Abstract:
:Familial resemblance in the blood pressure response to sodium restriction in normotensive persons was investigated. Forty-four families of identical twin children participated in a sodium restriction (less than or equal to 75 meq/day) protocol for a period of 12 weeks. Subjects were residents of central Indiana, and the study was conducted over a three-year period. Parent-offspring and sibling-sibling resemblances for actual blood pressure were not different under conditions of ad lib sodium intake versus sodium restriction. Mother-offspring resemblance in blood pressure change with sodium restriction was significant for systolic (p less than 0.001), diastolic (p less than 0.05), and mean arterial (p less than 0.05) pressures. Sibling-sibling and twin-twin resemblances were also highly significant for the change in all three blood pressures. Father-offspring resemblances were marginal (p less than 0.10). This study is, to the author's knowledge, the first to demonstrate significant familial resemblances in blood pressure change with sodium restriction in normotensive persons.
journal_name
Am J Epidemioljournal_title
American journal of epidemiologyauthors
Miller JZ,Weinberger MH,Christian JC,Daugherty SAdoi
10.1093/oxfordjournals.aje.a114719subject
Has Abstractpub_date
1987-11-01 00:00:00pages
822-30issue
5eissn
0002-9262issn
1476-6256journal_volume
126pub_type
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