The effects of administration of the Lactobacillus gasseri strain CP2305 on quality of life, clinical symptoms and changes in gene expression in patients with irritable bowel syndrome.

Abstract:

AIMS:To clarify the effects of Lactobacillus gasseri CP2305 (CP2305) on quality of life and clinical symptoms and its functional mechanisms in patients with irritable bowel syndrome (IBS). METHODS AND RESULTS:After the patients were administered CP2305 daily for 4 weeks, the IBS-severity index score was significantly improved compared with that of the placebo group, and this improvement was accompanied by a reduction in health-related worry and changes in intestinal microbiota. The gene expression profiling of the peripheral blood leucocytes showed that CP2305 treatment significantly up-regulated genes related to eukaryotic initiation factor 2 (EIF2) signalling. Eighty-two genes were down-regulated in IBS patients compared with healthy controls. The expression of 23 of these genes exhibited a CP2305-dependent increase associated with an improvement in IBS severity. The majority of the restored genes were related to EIF2 signalling. CONCLUSIONS:CP2305 administration is a potential candidate therapeutic option for patients with IBS. SIGNIFICANCE AND IMPACT OF THE STUDY:Although probiotics have been proposed to benefit IBS patients, objective clinical evidence and elucidation of the functional mechanism remain insufficient. Our study demonstrated that CP2305 administration beneficially influences IBS patients in both subjective and objective evaluations, and gene expression profiling provided insights into the functional mechanism.

journal_name

J Appl Microbiol

authors

Nobutani K,Sawada D,Fujiwara S,Kuwano Y,Nishida K,Nakayama J,Kutsumi H,Azuma T,Rokutan K

doi

10.1111/jam.13329

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

212-224

issue

1

eissn

1364-5072

issn

1365-2672

journal_volume

122

pub_type

临床试验,杂志文章
  • UV-B radiation reduces in vitro germination of Metarhizium anisopliae s.l. but does not affect virulence in fungus-treated Aedes aegypti adults and development on dead mosquitoes.

    abstract:AIMS:Control of diurnal Aedes aegypti with mycoinsecticides should consider the exposure of fungus-treated adults to sunlight, and especially to UV-B radiation that might affect activity of conidia applied on the mosquito's surface. METHODS AND RESULTS:Germination of Metarhizium anisopliae s.l. IP 46 conidia on SDAY m...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.13309

    authors: Falvo ML,Pereira-Junior RA,Rodrigues J,López Lastra CC,García JJ,Fernandes ÉK,Luz C

    更新日期:2016-12-01 00:00:00

  • Genetic variability of the stolbur phytoplasma vmp1 gene in grapevines, bindweeds and vegetables.

    abstract:AIM:Evaluation of the genetic variability of stolbur phytoplasma infecting grapevines, bindweeds and vegetables, collected in different central and southern Italian regions. MATERIALS AND RESULTS:Phytoplasma isolates belonging to stolbur subgroup 16SrXII-A were subjected to molecular characterization by polymerase cha...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2010.04835.x

    authors: Murolo S,Marcone C,Prota V,Garau R,Foissac X,Romanazzi G

    更新日期:2010-12-01 00:00:00

  • Comparison of Campylobacter jejuni genotypes from dairy cattle and human sources from the Matamata-Piako District of New Zealand.

    abstract:AIMS:To identify the prevalence and types of Campylobacter jejuni carried by dairy cattle and the extent of overlap of these types with those causing disease in humans. METHODS AND RESULTS:Faecal samples from 410 dairy cattle were collected from 36 farms in the Matamata-Piako district in New Zealand. Campylobacter jej...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2008.03863.x

    authors: Gilpin BJ,Thorrold B,Scholes P,Longhurst RD,Devane M,Nicol C,Walker S,Robson B,Savill M

    更新日期:2008-11-01 00:00:00

  • Persistence of Shiga toxin-producing Escherichia coli O26 in various manure-amended soil types.

