Abstract:
:Properly performed, biomarker discovery can lead to effective candidates that can ultimately serve as predictors of disease, medical condition, define therapeutic parameters, and many other applications in medicine. Preferably, biomarkers comprise a panel of indicators, e.g. proteins and/or peptides that can be predictive or diagnostic of the medical condition of interest. Emphasis here is placed on "panel," as single candidates are rarely sufficient to provide the necessary sensitivity and specificity. To develop an effective panel that survives the development process described in Chap. 19 , proper experimental design and attention to important statistical parameters are critical to ensure success. Errors in discovery can lead to an inefficient use of expensive resources, as these may not be uncovered until the latter stages in biomarker development. Hence, accuracy, precision, and an estimate of the power of the proposed analyses are critical in the discovery of the panel of candidate biomarkers by proteomic methods, as is the selection of statistical approaches to refine and appropriately reduce the dataset for subsequent confirmatory assays.
journal_name
Adv Exp Med Bioljournal_title
Advances in experimental medicine and biologyauthors
Wiktorowicz JE,Soman KVdoi
10.1007/978-3-319-41448-5_21subject
Has Abstractpub_date
2016-01-01 00:00:00pages
443-462eissn
0065-2598issn
2214-8019journal_volume
919pub_type
杂志文章,评审abstract::The primary goal of this project was to elucidate the spatial pattern of capillaries in three hamster striated muscles according to statistical techniques of pattern analysis. The spatial pattern of capillaries and traditional measures of capillarity are important to understanding the supply and distribution of oxygen...
journal_title:Advances in experimental medicine and biology
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更新日期:2020-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1993-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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更新日期:2010-01-01 00:00:00