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Comparison of Standardization Methods for the Harmonization of Phenotype Data: An Application to Cognitive Measures.

Abstract：

:Standardization procedures are commonly used to combine phenotype data that were measured using different instruments, but there is little information on how the choice of standardization method influences pooled estimates and heterogeneity. Heterogeneity is of key importance in meta-analyses of observational studies because it affects the statistical models used and the decision of whether or not it is appropriate to calculate a pooled estimate of effect. Using 2-stage individual participant data analyses, we compared 2 common methods of standardization, T-scores and category-centered scores, to create combinable memory scores using cross-sectional data from 3 Canadian population-based studies (the Canadian Study on Health and Aging (1991-1992), the Canadian Community Health Survey on Healthy Aging (2008-2009), and the Quebec Longitudinal Study on Nutrition and Aging (2004-2005)). A simulation was then conducted to assess the influence of varying the following items across population-based studies: 1) effect size, 2) distribution of confounders, and 3) the relationship between confounders and the outcome. We found that pooled estimates based on the unadjusted category-centered scores tended to be larger than those based on the T-scores, although the differences were negligible when adjusted scores were used, and that most individual participant data meta-analyses identified significant heterogeneity. The results of the simulation suggested that in terms of heterogeneity, the method of standardization played a smaller role than did different effect sizes across populations and differential confounding of the outcome measure across studies. Although there was general consistency between the 2 types of standardization methods, the simulations identified a number of sources of heterogeneity, some of which are not the usual sources considered by researchers.

journal_name

Am J Epidemiol

journal_title

American journal of epidemiology

authors

Griffith LE,van den Heuvel E,Raina P,Fortier I,Sohel N,Hofer SM,Payette H,Wolfson C,Belleville S,Kenny M,Doiron D

doi

10.1093/aje/kww098

subject

Has Abstract

pub_date

2016-11-15 00:00:00

pages

770-778

issue

eissn

0002-9262

issn

1476-6256

pii

kww098

journal_volume

184

pub_type

杂志文章

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Comparison of Standardization Methods for the Harmonization of Phenotype Data: An Application to Cognitive Measures.