    abstract:AIMS:To evaluate the behaviour of Shiga toxin-producing Escherichia coli (STEC) O26 strains inoculated in manure-amended soils under in vitro conditions. METHODS AND RESULTS:Four green fluorescent protein (GFP)-labelled STEC O26 strains were inoculated in duplicate (at 10(6) CFU g(-1)) in three different manure-amende...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2007.03532.x

    authors: Fremaux B,Prigent-Combaret C,Delignette-Muller ML,Mallen B,Dothal M,Gleizal A,Vernozy-Rozand C

    更新日期:2008-01-01 00:00:00

  • Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis.

    abstract:AIMS:To improve lincomycin A production and decrease the content of byproduct lincomycin B in an industrial lincomycin-producing strain. METHODS AND RESULTS:The in silico analysis indicated that LmbW could be involved in propylproline biosynthesis of lincomyin A. In this study, we constructed an lmbW deletion mutant a...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.12919

    authors: Pang AP,Du L,Lin CY,Qiao J,Zhao GR

    更新日期:2015-10-01 00:00:00

  • Inhibition of Bacillus licheniformis LMG 19409 from ropy cider by enterocin AS-48.

    abstract:AIMS:To determine the activity of enterocin AS-48 against ropy-forming Bacillus licheniformis from cider. METHODS AND RESULTS:Enterocin AS-48 was tested on B. licheniformis LMG 19409 from ropy cider in MRS-G broth, fresh-made apple juice and in two commercial apple ciders (A and B). Bacillus licheniformis was rapidly ...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2006.02942.x

    authors: Grande MJ,Lucas R,Abriouel H,Valdivia E,Ben Omar N,Maqueda M,Martínez-Cañamero M,Gálvez A

    更新日期:2006-08-01 00:00:00

  • Survival kinetics of faecal bacterial indicators in spent broiler litter composting.

    abstract:AIMS:The objective of this study was to deduce and analyse equations that best describe the behaviour of faecal bacterial indicators and two decomposition parameters during broiler litter composting. Mathematical models were fitted and the order of rate equations were identified. METHODS AND RESULTS:The Levenburg-Marq...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2007.03542.x

    authors: Sobratee N,Mohee R,Driver MF,Mudhoo A

    更新日期:2008-01-01 00:00:00

  • Photobacterium damselae subsp. piscicida responds to antimicrobial peptides through phage-shock-protein A (PspA)-related extracytoplasmic stress response system.

    abstract:AIMS:To investigate whether Photobacterium damselae subsp. piscicida (Phdp) can sense and directly respond to the presence of cationic antimicrobial peptides (AMPs). METHODS AND RESULTS:We performed proteomic methodologies to investigate the responsive proteins of Phdp on exposure to AMP Q6. Proteins significantly alt...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.12672

    authors: Tsai WC,Kuo TY,Lin CY,Lin JC,Chen WJ

    更新日期:2015-01-01 00:00:00

  • Flavanols protect the yeast Saccharomyces cerevisiae against heating and freezing/thawing injury.

    abstract:AIMS:The aim of the study was to check whether two flavanols ((-)-epigallocatechin gallate and (+)-catechin) can ameliorate oxidative stress (OS) accompanying and contributing to the lethal effects of heating (50°C) and freezing-thawing on the yeast Saccharomyces cerevisiae. METHODS AND RESULTS:The flavanols studied i...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.14170

    authors: Naparlo K,Zyracka E,Bartosz G,Sadowska-Bartosz I

    更新日期:2019-03-01 00:00:00

  • Thiol redox state and oxidative stress affect sclerotial differentiation of the phytopathogenic fungi Sclerotium rolfsii and Sclerotinia sclerotiorum.

    abstract:AIMS:To investigate the involvement of oxidative stress and thiol redox state (TRS) in sclerotial differentiation of Sclerotium rolfsii and Sclerotinia sclerotiorum. METHODS AND RESULTS:Oxidative stress in these fungi was assessed by lipid peroxidation, which was higher in comparison with their nonsclerotiogenic count...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2007.03527.x

    authors: Patsoukis N,Georgiou CD

    更新日期:2008-01-01 00:00:00

  • Influence of isomalto-oligosaccharides on intestinal microbiota in rats.

