Abstract:
:Intrinsically Disordered Proteins (IDPs) perform a broad range of biological functions. Their relevance has motivated intense research activity seeking to characterize their sequence/structure/function relationships. However, the conformational plasticity of these molecules hampers the application of traditional structural approaches, and new tools and concepts are being developed to address the challenges they pose. Small-Angle Scattering (SAS) is a structural biology technique that probes the size and shape of disordered proteins and their complexes with other biomolecules. The low-resolution nature of SAS can be compensated with specially designed computational tools and its combined interpretation with complementary structural information. In this review, we describe recent advances in the application of SAS to disordered proteins and highly flexible complexes and discuss current challenges.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Cordeiro TN,Herranz-Trillo F,Urbanek A,Estaña A,Cortés J,Sibille N,Bernadó Pdoi
10.1016/j.sbi.2016.10.011subject
Has Abstractpub_date
2017-02-01 00:00:00pages
15-23eissn
0959-440Xissn
1879-033Xpii
S0959-440X(16)30174-9journal_volume
42pub_type
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