Abstract:
:Subacute sclerosing panencephalitis is an almost universally fatal late complication of measles infection for which there is no established treatment. We report a patient with subacute sclerosing panencephalitis who was bed-bound and ataxic and had a left hemiparesis and frequent myoclonus. He was started on a new regimen consisting of intraventricular interferon-alpha (starting at 100,000 U/m2/day, building up to 1 million U/m2/day), ribavirin (60 mg/kg/day intravenously), and inosiplex (3 g/day) and improved markedly. At 10 weeks, the intraventricular reservoir was removed because of bacterial infection, and he was discharged home on oral ribavirin (1200 mg/kg/day) and inosiplex. He continued to improve as judged by neurologic examination, functional independence measurement, neuropsychometry and single photon emission computed tomography (SPECT) imaging. However, after 10 months, he deteriorated suddenly and died before further intraventricular treatment could be instituted. Further trials are needed to evaluate long-term combination therapy in subacute sclerosing panencephalitis.
journal_name
J Child Neuroljournal_title
Journal of child neurologyauthors
Solomon T,Hart CA,Vinjamuri S,Beeching NJ,Malucci C,Humphrey Pdoi
10.1177/088307380201700911subject
Has Abstractpub_date
2002-09-01 00:00:00pages
703-5issue
9eissn
0883-0738issn
1708-8283journal_volume
17pub_type
杂志文章abstract:BACKGROUND:The classic phenotype of CLN2 disease (neuronal ceroid lipofuscinosis type 2) typically manifests between ages 2 and 4 years with a predictable clinical course marked by epilepsy, language developmental delay, and rapid psychomotor decline. Atypical phenotypes exhibit variable time of onset, symptomatology, ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820977997
更新日期:2020-12-23 00:00:00
abstract::Current guidelines permitting return to play for athletes who have sustained a concussion rely on resolution of cognitive and physical symptoms. Evolving evidence suggest that vascular, radiologic and cerebral metabolic abnormalities persist in some athletes beyond the period of clinical recovery. This commentary addr...
journal_title:Journal of child neurology
pub_type: 社论
doi:10.1177/0883073818790169
更新日期:2018-10-01 00:00:00
abstract::The prognosis in infants with brain tumors has historically been very poor. This study reviews 16 infants under the age of 12 months with brain tumors who presented to our institution between 1988 and 1999. The aim was to describe the clinical presentation, diagnosis, and management of these patients and to establish ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380401900605
更新日期:2004-06-01 00:00:00
abstract::Intractable epilepsies pose a therapeutic challenge. Precise localization of the epileptic focus is imperative before planning surgical intervention. Functional imaging is an important component of presurgical work-up. Positron emission tomography is unavailable in developing countries; hence, the need to evaluate the...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380101600405
更新日期:2001-04-01 00:00:00
abstract::Autism is etiologically heterogeneous; medical conditions are implicated in only a minority of cases, whereas metabolic disorders are even less common. Recently, there have been articles describing the association of autism with mitochondrial abnormalities. We critically review the current literature and conclude that...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/088307380401900510
更新日期:2004-05-01 00:00:00
abstract::Managing severe epilepsy syndromes of early childhood is challenging as the seizures are typically resistant to treatment and may cause disabling mental and behavioral problems in later life. A comprehensive treatment plan includes pharmacologic, nonpharmacologic, and surgical options. This article reviews clinical st...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073809338153
更新日期:2009-08-01 00:00:00
abstract::This article assessed how Indian providers and mothers value quality of life in pediatric disabilities, hypothesizing lower values with increasing disability, lower values among providers than mothers, and lower values among mothers with versus mothers without a disabled child. We asked 175 participants: "If born tomo...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073818773941
更新日期:2018-08-01 00:00:00
abstract::Cochlear implantation has altered the life-course of thousands of children who have significant hearing loss. Since the United States Food and Drug Administration approved multichannel cochlear implants for children in 1989, growing numbers of parents are choosing this option for their offspring and seeking opportunit...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812442590
更新日期:2012-06-01 00:00:00
abstract:AIM:To investigate etiology and prognostic significance of pontine tegmentum lesions accompanying a cluster of acute flaccid myelitis. METHOD:We retrospectively examined patients from 6 centers in Turkey who manifested encephalitis or myelitis associated with dorsal pontine lesions on magnetic resonance imaging (MRI) ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820911737
更新日期:2020-07-01 00:00:00