    abstract:AIMS:Isomalto-oligosaccharides (IMO) with α(1 --> 6) and α(1 --> 4) glucosidic linkages are produced by enzymatic conversion of starch. IMO are only partially digestible but data on their influence on intestinal microbiota are limited. It was the aim of this study to investigate the effect of IMO diet on intestinal mic...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2011.04984.x

    authors: Ketabi A,Dieleman LA,Gänzle MG

    更新日期:2011-05-01 00:00:00

  • The survival of Salmonella enterica serovar Typhimurium DT104 and total viable counts on beef surfaces at different relative humidities and temperatures.

    abstract:AIMS:The aim of this study was to investigate changes in Salmonella and total viable count (TVC) survival on beef carcass surfaces stored for 72 h under different combinations of relative humidity (i.e. RH 75% or 96%) and temperature (5 degrees C or 10 degrees C). METHODS AND RESULTS:The influence of low water activit...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2008.03989.x

    authors: Kinsella KJ,Prendergast DM,McCann MS,Blair IS,McDowell DA,Sheridan JJ

    更新日期:2009-01-01 00:00:00

  • Functional analysis of the biosynthetic gene cluster required for immunity and secretion of a novel Lactococcus-specific bacteriocin, lactococcin Z.

    abstract:AIMS:Characterization of the biosynthesis (secretion and immunity) of lactococcin Z. METHODS AND RESULTS:Lactococcin Z is produced by Lactococcus lactisQU 7. DNA sequence analysis revealed that the lactococcin Z gene cluster (c. 5·1 kb) includes four genes encoding putative biosynthetic proteins, LczB (self-immunity p...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.13564

    authors: Daba GM,Ishibashi N,Zendo T,Sonomoto K

    更新日期:2017-11-01 00:00:00

  • Isolation and characterization of antifungal compound from Lactobacillus plantarum KCC-10 from forage silage with potential beneficial properties.

    abstract:AIMS:The purpose of this study was to isolate, identify and characterize an antifungal compound from Lactobacillus plantarum KCC-10 from forage silage with potential beneficial properties. METHODS AND RESULTS:The 16S rRNA gene-based phylogenetic affiliation was determined using bioinformatic tools and identified as La...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.12319

    authors: Valan Arasu M,Jung MW,Ilavenil S,Jane M,Kim DH,Lee KD,Park HS,Hur TY,Choi GJ,Lim YC,Al-Dhabi NA,Choi KC

    更新日期:2013-11-01 00:00:00

  • Isolation of lytic bacteriophage against Vibrio harveyi.

    abstract:AIMS:The isolation of lytic bacteriophage of Vibrio harveyi with potential for phage therapy of bacterial pathogens of phyllosoma larvae from the tropical rock lobster Panulirus ornatus. METHODS AND RESULTS:Water samples from discharge channels and grow-out ponds of a prawn farm in northeastern Australia were enriched...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2009.04578.x

    authors: Crothers-Stomps C,Høj L,Bourne DG,Hall MR,Owens L

    更新日期:2010-05-01 00:00:00

  • Survival of Salmonella enterica subsp. enterica serovar Javiana and Listeria monocytogenes is dependent on type of soil-free microgreen cultivation matrix.

    abstract:AIMS:This study measured the survival of Listeria monocytogenes and Salmonella enterica subsp. enterica serovar Javiana over a 10-day period on four soil-free cultivation matrix (SFCM) types in the absence of microgreens and fertilizers. METHODS AND RESULTS:Coco coir (CC), a Sphagnum peat/vermiculite mix, Biostrate® a...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.14696

    authors: Misra G,Gibson KE

    更新日期:2020-12-01 00:00:00

  • Colonization of peanut roots by biofilm-forming Paenibacillus polymyxa initiates biocontrol against crown rot disease.

