264

    authors: Ostrovskaya MA,Rojas M,Kupferman JC,Lande MB,Paterno K,Brosgol Y,Pavlakis SG

    更新日期:2015-04-01 00:00:00

  • Developmental and behavior problems predict parenting stress in young children with global delay.

    abstract::To identify parent-reported symptoms that predict parenting stress in preschoolers with global developmental delay, 201 parents/guardians of 142 boys and 59 girls with global delay, mean age 39.1 months (range, 18 to 63 months) were studied retrospectively. Parents completed the following: (a) a semistructured intervi...

    journal_title:Journal of child neurology

    pub_type: 杂志文章

    doi:10.1177/0883073811418230

    authors: Tervo RC

    更新日期:2012-03-01 00:00:00

  • Topiramate in children with west syndrome: a retrospective multicenter evaluation of 100 patients.

    abstract::The aim of this study is to investigate the efficacy and tolerability of topiramate in a large number of children with West syndrome. The authors performed a retrospective, questionnaire-based data collection in specialized epilepsy units in Germany. Patients with West syndrome and hypsarrhythmia could be included if ...

    journal_title:Journal of child neurology

    pub_type: 杂志文章,多中心研究

    doi:10.1177/0883073807300535

    authors: Korinthenberg R,Schreiner A

    更新日期:2007-03-01 00:00:00