abstract::Neurological disorders, including neurodevelopmental disorders, have been identified by the World Health Organization (WHO) as one of the greatest threats to global public health. It is generally believed that these conditions are more prevalent in the developing than the developed world because of multiple known risk...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073809357792
更新日期:2010-04-01 00:00:00
abstract::Aminoacyl-transfer ribonucleic acid (RNA) synthetases (ARSs) are a group of enzymes required for the first step of protein translation. Each aminoacyl-transfer RNA synthetase links a specific amino acid to its corresponding transfer RNA component within the cytoplasm, mitochondria, or both. Mutations in ARSs have been...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073814553272
更新日期:2015-07-01 00:00:00
abstract::High throughput sequencing is discovering many likely causative genetic variants in individuals with cerebral palsy. Some investigators have suggested that this changes the clinical diagnosis of cerebral palsy and that these individuals should be removed from this diagnostic category. Cerebral palsy is a neurodevelopm...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/0883073819840449
更新日期:2019-07-01 00:00:00
abstract::A 3 1/2-year-old boy presented with megaloblastic anemia and recurrent episodes of severe lactic acidosis and coma. At age 4 years, he developed sepsis and died; postmortem examination failed to show any gross abnormality in any tissue. Biochemical analysis of muscle showed decreased activities for all respiratory cha...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380401900403
更新日期:2004-04-01 00:00:00
abstract::Paroxysmal tonic upgaze of childhood is an eye movement abnormality characterized by periodic episodes of conjugate upward eye deviation. Although the spectrum of paroxysmal tonic upgaze has broadened considerably, a specific pathophysiology has not been elucidated. We report an infant with paroxysmal tonic upgaze who...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200021601
更新日期:2005-02-01 00:00:00
abstract::Acquired toxoplasmosis, although relatively common in children, is usually asymptomatic but can also be clinically manifested by a benign and self-limited infectious mononucleosis-like syndrome. Neurological complications are very rare in immunocompetent children. The authors report a 5-year-old boy who presented with...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073810370480
更新日期:2010-12-01 00:00:00
abstract::Two boys, aged 7 and 12 years, with nondominant (right) hemispheric acquired vascular lesions and left visual-field disturbances had right spatial constructional disabilities, contralateral to that which would be expected. These unusual disturbances may represent the previously unreported phenomena of ipsilateral negl...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389400900109
更新日期:1994-01-01 00:00:00
abstract::The authors describe the case of an 8-year-old boy, otherwise healthy, who presented with symptoms consistent with attention-deficit hyperactivity disorder (ADHD) and was started on a trial of methylphenidate. Within 4 weeks, he experienced a rapid decline in fine motor skills, with dysarthria, intention tremor, motor...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808314152
更新日期:2008-07-01 00:00:00
abstract::Children with neurodevelopmental disorders are at increased risk for sleep issues, which affect quality of life, cognitive function, and behavior. To determine the prevalence of sleep problems in children with the common neurodevelopmental disorder neurofibromatosis type 1, a cross-sectional study was performed on 129...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813500849
更新日期:2013-11-01 00:00:00
abstract::More than half of neonatal stroke survivors have long-term sequelae, including seizures and neurological deficits. Although the immature brain has tremendous potential for recovery, mechanisms governing repair are essentially unexplored. We investigated whether magnetic resonance imaging (MRI) early or late after tran...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073811408308
更新日期:2011-09-01 00:00:00
abstract::This study aimed to identify the age at first concern and age at referral for rehabilitation services in children with developmental disabilities in India. Two hundred fifty-nine children were included and data were collected from the parents. In children with developmental disabilities (excluding autism spectrum diso...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812447685
更新日期:2013-04-01 00:00:00
abstract:AIM:To investigate the impact of concussion on pupillary function in children by examining pupillometric parameters and assessing for differences in children reporting photosensitivity. METHODS:Retrospective chart review was performed of pediatric patients referred for visual symptoms after concussion from 2017 to 201...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073820964040
更新日期:2021-03-01 00:00:00
abstract::Seven children between 2 and 15 years of age with cerebral palsy and upper extremity dystonia were enrolled in an open-label, dose-escalation pilot clinical trial of botulinum toxin type B (Myobloc), injected into the biceps and brachioradialis muscles of I or both arms. The primary outcome measure was the change in m...