    abstract:AIM:To investigate the role of biofilm-forming Paenibacillus polymyxa strains in controlling crown root rot disease. METHODS AND RESULTS:Two plant growth-promoting P. polymyxa strains were isolated from the peanut rhizosphere, from Aspergillus niger-suppressive soils. The strains were tested, under greenhouse and fiel...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2007.03611.x

    authors: Haggag WM,Timmusk S

    更新日期:2008-04-01 00:00:00

  • Identification and characterization of starter lactic acid bacteria and probiotics from Columbian dairy products.

    abstract:AIMS:Considering the significant rise in the probiotic market in Columbia, and given the lack of reports concerning the microbial population and strain performance in products from different producers, this study aims at determining the number of viable starter bacteria and probiotics in bio-yoghurts available at the C...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2007.03294.x

    authors: Perea Vélez M,Hermans K,Verhoeven TL,Lebeer SE,Vanderleyden J,De Keersmaecker SC

    更新日期:2007-09-01 00:00:00

  • Occurrence of Helicobacter pylori in surface water in the United States.

    abstract::The primary mode of transmission of the human pathogen Helicobacter pylori is unresolved. This study examined the possibility that H. pylori is water-borne. Because methods for the direct culture of H. pylori from water samples remain elusive, a microscopic technique was used for detection of this organism. Actively r...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2672.1999.00912.x

    authors: Hegarty JP,Dowd MT,Baker KH

    更新日期:1999-11-01 00:00:00

  • Growth characterization of individual rye sourdough bacteria by isothermal microcalorimetry.

    abstract:AIMS:The present work tests the feasibility of the isothermal microcalorimetry method to study the performance of individual lactic acid bacteria during solid-state fermentation in rye sourdough. Another aim was to elucidate the key factors leading to the formation of different microbial consortia in laboratory and ind...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2010.04904.x

    authors: Mihhalevski A,Sarand I,Viiard E,Salumets A,Paalme T

    更新日期:2011-02-01 00:00:00

  • The influence of nutritional and environmental conditions on the accumulation of poly-beta-hydroxybutyrate in Bacillus mycoides RLJ B-017.

    abstract:AIMS:To optimize the nutritional and environmental conditions for growth of and poly-beta-hydroxybutyrate (PHB) accumulation in Bacillus mycoides RLJ B-017. METHODS AND RESULTS:An isolate, identified as B. mycoides, was grown on different sources of carbon and nitrogen. Among these, sucrose, beef extract and di-ammoni...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2672.2002.01590.x

    authors: Borah B,Thakur PS,Nigam JN

    更新日期:2002-01-01 00:00:00

  • CodY, ComA, DegU and Spo0A Controlling Lipopeptides Biosynthesis in Bacillus amyloliquefaciens fmbJ.

    abstract:AIM:In the study, we investigated the regulatory effects of these genes (codY, comA, degU and spo0A) on the biosynthesis of three lipopeptides (bacillomycin D, fengycin and surfactin) in Bacillus amyloliquefaciens. METHODS AND RESULTS:The codY, comA, degU and spo0A genes in B. amyloliquefaciens fmbJ were knocked out. ...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.15007

    authors: Sun J,Liu Y,Lin F,Lu Z,Lu Y

    更新日期:2021-01-18 00:00:00

  • Efficacy of liquid spray decontaminants for inactivation of Bacillus anthracis spores on building and outdoor materials.

    abstract:AIMS:To obtain data on the efficacy of various liquid and foam decontamination technologies to inactivate Bacillus anthracis Ames and Bacillus subtilis spores on building and outdoor materials. METHODS AND RESULTS:Spores were inoculated onto test coupons and positive control coupons of nine different materials. Six di...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2011.04980.x

    authors: Wood JP,Choi YW,Rogers JV,Kelly TJ,Riggs KB,Willenberg ZJ

    更新日期:2011-05-01 00:00:00

  • Biodegradation of ochratoxin A by Alcaligenes faecalis isolated from soil.

