Treatment of subacute sclerosing panencephalitis with interferon-alpha, ribavirin, and inosiplex.

Abstract:

:Subacute sclerosing panencephalitis is an almost universally fatal late complication of measles infection for which there is no established treatment. We report a patient with subacute sclerosing panencephalitis who was bed-bound and ataxic and had a left hemiparesis and frequent myoclonus. He was started on a new regimen consisting of intraventricular interferon-alpha (starting at 100,000 U/m2/day, building up to 1 million U/m2/day), ribavirin (60 mg/kg/day intravenously), and inosiplex (3 g/day) and improved markedly. At 10 weeks, the intraventricular reservoir was removed because of bacterial infection, and he was discharged home on oral ribavirin (1200 mg/kg/day) and inosiplex. He continued to improve as judged by neurologic examination, functional independence measurement, neuropsychometry and single photon emission computed tomography (SPECT) imaging. However, after 10 months, he deteriorated suddenly and died before further intraventricular treatment could be instituted. Further trials are needed to evaluate long-term combination therapy in subacute sclerosing panencephalitis.

journal_name

J Child Neurol

authors

Solomon T,Hart CA,Vinjamuri S,Beeching NJ,Malucci C,Humphrey P

doi

10.1177/088307380201700911

subject

Has Abstract

pub_date

2002-09-01 00:00:00

pages

703-5

issue

9

eissn

0883-0738

issn

1708-8283

journal_volume

17

pub_type

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