journal_title:Journal of child neurology
pub_type: 临床试验,杂志文章
doi:10.1177/0883073807299975
更新日期:2007-01-01 00:00:00
abstract::A 15-month-old girl demonstrated progressive weakness in all limbs. Magnetic resonance imaging (MRI) on admission revealed (1) diffuse and symmetric cervical cord swelling, (2) diffuse decrease and increase in signal intensity within the affected cord on T1- and T2-weighted images, respectively, (3) preserved anatomic...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307389200700214
更新日期:1992-04-01 00:00:00
abstract::Visual electrophysiological techniques represent excellent means for assessing retinal, optic pathways and visual cortex function. Electroretinograms, visual evoked potentials, and clinical records of 17 patients with mucopolysaccharidosis registered in the neurophysiological database of our institution were reviewed ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073812453322
更新日期:2013-10-01 00:00:00
abstract::Thromboembolic events during the perinatal period are responsible for irreversible brain damage owing to cerebral hypoxia and neuronal necrosis. We investigated the presence of thrombophilia risk factors in children with congenital neurologic disorders. Nineteen children (9 males and 10 females), aged 1 to 14 years (m...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/08830738050200060701
更新日期:2005-06-01 00:00:00
abstract::Opsoclonus-myoclonus syndrome is characterized by abnormal lymphocyte trafficking into brain. The authors hypothesized that mycophenolate mofetil, a lymphocyte proliferation inhibitor, might be therapeutic. The cerebrospinal fluid and blood immunophenotypes of 15 children with predominantly chronic-relapsing opsoclonu...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073808324217
更新日期:2009-03-01 00:00:00
abstract::Mutations in MECP2 gene are the primary cause of Rett syndrome, a neurodevelopmental disorder that primarily affects girls, and affect 90% to 95% patients with classical Rett syndrome. MECP2 mutations, once thought to be lethal in males, now present a broad spectrum of clinical manifestations in males. This article re...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073810378535
更新日期:2011-02-01 00:00:00
abstract::Tics, patterned movements distinct from stereotypies, myoclonus, and other hyperkinetic movements, are quite common in children, particularly among those with developmental and psychiatric disorders. Thus, tics can indicate the presence of atypical neurodevelopment or broader difficulties with cognition or mood. Tics ...
journal_title:Journal of child neurology
pub_type: 杂志文章,评审
doi:10.1177/08830738060210080401
更新日期:2006-08-01 00:00:00
abstract::In addition to the typical infantile spasm symptoms, several other symptoms, such as eye movements, have been reported to be associated with infantile spasms, although the relationship between the typical spasms and these other events is not fully understood. Here we present a case with West syndrome. We observed the ...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/0883073813489169
更新日期:2013-11-01 00:00:00
abstract::Gelastic seizure is a rare symptom often associated with hypothalamic hamartoma. We present here a 4-year-old girl with gelastic epilepsy caused by hypothalamic hamartoma and report the magnetic resonance spectrometry and electroencephalographic (EEG) findings. At the age of 2 1/2 years, she developed brief, repetitiv...
journal_title:Journal of child neurology
pub_type: 杂志文章
doi:10.1177/088307380201700111
更新日期:2002-01-01 00:00:00