    abstract:AIMS:The aim of this study is to report on the hydrolytic action of Alcaligenes faecalis isolated from soil samples and its ability to degrade ochratoxin A. METHODS AND RESULTS:An A. faecalis strain was identified and characterized by employing both a phenotypic analysis and 16S rDNA sequence analysis. The results sho...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.13537

    authors: Zhang HH,Wang Y,Zhao C,Wang J,Zhang XL

    更新日期:2017-09-01 00:00:00

  • Purification and characterization of a feruloyl esterase from the fungus Penicillium expansum.

    abstract::An extracellular phenolic acid esterase produced by the fungus Penicillium expansum in solid state culture released ferulic and rho-coumaric acid from methyl esters of the acids, and from the phenolic-carbohydrate esters O-[5-O-(trans-feruloyl)-alpha-L-arabinofuranosyl]-(1-->3)-O-beta- D-xylopyranosyl-(1-->4)-D-xylopy...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2672.1997.00307.x

    authors: Donaghy J,McKay AM

    更新日期:1997-12-01 00:00:00

  • Application of deep neural techniques in predictive modelling for the estimation of Escherichia coli growth rate.

    abstract:AIMS:To develop a predictive model for Escherichia coli using deep neural networks. METHODS AND RESULTS:Batch experiments are conducted at different temperatures closer to optimum value (36·5°C, 37°C, 37·5°C, 38°C and 38·5°C) to obtain the growth curves of E .coli K-12. Two primary models namely modified Gompertz and ...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.14901

    authors: Chitra M,Sutha S,Pappa N

    更新日期:2020-10-16 00:00:00

  • Comparative typing of Pseudomonas species isolated from the aquatic environment in Greece by SDS-PAGE and RAPD analysis.

    abstract:AIMS:Three broadly used typing methods were employed in order to assess and compare the identification and classification of environmental Pseudomonas strains. The reproducibility, typeability and discriminatory power of the methods were also compared to evaluate their application. Finally, the potential impact on publ...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2005.02691.x

    authors: Sazakli E,Leotsinidis M,Vantarakis A,Papapetropoulou M

    更新日期:2005-01-01 00:00:00

  • In vitro activity of antimicrobial-impregnated catheters against biofilms formed by KPC-producing Klebsiella pneumoniae.

    abstract:AIM:To evaluate the activity and effectiveness of impregnated central venous catheters (CVC) against Klebsiella pneumoniae biofilms. METHODS AND RESULTS:The antimicrobial activity and durability of impregnated-CVCs were evaluated over time and the size of zones of inhibition (ZI) was measured. Biofilm formation was ob...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/jam.14372

    authors: de Sousa JKT,Haddad JPA,de Oliveira AC,Vieira CD,Dos Santos SG

    更新日期:2019-10-01 00:00:00

  • Kinetics of carbon sharing in a bacterial consortium revealed by combining stable isotope probing with fluorescence-activated cell sorting.

    abstract:AIMS:  To determine the kinetics of substrate fluxes in a microbial community in order to elucidate the roles of the community members. METHODS AND RESULTS:  The kinetics of substrate sharing in a bacterial consortium were measured by a new analytical approach combining immunostaining, stable isotope probing and fluor...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2011.04964.x

    authors: Pawelczyk S,Bumann D,Abraham WR

    更新日期:2011-04-01 00:00:00

  • Components derived from Pelargonium stimulate macrophage killing of Mycobacterium species.

    abstract:AIMS:To determine the capacity of extracts of Pelargonium reniforme and Pelargonium sidoides, plants of the Geraniaceae family, to stimulate the uptake and killing of mycobacteria by murine macrophages and to identify the constituents that are responsible. METHODS AND RESULTS:Bioassay-guided fractionation of aqueous P...

    journal_title:Journal of applied microbiology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2672.2008.04085.x

    authors: Kim CE,Griffiths WJ,Taylor PW

    更新日期:2009-04-01 00:00:00